Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

sigH from Mycobacterium tuberculosis H37Ra

Victor ID 1883
Gene Name sigH from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214150
NCBI Protein GI 148663085
Locus Tag MRA_3263
Protein Accession YP_001284608.1
Other Database IDs UniProtKB-ID: A5U7P6_MYCTA
UniRef100: UniRef100_P66808
UniRef90: UniRef90_P66808
UniRef50: UniRef50_P66808
UniParc: UPI0000033263
EMBL: CP000611
EMBL-CDS: ABQ75046.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000065584.
EnsemblGenome_TRS: EBMYCT00000065589
EnsemblGenome_PRO: EBMYCP00000063699
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3263
eggNOG: COG1595
HOGENOM: HBG753452
OMA: GAALRMT
ProtClustDB: PRK09652
BioCyc: MTUB419947:MRA_3263-MONOMER
Taxonomy ID 419947
Gene Starting Position 3609683
Gene Ending Position 3610333
Gene Strand (Orientation) -
Protein Name RNA polymerase sigma factor RpoE
DNA Sequence 
>gi|148659757:3609683-3610333 Mycobacterium tuberculosis H37Ra, complete genome
CTCATGACGACACCCCCTCGTGCGCCTGCTCGCCCCTGGCAAACCCCCGATCCCTGGCCACATCGGCTAA
AAGACCGCGCAACTGACGTCGGCCGCGATGAAGCCTCGACATCACGGTGCCGATCGGAGTATCCATGATC
TCGGCGATCTCCTTGTAGGGGAAACCTTCGACATCGGCGTAGTAGACCGCCATCCGGAACTCTTCCGGCA
ATGCCTGCAGCGCCTCTTTGATCTCGGTGTCCGGCAACGCTTCTAACGCTTCGACTTCAGCCGAGCGCAG
CCCGGTCGAGGAATGCTCGGCGTTGGACGCCAGTTGCCAATCGGTGATCTGCTCGGTCGGATACTCCGCC
GGTTGCCGCTGTTTCTTGCGATAGCTGTTGATGTAGGTGTTGGTCAGTATCCGGTAGAGCCAGGCCTTGA
GATTGGTACCGTGCCGGAACGAACGAAATCCCGCATAGGCCTTCACCATCGTCTCCTGGAGCAAGTCCTC
GGCGTCGGCCGGATTGCGCGTCATCCGCAGCGCACCGCCGTACAGCTGGTCCAACAGGGGAATCGCGTCG
CGCTCGAAACGCGCGGTCAACTCCTCGTCTGTCTCCTCAGACGGCCCAGGCTGCAGACCCGCCGAACCGG
TTACACCATCGATGTCGGCCA
Protein Sequence 
>gi|148663085|ref|YP_001284608.1| RNA polymerase sigma factor RpoE [Mycobacterium tuberculosis H37Ra] MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sigH mutant has diminished immunopathology and is nonlethal in mice (Kaushal et al., 2002).
COG COG1595K, under K: Transcription
References
Kaushal et al., 2002: Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, Carpenter L, Mehrotra J, Manabe YC, Fleischmann RD, Bishai WR. Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(12); 8330-8335. [PubMed: 12060776].