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prrA from Mycobacterium tuberculosis H37Ra

Victor ID 1886
Gene Name prrA from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214363
NCBI Protein GI 148660681
Locus Tag MRA_0910
Protein Accession YP_001282204.1
Other Database IDs UniProtKB-ID: A5U0U2_MYCTA
UniRef100: UniRef100_P0A5Z7
UniRef90: UniRef90_P0A5Z7
UniRef50: UniRef50_P0A5Z7
UniParc: UPI00000D1227
EMBL: CP000611
EMBL-CDS: ABQ72642.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000065844.
EnsemblGenome_TRS: EBMYCT00000065849
EnsemblGenome_PRO: EBMYCP00000063959
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0910
eggNOG: COG0745
HOGENOM: HBG753323
OMA: VDDRISG
ProtClustDB: CLSK790822
BioCyc: MTUB419947:MRA_0910-MONOMER
Taxonomy ID 419947
Gene Starting Position 1007158
Gene Ending Position 1007868
Gene Strand (Orientation) -
Protein Name two component response transcriptional regulatory protein PrrA
DNA Sequence 
>gi|148659757:1007158-1007868 Mycobacterium tuberculosis H37Ra, complete genome
GTCACTGCATACGCAGCACGAATCCGACTCCGCGGACGGTATGCAGCAGCCTAGGGCCACCGCCGGCCTC
CAGTTTGCGCCGCAGGTACCCGATGAAGACGTCCACCACGTTGGTGTCGGCGGCGAAGTCGTAGCCCCAC
ACCAATTCCAGGAGTTGCGCTCGGGAGAGCACCGCGGTCTTGTGCTCGGCCAGCACCGCGAGCAGGTCGA
ATTCGCGCTTGGTCAGGTCGACGTCGACGCCGTTGACCCGGGCCCGCCGGCCGGGGATGTCCACCTCCAG
CGGGCCCACCGTGATGGTTTCCGAGGACGACGTTGCAGTGGAGCCGCGGCGGCGCAGCAGCGCCTTCACC
CGTGCCACCAGCTCGGCCAGCACGAACGGTTTCACCAGGTAATCGTCGGCGCCGGCCTCCAATCCGGCCA
CTCGGTCATCGACAGAGCTGCGTGCGGATAGCACACAGACCGGGACGTCGTTGTCCATCGCGCGTAGTGC
CGTCACGACGCTGACTCCATCGAGCACTGGCATGTTGATGTCGAGCACGATCGCGTCCGGCCGGTTCTCG
GTGGCGCTGCGCAAGGCCTCGGCGCCGTCCACCGCGGTCGCTACCTCGAATCCGGACAGCCGTAAGCCGC
GTTCCAGCGAGGCGAGCACATCGGAGTCGTCGTCGACGACCAACACCCGAGGTGAGGTCACACCAGTGTC
CATGCCGCCCA
Protein Sequence 
>gi|148660681|ref|YP_001282204.1| two component response transcriptional regulatory protein PrrA [Mycobacterium tuberculosis H37Ra] MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: prrA mutant is attenuated in murine macrophages (Ewann et al., 2002).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Ewann et al., 2002: Ewann F, Jackson M, Pethe K, Cooper A, Mielcarek N, Ensergueix D, Gicquel B, Locht C, Supply P. Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis. Infection and immunity. 2002; 70(5); 2256-2263. [PubMed: 11953357].