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trpD from Mycobacterium tuberculosis H37Ra

Victor ID 1868
Gene Name trpD from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212696
NCBI Protein GI 148662009
Locus Tag MRA_2208
Protein Accession YP_001283532.1
Other Database IDs UniProtKB-ID: TRPD_MYCTA
UniRef100: UniRef100_A1KKN4
UniRef90: UniRef90_A1KKN4
UniRef50: UniRef50_A1KKN4
UniParc: UPI000013758F
EMBL: CP000611
EMBL-CDS: ABQ73970.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000065723
EnsemblGenome_TRS: EBMYCT00000065728
EnsemblGenome_PRO: EBMYCP00000063838
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2208
eggNOG: COG0547
HOGENOM: HBG559996
OMA: LGVYSPE
ProtClustDB: PRK00188
BioCyc: MTUB419947:MRA_2208-MONOMER
Taxonomy ID 419947
Gene Starting Position 2465532
Gene Ending Position 2466644
Gene Strand (Orientation) -
Protein Name anthranilate phosphoribosyltransferase
DNA Sequence 
>gi|148659757:2465532-2466644 Mycobacterium tuberculosis H37Ra, complete genome
GTCAGATCTGCCGACCGAACCGCACCCATCGCGCGAGCAACTGTTCGGCCGCACCGGTGTCGATTGCCGC
ACTGGCCCGCCGCAACCCCTCCTCCCAGGCCGGCAGCCATTCAGCACGGCTGGATAATCCGGCGTGGGCG
ACGATCGCACCGGCGGCGTTGAGCACCACAGCGTCCCGGACCGGGCCCCTGGCACCGCCCAACACCGCGC
GCACCGCGGCCGCGTTGGCTTGCGCATCGCCTCCAGCCAGCTGGTCAAGCTGGGCGCGCGCAAACCCGAA
TCCGGCGGGATCAAACGTCAACTTATCCACGCTGCCCGCCGCAACGCGCCAGATCGTGCTCGTGGTGGTG
GTGGTCAACTCGTCCAGCCCATCGTCGCCGTGTACCACCAGCACACTGGACCGGCGCGCAGCAAACACCC
CGGCCATCACTTCGGCGAGGTCGGCGAACGCGCATCCGATCAGTCCAGCCCGGGGCCGGGCCGGATTGGT
CAGCGGCCCGAGAAGATTGAACACGGTGGGCACACCGATCTCGCGGCGTACCGCGGCCGCGTGCCGGTAG
GAGGGATGGAACCGCGGCGCGAAGCAGAACCCGATCCCAACCTCCGCGAGGCTGCGCGCGACCAGGTCGG
GTCCCAGGTCGATGCGCACCCCCAGCGCCTCCAGCGTGTCGGCGCCACCGGACAACGAGGACGCCGCTCG
GTTGCCGTGCTTGACCACCGGCACACCCGCAGCCGCCACCACAATCGCCGCCATGGTGGATAGGTTCACC
GTGTTGACTCCGTCGCCACCGGTGCCGACGACGTCGACGGCGTCGTCGGGGACCGTATCGGCGGGCAACG
GATGCGCGTGGCTGAGCATGACGCCAGCGAGCTCACCGACTTCGTCGGCGGTCGGAGCCTTCATCGTCAT
CGCCACCGCGAAGGCGGCGATCTGCGCCGGCCGCGCATTGCCGGTCATGATCTGGTCCATGGCCCAGGCA
GCCTGGCCCCGCGCCAGATCGCGGTTGTCGGTCAACCGCCCCAAAATCTGCGGCCAGGACGGCACCGATG
CGGCTTCTGCTTTCGGCGAGCCCCCGCGAGATCCCCCCGAAGAACCCTCAGCTGACAGCGCCA
Protein Sequence 
>gi|148662009|ref|YP_001283532.1| anthranilate phosphoribosyltransferase [Mycobacterium tuberculosis H37Ra] MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: trpD mutant is attenuated in mice (Smith et al., 2001).
COG COG0547E, under E: Amino acid transport and metabolism
References
Smith et al., 2001: Smith DA, Parish T, Stoker NG, Bancroft GJ. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infection and immunity. 2001; 69(2); 1142-1150. [PubMed: 11160012].