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pknG from Mycobacterium tuberculosis H37Ra

Victor ID 1885
Gene Name pknG from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214250
NCBI Protein GI 148660175
Locus Tag MRA_0416
Protein Accession YP_001281698.1
Other Database IDs UniProtKB-ID: A5TZD6_MYCTA
UniRef100: UniRef100_P65729
UniRef90: UniRef90_P65729
UniRef50: UniRef50_P65729
UniParc: UPI0000131B7D
EMBL: CP000611
EMBL-CDS: ABQ72136.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000064933.
EnsemblGenome_TRS: EBMYCT00000064938
EnsemblGenome_PRO: EBMYCP00000063048
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0416
eggNOG: COG0515
HOGENOM: HBG483125
OMA: HRYALVD
ProtClustDB: CLSK790502
BioCyc: MTUB419947:MRA_0416-MONOMER
Taxonomy ID 419947
Gene Starting Position 496371
Gene Ending Position 498623
Gene Strand (Orientation) -
Protein Name serine/threonine protein kinase
DNA Sequence 
>gi|148659757:496371-498623 Mycobacterium tuberculosis H37Ra, complete genome
CTTAGAACGTGCTGGTGGGCCGGACCTTGTTGGCCATGTCCACCAGCGTGTAGCGATGCCGTTGAGTGGG
AGCTACCCGGGCCAGGCTGCGCAGTGACGCCTCGACACCCAGCCGCAGCCCGTGACTGGTGAACGGGAAA
CCGAGGATGTGGTTGGTGCTGGCCTTGTTGTCCTTCAGCCAGTCCAGCGCGCCACCCAGCACCAGGGCGC
GGATCTGCAGCACGCGTGGTTCGGTCGGGGGCAGCGCCTCCACTCTTCGGGCGGCGTCGCGGATCTGTTC
CTCGGTGACTTCACTCGTTGACCGGCCGGACAACAGAGTCACCGCGCTGGTCAGCCGTGCCGTGGTGAAA
TGCCGAGAAGTGGGCGGTACCTCGTCGAGCGTGCGCACGGCGCCGACCCGATCACCTTCGGCCGACCGGG
CTCTGGCCAGTCCGAAAGCCGCCGAGATCACGCCGTCGTTGGTGCTCCACACCGTCTGATAGAACTTGTG
TTCGTCGGTGTTGCCGGCTAGTTCGGCGGTGGCGGCCAGGGCGAGCTTGGGCGCCAGCTCGCCGGGAAAG
GTATCCAGCACCTCGGTGAAATGTTTGGTGGCCGAGTCATAGTCGCCGGTGAGCAGCTCGGCGACGGCCC
GGTACCAGACCAATCGCCATCGCCAGCCAACGCGTTCGGCCAGATCGTCGAGTTTTCGGGTGGCCTTGGC
CACATCGCCGAGATCCAGCAGCGCGCGGACTTCCATTAGCGGCAGCTCCACTGACTCGGAGAAGTCGACG
CCGTCGGCGTCCAGCGCACCGTGGCGGGCCGCGCGCAGCGAGTCTAGGGTCTGCACCGGCTGGGAGAGCA
CCGTGGCCTGCAGGACCGAAGCTGCGACGTCGGTCGGATCGACCAGCGGCACCGACAGCGCGGTCACGAT
CTCGTTGGCGGTCAGCTTCTCCGCGTGCACCTGCCCGTCCAGATACACGTCGGTGTGCGCCACCAGCAGG
TCCACTCCAAATGTCGACCGACTGGGACTGAAGATCGTTGATAGCCCTGGCCGCGGCACCCCGGTGTCCT
GGGCGACCACCTCCCGCAACACGCCCGTCAATTGCGCGGACATCTCTTCGGCGGTGGTGAACCGTTGCCG
CGGATCGGGGTCGATGGCCCTGCGCAGCAACCGGCCGTAAGAGTCGTAGGTTTTCAGCACCGGGTCGTCT
TCGGGTAGCCCATCCACATAACGGCCATTGCGGGTGGGCAGGTCCAGCGTGAGCGCCGCGAGCGTGCGTC
CCACGGTGTAGATGTCGGTGGCCACCGTCGGACCGGTCCGCACGATCTCGGGCGCCTGGAAGCCTGGGGT
CCCGTAGAGGTAGCCGAACGAGTTGATCCGCGATACCGCGCCCAGGTCGATCAGCTTGAGCTGTTCCTCG
GTCAGCATGATGTTTTCCGGCTTCAGGTCGTTGTAGACCAAGCCGATGGAATGCAGGTAGCTCAGCGCCG
GCAGGATCTCCAGCAGGTAGGCGATGGCCTCCGCGACGGGCAGTTTCTGACCCTTGCTGCGTTTGAGCGA
TTGCCCGCCGACGTATTCCATCACGATGTAGCCGACCGGATCCCCGTGCCTGTCGGTGTGCTCGACAAAG
TTGAAGATCTGCACGATCGACGGGTGCACCACCTCGGCCAGGAACTGGCGTTCGGCCATCGCCATTGCCT
GCGCTTCGGCATCACCGGAATGCACCAGGCCCTTGAGCACCACCGGACGGCCGTTGACATTGCGGTCGAG
AGCGAGGTAGATCCAGCCCAGTCCGCCGTGCGCGATGCAGCCTTTGACCTCGTACTGGCCGGCGACGATG
TCCCCGGGATTTAGCTGCGGCAGGAACGAATACGGGCTGCCGCAATAGGGACACCAGCCCTCTGAAGCTC
CCTTGGTCTCCGAGTCGGACCGGCCGACGGGACGTCCACAGTTCCAGCAGAACCGCTTGGACTCCGGCAC
CACCGGGTTGGTCATCAGGGCCTCAAGCGGATCGATATCGGGCGCCCGCGGGATTTCCACCAGGCCGCCG
CCCAGCCGTCTGACCGGCGGGCGCACCCGGCTGGTGGTGGCCATCCGGTCTTGCGGCTCGGTGTCCGGGC
CGAGCGTCGGATGGGGGAAGTTGTCCTCATCGCCGAAATCGGGGCGGAACACCGCCTGGGTGCTCAGGGG
TCGAACCGTCGCGGACGTCGCGGTCTGGGCGTCCGCCGGTTGGGTGCCGGGGCCCGAACGTTCGGTCTCT
GACGCTTTGGCCA
Protein Sequence 
>gi|148660175|ref|YP_001281698.1| serine/threonine protein kinase [Mycobacterium tuberculosis H37Ra] MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pknG mutant is attenuated in mice (Cowley et al., 2004).
COG COG0515RTKL, under R: General function prediction only; T: Signal transduction mechanisms; K: Transcription; L: Replication, recombination and repair
References
Cowley et al., 2004: Cowley S, Ko M, Pick N, Chow R, Downing KJ, Gordhan BG, Betts JC, Mizrahi V, Smith DA, Stokes RW, Av-Gay Y. The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Molecular microbiology. 2004; 52(6); 1691-1702. [PubMed: 15186418].