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senX3 from Mycobacterium tuberculosis CDC1551

Victor ID 66
Gene Name senX3 from Mycobacterium tuberculosis CDC1551
Sequence Strain (Species/Organism) Mycobacterium tuberculosis CDC1551
NCBI Gene ID 923873
NCBI Protein GI 15839881
Locus Tag MT0509
Protein Accession NP_334918.1
Other Database IDs UniProtKB-ID: SENX3_MYCTU
UniRef100: UniRef100_P0A601
UniRef90: UniRef90_P0A601
UniRef50: UniRef50_A0QR01
UniParc: UPI000013589E
EMBL: Y13628
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: CAA73957.1
EMBL-CDS: CAB00951.1
EMBL-CDS: AAK44732.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000000454
EnsemblGenome_TRS: EBMYCT00000000454
EnsemblGenome_PRO: EBMYCP00000000454
EnsemblGenome: EBMYCG00000070594
EnsemblGenome_TRS: EBMYCT00000070599
EnsemblGenome_PRO: EBMYCP00000068658
Genom
Taxonomy ID 83331
Gene Starting Position 580738
Gene Ending Position 581970
Gene Strand (Orientation) +
Protein Name sensor histidine kinase SenX3
DNA Sequence 
>gi|50953765:580738-581970 Mycobacterium tuberculosis CDC1551, complete genome
TGTGACTGTGTTCTCGGCGCTGTTGCTGGCCGGGGTTTTGTCCGCGCTGGCACTGGCCGTCGGTGGTGCT
GTTGGAATGCGGCTGACGTCGCGGGTCGTCGAACAGCGCCAACGGGTGGCCACGGAGTGGTCGGGAATCA
CGGTTTCGCAGATGTTGCAATGCATTGTCACGCTGATGCCGCTGGGCGCCGCGGTGGTGGACACCCATCG
CGACGTTGTCTACCTCAACGAACGGGCCAAAGAGCTAGGTCTGGTGCGCGACCGCCAGCTCGATGATCAG
GCCTGGCGGGCCGCCCGGCAGGCGCTGGGTGGTGAAGACGTCGAGTTCGACCTGTCGCCGCGCAAGCGGT
CGGCCACGGGTCGATCCGGGCTATCAGTGCATGGGCATGCCCGGTTGCTGAGCGAGGAAGACCGCCGGTT
CGCCGTGGTGTTCGTGCACGACCAGTCGGATTATGCGCGGATGGAGGCGGCTAGGCGTGACTTCGTGGCC
AACGTCAGTCACGAGCTCAAGACGCCCGTCGGTGCCATGGCTCTACTCGCCGAGGCGCTGCTGGCGTCGG
CCGACGACTCCGAAACCGTTCGGCGGTTCGCCGAGAAGGTGCTCATTGAGGCCAACCGGCTCGGTGACAT
GGTCGCCGAGTTGATCGAGCTATCCCGGCTACAGGGCGCCGAGCGGCTACCCAATATGACCGACGTCGAC
GTCGATACGATTGTGTCGGAAGCGATTTCACGCCATAAGGTGGCGGCCGACAACGCCGACATCGAAGTCC
GCACCGACGCGCCCAGCAATCTGCGGGTGCTGGGCGACCAAACTCTGCTGGTTACCGCACTGGCAAACCT
GGTTTCCAATGCGATTGCCTATTCGCCGCGCGGGTCGCTGGTGTCGATCAGCCGTCGCCGTCGCGGTGCC
AACATCGAGATCGCCGTCACCGACCGGGGCATCGGCATCGCGCCGGAAGACCAGGAGCGGGTCTTCGAAC
GGTTCTTCCGGGGGGACAAGGCGCGCTCGCGTGCCACCGGAGGCAGCGGACTCGGGTTGGCCATCGTCAA
ACACGTCGCGGCTAATCACGACGGCACCATCCGCGTGTGGAGCAAACCGGGAACCGGGTCAACGTTCACC
TTGGCTCTTCCGGCGTTGATCGAGGCCTATCACGACGACGAGCGACCCGAGCAGGCGCGAGAGCCCGAAC
TGCGGTCAAACAGGTCACAACGAGAGGAAGAGCTGAGCCGATG
Protein Sequence 
>gi|15839881|ref|NP_334918.1| sensor histidine kinase SenX3 [Mycobacterium tuberculosis CDC1551] MTVFSALLLAGVLSALALAVGGAVGMRLTSRVVEQRQRVATEWSGITVSQMLQCIVTLMPLGAAVVDTHRDVVYLNERAKELGLVRDRQLDDQAWRAARQALGGEDVEFDLSPRKRSATGRSGLSVHGHARLLSEEDRRFAVVFVHDQSDYARMEAARRDFVANVSHELKTPVGAMALLAEALLASADDSETVRRFAEKVLIEANRLGDMVAELIELSRLQGAERLPNMTDVDVDTIVSEAISRHKVAADNADIEVRTDAPSNLRVLGDQTLLVTALANLVSNAIAYSPRGSLVSISRRRRGANIEIAVTDRGIGIAPEDQERVFERFFRGDKARSRATGGSGLGLAIVKHVAANHDGTIRVWSKPGTGSTFTLALPALIEAYHDDERPEQAREPELRSNRSQREEELSR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: senX3-regX3 deletion mutant is attenuated in mice (Parish et al., 2003).
COG COG5002T, under T: Signal transduction mechanisms
References
Parish et al., 2003: Parish T, Smith DA, Roberts G, Betts J, Stoker NG. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, England). 2003; 149(Pt 6); 1423-1435. [PubMed: 12777483].