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leuD from Mycobacterium tuberculosis H37Rv

Victor ID 296
Gene Name leuD from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888225
NCBI Protein GI 15610124
Locus Tag Rv2987c
Protein Accession NP_217503.1
Other Database IDs UniProtKB-ID: LEUD_MYCTU
UniRef100: UniRef100_A1KMY1
UniRef90: UniRef90_A1KMY1
UniRef50: UniRef50_A0ZZS8
UniParc: UPI000012E58F
EMBL: BX842581
EMBL: AE000516
EMBL-CDS: CAA16072.1
EMBL-CDS: AAK47394.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 3H5E
PDB: 3H5H
PDB: 3H5J
EnsemblGenome: EBMYCG00000003651
EnsemblGenome_TRS: EBMYCT00000003653
EnsemblGenome_PRO: EBMYCP00000003653
EnsemblGenome: EBMYCG00000069102
EnsemblGenome_TRS: EBMYCT00000069107
EnsemblGenome_PRO: EBMYCP00000067166
GenomeRevi
Taxonomy ID 83332
Gene Starting Position 3344032
Gene Ending Position 3344628
Gene Strand (Orientation) -
Protein Name isopropylmalate isomerase small subunit
DNA Sequence 
>gi|57116681:3344032-3344628 Mycobacterium tuberculosis H37Rv, complete genome
CTCAGGGGGCGGGTAGAGTGCGCGGTTTCCAGTACGCGCACGCACCCTCAAAGGCCTCGATCTCGTCGAG
TTTCCGCAGCGTAAGGGCTATATCGTCGAGACCTTCAAGCAGCCGCCACGCCGAGTGGTCGTCAATCTTG
AACGGCAGCACCACTGTTGCTGCGGTGATAATTCGATCTTGAAGATTGGCAGTGATTTCCAGGCCCGGAC
TCTGCTCAATGAGCTTCCACAGGAGTTCCACATCGTCTTGGGCAACCTCGGCCGCCAGCAGCCCGGCCTT
GCCCGCGTTGCCGCGGAAAATGTCACCAAATCGGGATGAGATAACCACCCGGAATCCGTAGTCCATGAGC
GCCCAGACCGCATGCTCTCGCGAGGATCCGGTGCCGAAATCGGGCCCGGCAACCAGGACCGAACCCCGGT
CAAAGGGACTGAGGTTTAGCACGAATGCAGGATCCGACCGCCAACCCGCGAACAAGCCGTCCTCGAAACC
GGTTCGGGTGACCCGCTTCAGAAAGACCGCGGGAATGATCTGATCGGTGTCGACATTGGACCGCCGCAAC
GGCACGCCAATACCAGAGTGGGTGTGAAAGGCTTCCA
Protein Sequence 
>gi|15610124|ref|NP_217503.1| 3-isopropylmalate dehydratase small subunit [Mycobacterium tuberculosis H37Rv] MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDPAFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDIFRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVVLPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: leuD mutant is attenuated in mice (Hondalus et al., 2000).
COG COG0066E, under E: Amino acid transport and metabolism
References
Hondalus et al., 2000: Hondalus MK, Bardarov S, Russell R, Chan J, Jacobs WR Jr, Bloom BR. Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infection and immunity. 2000; 68(5); 2888-2898. [PubMed: 10768986].