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pcaA from Mycobacterium tuberculosis H37Rv

Victor ID 175
Gene Name pcaA from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886284
NCBI Protein GI 57116736
Locus Tag Rv0470c
Protein Accession YP_177730.1
Other Database IDs UniProtKB-ID: CMAS3_MYCTU
UniRef100: UniRef100_Q7D9R5
UniRef90: UniRef90_Q7D9R5
UniRef50: UniRef50_A5U029
UniParc: UPI00000D5FB5
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: CAE55286.1
EMBL-CDS: AAK44709.1
RefSeq_NT: NC_002755.2
RefSeq_NT: NC_000962.2
PDB: 1L1E
EnsemblGenome: EBMYCG00000003119
EnsemblGenome_TRS: EBMYCT00000003121
EnsemblGenome_PRO: EBMYCP00000003121
EnsemblGenome: EBMYCG00000070339
EnsemblGenome_TRS: EBMYCT00000070344
EnsemblGenome_PRO: EBMYCP00000068403
GenomeReviews: AE000516_GR
Ge
Taxonomy ID 83332
Gene Starting Position 560847
Gene Ending Position 561710
Gene Strand (Orientation) -
Protein Name MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE)
DNA Sequence 
>gi|57116681:560847-561710 Mycobacterium tuberculosis H37Rv, complete genome
GTTACTTTTCCAGTGTGAACTGGTCGACGTCGGTGTAACCCTGGCGGAACAGCTTCGCGCAGCCGGTCAG
GTACTTCATGTAGCGGTCGTAGACAGTCTGCGACTGGATCGCGATGGCCTGATCTTTGTTGGCCTCGAGC
GCTGTGGCCCACATGTCCAGCGTCCTGGCGTAGTGCAGCTGCAATGACTGGACCGCGGTGACCCGGAAGC
CGACCTTCTCGGCGTACTCGTGCACCGTCGGGATGGACGGCAGCCAGCCACCGGGGAAGATCTCGGCCAG
GATGAATTTGGTGAAGTGAACCAGTTCGTGGGTCAACGTCAGGCCCTTTTCCCTGCCTTCTTTGAAGGTG
GGGCGCACGATGGTGTGCAGCAACATCTTGCCGTCGGCCGGCAACGTGCGGTGGGTCACCTCGAAGAAAT
GGTGGTAGCGCTGGTGGCCGAAGTGCTCGAACGCGCCGATCGAGACGATGCGGTCGACGGGCTCGTCAAA
TTTCTCCCATCCCTCCAGCAACACTCGTCTGGAGCGGGGGGTGTCCATTTGGTCGAACATTTTCTGGACA
TGACCGGCCTGGTTCTCCGACAACGTCAGGCCCACGACATTGACGTCGTATTTCTCGATGGCGCGCCGCA
TGGTCGCGCCCCAGCCGCAGCCGATGTCCAGCAACGTCATCCCGGGTTCGAGGTTCAGCTTGCCCAGGGC
CAGGTCGATCTTGGCGATCTGGGCCTCCTGCAGCGTCATGTCGTCGCGTTCGAAGTAGGCACAGCTGTAG
GTCTGGGTGGGGTCCAAGAACAGCCGGAAAAAGTCGTCGGAGAGGTCGTAATGAGCTTGCACGTTTCCAA
AATGCGGCGTGAGCTGCACGGACA
Protein Sequence 
>gi|57116736|ref|YP_177730.1| cyclopropane mycolic acid synthase [Mycobacterium tuberculosis H37Rv] MSVQLTPHFGNVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLNLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAGHVQKMFDQMDTPRSRRVLLEGWEKFDEPVDRIVSIGAFEHFGHQRYHHFFEVTHRTLPADGKMLLHTIVRPTFKEGREKGLTLTHELVHFTKFILAEIFPGGWLPSIPTVHEYAEKVGFRVTAVQSLQLHYARTLDMWATALEANKDQAIAIQSQTVYDRYMKYLTGCAKLFRQGYTDVDQFTLEK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pcaA mutant is attenuated in mice (Glickman et al., 2000).
COG COG2230M, under M: Cell wall/membrane/envelope biogenesis
References
Glickman et al., 2000: Glickman MS, Cox JS, Jacobs WR Jr. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Molecular cell. 2000; 5(4); 717-727. [PubMed: 10882107].