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pks5 from Mycobacterium tuberculosis H37Ra

Victor ID 1879
Gene Name pks5 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5213745
NCBI Protein GI 148661323
Locus Tag MRA_1539
Protein Accession YP_001282846.1
Other Database IDs UniProtKB-ID: A5U2N4_MYCTA
UniRef100: UniRef100_A5WML4
UniRef90: UniRef90_A5WML4
UniRef50: UniRef50_A1KQG0
UniParc: UPI00000D3B08
EMBL: CP000611
EMBL-CDS: ABQ73284.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067772.
EnsemblGenome_TRS: EBMYCT00000067777
EnsemblGenome_PRO: EBMYCP00000065887
GenomeReviews: CP000611_GR
KEGG: mra:MRA_1539
eggNOG: COG3321
HOGENOM: HBG669988
OMA: AQHTGKL
ProtClustDB: CLSK2299986
BioCyc: MTUB419947:MRA_1539-MONOMER
Taxonomy ID 419947
Gene Starting Position 1723599
Gene Ending Position 1729925
Gene Strand (Orientation) -
Protein Name putative polyketide synthase pks5
DNA Sequence 
>gi|148659757:1723599-1729925 Mycobacterium tuberculosis H37Ra, complete genome
GTCAGGCGGGTGCCGGCGCGTCCCTGTCGGCCGCCAACTTGTCGCACATCAGATCCGCCAGGCCACGAAC
GGTGGTGTTGATTTCGGTGGCGGAAATGCGGATCCCGGTTTCGGCTTCCACCCGCGCACGCAGTTCCTGG
CTGCTCAGTGAGTCCAGGCCGTACTCGCTGAGCAGCCGGTCGGTGTCGATGGTGCGGCGTAGGATTAGGC
CGACCTGCTTGGAGAGTAGCCGCCGCAGCCGGTCTGGCCATTCCTCGCGGGGCAGGTCCACCAGCTCGGC
AAGGAATTTGCTTGTGCCTGAACGGTTTTGCCCCAGGGATTGGAACTTCTCCGCGAATGGGCTGTGCTGG
GCGAAGGCTGTCAGCCAGGGTGATCCGATCACCGGGGCGTAGCCGCTGTAGGCGCGGTTGTGGCGCAGCA
GGGTCTCGAAGGCGTAGGCGCCTTCCTCGGGGGCGATGGCGTCGCCGGTTTGTTCGGCAAAGGCGATCGC
GCGGCCGATCTGGCCCCAGGCGCCCCAGGCGATGGAGGTGGCTGGTAGGTCTTGGGCTCGCCGCCAGTGG
GTGAAGGTGTCCAGCCAGCTGTTGGCCGCGGCGTAGGCGCCCTGACCCGGCGAGCCCACCAGGGCGGCCG
CTGAGGAGAATGAGCAGAACCAGTCCAGCGGCTGGTCCGCGGTGGCCCGGTGCAGTTGCCAGGCGCCATA
TGCCTTGGGCGCCCAGTCGCGTTCGATGAGTTCGTCGGTGATGTTGGCCAAGGTGGCGTCCTCGACCACC
GCGGCCGCGTGCAGCACGCCGCGCAGCGGCAAACCCGTCGCGGTGGCCGCCGTGACCAACCGGTCGGCGG
TGTCCGGCTGGGCGATATCGCCGCACTCCACCACTACGTCAGACCCGATCGCGCGGACGAGTTCGATGGT
CTCCAACGCCTTTTGGCTGGGCTGTGAGCGCGAGCTGAGCACGATGCGGCCGGCCCCGGCGTTGGCCATC
TTCTCGGCCAGGAATAAGCCCAGCCCACCCAGGCCACCGGTGATGATGTAGGACCCGTCTGAACGGAAAA
CCCGAGCCTGTTCGGGGGGAAGCACCACGCTGCTGCGCCCGGCGTGGGGGACGTCGAGGATGAGCTTGCC
GGTGTGCTCGGCCGCGCCCATCACCCGGATCGCGGTGGCCGCCTCGGCCAGCGGGTAATGGGTGCTCTGC
GGCATCGGCAGCACACCCTCGACGGTCAACCGATACACCGTGCTCAACAGTTCGCGGACCGCAGCCGGAT
GGCTCACCGACATCAACCCCAGGTCTAGACCGTAGAACGCCAGATTGCGCCGGAATGGCAAGAGTTCCAG
TCGGGTATTGGAGTAGATGTCGCGTTTGCCGATTTCGATGAAGCGGCCGCCCAGGGCCAGTAGTTTGAGG
CCGGCCAACTGTGCGGCACCGGTCACGGAGTTGAGCACGATGTCCACGCCGTAGCCGGCGGTGTCGCGGC
GGATCTGCTCGGCGAACTCGACGCTGCGCGAGTCATAGACGTGTTCGATGCCCATGTCGCGCAGCAGGTC
TCGACGCTTTTCGTTGCCTGCGGTGGCGTAGATCTGGGCTCCGGCCGCACGCGCGATCGCGATTGCGGCC
TGGCCCACTCCGCCGGTGGCGGAGTGGATGAGCACCTTGTCGCCGGCCTTGATCCGCGCCAGGTCCTGCA
GCCCGTACCACGCGGTGGCGCTGGCGGTGGTCACTGCCGCGGCTTGGGCGTCGGTCAGCCCCTCGGGCAG
TCTGGTGGCCAGGCGGGCGTCGCAGGTGACGAACGTGGCCCAGCAGCCGTTGGGTGACATGCCGCCGACC
CGGTCACCGACCTTGAGTTCGCTGACCCCGGGCCCGACCGCGCTCACCACCCCGGCGAAATCGGTGCCCA
GCTGCGGCTGTCGCCCGTCGAGGGTTTGGTAGCGGCCGAAGGTGACCAGCACGTCGGCGAAGTTGATGCT
GGACGCGGTGACGGCGACCTCGATCTCTCCCGGGCCCGGCGGGACCCGGTCGAACGCGGCGAACTCCAAG
GTTTGCAGGTCACCGGGAGTACGGATCTGTAGGCGCATGCCGGCCTCGGCGTGGTCGACGACGGTGGTTT
GCCGCTCCTCGGGGCGCAGCGGGGCTGGGCACAACCGGGCGGTGTACCACTGGTCGTTGCGCCAGGCGGT
CTCATCCTCGCCGCTGGCCGCCAGCAGCTGACGCGCCACCGACTCCGCGCCGGTCTGCTCATCCACATCG
ACATAGCTGGCCTTCAAATGCGGATGCTCAGCACCAATCACCCGCAACAACCCCCGCATCCCACCCTGCT
CAAGATTGGGTCGGTCACCAGACAACACCGCCTGAGCATTGTGGGTCAGCACATACAACCGCGGCTCTTG
GGCCGTGATCTCTGGAATCTCGCGGGCGATACGCACCACATGTTTGACAAGCTCGCCGCCGCGCACGGGG
GATTCCGCGTCGGGGTCGCCGGTCTGCGGCGCGGTCAACACGAATACGCCGGTGAACCCGCCGGTGCCGA
GCTGGTCGCGCAGCCGCGCGGCCTGGGCTGCGTGGTCGGCGCGCTGCGGCCAGGACATCGTTGTGCACTG
CGCGTCGTGCACCTTCAGCGCGTCGGTCAACTGTGCGGCCACCAAATCCGTAGCGTCACACGTGCTGATC
AGCAGCCAGGCGCCGGGTTCGGCGTGGCTGTTTTCGGGCAGCTCACGTTCGTGCCATTCGATGCTCAGCA
GCCGCTCACCCAAAACCCGGGCACGTTCGCTGGCCTGCGACGCGCCGGTACCCAACTGCAGCCCACGCAC
CGCCAACACCACCGCGCCGTGCTCGTCCAACACGTCCAGGTCGGCTTCCACGCCCACACCGCACGCGGTC
ACCGTCGTGCAGCAGTACCGGGCATGACGGGCCGACCCATAGGACCGCAACCGCCGCACACCCAACGGCA
GCAACAAACCACCGTCGGCCATACCCTGGACGGCGGGATGAGCCGCCACCGACTGGAAGCACGCATCCAG
CAGCACGGGATGCACGCCGTAAGCTTTGACCTGCGAGCGAAGCGGGCCCGGTAGGTTGACCTCGGCCAGC
ACCGTGTCGCCGGCCCCTTCGGCGATGTACGCGTCAACCAGACCCGCAAAAGCCGGCCCTAAGCGATGAC
CACGCTTGTCCAGCCATTGCCGAACCTCGGCGCCGTCCACCTTGTGGGGATGGCTGGCCAGCAGTTCGGC
GATGTTTTTCTGGGGTGGCTGGTCCGGGGCGTCGTCGGCTTCCCGGACAACGTGCAGAACCGCGGCGAGT
TGCCGTGTGTACCTACCATCATGGCTGGTCTCTACTGTGAGTGGGACAACGCCGGGGGCTTCTACCGTGG
CGGTGACGCCGATGGGGGTTTCGTCGTCGAGCAGCAACATCTGCTCGAATCGGATGTCGCGGACTTCGGA
GGCTTCGCCGAGGACGGCGCGGGCTGCGGCCAACGCCATCTCGCAGTAGGCGGCTCCCGGAAGGGCGGCC
GCGCCGTGGATTTGGTGATCGGCCAGCCAGGGTTGTGTCACGGTGCCGACCTCGCCCTGCCAGACGTGGC
GTTCCGGCTCCTCGGGCAGGCGCACGTGGGAGCCCAGCAATGGGTGTACGGCGACGGTATTGGCGTGGGC
GATGCGACGGGTCGTGTCGTCGAGCAGCAGACGACGGTGGTTCCATGTGGGCAGTGGTGCGTTGATCAGT
CGGCCGGTGGGGTAGAGCACGGCGAAGTCGACGGCGGCGCCGGCGGCGTAGAGGTCGCCGGCCAGTGCGC
GCAGCCCGTGGGGCAGTGGTTGTTCGCGGCGCATGCCGGCCAGCGCAGCCGCGGACATGTCGAGGCTGCG
GGCGGTCTGGTCGACCGCGTGGGTCAGCAGGGGGTGGGGGGTCAGCTCGGTGAAGACCCGGTAGCCGTCT
TCGAGGGCGGCTTGCACCGCCGCGGCGAAGCGTACGGTGTGGCGCAGGTTGTCCACCCAGTAGTAGGCGT
CGCAGTAGGGCTCCTCGCGCGGGTCGAACGAGGTCGCCGAGTAGTAGGGGATTTCCGGTTGCAGCGGGCT
GATTTCGGCGAGCGCTTCGGCCAGTTCGTCGAGGATCGGGTCGACCTGCGGGGAGTGCGATGCTACGTCG
ACGGCCACCTCACGGGCCAGCACGTCGCGTTGCTCCCAGGCGGCCACCAGGTCGCGTACCGTCTGGGTGG
CCCCGCCGATCACGGTGGACTGCGGGGAGGCCACCACCGCGACCACGGCGTCGTTGACGCCGCGCGCCAT
CAACTCCGAAAGCACTTGTTGAGCAGGCAGTTCCACCGATGCCATGGCGCCGGCGCCGGCGATACGGGTC
ATCAGCGCCGACCGCCGGCAGATGACGCGCACTCCGTCTTCGAGGCAGAGCGCGCCGGCGACCACCGCGG
CCGCGGACTCGCCCAGCGAGTGGCCGATGACCGCGCCGGGCGCTACGCCGTAGGACTTCATTGTGGCCGC
CAGCGCGACCTGCATGGCAAACAGGGTCGGTTGCACCCGGTCGATGCCGGTCACGACCTCGGGGGCGGTC
ATGGCTTCGGTCACCGAGAAGCCGGATTCCGCGGCGATCAGTGGTTCGATCGCGGCGATGGTGGCGGCGA
ATACCGGTTCGGTGGCCAGCAGGTCGGCGCCCATGCCCGCCCATTGCGAGCCTTGCCCGGAGAACACCCA
GACCGGTCCGCGGTCGTCTTGGCCGACCGCGGGTGGGTAGGGGGGTTCGCCGGTGGCGACTTCCCGCAGC
GCCTCGGTCAGCTCCGCGGTGGTGGCGGCCAGTACGGCGGTGCGCACCGGCCGGTGTCCGCGCCGGCGGG
CCAGGGTGTAGGCCAGATCCGCCGGCGCCAGCTCGGGTCCTTGGGCGTCGACCCAATCGGCCAGCCGCGC
GGCGGTCTGCCGCAGCGCGTCCTGCGAGCTGGCCGACAGCGCGAACAGCAGCGCGCCGTCGATACCGGGT
GTGGCCGGGGTGTCGCCTGGTGCACCGGATTCGGGGGCTGGCACCGGTGCCTGCTCGACAATGGCGTGCA
CATTGGTGCCCGTCATGCCATACGACGACACCGCCGCGCGCCGGGGCGTTTCTTGATCGGCGCCGGGCCA
CGGCGTAATCTCTTGCGGCACAAACAGGTTGGTTTCGATTGCGGCAAGCTTGTCAGGCAGGGCCGTGAAG
TGCAGATTCTGTGGGACCACGCCGTGTTGGAGGGCCAGGACCGCCTTCATCAGTCCCAGCGCTCCAGCGG
CCGACTGGGTGTGGCCGAAATTGGTCTTCACCGATGCCAGCGCGCAGGGGCCGTCGTTGCCGTATACCTC
GGCCAGGCTGGCGTATTCGATGGGGTCACCCACCGGGGTGCCCGGGCCGTGCGCCTCGACCATGCCCACC
GTAGCCGGGTCCACACCGGCCACATCCAACGCCTCCCGATACGCCGCGACCTGCGCGGACCGTGATGGTG
TCGCGATATTGACGGTGTGGCCGTCTTGGTTGGCGGCCGTGCCACGAATTACGGCCAGGATCCGGTCCCC
ATCGGCCAGCGCATCCGGCAACCGCTTGAGCGCCAACATGACACAACCCTCACCGGAGACGAAACCGTCC
GCGGAAACGTCGAACGCATGACAGCGCCCGGTCGCAGACAACATGCCCAACGCCGAGCCCGAGGCGAACC
GCCGCGGTTCGAGCATCACGTAGACACCGCCGGCTAGCGCAATGTCGCTTTCGCCGTCGTGCAGGCTACG
ACAAGCCAGGTGGATAGCGGTGAGGCCAGACGAGCATGCGGTATCTACCGTGATCGCGGGACCCTGCAAG
CCCATGGCGTACGCCACCCGCCCGGATGCGAAGCAGGCATTGGTGCCCGTGTTGCCGTACGGCCCTTCGA
AAGTCTGGTTGTCGGCGTGTACCAATATGTAGTCGGTATGAACCAACCCCACGAAAACCCCTGTCCGCGA
GGCCATCTGGTTCGGTGTTAGGCCGCCGTGCTCCATGGCTTCCCAGGAGGTTTCCAGCAACAAGCGGTGC
TGCGGATCGATCGCTATCGCTTCTTTCTCCCCGATCCCGAAGAACTCGGGATCAAAGTCGCCGACGTTAT
CGAGGTACGCGCCCCATTTGCAGTCGGTGCGTCCGGGCACGCCGGGTTCGGGGTCGTAGTACTCGTCGAT
GTCCCAGCGGTCGGCGGGGATCTCGGTGACCAGATCGTCGCCCCGCAGCAACGCCTCCCACAACCGATCG
GGTGAGTCGATGCCCCCCGGCAGCCGGCACCCCATACCAATGACAGCTACCGGCGTAACACGTGTCCTAT
CCACGGTCTTTGTTCTCTCCTTACCCA
Protein Sequence 
>gi|148661323|ref|YP_001282846.1| polyketide synthase pks5 [Mycobacterium tuberculosis H37Ra] MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGDDLVTEIPADRWDIDEYYDPEPGVPGRTDCKWGAYLDNVGDFDPEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGLTPNQMASRTGVFVGLVHTDYILVHADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAITVDTACSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFASGSALGMLSATGRCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQDGHTVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYASLAEVYGNDGPCALASVKTNFGHTQSAAGALGLMKAVLALQHGVVPQNLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAVSSYGMTGTNVHAIVEQAPVPAPESGAPGDTPATPGIDGALLFALSASSQDALRQTAARLADWVDAQGPELAPADLAYTLARRRGHRPVRTAVLAATTAELTEALREVATGEPPYPPAVGQDDRGPVWVFSGQGSQWAGMGADLLATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVTGIDRVQPTLFAMQVALAATMKSYGVAPGAVIGHSLGESAAAVVAGALCLEDGVRVICRRSALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVASPQSTVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSPQVDPILDELAEALAEISPLQPEIPYYSATSFDPREEPYCDAYYWVDNLRHTVRFAAAVQAALEDGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMRREQPLPHGLRALAGDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDTTRRIAHANTVAVHPLLGSHVRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAYCEMALAAARAVLGEASEVRDIRFEQMLLLDDETPIGVTATVEAPGVVPLTVETSHDGRYTRQLAAVLHVVREADDAPDQPPQKNIAELLASHPHKVDGAEVRQWLDKRGHRLGPAFAGLVDAYIAEGAGDTVLAEVNLPGPLRSQVKAYGVHPVLLDACFQSVAAHPAVQGMADGGLLLPLGVRRLRSYGSARHARYCCTTVTACGVGVEADLDVLDEHGAVVLAVRGLQLGTGASQASERARVLGERLLSIEWHERELPENSHAEPGAWLLISTCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHAAQAARLRDQLGTGGFTGVFVLTAPQTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPRLYVLTHNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQLLAASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEFAAFDRVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDGRQPQLGTDFAGVVSAVGPGVSELKVGDRVGGMSPNGCWATFVTCDARLATRLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGDKVLIHSATGGVGQAAIAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIRRDTAGYGVDIVLNSVTGAAQLAGLKLLALGGRFIEIGKRDIYSNTRLELLPFRRNLAFYGLDLGLMSVSHPAAVRELLSTVYRLTVEGVLPMPQSTHYPLAEAATAIRVMGAAEHTGKLILDVPHAGRSSVVLPPEQARVFRSDGSYIITGGLGGLGLFLAEKMANAGAGRIVLSSRSQPSQKALETIELVRAIGSDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATLANITDELIERDWAPKAYGAWQLHRATADQPLDWFCSFSSAAALVGSPGQGAYAAANSWLDTFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDAIAPEEGAYAFETLLRHNRAYSGYAPVIGSPWLTAFAQHSPFAEKFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVGLILRRTIDTDRLLSEYGLDSLSSQELRARVEAETGIRISATEINTTVRGLADLMCDKLAADRDAPAPA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks5 mutant is attenuated in mice (Rousseau et al., 2003).
COG COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Rousseau et al., 2003: Rousseau C, Sirakova TD, Dubey VS, Bordat Y, Kolattukudy PE, Gicquel B, Jackson M. Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis. Microbiology (Reading, England). 2003; 149(Pt 7); 1837-1847. [PubMed: 12855735].