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plcC from Mycobacterium tuberculosis H37Rv

Victor ID 136
Gene Name plcC from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886000
NCBI Protein GI 15609486
Locus Tag Rv2349c
Protein Accession NP_216865.1
Other Database IDs UniProtKB-ID: PHLC_MYCTU
UniRef100: UniRef100_P95245
UniRef90: UniRef90_P95245
UniRef50: UniRef50_P95246
UniParc: UPI000013197E
EMBL: BX842579
EMBL: AE000516
EMBL-CDS: CAB06146.1
EMBL-CDS: AAK46707.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000001983
EnsemblGenome_TRS: EBMYCT00000001985
EnsemblGenome_PRO: EBMYCP00000001985
EnsemblGenome: EBMYCG00000070845
EnsemblGenome_TRS: EBMYCT00000070850
EnsemblGenome_PRO: EBMYCP00000068909
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 2627171
Gene Ending Position 2628697
Gene Strand (Orientation) -
Protein Name PROBABLE PHOSPHOLIPASE C 3 PLCC
DNA Sequence 
>gi|57116681:2627171-2628697 Mycobacterium tuberculosis H37Rv, complete genome
GCTAGCAGATGCCGCTGGGAATCGGCCGCGCGGGACCGGATTCCTGGACTGGCGTTGTTTGGGGGTAGGG
CACCCGATACGGCAGGCCTTCGTTCAAGAAACCCAGCACCACATTGGGCACGCACTTGGCGACCTTCGGC
AATTGACGGACCGGGTGGTCCAGATTGGGTGGCGACGGGTCCGGCGGGGCCGCGAAATTGAATGCCGACG
TCATATCGCCGGTGACACTGGCACGCCAGGGTGTCAAGTTGGGAACCGGCACCCCGAAACGCTTGCCGAT
CAATTGCAGCTGCGATGTGTGGTCGAACCGATCATGGACCATCAGCCCGCCGCGACTGTAAGGCGAAATG
ACGAAGCAGGGCACGCGAAAGCCCAAGCCGATGGGTCCACGTATTCCGCCGGAGCCGTCGACCTTGTCGA
TGTCAACACTGTTGGGAATCCATTCGCCGGGTGTGCCCTCCGGCGCGGTGAGCGGTGTGACGTGGTCGAA
GAAGCCGCCATGTTCGTCATAGGCGATGATCAACGCGGTTTTCTCCCACACCGCCGGATTGCGCAGCAAC
ACCCTTATCAAGTTCACGATCGTCACCGCACCGACTGCCACCGGGAATGACGGATGTTCGGACTCGACGG
TCAACGGAACGACCCAGGACACCTGGGGCAGCGTGTTGTTGATGACGTCGCGGATGAAATCCCACGGGTA
GGCCGGGGCGATGCCATAACGGGCCAGGTCCGACCTCGGATCTGCGGCCTGTTTGAAACTGCCCACATAC
CCGTTACGGCTCAAGGAAGTGTCGTTGAGCCCGCCGAGCAGCTTGCTGTTGTACACCTTCCAACTGATGC
CGGCGTCACTGAGGTTCTGCGGCATGATGCGCCAGGTGAAGGTCAACTTCGGCTGGATGGCGGGTTCGAC
GATCTGCGGCCCACCTTGATCCCCGTCGGGATTGACGGTGGCGCTGATCCAATAGAGCCGGTTAGGCATC
GTCCCGCCAAGAAGCGACGAGAAGTACTGGTCGCAGATCGTGAAGGTATCGGCCAACAAGTAGTGGATCG
GTATGTCAGGACGTGCGTAATAGCCCATCACCACGGGCGTGTTGGCCACCGACCGGGTCCGCGCCTGCGC
CGGCAGCCAGCCGTCATTGGCGCCGCCGTTCCATGACAAGTGCGCGGCAATCCACTGGTGGTCTGGGTCG
TTGACGCACTCGCCAACCCCGTTGGGACCCCCGGTGGTATTGATGCGGTAGGGCAGCGTAATGCCGGTGG
GGTCCAGCGCCTGCGTCTCCGGGTTCCAGCCCTTTTGTTGAAACAGCGGCGTCGGAGTGTCGAACCCGTC
GACGGCAGAAAGCGTGCCGAAATAGTGATCGAACGACCTGTTCTCCTGTAGGCACAGCACGATGTGCTCG
ATATCGGTCAAATGACCCGAGCAGGGACCGGCACCATAGGCCTTTTCGATCACCGGTGCGGCCCAGTCCG
TCAAAACCGCCGCTGCCCCGGCTCCAGCCGCCTTAGCCAGGAATGCTCGGCGTGACA
Protein Sequence 
>gi|15609486|ref|NP_216865.1| phospholipase C [Mycobacterium tuberculosis H37Rv] MSRRAFLAKAAGAGAAAVLTDWAAPVIEKAYGAGPCSGHLTDIEHIVLCLQENRSFDHYFGTLSAVDGFDTPTPLFQQKGWNPETQALDPTGITLPYRINTTGGPNGVGECVNDPDHQWIAAHLSWNGGANDGWLPAQARTRSVANTPVVMGYYARPDIPIHYLLADTFTICDQYFSSLLGGTMPNRLYWISATVNPDGDQGGPQIVEPAIQPKLTFTWRIMPQNLSDAGISWKVYNSKLLGGLNDTSLSRNGYVGSFKQAADPRSDLARYGIAPAYPWDFIRDVINNTLPQVSWVVPLTVESEHPSFPVAVGAVTIVNLIRVLLRNPAVWEKTALIIAYDEHGGFFDHVTPLTAPEGTPGEWIPNSVDIDKVDGSGGIRGPIGLGFRVPCFVISPYSRGGLMVHDRFDHTSQLQLIGKRFGVPVPNLTPWRASVTGDMTSAFNFAAPPDPSPPNLDHPVRQLPKVAKCVPNVVLGFLNEGLPYRVPYPQTTPVQESGPARPIPSGIC
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002).
COG COG3511M, under M: Cell wall/membrane/envelope biogenesis
References
Raynaud et al., 2002: Raynaud C, Guilhot C, Rauzier J, Bordat Y, Pelicic V, Manganelli R, Smith I, Gicquel B, Jackson M. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Molecular microbiology. 2002; 45(1); 203-217. [PubMed: 12100560].