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cobL

Victor ID 303
Gene Name cobL
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888321
NCBI Protein GI 15609209
Locus Tag Rv2072c
Protein Accession NP_216588.1
Other Database IDs UniProtKB-ID: COBL_MYCTU
UniRef100: UniRef100_Q10671
UniRef90: UniRef90_Q10671
UniRef50: UniRef50_Q10671
UniParc: UPI0000127DED
EMBL: BX842578
EMBL: AE000516
EMBL-CDS: CAA98225.1
EMBL-CDS: AAK46412.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000003369
EnsemblGenome_TRS: EBMYCT00000003371
EnsemblGenome_PRO: EBMYCP00000003371
EnsemblGenome: EBMYCG00000073091
EnsemblGenome_TRS: EBMYCT00000073096
EnsemblGenome_PRO: EBMYCP00000071155
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 2328973
Gene Ending Position 2330145
Gene Strand (Orientation) -
Protein Name Probable precorrin-6y methyltransferase CobL
DNA Sequence 
>gi|57116681:2328973-2330145 Mycobacterium tuberculosis H37Rv, complete genome
GTCATCGCTTGGTCACCGACCACTGGGTGACCGGCAGCTGTGGGCGCCAACCGGTGAAGCCGCCCAGCGG
TTCGCCGAGATAGTGCTGGAATCGTCGTAGCTCGCCACCGAGGCGCGAATATGCATGCGCCAGAGCGGCT
TCCGATTCGACGGTGACAGCGTTGGCGACCAAGTTCCCGCCTGCGGGCAGGCTGTCCAGGCAGGCCTCAA
GCAGGCCTGGCTGGGTTACACCACCGCCAAGAAAAATCACCGACGGCCGTGCGGCGTCGTCGAACGCATC
GGGCGCGTCGCCGCGCACGTCGACGCTCACCCCGAAGGCCGCGGCATTGAACCCAATGTTGCGGCGGCGC
CGTTCGTCGCGCTCGAACGCCACCGCGGTGCAGCCCGGCCAGCTCCGACACCACTGGACCGCGATGGCGC
CTGAGCCCGCGCCGACGTCCCATAACCGCTGCCCGGGCCTTGGCGCCAGCGCAGCCAGGGTCAGCACGCG
GATCGGGTGTTTGGTGATCTGCCCGTCGTGCGCGAATGCCTCGTCGGGTGCCCACGACGTGCGCTCGTCG
AGCAGGTAGCGCACGGCGATCACGTTGAGCTCATCGACATCGAGGGGTGGGTCGCAGGCCCATGCCCGGG
CCGTACCGTCGCGGCGGCGTTCGGCCGGGCCGCCAAGCTGTTCGAGCACGCTGAACTTGGAGTCACCGCG
ACCGTGCTCGGTCAGCAGCACCGCCAGCGCCTGCGGGGTGGACCGATCGCCGGACAGCACGATGGCCCGG
CCGCCGCGGCGCACCGCGGTGTGTGGTTGCGCGGTGACCAGGCTGATCACCTCGGTGTCATACACGTTCC
AGCCCATCCGGGCGCACGCCAACGTCACCGCGGACACGTGCGGCAACACGGTCACGTTGTCGTGGCCGAA
CAGCCGGATCAGGGTGGAGCCGATACCATGCAACAACGGGTCGCCGCTGGCAACCACGTGTAGGTCAGCC
CCATCCGGTGACAGGCCTTGCACCGCGGGCAGCATCGGCGTCGGCCACTCCCAGCGCTCGGCGGTGACGG
TATCGTCGAGCAGGGCAAGTTGCCGTTTCGAGCCGTAAATTACTGTGGCCCTGCGCAATTCGGAGCGAGA
ATGCTCGGAGAGACCGGTCATGCCGTCGGCGCCGATCCCGACAACGATGATCA
Protein Sequence 
>gi|15609209|ref|NP_216588.1| precorrin-6Y C(5,15)-methyltransferase [Mycobacterium tuberculosis H37Rv] MIIVVGIGADGMTGLSEHSRSELRRATVIYGSKRQLALLDDTVTAERWEWPTPMLPAVQGLSPDGADLHVVASGDPLLHGIGSTLIRLFGHDNVTVLPHVSAVTLACARMGWNVYDTEVISLVTAQPHTAVRRGGRAIVLSGDRSTPQALAVLLTEHGRGDSKFSVLEQLGGPAERRRDGTARAWACDPPLDVDELNVIAVRYLLDERTSWAPDEAFAHDGQITKHPIRVLTLAALAPRPGQRLWDVGAGSGAIAVQWCRSWPGCTAVAFERDERRRRNIGFNAAAFGVSVDVRGDAPDAFDDAARPSVIFLGGGVTQPGLLEACLDSLPAGGNLVANAVTVESEAALAHAYSRLGGELRRFQHYLGEPLGGFTGWRPQLPVTQWSVTKR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG2241H, under H: Coenzyme transport and metabolism
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].