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proC from Mycobacterium tuberculosis H37Ra

Victor ID 1884
Gene Name proC from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214181
NCBI Protein GI 148660268
Locus Tag MRA_0507
Protein Accession YP_001281791.1
Other Database IDs UniProtKB-ID: A5TZM9_MYCTA
UniRef100: UniRef100_Q11141
UniRef90: UniRef90_Q11141
UniRef50: UniRef50_Q11141
UniParc: UPI00001322FD
EMBL: CP000611
EMBL-CDS: ABQ72229.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067691.
EnsemblGenome_TRS: EBMYCT00000067696
EnsemblGenome_PRO: EBMYCP00000065806
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0507
eggNOG: COG0345
HOGENOM: HBG726602
OMA: PQMFREA
ProtClustDB: PRK11880
BioCyc: MTUB419947:MRA_0507-MONOMER
Taxonomy ID 419947
Gene Starting Position 591392
Gene Ending Position 592279
Gene Strand (Orientation) +
Protein Name pyrroline-5-carboxylate reductase
DNA Sequence 
>gi|148659757:591392-592279 Mycobacterium tuberculosis H37Ra, complete genome
GATGCTTTTCGGCATGGCAAGGATCGCGATTATCGGCGGCGGCAGCATCGGTGAGGCATTGCTGTCGGGT
CTGCTGCGGGCGGGCCGGCAGGTCAAAGACCTGGTAGTGGCCGAGCGGATGCCCGATCGCGCCAACTACC
TGGCGCAGACCTATTCGGTGTTGGTGACGTCGGCGGCCGACGCGGTGGAGAACGCGACGTTCGTCGTCGT
CGCGGTCAAACCAGCCGACGTCGAGCCGGTGATCGCGGATCTGGCGAACGCGACTGCGGCGGCCGAAAAC
GACAGTGCTGAGCAGGTGTTCGTCACCGTGGTAGCGGGCATCACGATCGCGTATTTCGAATCCAAGCTAC
CGGCTGGGACGCCAGTGGTGCGTGCGATGCCGAACGCGGCGGCATTGGTGGGAGCGGGGGTTACAGCGCT
GGCCAAAGGCCGCTTTGTCACCCCGCAACAGCTTGAGGAGGTCTCGGCCTTGTTCGACGCGGTCGGCGGC
GTGCTGACCGTTCCGGAATCGCAGTTGGACGCGGTGACCGCGGTGTCCGGCTCGGGTCCGGCCTATTTCT
TTCTGCTGGTCGAGGCCCTGGTGGATGCCGGAGTCGGGGTGGGCTTGAGCCGTCAGGTGGCCACCGATCT
CGCCGCGCAGACAATGGCTGGCTCAGCGGCGATGCTGCTGGAGCGGATGGAGCAAGACCAGGGTGGCGCC
AATGGCGAGCTGATGGGGCTGCGCGTGGACCTTACCGCATCACGGCTGCGCGCCGCGGTTACCTCGCCGG
GCGGTACGACCGCCGCTGCGCTGCGGGAACTCGAACGCGGCGGGTTTCGGATGGCTGTCGACGCGGCGGT
TCAAGCCGCCAAAAGCCGCTCTGAGCAGCTCAGAATTACACCGGAATG
Protein Sequence 
>gi|148660268|ref|YP_001281791.1| pyrroline-5-carboxylate reductase [Mycobacterium tuberculosis H37Ra] MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAERMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANATAAAENDSAEQVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVGAGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPAYFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGANGELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAKSRSEQLRITPE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: proC mutant is attenuated in mice (Smith et al., 2001).
COG COG0345E, under E: Amino acid transport and metabolism
References
Smith et al., 2001: Smith DA, Parish T, Stoker NG, Bancroft GJ. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infection and immunity. 2001; 69(2); 1142-1150. [PubMed: 11160012].