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plcA from Mycobacterium tuberculosis H37Ra

Victor ID 1860
Gene Name plcA from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212287
NCBI Protein GI 148662179
Locus Tag MRA_2371
Protein Accession YP_001283702.1
Other Database IDs UniProtKB-ID: A5U540_MYCTA
UniRef100: UniRef100_Q04001
UniRef90: UniRef90_Q04001
UniRef50: UniRef50_P95246
UniParc: UPI00001652E3
EMBL: CP000611
EMBL-CDS: ABQ74140.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067110.
EnsemblGenome_TRS: EBMYCT00000067115
EnsemblGenome_PRO: EBMYCP00000065225
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2371
eggNOG: COG3511
HOGENOM: HBG565180
OMA: MEPQISA
ProtClustDB: CLSK791798
BioCyc: MTUB419947:MRA_2371-MONOMER
Taxonomy ID 419947
Gene Starting Position 2640440
Gene Ending Position 2641978
Gene Strand (Orientation) -
Protein Name membrane-associated phospholipase C 1
DNA Sequence 
>gi|148659757:2640440-2641978 Mycobacterium tuberculosis H37Ra, complete genome
TTCAGCTGCACAGCCCGCTGGGAGTCCCGCGGACGGGTGTGGTTTCCTGAGTTGGCATCACCTGCGGATA
GGGCACCCGATAGGGAATGCTCGGCAACGCGCCGTCGGTGGTTCCCAACACCACGTTAGGGATGCACTGC
GGCAGCTTCGGCAGCGCTCCCAGCAACGGGTGGCTCAAGTTGGGTCTGGTCGAATTCGGTGGAGTCGCAA
AGTTGAACGCTGAGGTCATGTCGCCAACCACGCCGTCGCGCCAGGCGGTCATGTTGGGAACCGGCACGCC
GAACCGGGCGCGAATCAACTTCAATTGCGAGGTGTGGTCGAACGTGTCGGAGACCATCAGCGGGCCGCGG
CTGTACGGCGAAATGACAATGCAGGGAACGCGAAAACCCAGACCGAGCGGACCACGAATGCCACCGGACC
CGGGTACTGCGTCGATGTTGGGCACCGTGACGAATTCGCCGGGTGTCCCGGGCGGTGCCGTGGGGGGCGT
GACGTGGTCGAAGAAGCCGCCGTTCTCGTCATAGCTGACGATAAGTGCGGTCTTTTCCCACACCGCGGGA
TTGGACAGCAAGATCCGCAGCGCGGTCACCATGGACACCGCGCCAAGCGCTACCGGCAGGGCGGGGTGTT
CGGACTGCAGGATGTTGGGAACTAACCAGGAGACCTTGGGTAGCCGGTTGGCCCTGACGTCGGCAGCGAA
GTCCCCAGGGTAGGTCGGGGCGATACCGTAGCGGGCCAAGTTCGACCTCGGATCAGCTGCCTGGCGGAAG
GCCTGCACCAGCCCGTTATTGCTGATGGGCGTGTTGATGAATCGCCCGAGGCCCTTGTTCTGGTACACCT
TCCAGCTGACCCCGGCATCTTCGAGGTTTTCCGGCATGATGCGCCAACTGAATTGCTGCAGCGGCAGGAA
GCCCGGCTCTACCAATTGGGGTCCCCCGTCGGTGCCGGCGGGGTCGATGTTGGCGCTCAACCAGTAGAGC
CGGTTGGGCAGGGTGCCCGTCAGCAGCGAGCAATGGTAGCCGTCGCAGATGGTGAACGTGTCGGCCAGCA
GATAGTGGATCGGGATGTCTTGGCGCGTGTAGTAACCCATGGTCAAAGGGACATATGGTCCTGCGCGGGT
GGTCGCCTGCGCCGGCAGCCAGTTGTCGTTGGCACCACCGTTCCAGGCCAGGTGCATCCCCACCCACTGG
TGCTCGGGGTCGTTGACGCACTCGCCGTCCAGGAAGGGGCCTCGGGTGGTGTCCAAGCGGAACGGAATGG
TGACCCCGGCGGGGTCCAACGCCTGCGTCATGGGGTTCCAACCCATTTGTTGGAATGCCGGCGACGCGGC
GTTGAACCCATTGGTGCTGGAAAGCGTTCCGAAATAGTGGTCGAATGACCGGTTCTCCTGCATCAGCAAC
ACGATATGCTCGATGTCGGTCAAATGTCCGGGACAAGGCCCGGCGCCGTAGGCCTTTTCAATCACCGGTG
CAGCCCAGTCCATCAGGAATGCCGCTGCGCCTGCGCCAGTGAGCTTTGTCAAAAACTCTCGACGTGACA
Protein Sequence 
>gi|148662179|ref|YP_001283702.1| membrane-associated phospholipase C 1 [Mycobacterium tuberculosis H37Ra] MSRREFLTKLTGAGAAAFLMDWAAPVIEKAYGAGPCPGHLTDIEHIVLLMQENRSFDHYFGTLSSTNGFNAASPAFQQMGWNPMTQALDPAGVTIPFRLDTTRGPFLDGECVNDPEHQWVGMHLAWNGGANDNWLPAQATTRAGPYVPLTMGYYTRQDIPIHYLLADTFTICDGYHCSLLTGTLPNRLYWLSANIDPAGTDGGPQLVEPGFLPLQQFSWRIMPENLEDAGVSWKVYQNKGLGRFINTPISNNGLVQAFRQAADPRSNLARYGIAPTYPGDFAADVRANRLPKVSWLVPNILQSEHPALPVALGAVSMVTALRILLSNPAVWEKTALIVSYDENGGFFDHVTPPTAPPGTPGEFVTVPNIDAVPGSGGIRGPLGLGFRVPCIVISPYSRGPLMVSDTFDHTSQLKLIRARFGVPVPNMTAWRDGVVGDMTSAFNFATPPNSTRPNLSHPLLGALPKLPQCIPNVVLGTTDGALPSIPYRVPYPQVMPTQETTPVRGTPSGLCS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: plcABC triple mutants are attenuated in mice (Raynaud et al., 2002).
COG COG3511M, under M: Cell wall/membrane/envelope biogenesis
References
Raynaud et al., 2002: Raynaud C, Guilhot C, Rauzier J, Bordat Y, Pelicic V, Manganelli R, Smith I, Gicquel B, Jackson M. Phospholipases C are involved in the virulence of Mycobacterium tuberculosis. Molecular microbiology. 2002; 45(1); 203-217. [PubMed: 12100560].