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Rv0485

Victor ID 233
Gene Name Rv0485
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887170
NCBI Protein GI 15607626
Locus Tag Rv0485
Protein Accession NP_214999.1
Other Database IDs UniProtKB-ID: Y485_MYCTU
UniRef100: UniRef100_P64705
UniRef90: UniRef90_P64705
UniRef50: UniRef50_P64705
UniParc: UPI000013988D
EMBL: BX842573
EMBL: AE000516
EMBL-CDS: CAB00946.1
EMBL-CDS: AAK44726.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
EnsemblGenome: EBMYCG00000002552
EnsemblGenome_TRS: EBMYCT00000002554
EnsemblGenome_PRO: EBMYCP00000002554
EnsemblGenome: EBMYCG00000072068
EnsemblGenome_TRS: EBMYCT00000072073
EnsemblGenome_PRO: EBMYCP00000070132
GenomeReviews: AE000516_GR
GenomeReviews
Taxonomy ID 83332
Gene Starting Position 573983
Gene Ending Position 575299
Gene Strand (Orientation) +
Protein Name POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN
DNA Sequence 
>gi|57116681:573983-575299 Mycobacterium tuberculosis H37Rv, complete genome
CGTGTACTCGACTAACCGCACCTCACAGTCACTCAGCCGCAAGCCCGGCCGCAAGCACCAGCTGCGATCG
CACCGTTACGTCATGCCGCCGTCGCTGCACCTGTCCGATTCCGCGGCTGCGTCCGTCTTCCGGGCCGTGC
GTTTGCGTGGTCCGGTCGGTCGGGACGTAATTGCTGGATCTACGTCGCTGAGCATCGCGACGGTGAACCG
CCAGGTCATCGCACTGCTGGAAGCGGGCCTCCTGCGTGAGCGGGCGGACCTGGCGGTTTCCGGGGCTATC
GGGCGCCCACGCGTGCCTGTCGAAGTAAACCACGAGCCTTTTGTCACCCTGGGCATCCACATCGGTGCCC
GGACCACCAGCATCGTGGCCACCGACCTGTTCGGCCGCACGCTCGACACGGTGGAGACCCCGACCCCGCG
TAACGCTGCCGGGGCCGCGCTGACCTCACTGGCCGACAGCGCTGACCGATACTTGCAGCGCTGGCGCCGG
CGCCGTGCGCTGTGGGTCGGGGTGACGCTTGGTGGTGCAGTCGACAGTGCCACCGGTCATGTCGACCATC
CGCGGCTCGGTTGGCGTCAGGCTCCGGTCGGACCCGTGCTGGCGGATGCCCTAGGCCTGCCCGTGTCGGT
GGCGTCCCACGTCGACGCCATGGCCGGGGCCGAGCTGATGCTCGGCATGCGGCGGTTCGCACCGAGCTCG
TCGACGAGCCTCTACGTCTACGCCCGCGAAACCGTAGGCTATGCGCTGATGATCGGTGGGCGGGTGCACT
GCCCGGCCAGTGGTCCCGGCACCATCGCGCCCCTGCCCGTCCACTCTGAAATGCTCGGCGGTACCGGGCA
GCTGGAGTCCACTGTCAGCGACGAGGCGGTTTTGGCTGCTGCCCGCCGGCTGCGGATCATCCCCGGCATC
GCTTCGAGGACCCGGACCGGTGGGTCCGCTACCGCCATCACCGACTTGCTGCGAGTGGCACGAGCCGGTA
ATCAGCAAGCCAAGGAGCTGCTGGCGGAGCGGGCCCGCGTGCTCGGTGGGGCGGTCGCGCTGCTGCGTGA
CTTACTCAATCCCGACGAAGTGGTGGTGGGTGGCCAGGCGTTTACCGAATATCCCGAGGCGATGGAGCAG
GTGGAGGCGGCGTTTACGGCAGGGTCGGTGCTGGCGCCGCGTGACATCCGCGTGACCGTTTTCGGCAACC
GGGTGCAGGAGGCCGGGGCAGGCATCGTGTCCCTAAGCGGGCTCTATGCCGATCCATTGGGTGCCTTGCG
GCGATCGGGCGCGCTGGATGCCCGGCTGCAGGACACCGCCCCGGAGGCGCTCGCGTG
Protein Sequence 
>gi|15607626|ref|NP_214999.1| transcriptional regulator [Mycobacterium tuberculosis H37Rv] MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAAASVFRAVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAVSGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNAAGAALTSLADSADRYLQRWRRRRALWVGVTLGGAVDSATGHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAELMLGMRRFAPSSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGTGQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQQAKELLAERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAFTAGSVLAPRDIRVTVFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDARLQDTAPEALA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Rv0485 mutant is attenuated in mice (Goldstone et al., 2009).
COG COG1940KG, under K: Transcription; G: Carbohydrate transport and metabolism
References
Goldstone et al., 2009: Goldstone RM, Goonesekera SD, Bloom BR, Sampson SL. The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. Infection and immunity. 2009; 77(10); 4654-4667. [PubMed: 19651861].