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leuD from Mycobacterium tuberculosis H37Ra

Victor ID 1882
Gene Name leuD from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214120
NCBI Protein GI 148662837
Locus Tag MRA_3016
Protein Accession YP_001284360.1
Other Database IDs UniProtKB-ID: LEUD_MYCTA
UniRef100: UniRef100_A1KMY1
UniRef90: UniRef90_A1KMY1
UniRef50: UniRef50_A0ZZS8
UniParc: UPI000012E58F
EMBL: CP000611
EMBL-CDS: ABQ74798.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067969
EnsemblGenome_TRS: EBMYCT00000067974
EnsemblGenome_PRO: EBMYCP00000066084
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3016
eggNOG: COG0066
HOGENOM: HBG304838
OMA: DEISITM
ProtClustDB: PRK01641
BioCyc: MTUB419947:MRA_3016-MONOMER
Taxonomy ID 419947
Gene Starting Position 3356201
Gene Ending Position 3356797
Gene Strand (Orientation) -
Protein Name isopropylmalate isomerase small subunit
DNA Sequence 
>gi|148659757:3356201-3356797 Mycobacterium tuberculosis H37Ra, complete genome
CTCAGGGGGCGGGTAGAGTGCGCGGTTTCCAGTACGCGCACGCACCCTCAAAGGCCTCGATCTCGTCGAG
TTTCCGCAGCGTAAGGGCTATATCGTCGAGACCTTCAAGCAGCCGCCACGCCGAGTGGTCGTCAATCTTG
AACGGCAGCACCACTGTTGCTGCGGTGATAATTCGATCTTGAAGATTGGCAGTGATTTCCAGGCCCGGAC
TCTGCTCAATGAGCTTCCACAGGAGTTCCACATCGTCTTGGGCAACCTCGGCCGCCAGCAGCCCGGCCTT
GCCCGCGTTGCCGCGGAAAATGTCACCAAATCGGGATGAGATAACCACCCGGAATCCGTAGTCCATGAGC
GCCCAGACCGCATGCTCTCGCGAGGATCCGGTGCCGAAATCGGGCCCGGCAACCAGGACCGAACCCCGGT
CAAAGGGACTGAGGTTTAGCACGAATGCAGGATCCGACCGCCAACCCGCGAACAAGCCGTCCTCGAAACC
GGTTCGGGTGACCCGCTTCAGAAAGACCGCGGGAATGATCTGATCGGTGTCGACATTGGACCGCCGCAAC
GGCACGCCAATACCAGAGTGGGTGTGAAAGGCTTCCA
Protein Sequence 
>gi|148662837|ref|YP_001284360.1| isopropylmalate isomerase small subunit [Mycobacterium tuberculosis H37Ra] MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDPAFVLNLSPFDRGSVLVAGPDFGTGSSREHAVWALMDYGFRVVISSRFGDIFRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQDRIITAATVVLPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: leuD mutant is attenuated in mice (Hondalus et al., 2000).
COG COG0066E, under E: Amino acid transport and metabolism
References
Hondalus et al., 2000: Hondalus MK, Bardarov S, Russell R, Chan J, Jacobs WR Jr, Bloom BR. Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis. Infection and immunity. 2000; 68(5); 2888-2898. [PubMed: 10768986].