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ilvB1 from Mycobacterium tuberculosis H37Rv

Victor ID 246
Gene Name ilvB1 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887286
NCBI Protein GI 57117044
Locus Tag Rv3003c
Protein Accession YP_177917.1
Other Database IDs UniProtKB-ID: ILVB1_MYCTU
UniRef100: UniRef100_P0A622
UniRef90: UniRef90_P0A622
UniRef50: UniRef50_Q59498
UniParc: UPI000012D536
EMBL: BX842581
EMBL: AE000516
EMBL-CDS: CAE55537.1
EMBL-CDS: AAK47412.1
RefSeq_NT: NC_002755.2
RefSeq_NT: NC_000962.2
EnsemblGenome: EBMYCG00000003779
EnsemblGenome_TRS: EBMYCT00000003781
EnsemblGenome_PRO: EBMYCP00000003781
EnsemblGenome: EBMYCG00000072985
EnsemblGenome_TRS: EBMYCT00000072990
EnsemblGenome_PRO: EBMYCP00000071049
GenomeReviews: AE000516_GR
GenomeReview
Taxonomy ID 83332
Gene Starting Position 3361129
Gene Ending Position 3362985
Gene Strand (Orientation) -
Protein Name acetolactate synthase 1 catalytic subunit
DNA Sequence 
>gi|57116681:3361129-3362985 Mycobacterium tuberculosis H37Rv, complete genome
ATCAGGCGTGGCCTTCGGTGATGTCGTCGAACAGGGGGCGAATGCCGCGGGCGGCCTGGATCTCGTCATT
GCTGGTGCCCGCGGCCACCATCGGCCACACTTGCGCGTCGGCACCGACGATGAAGTCGATCACCACCGGG
CAGTCGTTGATCGCCCGCGCCTGGTTGATGACGTCGACGACGTCCTCTTCCCGCTCGCACCGCAACCCCA
CACACCCCAAGGCCTCGGCCAGTTTCACGAAGTCGGGGATGCGGTGCGAATGAGTGGCCAGGTCGGTCTG
CGAGTACCGCTCGGCATAGAACAGGCTCTGCCACTGCCGCACCATGCCCAGGTTGCCGTTGTTGATCAGC
GCCACCTTGACCGGTATGCCCTCGACCGCGCAGGTGGCCAGCTCCTGGTTGGTCATCTGGAAGCAACCGT
CGCCGTCGATCGCCCAGACCTCGGTGCCGGGGAGGGCGATCTTGGCGCCCATGGCCGCCGGGATGGCAAA
CCCCATGGTGCCCAGACCGCCGGAGTTCAGCCAGCTGCGCGGCTTTTCGTATCTGATGAACTGCGCGGCC
CACATCTGGTGCTGGCCGACGCCGGCGACGAAGACGGCGTCCGGCCCGGCGATCTCGCCGAGCTTTTCGA
TCACGTATTCCGGGCTCAGGCTGCCGTCGCTCTGCGGCCCATAGCTCAGCGGATAGGTCTTGCGCACACC
GTTCAGGTATGCCCACCAGTCGGCCATCTCGATGGTGCCGGGAATGTGGTGGTGGCGCAGCATCGCGATC
AGTTCGGTGATGACGGCCTTGACGTCACCGACGATGGGCACGTCGGCGTGGCGGTTCTTGCCGATCTCGG
CCGGGTCGATGTCGGCGTGGATGACCTTGGCTTCCGGCGCGAACGAGTCGAGCTTGCCGGTCACCCGGTC
GTCGAAGCGGGTACCCAGCGCGATCAGCAGGTCGCTGCGCTGCAGCGCCGCCACGGCGGCCACCGTGCCG
TGCATGCCGGGCATGCCGAGGTTTTGCCGGTGGCTGTCGGGAAACGCGCCGCGGGCCATCAGCGTGGTGA
CCACCGGGATGCCGGTCAGCTCGGCCAGCTCCCGGAGCTGCTCGGTGGCCTCACCGCGGATGACGCCGCC
GCCGACATACAGCACCGGCTTGCGCGCGGCCGCGATCAGCTTGGCGGCCTCGCGGACCTGCCGGCTGTGC
GGTTTGGTGTTGGGCTTGTAGCCGGGCAGCTCCATCCGCGGCGGCCAGCTGAACGTGCACTGGCCCTGCA
GCACGTCCTTGGGGATGTCGACCAGCACCGCGCCCGGACGGCCGGAGGCCGCGATGTGGAAGGCCTCGGC
CAGCACCCGCGGAATGTCGTCACCGGAGCGGACCAGAAAGTTGTGCTTGGTGATCGGCATCGTGATGCCC
GAGATGTCGGCCTCCTGGAAGGCGTCGGTGCCGATCAGCCCCCGCCCGACCTGACCGGTGATAGCGACCA
CCGGGATCGAGTCCATCTGCGCGTCGGCCAGCGGGGTCACCAGGTTGGTCGCTCCGGGACCCGACGTTGC
CATGCACACGCCCACCCGGCCGGTGACGTGCGCGTAGCCGCTGGCGGCATGCCCGGCGCCCTGTTCGTGG
CGGACCAGCACGTGGCGCAGCTTTTTCGAGTCGAACAGCGGGTCATACACCGGCAGCACCGCACCGCCCG
GAATCCCGAAAATGACGTCGACGCCGAGTTCCTCCAGCGACCGGATGACCGCCTGTGCACCGGTAAGCTG
CTGCAGTGCAACATGTTTCGGACGAGCCGCCGGGTGCTTTGGCTCATTCGCCGCGCTGTGTGGCTCTGGC
TTGAATGTCGGTGAGTGTGGCTTGGTTGGTGCGCTCA
Protein Sequence 
>gi|57117044|ref|YP_177917.1| acetolactate synthase large subunit IlvB [Mycobacterium tuberculosis H37Rv] MSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAVIRSLEELGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTGRVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPITKHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGYKPNTKPHSRQVREAAKLIAAARKPVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMARGAFPDSHRQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADVPIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLSYGPQSDGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSGGLGTMGFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPVKVALINNGNLGMVRQWQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCVGLRCEREEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDITEGHA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvB1 mutant is attenuated in mice (Awasthy et al., 2009).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Awasthy et al., 2009: Awasthy D, Gaonkar S, Shandil RK, Yadav R, Bharath S, Marcel N, Subbulakshmi V, Sharma U. Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice. Microbiology (Reading, England). 2009; 155(Pt 9); 2978-2987. [PubMed: 19542000].