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pks15 from Mycobacterium tuberculosis H37Ra

Victor ID 1871
Gene Name pks15 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212916
NCBI Protein GI 148662794
Locus Tag MRA_2974
Protein Accession YP_001284317.1
Other Database IDs UniProtKB-ID: A5U6V5_MYCTA
UniRef100: UniRef100_A5U6V5
UniRef90: UniRef90_A5WRJ9
UniRef50: UniRef50_A8L4B2
UniParc: UPI00000D502D
EMBL: CP000611
EMBL-CDS: ABQ74755.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000068819.
EnsemblGenome_TRS: EBMYCT00000068824
EnsemblGenome_PRO: EBMYCP00000066934
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2974
eggNOG: COG3321
HOGENOM: HBG669988
OMA: ANDLDEY
ProtClustDB: CLSK792183
BioCyc: MTUB419947:MRA_2974-MONOMER
Taxonomy ID 419947
Gene Starting Position 3308341
Gene Ending Position 3309831
Gene Strand (Orientation) -
Protein Name polyketide synthase Pks15
DNA Sequence 
>gi|148659757:3308341-3309831 Mycobacterium tuberculosis H37Ra, complete genome
ATCACCCACGGCACCATCGACGGCCGCGGCCCCCGGTGCTTTCGCTCGCCTCAACCGGCGCCTCTGCGGG
GGCTGGTACGGGGGCCTCTTCCAAGATCAGATGCGCGTTGGTGCCGCTGATCCCAAAGGAGGACACCGCC
GCCCGGCGCGGACGCCCGTCAACCGACCACTCCCTGGCCTCGGTCAACACCGACACCGCGCCGCTGGTCC
AATCCACCCGCGGGGAAGGCTCATCCACATGCAACGTCGCCGGCATCACCCCATGACGCATCGCCTGCAC
CATCTTGATCACCCCGGCGACCCCCGCGGCGGCCTGGGTGTGGCCCATGTTCGACTTGATTGAGCCCACC
CACAGCGGCTGCTCCGCTGGACCTCCCTGCCCGTAGGTGGACAGCAATGCCTGCGCTTCGATGGGATCAC
CCAACGTGGTGGCGGTCCCGTGTGCCTCCACCACGTCTACGTCTGCGGCGGACAACCCGGCGTTGGCCAA
CGCCACCTGGATCACTCGCTGCTGGGCGAGCCCATTGGGCGCGGTCAGCCCATTGGACGCACCATCCTGG
TTGACCGCGCTCCCCCGCACCACCGCCAGCACCGAATGCCCCAACCGCCGGGCGTCCGATAGCCGCTCCA
GCACAACCACCCCGGCGCCCTCGCCCCACCCGGTGCCGTCGGCCGCGGCCGCAAACGCCTTACATCGCCC
ATCGGCAGCCAACCCCCGCTGCCGGGAAAACCCCACAAAAATCGACGGCAGCCCCATCACCGTCACCCCA
CCGGCCAACGCCAAATCACACTCCCCGGAGCGCAATGACGACATCGCCCAATGGATCGCCACCAACGACG
ACGAACAAGCGGTATCCACTGACACCGCCGGGCCCTGCAGCCCCAATACGTACGACACACGTCCCGAGGC
CACGCTGATTGACGTGCCGGTCAACCCGTACCCTTGCAGCCCCCCGGTATCCCTATTGCCGTAACTCGCC
GCGAAAATGCCGGTGTACACCCCGGTCGCCGAACCACGCAACGACAACGGGTCAATCCCCGCGTGCTCCA
ACGCCTCCCACGAAACCTCCAGCATCAACCGCTGCTGAGGATCCATCGCCAACACTTCACTAGGAGCGAT
GCCGAAGAACCCGGCGTCAAAGCCGGTGGCGTCGTCTAGAAATGCCCCCCATCGCGTGTAGGTTTTGCCC
TCAGCGTCGGGATCCGGATCGTATAGCCCCTCAACATCCCAGCCCCGATCGGTCGGAAACTCCGACACCA
CGTCGCGCCCCGCCGAAACGACATCCCAGAGTCCGTCCGGGCCATCCACGCCGCCCGGAAATCGGCAGCC
GATTCCCACCACCGCCACCGGTTCTGTCGCGCGTTGCTCATATTCACGCAGCCGAGCGCGTGTCTCATCG
AGCTCGACAGCAACCTTCTTTAGGTAGTGAAAAAGCTTTTCGCTCTGCTGGTCGGCACCTTCAACGCTCA
TCGTCCGTTGCTCCTCTATCA
Protein Sequence 
>gi|148662794|ref|YP_001284317.1| polyketide synthase [Mycobacterium tuberculosis H37Ra] MIEEQRTMSVEGADQQSEKLFHYLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGRRWCRG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks15 mutant is attenuated in mice (Sirakova et al., 2003).
COG COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sirakova et al., 2003: Sirakova TD, Dubey VS, Cynamon MH, Kolattukudy PE. Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis. Journal of bacteriology. 2003; 185(10); 2999-3008. [PubMed: 12730158].