Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

fadD28 from Mycobacterium tuberculosis H37Rv

Victor ID 250
Gene Name fadD28 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887454
NCBI Protein GI 15610078
Locus Tag Rv2941
Protein Accession NP_217457.1
Other Database IDs UniProtKB-ID: P96290_MYCTU
UniRef100: UniRef100_A5U6U8
UniRef90: UniRef90_Q02278
UniRef50: UniRef50_P86249
UniParc: UPI0000036B9F
EMBL: AE000516
EMBL: BX842581
EMBL-CDS: AAK47338.1
EMBL-CDS: CAB06100.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 3E53
EnsemblGenome: EBMYCG00000002902.
EnsemblGenome_TRS: EBMYCT00000002904
EnsemblGenome_PRO: EBMYCP00000002904
EnsemblGenome: EBMYCG00000069028.
EnsemblGenome_TRS: EBMYCT00000069033
EnsemblGenome_PRO: EBMYCP00000067092
GenomeReviews: AE000516_GR
Taxonomy ID 83332
Gene Starting Position 3283334
Gene Ending Position 3285076
Gene Strand (Orientation) +
Protein Name acyl-CoA synthetase
DNA Sequence 
>gi|57116681:3283334-3285076 Mycobacterium tuberculosis H37Rv, complete genome
CATGAGTGTGCGTTCCCTTCCCGCTGCGTTGCGCGCGTGTGCGCGTCTGCAACCCCATGACCCGGCCTTC
ACGTTTATGGATTACGAACAGGACTGGGACGGCGTTGCGATAACCCTGACGTGGTCGCAGCTGTATCGGC
GAACGCTGAATGTGGCACAGGAGCTGAGCCGTTGTGGTTCCACGGGTGACCGCGTGGTGATCTCTGCTCC
GCAGGGACTCGAGTACGTCGTCGCCTTTCTCGGCGCGTTGCAGGCCGGGCGCATCGCCGTGCCGCTTTCG
GTTCCACAAGGCGGCGTTACCGATGAACGTTCCGATTCGGTACTGAGTGATTCGTCGCCGGTGGCCATTC
TCACTACATCGTCTGCCGTGGACGACGTCGTGCAACATGTTGCGCGGCGGCCCGGGGAATCCCCGCCATC
AATTATCGAAGTTGATTTGCTCGATCTGGACGCTCCGAATGGGTATACCTTCAAAGAAGACGAGTATCCA
TCTACCGCGTATTTGCAATACACCTCCGGGTCCACCCGCACGCCCGCTGGCGTGGTGATGTCCCATCAGA
ACGTTCGGGTTAATTTCGAACAGCTGATGTCTGGCTACTTTGCGGATACCGACGGGATTCCACCGCCAAA
TTCCGCACTCGTATCCTGGCTACCCTTCTACCACGACATGGGTTTGGTAATAGGAATTTGCGCACCAATT
CTGGGTGGATACCCCGCGGTGCTCACCAGCCCGGTGTCGTTCCTGCAGCGCCCGGCCCGGTGGATGCACT
TGATGGCCAGCGATTTTCACGCCTTTTCGGCAGCACCGAATTTCGCCTTTGAACTAGCGGCACGAAGAAC
AACCGACGACGACATGGCCGGGCGTGACCTCGGCAACATACTGACCATCCTCAGCGGTAGCGAGCGGGTA
CAGGCCGCGACGATCAAGCGCTTCGCCGACCGCTTTGCTCGCTTCAATCTGCAGGAGAGGGTGATCCGGC
CTTCATACGGGCTCGCAGAAGCAACGGTGTACGTGGCGACGAGCAAACCGGGTCAACCACCGGAGACCGT
CGACTTCGATACTGAAAGTTTATCCGCCGGCCATGCGAAGCCGTGCGCAGGCGGCGGCGCTACATCGTTG
ATCAGCTACATGTTGCCGCGGTCACCGATCGTGCGGATCGTCGACTCGGACACCTGCATCGAATGTCCGG
ACGGAACCGTCGGCGAGATCTGGGTGCACGGCGACAACGTCGCTAATGGCTATTGGCAAAAACCCGACGA
GAGTGAGCGCACGTTCGGCGGAAAGATTGTCACCCCTTCGCCGGGCACACCCGAAGGTCCTTGGCTAAGA
ACGGGCGACTCAGGTTTCGTCACCGATGGCAAAATGTTCATCATCGGTCGGATCAAAGATCTCCTAATTG
TGTACGGACGCAACCACTCCCCCGACGACATCGAGGCAACGATCCAGGAGATCACCCGCGGGCGCTGCGC
GGCGATCTCGGTTCCCGGTGACCGCAGCACCGAAAAGCTGGTCGCCATTATCGAACTCAAGAAGCGTGGC
GACTCAGATCAGGACGCGATGGCTAGACTGGGCGCTATTAAACGCGAAGTCACGTCGGCTTTATCGAGTT
CGCACGGTCTCAGCGTCGCGGATCTGGTTCTGGTTGCGCCTGGCTCGATCCCCATTACCACCAGCGGGAA
GGTCAGGAGAGGGGCGTGTGTCGAGCAATATCGACAGGATCAATTCGCCCGCTTGGATGCCTA
Protein Sequence 
>gi|15610078|ref|NP_217457.1| long-chain-fatty-acid--AMP ligase FadD28 [Mycobacterium tuberculosis H37Rv] MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQELSRCGSTGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILTTSSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPSTAYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLPFYHDMGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGTVGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVTDGKMFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAISVPGDRSTEKLVAIIELKKRGDSDQDAMARLGAIKREVTSALSSSHGLSVADLVLVAPGSIPITTSGKVRRGACVEQYRQDQFARLDA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fadD28 mutant is attenuated in mice (Cox et al., 1999).
COG COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Cox et al., 1999: Cox JS, Chen B, McNeil M, Jacobs WR Jr. Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature. 1999; 402(6757); 79-83. [PubMed: 10573420].