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panC from Mycobacterium tuberculosis H37Ra

Victor ID 1894
Gene Name panC from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5214617
NCBI Protein GI 148663466
Locus Tag MRA_3641
Protein Accession YP_001284989.1
Other Database IDs UniProtKB-ID: PANC_MYCTA
UniRef100: UniRef100_A1KPT7
UniRef90: UniRef90_A1KPT7
UniRef50: UniRef50_A0PV50
UniParc: UPI000013129B
EMBL: CP000611
EMBL-CDS: ABQ75427.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000066551
EnsemblGenome_TRS: EBMYCT00000066556
EnsemblGenome_PRO: EBMYCP00000064666
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3641
eggNOG: COG0414
HOGENOM: HBG428839
OMA: EDFGSYP
ProtClustDB: PRK00380
BioCyc: MTUB419947:MRA_3641-MONOMER
Taxonomy ID 419947
Gene Starting Position 4052945
Gene Ending Position 4053874
Gene Strand (Orientation) -
Protein Name pantoate--beta-alanine ligase
DNA Sequence 
>gi|148659757:4052945-4053874 Mycobacterium tuberculosis H37Ra, complete genome
ATCAGTTTCTCCAATGTGATTCGAGGATTGCCCGGTATCCGTCCGGGCGGTCGGTGCCGGCGAAAGTTCC
GATTTCAATCGCAATGTTGTCCAGCAGCCTGGTGGTGCCAAGCCGGGCAGCAACCAGCAGCCGACCGGAA
CCGTTGAGCGGCATCGGGCCAAGCCCGATATCGCGCAGCTCCAGGTAGTCGACCGCCACGCCGGGTGCAG
CGTCGAGCACCGCACGGGCGGCATCCAGCGCGGCCTGCGCGCCAGCCGTTGCCGCATGCGCTGCGGCCGT
TAGCGCCGCCGAGAGCGCGACGGCCGCCGCACGCTGGGCCGGGTCCAGGTAGCGGTTGCGCGACGACATC
GCCAGCCCGTCGGCTTCGCGCACGGTCGGCACGCCGACCACCGCGACATCGAGGTTGAAGTCCGCGACCA
GCTGCCGGATCAGCACCAGCTGCTGGTAGTCCTTCTCACCGAAGAACACCCGATCCGGGCGCACGATCTG
CAGCAGCTTTAGCACGACCGTCAGCACGCCGGCGAAATGGGTTGGCCGCGGGCCGCCCTCGAGTTCGGCG
GCCAACGGACCGGGTTGCACGGTGGTGCGCAGGCCGTCGGGATACATCGCCGCGGTAGTTGGCGTGAAAG
CGATTTCCACGCCTTCGGCCCGCAGTTGCGCCAGGTCGTCGTCCGGGGTGCGGGGATAGGCGTCGAGATC
TTCCCCGGCACCGAATTGCATCGGGTTGACGAAGATCGACACGACGACGACCGATCCGGGCACCCGCTTG
GCCGCACGCACCAACGCGAGGTGGCCTTCGTGCAGCGCACCCATAGTAGGCACCAACATCACTCGCCGGC
CGGTGAGTCGCAGTGCGCGACTGACATCGGCGACATCCCCCGGTGCCGAGTACACATTGAGTTCACCGGG
ATGGAACGCAGGAATCGTCA
Protein Sequence 
>gi|148663466|ref|YP_001284989.1| pantoate--beta-alanine ligase [Mycobacterium tuberculosis H37Ra] MTIPAFHPGELNVYSAPGDVADVSRALRLTGRRVMLVPTMGALHEGHLALVRAAKRVPGSVVVVSIFVNPMQFGAGEDLDAYPRTPDDDLAQLRAEGVEIAFTPTTAAMYPDGLRTTVQPGPLAAELEGGPRPTHFAGVLTVVLKLLQIVRPDRVFFGEKDYQQLVLIRQLVADFNLDVAVVGVPTVREADGLAMSSRNRYLDPAQRAAAVALSAALTAAAHAATAGAQAALDAARAVLDAAPGVAVDYLELRDIGLGPMPLNGSGRLLVAARLGTTRLLDNIAIEIGTFAGTDRPDGYRAILESHWRN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: panCD mutant is attenuated in mice (Sambandamurthy et al., 2002).
COG COG0414H, under H: Coenzyme transport and metabolism
References
Sambandamurthy et al., 2002: Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL, Jacobs WR Jr. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nature medicine. 2002; 8(10); 1171-1174. [PubMed: 12219086].