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devR from Mycobacterium tuberculosis H37Ra

Victor ID 1861
Gene Name devR from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212298
NCBI Protein GI 148662987
Locus Tag MRA_3165
Protein Accession YP_001284510.1
Other Database IDs UniProtKB-ID: A5U7E8_MYCTA
UniRef100: UniRef100_P95193
UniRef90: UniRef90_P95193
UniRef50: UniRef50_P95193
UniParc: UPI00000BFDEE
EMBL: CP000611
EMBL-CDS: ABQ74948.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000065771.
EnsemblGenome_TRS: EBMYCT00000065776
EnsemblGenome_PRO: EBMYCP00000063886
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3165
eggNOG: COG2197
HOGENOM: HBG753323
OMA: LHCLILT
ProtClustDB: CLSK792301
BioCyc: MTUB419947:MRA_3165-MONOMER
Taxonomy ID 419947
Gene Starting Position 3511417
Gene Ending Position 3512070
Gene Strand (Orientation) -
Protein Name two component transcriptional regulatory protein DevR
DNA Sequence 
>gi|148659757:3511417-3512070 Mycobacterium tuberculosis H37Ra, complete genome
GTCATGGTCCATCACCGGGTGGCCGCGAGCGCTTCAACTCCGTCGCGAATACCGCGGCTTGCGTCCGACG
TTCCATGCCCAGCTTGGCCAGCAACCGCGACACGTAGTTCTTCACCGTCTTTTCGGCTAGGAACATTCGG
TCGGCGATCTGCTTGTTGGTCAGGCCCTCGCTAAGCAGGCCCAGTAGCGTCCGCTCCTGGTCGGTAAGGC
CTGATAGCGGGTCCTGCTTCTCGGCGGCACCGCGCAGCTTGGCCATCAGCGCGGCCGCGGCCCGATTGTC
CAGCAGCGACCGTCCAGCGCCCACATCTTTGACGGCGCGCGCCAACTCCATTCCCTTGATGTCTTTGACG
ACATATCCGCTGGCACCGGCGAGAATCGCATCTAGCATGGCCTCGTCAGAGGTGTAGGACGTGAGGATCA
GACAGCGCAGATCGGGCATGCGGGACAACAGATCGCGGCACAGTTCAATGCCGTTGCCATCGGGCAACCG
GACATCCAGCACCGCGACATCTGGGCGCGCGGCAGGAACCCTGGCCATCGCCTCGGCGACCGAACCCGCC
TCACCTACGACGTCAAGCTCGGGATCGGCCCCAAGCAAGTCAACCAGACCACGACGCACCACCTCGTGGT
CATCGACCAAGAAGACCTTTACCA
Protein Sequence 
>gi|148662987|ref|YP_001284510.1| two component transcriptional regulatory protein DevR [Mycobacterium tuberculosis H37Ra] MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: devR mutant is attenuated in guinea pigs (Malhotra et al., 2004).
COG COG2197TK, under T: Signal transduction mechanisms; K: Transcription
References
Malhotra et al., 2004: Malhotra V, Sharma D, Ramanathan VD, Shakila H, Saini DK, Chakravorty S, Das TK, Li Q, Silver RF, Narayanan PR, Tyagi JS. Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS microbiology letters. 2004; 231(2); 237-245. [PubMed: 14987770].