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fadD28 from Mycobacterium tuberculosis H37Ra

Victor ID 1876
Gene Name fadD28 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5213527
NCBI Protein GI 148662787
Locus Tag MRA_2967
Protein Accession YP_001284310.1
Other Database IDs UniProtKB-ID: A5U6U8_MYCTA
UniRef100: UniRef100_A5U6U8
UniRef90: UniRef90_Q02278
UniRef50: UniRef50_P86249
UniParc: UPI0000036B9F
EMBL: CP000611
EMBL-CDS: ABQ74748.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000066794.
EnsemblGenome_TRS: EBMYCT00000066799
EnsemblGenome_PRO: EBMYCP00000064909
GenomeReviews: CP000611_GR
KEGG: mra:MRA_2967
eggNOG: COG0318
HOGENOM: HBG547964
OMA: ARELSSC
ProtClustDB: PRK05850
BioCyc: MTUB419947:MRA_2967-MONOMER
Taxonomy ID 419947
Gene Starting Position 3295326
Gene Ending Position 3297068
Gene Strand (Orientation) +
Protein Name acyl-CoA synthetase
DNA Sequence 
>gi|148659757:3295326-3297068 Mycobacterium tuberculosis H37Ra, complete genome
CATGAGTGTGCGTTCCCTTCCCGCTGCGTTGCGCGCGTGTGCGCGTCTGCAACCCCATGACCCGGCCTTC
ACGTTTATGGATTACGAACAGGACTGGGACGGCGTTGCGATAACCCTGACGTGGTCGCAGCTGTATCGGC
GAACGCTGAATGTGGCACAGGAGCTGAGCCGTTGTGGTTCCACGGGTGACCGCGTGGTGATCTCTGCTCC
GCAGGGACTCGAGTACGTCGTCGCCTTTCTCGGCGCGTTGCAGGCCGGGCGCATCGCCGTGCCGCTTTCG
GTTCCACAAGGCGGCGTTACCGATGAACGTTCCGATTCGGTACTGAGTGATTCGTCGCCGGTGGCCATTC
TCACTACATCGTCTGCCGTGGACGACGTCGTGCAACATGTTGCGCGGCGGCCCGGGGAATCCCCGCCATC
AATTATCGAAGTTGATTTGCTCGATCTGGACGCTCCGAATGGGTATACCTTCAAAGAAGACGAGTATCCA
TCTACCGCGTATTTGCAATACACCTCCGGGTCCACCCGCACGCCCGCTGGCGTGGTGATGTCCCATCAGA
ACGTTCGGGTTAATTTCGAACAGCTGATGTCTGGCTACTTTGCGGATACCGACGGGATTCCACCGCCAAA
TTCCGCACTCGTATCCTGGCTACCCTTCTACCACGACATGGGTTTGGTAATAGGAATTTGCGCACCAATT
CTGGGTGGATACCCCGCGGTGCTCACCAGCCCGGTGTCGTTCCTGCAGCGCCCGGCCCGGTGGATGCACT
TGATGGCCAGCGATTTTCACGCCTTTTCGGCAGCACCGAATTTCGCCTTTGAACTAGCGGCACGAAGAAC
AACCGACGACGACATGGCCGGGCGTGACCTCGGCAACATACTGACCATCCTCAGCGGTAGCGAGCGGGTA
CAGGCCGCGACGATCAAGCGCTTCGCCGACCGCTTTGCTCGCTTCAATCTGCAGGAGAGGGTGATCCGGC
CTTCATACGGGCTCGCAGAAGCAACGGTGTACGTGGCGACGAGCAAACCGGGTCAACCACCGGAGACCGT
CGACTTCGATACTGAAAGTTTATCCGCCGGCCATGCGAAGCCGTGCGCAGGCGGCGGCGCTACATCGTTG
ATCAGCTACATGTTGCCGCGGTCACCGATCGTGCGGATCGTCGACTCGGACACCTGCATCGAATGTCCGG
ACGGAACCGTCGGCGAGATCTGGGTGCACGGCGACAACGTCGCTAATGGCTATTGGCAAAAACCCGACGA
GAGTGAGCGCACGTTCGGCGGAAAGATTGTCACCCCTTCGCCGGGCACACCCGAAGGTCCTTGGCTAAGA
ACGGGCGACTCAGGTTTCGTCACCGATGGCAAAATGTTCATCATCGGTCGGATCAAAGATCTCCTAATTG
TGTACGGACGCAACCACTCCCCCGACGACATCGAGGCAACGATCCAGGAGATCACCCGCGGGCGCTGCGC
GGCGATCTCGGTTCCCGGTGACCGCAGCACCGAAAAGCTGGTCGCCATTATCGAACTCAAGAAGCGTGGC
GACTCAGATCAGGACGCGATGGCTAGACTGGGCGCTATTAAACGCGAAGTCACGTCGGCTTTATCGAGTT
CGCACGGTCTCAGCGTCGCGGATCTGGTTCTGGTTGCGCCTGGCTCGATCCCCATTACCACCAGCGGGAA
GGTCAGGAGAGGGGCGTGTGTCGAGCAATATCGACAGGATCAATTCGCCCGCTTGGATGCCTA
Protein Sequence 
>gi|148662787|ref|YP_001284310.1| acyl-CoA synthetase [Mycobacterium tuberculosis H37Ra] MSVRSLPAALRACARLQPHDPAFTFMDYEQDWDGVAITLTWSQLYRRTLNVAQELSRCGSTGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQGGVTDERSDSVLSDSSPVAILTTSSAVDDVVQHVARRPGESPPSIIEVDLLDLDAPNGYTFKEDEYPSTAYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDGIPPPNSALVSWLPFYHDMGLVIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHAFSAAPNFAFELAARRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERVIRPSYGLAEATVYVATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIVRIVDSDTCIECPDGTVGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRTGDSGFVTDGKMFIIGRIKDLLIVYGRNHSPDDIEATIQEITRGRCAAISVPGDRSTEKLVAIIELKKRGDSDQDAMARLGAIKREVTSALSSSHGLSVADLVLVAPGSIPITTSGKVRRGACVEQYRQDQFARLDA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fadD28 mutant is attenuated in mice (Cox et al., 1999).
COG COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Cox et al., 1999: Cox JS, Chen B, McNeil M, Jacobs WR Jr. Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature. 1999; 402(6757); 79-83. [PubMed: 10573420].