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pks5 from Mycobacterium tuberculosis H37Rv

Victor ID 188
Gene Name pks5 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886442
NCBI Protein GI 15608665
Locus Tag Rv1527c
Protein Accession NP_216043.1
Other Database IDs UniProtKB-ID: O53901_MYCTU
UniRef100: UniRef100_A5WML4
UniRef90: UniRef90_A5WML4
UniRef50: UniRef50_A1KQG0
UniParc: UPI00000D3B08
EMBL: BX842576
EMBL-CDS: CAA17592.1
RefSeq_NT: NC_000962.2
HSSP: P96202
EnsemblGenome: EBMYCG00000003408.
EnsemblGenome_TRS: EBMYCT00000003410
EnsemblGenome_PRO: EBMYCP00000003410
GenomeReviews: AL123456_GR
KEGG: mtu:Rv1527c
TubercuList: Rv1527c
HOGENOM: HBG669988
OMA: AQHTGKL
ProtClustDB: CLSK2299986
Taxonomy ID 83332
Gene Starting Position 1722082
Gene Ending Position 1728408
Gene Strand (Orientation) -
Protein Name Probable polyketide synthase pks5
DNA Sequence 
>gi|57116681:1722082-1728408 Mycobacterium tuberculosis H37Rv, complete genome
GTCAGGCGGGTGCCGGCGCGTCCCTGTCGGCCGCCAACTTGTCGCACATCAGATCCGCCAGGCCACGAAC
GGTGGTGTTGATTTCGGTGGCGGAAATGCGGATCCCGGTTTCGGCTTCCACCCGCGCACGCAGTTCCTGG
CTGCTCAGTGAGTCCAGGCCGTACTCGCTGAGCAGCCGGTCGGTGTCGATGGTGCGGCGTAGGATTAGGC
CGACCTGCTTGGAGAGTAGCCGCCGCAGCCGGTCTGGCCATTCCTCGCGGGGCAGGTCCACCAGCTCGGC
AAGGAATTTGCTTGTGCCTGAACGGTTTTGCCCCAGGGATTGGAACTTCTCCGCGAATGGGCTGTGCTGG
GCGAAGGCTGTCAGCCAGGGTGATCCGATCACCGGGGCGTAGCCGCTGTAGGCGCGGTTGTGGCGCAGCA
GGGTCTCGAAGGCGTAGGCGCCTTCCTCGGGGGCGATGGCGTCGCCGGTTTGTTCGGCAAAGGCGATCGC
GCGGCCGATCTGGCCCCAGGCGCCCCAGGCGATGGAGGTGGCTGGTAGGTCTTGGGCTCGCCGCCAGTGG
GTGAAGGTGTCCAGCCAGCTGTTGGCCGCGGCGTAGGCGCCCTGACCCGGCGAGCCCACCAGGGCGGCCG
CTGAGGAGAATGAGCAGAACCAGTCCAGCGGCTGGTCCGCGGTGGCCCGGTGCAGTTGCCAGGCGCCATA
TGCCTTGGGCGCCCAGTCGCGTTCGATGAGTTCGTCGGTGATGTTGGCCAAGGTGGCGTCCTCGACCACC
GCGGCCGCGTGCAGCACGCCGCGCAGCGGCAAACCCGTCGCGGTGGCCGCCGTGACCAACCGGTCGGCGG
TGTCCGGCTGGGCGATATCGCCGCACTCCACCACTACGTCAGACCCGATCGCGCGGACGAGTTCGATGGT
CTCCAACGCCTTTTGGCTGGGCTGTGAGCGCGAGCTGAGCACGATGCGGCCGGCCCCGGCGTTGGCCATC
TTCTCGGCCAGGAATAAGCCCAGCCCACCCAGGCCACCGGTGATGATGTAGGACCCGTCTGAACGGAAAA
CCCGAGCCTGTTCGGGGGGAAGCACCACGCTGCTGCGCCCGGCGTGGGGGACGTCGAGGATGAGCTTGCC
GGTGTGCTCGGCCGCGCCCATCACCCGGATCGCGGTGGCCGCCTCGGCCAGCGGGTAATGGGTGCTCTGC
GGCATCGGCAGCACACCCTCGACGGTCAACCGATACACCGTGCTCAACAGTTCGCGGACCGCAGCCGGAT
GGCTCACCGACATCAACCCCAGGTCTAGACCGTAGAACGCCAGATTGCGCCGGAATGGCAAGAGTTCCAG
TCGGGTATTGGAGTAGATGTCGCGTTTGCCGATTTCGATGAAGCGGCCGCCCAGGGCCAGTAGTTTGAGG
CCGGCCAACTGTGCGGCACCGGTCACGGAGTTGAGCACGATGTCCACGCCGTAGCCGGCGGTGTCGCGGC
GGATCTGCTCGGCGAACTCGACGCTGCGCGAGTCATAGACGTGTTCGATGCCCATGTCGCGCAGCAGGTC
TCGACGCTTTTCGTTGCCTGCGGTGGCGTAGATCTGGGCTCCGGCCGCACGCGCGATCGCGATTGCGGCC
TGGCCCACTCCGCCGGTGGCGGAGTGGATGAGCACCTTGTCGCCGGCCTTGATCCGCGCCAGGTCCTGCA
GCCCGTACCACGCGGTGGCGCTGGCGGTGGTCACTGCCGCGGCTTGGGCGTCGGTCAGCCCCTCGGGCAG
TCTGGTGGCCAGGCGGGCGTCGCAGGTGACGAACGTGGCCCAGCAGCCGTTGGGTGACATGCCGCCGACC
CGGTCACCGACCTTGAGTTCGCTGACCCCGGGCCCGACCGCGCTCACCACCCCGGCGAAATCGGTGCCCA
GCTGCGGCTGTCGCCCGTCGAGGGTTTGGTAGCGGCCGAAGGTGACCAGCACGTCGGCGAAGTTGATGCT
GGACGCGGTGACGGCGACCTCGATCTCTCCCGGGCCCGGCGGGACCCGGTCGAACGCGGCGAACTCCAAG
GTTTGCAGGTCACCGGGAGTACGGATCTGTAGGCGCATGCCGGCCTCGGCGTGGTCGACGACGGTGGTTT
GCCGCTCCTCGGGGCGCAGCGGGGCTGGGCACAACCGGGCGGTGTACCACTGGTCGTTGCGCCAGGCGGT
CTCATCCTCGCCGCTGGCCGCCAGCAGCTGACGCGCCACCGACTCCGCGCCGGTCTGCTCATCCACATCG
ACATAGCTGGCCTTCAAATGCGGATGCTCAGCACCAATCACCCGCAACAACCCCCGCATCCCACCCTGCT
CAAGATTGGGTCGGTCACCAGACAACACCGCCTGAGCATTGTGGGTCAGCACATACAACCGCGGCTCTTG
GGCCGTGATCTCTGGAATCTCGCGGGCGATACGCACCACATGTTTGACAAGCTCGCCGCCGCGCACGGGG
GATTCCGCGTCGGGGTCGCCGGTCTGCGGCGCGGTCAACACGAATACGCCGGTGAACCCGCCGGTGCCGA
GCTGGTCGCGCAGCCGCGCGGCCTGGGCTGCGTGGTCGGCGCGCTGCGGCCAGGACATCGTTGTGCACTG
CGCGTCGTGCACCTTCAGCGCGTCGGTCAACTGTGCGGCCACCAAATCCGTAGCGTCACACGTGCTGATC
AGCAGCCAGGCGCCGGGTTCGGCGTGGCTGTTTTCGGGCAGCTCACGTTCGTGCCATTCGATGCTCAGCA
GCCGCTCACCCAAAACCCGGGCACGTTCGCTGGCCTGCGACGCGCCGGTACCCAACTGCAGCCCACGCAC
CGCCAACACCACCGCGCCGTGCTCGTCCAACACGTCCAGGTCGGCTTCCACGCCCACACCGCACGCGGTC
ACCGTCGTGCAGCAGTACCGGGCATGACGGGCCGACCCATAGGACCGCAACCGCCGCACACCCAACGGCA
GCAACAAACCACCGTCGGCCATACCCTGGACGGCGGGATGAGCCGCCACCGACTGGAAGCACGCATCCAG
CAGCACGGGATGCACGCCGTAAGCTTTGACCTGCGAGCGAAGCGGGCCCGGTAGGTTGACCTCGGCCAGC
ACCGTGTCGCCGGCCCCTTCGGCGATGTACGCGTCAACCAGACCCGCAAAAGCCGGCCCTAAGCGATGAC
CACGCTTGTCCAGCCATTGCCGAACCTCGGCGCCGTCCACCTTGTGGGGATGGCTGGCCAGCAGTTCGGC
GATGTTTTTCTGGGGTGGCTGGTCCGGGGCGTCGTCGGCTTCCCGGACAACGTGCAGAACCGCGGCGAGT
TGCCGTGTGTACCTACCATCATGGCTGGTCTCTACTGTGAGTGGGACAACGCCGGGGGCTTCTACCGTGG
CGGTGACGCCGATGGGGGTTTCGTCGTCGAGCAGCAACATCTGCTCGAATCGGATGTCGCGGACTTCGGA
GGCTTCGCCGAGGACGGCGCGGGCTGCGGCCAACGCCATCTCGCAGTAGGCGGCTCCCGGAAGGGCGGCC
GCGCCGTGGATTTGGTGATCGGCCAGCCAGGGTTGTGTCACGGTGCCGACCTCGCCCTGCCAGACGTGGC
GTTCCGGCTCCTCGGGCAGGCGCACGTGGGAGCCCAGCAATGGGTGTACGGCGACGGTATTGGCGTGGGC
GATGCGACGGGTCGTGTCGTCGAGCAGCAGACGACGGTGGTTCCATGTGGGCAGTGGTGCGTTGATCAGT
CGGCCGGTGGGGTAGAGCACGGCGAAGTCGACGGCGGCGCCGGCGGCGTAGAGGTCGCCGGCCAGTGCGC
GCAGCCCGTGGGGCAGTGGTTGTTCGCGGCGCATGCCGGCCAGCGCAGCCGCGGACATGTCGAGGCTGCG
GGCGGTCTGGTCGACCGCGTGGGTCAGCAGGGGGTGGGGGGTCAGCTCGGTGAAGACCCGGTAGCCGTCT
TCGAGGGCGGCTTGCACCGCCGCGGCGAAGCGTACGGTGTGGCGCAGGTTGTCCACCCAGTAGTAGGCGT
CGCAGTAGGGCTCCTCGCGCGGGTCGAACGAGGTCGCCGAGTAGTAGGGGATTTCCGGTTGCAGCGGGCT
GATTTCGGCGAGCGCTTCGGCCAGTTCGTCGAGGATCGGGTCGACCTGCGGGGAGTGCGATGCTACGTCG
ACGGCCACCTCACGGGCCAGCACGTCGCGTTGCTCCCAGGCGGCCACCAGGTCGCGTACCGTCTGGGTGG
CCCCGCCGATCACGGTGGACTGCGGGGAGGCCACCACCGCGACCACGGCGTCGTTGACGCCGCGCGCCAT
CAACTCCGAAAGCACTTGTTGAGCAGGCAGTTCCACCGATGCCATGGCGCCGGCGCCGGCGATACGGGTC
ATCAGCGCCGACCGCCGGCAGATGACGCGCACTCCGTCTTCGAGGCAGAGCGCGCCGGCGACCACCGCGG
CCGCGGACTCGCCCAGCGAGTGGCCGATGACCGCGCCGGGCGCTACGCCGTAGGACTTCATTGTGGCCGC
CAGCGCGACCTGCATGGCAAACAGGGTCGGTTGCACCCGGTCGATGCCGGTCACGACCTCGGGGGCGGTC
ATGGCTTCGGTCACCGAGAAGCCGGATTCCGCGGCGATCAGTGGTTCGATCGCGGCGATGGTGGCGGCGA
ATACCGGTTCGGTGGCCAGCAGGTCGGCGCCCATGCCCGCCCATTGCGAGCCTTGCCCGGAGAACACCCA
GACCGGTCCGCGGTCGTCTTGGCCGACCGCGGGTGGGTAGGGGGGTTCGCCGGTGGCGACTTCCCGCAGC
GCCTCGGTCAGCTCCGCGGTGGTGGCGGCCAGTACGGCGGTGCGCACCGGCCGGTGTCCGCGCCGGCGGG
CCAGGGTGTAGGCCAGATCCGCCGGCGCCAGCTCGGGTCCTTGGGCGTCGACCCAATCGGCCAGCCGCGC
GGCGGTCTGCCGCAGCGCGTCCTGCGAGCTGGCCGACAGCGCGAACAGCAGCGCGCCGTCGATACCGGGT
GTGGCCGGGGTGTCGCCTGGTGCACCGGATTCGGGGGCTGGCACCGGTGCCTGCTCGACAATGGCGTGCA
CATTGGTGCCCGTCATGCCATACGACGACACCGCCGCGCGCCGGGGCGTTTCTTGATCGGCGCCGGGCCA
CGGCGTAATCTCTTGCGGCACAAACAGGTTGGTTTCGATTGCGGCAAGCTTGTCAGGCAGGGCCGTGAAG
TGCAGATTCTGTGGGACCACGCCGTGTTGGAGGGCCAGGACCGCCTTCATCAGTCCCAGCGCTCCAGCGG
CCGACTGGGTGTGGCCGAAATTGGTCTTCACCGATGCCAGCGCGCAGGGGCCGTCGTTGCCGTATACCTC
GGCCAGGCTGGCGTATTCGATGGGGTCACCCACCGGGGTGCCCGGGCCGTGCGCCTCGACCATGCCCACC
GTAGCCGGGTCCACACCGGCCACATCCAACGCCTCCCGATACGCCGCGACCTGCGCGGACCGTGATGGTG
TCGCGATATTGACGGTGTGGCCGTCTTGGTTGGCGGCCGTGCCACGAATTACGGCCAGGATCCGGTCCCC
ATCGGCCAGCGCATCCGGCAACCGCTTGAGCGCCAACATGACACAACCCTCACCGGAGACGAAACCGTCC
GCGGAAACGTCGAACGCATGACAGCGCCCGGTCGCAGACAACATGCCCAACGCCGAGCCCGAGGCGAACC
GCCGCGGTTCGAGCATCACGTAGACACCGCCGGCTAGCGCAATGTCGCTTTCGCCGTCGTGCAGGCTACG
ACAAGCCAGGTGGATAGCGGTGAGGCCAGACGAGCATGCGGTATCTACCGTGATCGCGGGACCCTGCAAG
CCCATGGCGTACGCCACCCGCCCGGATGCGAAGCAGGCATTGGTGCCCGTGTTGCCGTACGGCCCTTCGA
AAGTCTGGTTGTCGGCGTGTACCAATATGTAGTCGGTATGAACCAACCCCACGAAAACCCCTGTCCGCGA
GGCCATCTGGTTCGGTGTTAGGCCGCCGTGCTCCATGGCTTCCCAGGAGGTTTCCAGCAACAAGCGGTGC
TGCGGATCGATCGCTATCGCTTCTTTCTCCCCGATCCCGAAGAACTCGGGATCAAAGTCGCCGACGTTAT
CGAGGTACGCGCCCCATTTGCAGTCGGTGCGTCCGGGCACGCCGGGTTCGGGGTCGTAGTACTCGTCGAT
GTCCCAGCGGTCGGCGGGGATCTCGGTGACCAGATCGTCGCCCCGCAGCAACGCCTCCCACAACCGATCG
GGTGAGTCGATGCCCCCCGGCAGCCGGCACCCCATACCAATGACAGCTACCGGCGTAACACGTGTCCTAT
CCACGGTCTTTGTTCTCTCCTTACCCA
Protein Sequence 
>gi|15608665|ref|NP_216043.1| polyketide synthase [Mycobacterium tuberculosis H37Rv] MGKERTKTVDRTRVTPVAVIGMGCRLPGGIDSPDRLWEALLRGDDLVTEIPADRWDIDEYYDPEPGVPGRTDCKWGAYLDNVGDFDPEFFGIGEKEAIAIDPQHRLLLETSWEAMEHGGLTPNQMASRTGVFVGLVHTDYILVHADNQTFEGPYGNTGTNACFASGRVAYAMGLQGPAITVDTACSSGLTAIHLACRSLHDGESDIALAGGVYVMLEPRRFASGSALGMLSATGRCHAFDVSADGFVSGEGCVMLALKRLPDALADGDRILAVIRGTAANQDGHTVNIATPSRSAQVAAYREALDVAGVDPATVGMVEAHGPGTPVGDPIEYASLAEVYGNDGPCALASVKTNFGHTQSAAGALGLMKAVLALQHGVVPQNLHFTALPDKLAAIETNLFVPQEITPWPGADQETPRRAAVSSYGMTGTNVHAIVEQAPVPAPESGAPGDTPATPGIDGALLFALSASSQDALRQTAARLADWVDAQGPELAPADLAYTLARRRGHRPVRTAVLAATTAELTEALREVATGEPPYPPAVGQDDRGPVWVFSGQGSQWAGMGADLLATEPVFAATIAAIEPLIAAESGFSVTEAMTAPEVVTGIDRVQPTLFAMQVALAATMKSYGVAPGAVIGHSLGESAAAVVAGALCLEDGVRVICRRSALMTRIAGAGAMASVELPAQQVLSELMARGVNDAVVAVVASPQSTVIGGATQTVRDLVAAWEQRDVLAREVAVDVASHSPQVDPILDELAEALAEISPLQPEIPYYSATSFDPREEPYCDAYYWVDNLRHTVRFAAAVQAALEDGYRVFTELTPHPLLTHAVDQTARSLDMSAAALAGMRREQPLPHGLRALAGDLYAAGAAVDFAVLYPTGRLINAPLPTWNHRRLLLDDTTRRIAHANTVAVHPLLGSHVRLPEEPERHVWQGEVGTVTQPWLADHQIHGAAALPGAAYCEMALAAARAVLGEASEVRDIRFEQMLLLDDETPIGVTATVEAPGVVPLTVETSHDGRYTRQLAAVLHVVREADDAPDQPPQKNIAELLASHPHKVDGAEVRQWLDKRGHRLGPAFAGLVDAYIAEGAGDTVLAEVNLPGPLRSQVKAYGVHPVLLDACFQSVAAHPAVQGMADGGLLLPLGVRRLRSYGSARHARYCCTTVTACGVGVEADLDVLDEHGAVVLAVRGLQLGTGASQASERARVLGERLLSIEWHERELPENSHAEPGAWLLISTCDATDLVAAQLTDALKVHDAQCTTMSWPQRADHAAQAARLRDQLGTGGFTGVFVLTAPQTGDPDAESPVRGGELVKHVVRIAREIPEITAQEPRLYVLTHNAQAVLSGDRPNLEQGGMRGLLRVIGAEHPHLKASYVDVDEQTGAESVARQLLAASGEDETAWRNDQWYTARLCPAPLRPEERQTTVVDHAEAGMRLQIRTPGDLQTLEFAAFDRVPPGPGEIEVAVTASSINFADVLVTFGRYQTLDGRQPQLGTDFAGVVSAVGPGVSELKVGDRVGGMSPNGCWATFVTCDARLATRLPEGLTDAQAAAVTTASATAWYGLQDLARIKAGDKVLIHSATGGVGQAAIAIARAAGAQIYATAGNEKRRDLLRDMGIEHVYDSRSVEFAEQIRRDTAGYGVDIVLNSVTGAAQLAGLKLLALGGRFIEIGKRDIYSNTRLELLPFRRNLAFYGLDLGLMSVSHPAAVRELLSTVYRLTVEGVLPMPQSTHYPLAEAATAIRVMGAAEHTGKLILDVPHAGRSSVVLPPEQARVFRSDGSYIITGGLGGLGLFLAEKMANAGAGRIVLSSRSQPSQKALETIELVRAIGSDVVVECGDIAQPDTADRLVTAATATGLPLRGVLHAAAVVEDATLANITDELIERDWAPKAYGAWQLHRATADQPLDWFCSFSSAAALVGSPGQGAYAAANSWLDTFTHWRRAQDLPATSIAWGAWGQIGRAIAFAEQTGDAIAPEEGAYAFETLLRHNRAYSGYAPVIGSPWLTAFAQHSPFAEKFQSLGQNRSGTSKFLAELVDLPREEWPDRLRRLLSKQVGLILRRTIDTDRLLSEYGLDSLSSQELRARVEAETGIRISATEINTTVRGLADLMCDKLAADRDAPAPA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks5 mutant is attenuated in mice (Rousseau et al., 2003).
COG COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Rousseau et al., 2003: Rousseau C, Sirakova TD, Dubey VS, Bordat Y, Kolattukudy PE, Gicquel B, Jackson M. Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis. Microbiology (Reading, England). 2003; 149(Pt 7); 1837-1847. [PubMed: 12855735].