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Rv3877

Victor ID 167
Gene Name Rv3877
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 886207
NCBI Protein GI 15611013
Locus Tag Rv3877
Protein Accession NP_218394.1
Other Database IDs UniProtKB-ID: ECCD1_MYCTU
UniRef100: UniRef100_O69741
UniRef90: UniRef90_O69741
UniRef50: UniRef50_O69741
UniParc: UPI00000CCBB9
EMBL: BX842584
EMBL: AE000516
EMBL-CDS: CAA17969.1
EMBL-CDS: AAK48359.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
TCDB: 9.A.25.1.1
EnsemblGenome: EBMYCG00000001420
EnsemblGenome_TRS: EBMYCT00000001420
EnsemblGenome_PRO: EBMYCP00000001420
GenomeReviews: AE000516_GR
GenomeReviews: AL123456_GR
KEGG: mtu:Rv3877
TIGR: MT3991
TubercuList: Rv3877
HOGENOM: HBG565400
OMA: V
Taxonomy ID 83332
Gene Starting Position 4355006
Gene Ending Position 4356541
Gene Strand (Orientation) +
Protein Name PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
DNA Sequence 
>gi|57116681:4355006-4356541 Mycobacterium tuberculosis H37Rv, complete genome
GTTGAGCGCACCTGCTGTTGCTGCTGGTCCTACCGCCGCGGGGGCAACCGCTGCGCGGCCTGCCACCACC
CGGGTGACGATCCTGACCGGCAGACGGATGACCGATTTGGTACTGCCAGCGGCGGTGCCGATGGAAACTT
ATATTGACGACACCGTCGCGGTGCTTTCCGAGGTGTTGGAAGACACGCCGGCTGATGTACTCGGCGGCTT
CGACTTTACCGCGCAAGGCGTGTGGGCGTTCGCTCGTCCCGGATCGCCGCCGCTGAAGCTCGACCAGTCA
CTCGATGACGCCGGGGTGGTCGACGGGTCACTGCTGACTCTGGTGTCAGTCAGTCGCACCGAGCGCTACC
GACCGTTGGTCGAGGATGTCATCGACGCGATCGCCGTGCTTGACGAGTCACCTGAGTTCGACCGCACGGC
ATTGAATCGCTTTGTGGGGGCGGCGATCCCGCTTTTGACCGCGCCCGTCATCGGGATGGCGATGCGGGCG
TGGTGGGAAACTGGGCGTAGCTTGTGGTGGCCGTTGGCGATTGGCATCCTGGGGATCGCTGTGCTGGTAG
GCAGCTTCGTCGCGAACAGGTTCTACCAGAGCGGCCACCTGGCCGAGTGCCTACTGGTCACGACGTATCT
GCTGATCGCAACCGCCGCAGCGCTGGCCGTGCCGTTGCCGCGCGGGGTCAACTCGTTGGGGGCGCCACAA
GTTGCCGGCGCCGCTACGGCCGTGCTGTTTTTGACCTTGATGACGCGGGGCGGCCCTCGGAAGCGTCATG
AGTTGGCGTCGTTTGCCGTGATCACCGCTATCGCGGTCATCGCGGCCGCCGCTGCCTTCGGCTATGGATA
CCAGGACTGGGTCCCCGCGGGGGGGATCGCATTCGGGCTGTTCATTGTGACGAATGCGGCCAAGCTGACC
GTCGCGGTCGCGCGGATCGCGCTGCCGCCGATTCCGGTACCCGGCGAAACCGTGGACAACGAGGAGTTGC
TCGATCCCGTCGCGACCCCGGAGGCTACCAGCGAAGAAACCCCGACCTGGCAGGCCATCATCGCGTCGGT
GCCCGCGTCCGCGGTCCGGCTCACCGAGCGCAGCAAACTGGCCAAGCAACTTCTGATCGGATACGTCACG
TCGGGCACCCTGATTCTGGCTGCCGGTGCCATCGCGGTCGTGGTGCGCGGGCACTTCTTTGTACACAGCC
TGGTGGTCGCGGGTTTGATCACGACCGTCTGCGGATTTCGCTCGCGGCTTTACGCCGAGCGCTGGTGTGC
GTGGGCGTTGCTGGCGGCGACGGTCGCGATTCCGACGGGTCTGACGGCCAAACTCATCATCTGGTACCCG
CACTATGCCTGGCTGTTGTTGAGCGTCTACCTCACGGTAGCCCTGGTTGCGCTCGTGGTGGTCGGGTCGA
TGGCTCACGTCCGGCGCGTTTCACCGGTCGTAAAACGAACTCTGGAATTGATCGACGGCGCCATGATCGC
TGCCATCATTCCCATGCTGCTGTGGATCACCGGGGTGTACGACACGGTCCGCAATATCCGGTTCTG
Protein Sequence 
>gi|15611013|ref|NP_218394.1| ESX-1 secretion system protein EccD1 [Mycobacterium tuberculosis H37Rv] MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Rv3877 (snm4) mutant is attenuated in mice (Stanley et al., 2003).
References
Stanley et al., 2003: Stanley SA, Raghavan S, Hwang WW, Cox JS. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 13001-13006. [PubMed: 14557536].