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ino1 from Mycobacterium tuberculosis H37Ra

Victor ID 1867
Gene Name ino1 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5212676
NCBI Protein GI 148659806
Locus Tag MRA_0049
Protein Accession YP_001281329.1
Other Database IDs UniProtKB-ID: A5TYB7_MYCTA
UniRef100: UniRef100_P71703
UniRef90: UniRef90_P71703
UniRef50: UniRef50_A0R7G6
UniParc: UPI00001119C3
EMBL: CP000611
EMBL-CDS: ABQ71767.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000067085.
EnsemblGenome_TRS: EBMYCT00000067090
EnsemblGenome_PRO: EBMYCP00000065200
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0049
eggNOG: COG1260
HOGENOM: HBG284345
OMA: ASSYFMK
ProtClustDB: CLSK871751
BioCyc: MTUB419947:MRA_0049-MONOMER
Taxonomy ID 419947
Gene Starting Position 51378
Gene Ending Position 52481
Gene Strand (Orientation) -
Protein Name 1L-myo-inositol-1-phosphate synthase
DNA Sequence 
>gi|148659757:51378-52481 Mycobacterium tuberculosis H37Ra, complete genome
GCTAACCGATGATGAACTCTTCGAGTTGCGCGCGCGCGATGTCGTCGGGCAGCTGCTCGGGCGGGCTCTT
CATCAGGTAGGCCGACGCCGGGATCACCGGTCCGCCGATGCCGCGGTCCTTGGCGATCTTGGCCGCCCGC
ACCGCGTCGATGATGACGCCGGCCGAGTTTGGCGAGTCCCACACCTCGAGCTTGTACTCCAGGTTCAACG
GCACATCTCCGAAGGCGCGGCCCTCAAGACGGACATAGGCCCATTTGCGATCGTCGAGCCATCCGACGTG
GTCGGACGGGCCGATGTGCACGTCCTTGGTCTTGAACTCGCGCTTCAGATTCGAAGTGACGGCCTGGGTC
TTGGAGATCTTCTTGGACTCCAGCCGTTCACGTTCGAGCATGTTGAGGAAGTCCATGTTGCCGCCCACGT
TGAGCTGCATGGTGCGGTCGAGCTGCACGCCGCGGTCCTCGAACAGCTTGGCCAGCACCCGGTGGGTGAT
CGTCGCGCCGACCTGGCTCTTGATGTCATCACCGACGATGGGTACCCTGGCGTCGGTGAACTTCTTGGCC
CACACCGGGTCGGAGGCGATGAACACCGGCAGCGCGTTGACGAACGCCACCCCGGCGTCGATAGCACACT
GGGCGTAGAACTTGTCGGCTTCCTCCGAGCCCACCGGCAAATAGGAGACCAGCACGTCGACCTTGGCCTC
CTTGAGCGCCTGGACGACGTCGACGGGCTCCGCGTCGGAGAGTTCGATGGTGTCGGCGTAGTACTTGCCG
ATGCCATCGAGGGTAGGCCCGCGCTGCACGATCACGTTGGTCGGCGCCACATCGGCGATCTTGATGGTGT
TGTTCTCCGAGGCGAAGATGGCGTCGGACAGGTCGAAGCCGACCTTCTTGGCGTCCACGTCGAACGCCGC
CACGAACTTGACGTCGCGAACGTGGTACGGGCCGAACCGCACGTGCATGAGGCCCGGTACGGTCGATGTG
TCGTCGGCGTTGTAGTAGTACTCGACGCCCTGGACCAGCGAGGACGCGCAGTTGCCGACGCCGACAATGG
CGACTCGAACCTCCGTCGACGCCTCCGGCGCCGGTAACGACTGGTGCTCACTCA
Protein Sequence 
>gi|148659806|ref|YP_001281329.1| 1L-myo-inositol-1-phosphate synthase [Mycobacterium tuberculosis H37Ra] MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVRDVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTIELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPVWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNMLERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQLEEFIIG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ino1 mutant is attenuated in resting macrophages and guinea pigs (Movahedzadeh et al., 2004).
COG COG1260I, under I: Lipid transport and metabolism
References
Movahedzadeh et al., 2004: Movahedzadeh F, Smith DA, Norman RA, Dinadayala P, Murray-Rust J, Russell DG, Kendall SL, Rison SC, McAlister MS, Bancroft GJ, McDonald NQ, Daffe M, Av-Gay Y, Stoker NG. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Molecular microbiology. 2004; 51(4); 1003-1014. [PubMed: 14763976].