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icl from Mycobacterium tuberculosis H37Ra

Victor ID 1905
Gene Name icl from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5215578
NCBI Protein GI 148660233
Locus Tag MRA_0473
Protein Accession YP_001281756.1
Other Database IDs UniProtKB-ID: A5TZJ4_MYCTA
UniRef100: UniRef100_P0A5H4
UniRef90: UniRef90_P0A5H4
UniRef50: UniRef50_P08216
UniParc: UPI0000125205
EMBL: CP000611
EMBL-CDS: ABQ72194.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000066858.
EnsemblGenome_TRS: EBMYCT00000066863
EnsemblGenome_PRO: EBMYCP00000064973
GenomeReviews: CP000611_GR
KEGG: mra:MRA_0473
eggNOG: COG2224
HOGENOM: HBG308645
OMA: LVWCETG
ProtClustDB: CLSK864507
BioCyc: MTUB419947:MRA_0473-MONOMER
Taxonomy ID 419947
Gene Starting Position 558836
Gene Ending Position 560122
Gene Strand (Orientation) +
Protein Name isocitrate lyase Icl
DNA Sequence 
>gi|148659757:558836-560122 Mycobacterium tuberculosis H37Ra, complete genome
TATGTCTGTCGTCGGCACCCCGAAGAGCGCGGAGCAGATCCAGCAGGAATGGGACACGAACCCGCGCTGG
AAGGACGTCACCCGCACCTACTCCGCCGAGGACGTCGTCGCCCTCCAGGGCAGCGTGGTCGAGGAGCACA
CGCTGGCCCGCCGCGGTGCGGAGGTGCTGTGGGAGCAGCTGCACGACCTCGAGTGGGTCAACGCGCTGGG
CGCGCTGACCGGCAACATGGCCGTCCAGCAGGTGCGCGCCGGCCTGAAGGCCATCTACCTGTCGGGCTGG
CAGGTCGCCGGCGATGCCAACCTGTCCGGGCACACCTACCCCGACCAGAGCCTGTATCCCGCCAACTCGG
TGCCGCAGGTGGTCCGCCGGATCAACAACGCACTGCAGCGCGCCGACCAGATCGCCAAGATCGAGGGCGA
TACTTCGGTGGAGAACTGGCTGGCGCCGATTGTCGCCGACGGCGAGGCCGGCTTTGGCGGCGCGCTCAAC
GTCTACGAGCTGCAGAAAGCCCTGATCGCCGCGGGCGTTGCGGGTTCGCACTGGGAGGACCAGTTGGCCT
CTGAGAAGAAGTGCGGCCACCTGGGCGGCAAGGTGTTGATCCCGACCCAGCAGCACATCCGCACTTTGAC
GTCTGCTCGGCTCGCGGCCGATGTGGCTGATGTTCCCACGGTGGTGATCGCCCGTACCGACGCCGAGGCG
GCCACGCTGATCACCTCCGACGTCGACGAGCGCGACCAGCCGTTCATCACCGGCGAGCGCACCCGGGAAG
GCTTCTACCGCACCAAGAACGGCATCGAGCCTTGCATCGCTCGGGCGAAGGCCTACGCCCCGTTCGCCGA
CTTGATCTGGATGGAGACCGGTACCCCGGACCTCGAGGCCGCCCGGCAGTTCTCCGAGGCGGTCAAGGCG
GAGTACCCGGACCAGATGCTGGCCTACAACTGCTCGCCATCGTTCAACTGGAAAAAGCACCTCGACGACG
CCACCATCGCCAAGTTCCAGAAGGAGCTGGCAGCCATGGGCTTCAAGTTCCAGTTCATCACGCTGGCCGG
CTTCCATGCGCTGAACTACTCGATGTTCGATCTGGCCTACGGCTACGCCCAGAACCAGATGAGCGCGTAT
GTCGAACTGCAGGAACGCGAGTTCGCCGCCGAAGAACGGGGCTACACCGCGACCAAGCACCAGCGCGAGG
TCGGCGCCGGCTACTTCGACCGGATTGCCACCACCGTGGACCCGAATTCGTCGACCACCGCGTTGACCGG
TTCCACCGAAGAGGGCCAGTTCCACTA
Protein Sequence 
>gi|148660233|ref|YP_001281756.1| isocitrate lyase Icl [Mycobacterium tuberculosis H37Ra] MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: icl mutant is attenuated in activated macrophages (McKinney et al., 2000).
COG COG2224C, under C: Energy production and conversion
References
McKinney et al., 2000: McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature. 2000; 406(6797); 735-738. [PubMed: 10963599].