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pks1 from Mycobacterium tuberculosis H37Rv

Victor ID 293
Gene Name pks1 from Mycobacterium tuberculosis H37Rv
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 888122
NCBI Protein GI 15610083
Locus Tag Rv2946c
Protein Accession NP_217462.1
Other Database IDs UniProtKB-ID: P96285_MYCTU
UniRef100: UniRef100_A5WRJ8
UniRef90: UniRef90_C6DWA7
UniRef50: UniRef50_C6DWA7
UniParc: UPI0000165323
EMBL: BX842581
EMBL-CDS: CAB06103.1
RefSeq_NT: NC_000962.2
HSSP: P96202
EnsemblGenome: EBMYCG00000003831.
EnsemblGenome_TRS: EBMYCT00000003833
EnsemblGenome_PRO: EBMYCP00000003833
GenomeReviews: AL123456_GR
KEGG: mtu:Rv2946c
TubercuList: Rv2946c
HOGENOM: HBG669988
OMA: RNINDAT
ProtClustDB: CLSK792182
Taxonomy ID 83332
Gene Starting Position 3291502
Gene Ending Position 3296352
Gene Strand (Orientation) -
Protein Name PROBABLE POLYKETIDE SYNTHASE PKS1
DNA Sequence 
>gi|57116681:3291502-3296352 Mycobacterium tuberculosis H37Rv, complete genome
GCTAGGCATGGACCGATACTTCCGCGGCGGCGGGTTCGACAACCTGCGACGTCGGATCACCGGATTCCGT
TGGGCGGCTGCCAGACATTTGCTGGGCGACATACTCGGCGACCGCAGTGGGAGTGGGATGATCGAAAATC
ACGGTAGGTGGCAGCGTCAGTCCGGTGGCGGTTTTGAGGCGGTTGCGTAACTCCACAGCCGTTAATGAGT
CGAAACCGAGGTCGCCGAATTCGGTGTCGGGGTCGACGTCCTCGGCGGAGGGCCTACCCAGCACTGCCGC
TGCCTGCAGACACACCAGCCCCACTAGCAGCTCGAGTTGTTCGTCCGCGGCCAGCCCGTGTAGGCGTTGA
GCCAGCGCCGACTTCGACGAGGTGGCGTCACCGGTGTCGTCGATTTGGCGTCGGCGTGGGCGGCGCGCGA
GCCCGCTGAACAGCGCCGGCAACGCACCGGCCTGGGCCCGGGCGTCTAGTGCAGCCCGGTCCAAGAGCGT
GGCCACCGCCAGAGGGTGATCGATGGCCAGCGCAGCGTCAAACAATTCCACCGCTTCGGCAGGGCTCATC
GGAGCCAGCCCGCTGCGGCTCATGCGGGCCAGATCTCGGCTGCTCAAATGCGCGGTCATGCCGCCAGGCT
GTTCCCACAAACCCCACGCCAGTGATATCCCGGCCAACCCTGCGGCCTGCCGGTGAGCGGCCAACCCGTC
CAGAAACGCGTTTGCCGCCGAGTAGTTGCCCTGCCCCGGCGAGCCGACCGTGGCCGCGATCGATGAGCAC
AGCGCAAACATCGACAAATCCAGGTCACTGGTGGCCTGGTGCAGGTTCCACGCCGCGTCCACCTTGGCCC
GCAACACCGTATCGATGCGGTCCGGTGTCAACGAGGTGATCACTGCGTCATCGAGCACGCCGGCGGCATG
AATCACCCCGCGCACCGGCGGGTACTCCCGCGACAGCTGGGCAAACAACCCCGCTACCGCAGCGCGATCG
GCCACGTCACAGGCCACCACCTGCACCTTGGCGCCGGCCTCCGTCAAGTCGGCGGCCAATTCGGCCGCTC
CCTCCGCGCGATCGCCCCGCCGACTGGCCAACACCAGATGACGCACCCCATAGGCGCCAACCAGGTGGCG
GGCCAACACCCCACCAACCGCCCCGGTGGCACCGGTGATCACCACCGTGCCGTCGGCAAGCCGGTCGGCC
AACGCCGAGGGCATGGTTAAGACAACCTTGCCGATATGGCGGGCCTGGCTCATGAACCGGAAGGCCGCCG
GGGCGCAGCGCACATCCCACGTGGTGACCGGTAGCCGGTGCAGCTCCCGGGTGTCGAACAGCTCCCGCAC
CTCGGCCAACATCTCCTGCATGCGTGCCGGGCCGGCCTCCGACAGGTCGAACGCCCGATACTGCACGCCG
GGATAATTAGCGGCGATCTCCTGCGCATCGCGGATATCCGTCTTGCCCATCTCGAGGAAACGCCCACCGC
GGACCAGTAAGCGCAGCGACGCATCCACGAACTCACCGGCCAGCGAGTCGAGCACCACATCAACCCCGCG
GCCCTCGGTGACCGCCAGGAACTTCTCCTCGAACTCGCATGTGCGGGAATCGCCGATATGGTCGTCGTCA
AACCCCATGGCGCGCAGCGTGTCCCACTTGCCACGGCTGGCGGTGACGAAAACCTCCACGCCCCACTGGC
GAGCCAGCTGCACAGCCGCCATGCCCACACCGCCGGTACCGGCATGGATCAGCACCGATTCGCCCGCCTT
GATCTCGGCTAAATCGGCCAACCCGTACCAGGCCGTCAAGAACACCACCGGCACAGCGGCTGCCTGAGCA
AACGACCAGCCTTGCGGCACCCGGGTAACCAGTTGCTGATCCACCACCGCCAGCGGACCGGCCCCGCCCA
GGAATCCCATCACGGCGTCACCGACGGCAAGATCGGTCACTTCGGGACCGGTCTCAAGCACCACCCCGGC
GCCTTCGGCACCCAGCGGTGGGGCCTGGCCGGGATACATCCCTAGGGCGGCCACCACATCGCGGAAGTTG
ACCCCGACGGCCGCCACCGCCACGCGCACCTGCCCCGCCTGTAGCGGTGCCTGTACCTCCGGGCAGGGCT
GGATCACCAAATCCTCCAGGGTCCCGCCACCACCGGCGGCCAATCGCCACGCCGACTCTGCCGCCGGTAA
CGCTAGCAACGCCGGGGCCGGGGACAGCCGGGGGGCGTGCACAGTGCCGCCGCGCACCAGCAGCTGGGGT
TCCCCGACGCCGGCTAGCACCGAGGCATCCACCGCCGCATCGGTGTCGATCAACACGATCCGGCCGGGAT
TTTCGGCCTGCGCGGAACGCGCCATGCCCCACACCGCGGCGGCGGCCAGGTCGCTGATGTCCTCGCCAGC
CAGCCCCACGCCACCATGGGTCAACACCACCAACGTGGCCGCCCGATCCGCGCCGAGCCAGGACTGCAAC
ACCTCCAGGGCGGTGTGGGTGGCCGCATACACCGAGCCCACCACCGAGGATGCTTGGCCACCGGCAGACT
CGAGTTCCCACACCACGACACTGGCGTCACCATCACTGCCGGCGCAAAAGTCCGCCCAAGACACCGGGGC
AGGTGGGGCGGACCCGTTAGCGCCGCCGCTGACCACCGAGATCGGCGACCACACCACTTCCAGCGGCCCC
TGATCGGACGCACCGCCGGCCGCGGTCACGGCGGCGCGCAGCTGTTCTGCGGTTATCGGGCGAGTAACCA
GCGAGCGCACCGTCAACACCGGCAGCCCAGTGGCGTCGCAGACGTCCACGGAAATCGCATCCGCGCCCGC
GGACGCGAAGCGGGCCCGCACCCGTCCAGCGCCGCCGGCATGCAGCGACACCCCACGCCAGCAAAACGGC
AGTCTCGTCTCGGTGCTCGCCTGGGTCTTCTCGACGGCCAGCCCGAGGGCATGCAGCACCGCGTCCAACA
CCGCCGGATGCATCCCCATTCGGTCGACGGCCACGCCGGCCTCGCCGGGGGCTACAACTTCGGCGAACAG
CTCCGACCCCCGCCGCCAGATCGCCACCAGACCCTGAAACGCGGGGCCGTAGGCATAACCGCGCTCGGCC
AACTGCGCATAGCCGTCCGAGATATCCACACTCTCCGCGCCCTCGGGCGGCCACACGGACAAATCCATCG
GCGTCTCAGCGGCAGCCACCCCCAGCATGCCTTCGGCGTTCAGCAACCAACCCTGGGATTGATCACCGCG
GGAATACACCGACACCGCACGGTGCCCGGATTCATCGGCAGCCCCGACGACCACCTGCACCTGAACCCCG
ACACCCGGGTGCATCACCAACGGTGCGGCCAGCACCAACTCTTCGATGAGCGCGCACCCGACCTCATCAC
CGGCGCGGATCACCAACTCCACAAAACCCGCCCCGGGGAACAGCACCACCCCGTTCACCACGTGGTCGGC
CAGCCACGGCTGATCCGCAAGCGACAACCGGCCGGTCAGCACCACCTCGTCAGAATCGGGCCGCTCGACC
ACCGCACCCAACAAGGCATGCTCGGTCGCGCCCAGACCCAACCCGGCCGCATCGGCGGGCCCATCCGCGC
CCGGCGTCTCCCAAAACCGCCGTCGCTGAAACGCATACGTGGGCAGCTGCACCCGCCGTCCACCCGAGCC
GGCGAACACCGCCGACCACTGCACCGGCACACCGGTGGTGAACACCTGACCGGCAGCACCGAGCGCCGAG
GCCAGCTCGGGCCGGTCTTTGCCCAGCATCGACACCACCATCGCCTCAGCCGGGGCCAAGGACTGCTCGA
TCGAGCCAGTCAAACCACTTCCCGGGCCGGCCTCGATGAAGTGGGTCGCCCCAAGGGTCTGCAAATGACG
CGCACTGTCCGCGAAGCGCACCGGCCGACGAACGTGGTCCACCCAGTACTGCGCCGACCCGAAATCAGGG
CCGGCCAACTCGCCCGTCACGTTCGACACCAGCCCAAGCTGGGGCTCGCGTGCCTGCACCCGGGCCGCGA
CACGCGCGAACTCCTCGAGCATCGGCTCCATCAACGGCGAATGAAACGCATGCGAGACCGCCAACTGGTG
CACCCGCCGACCCTGCGCGGCGAACCGATCCGCAATCGCATTTGCCGCGGCCTGCGCACCGGAGATCACC
ACCGATTCGGGCGCGTTGATCGCAGCGATCCCCACACCCTCACCCAGCAGCGGCTCCACCTCGTCCTCAC
TGGCAGCCACCGCCACCATCGCACCGCCTGCCGGCAGCGCCTGCATCAACCGGCCCCGCGCCACCACCAG
CATCGCCGCGTCCGCCAACGTCAACACACCGGCCGCGTGCGCCGCCGCCAGCTCTCCAACGGAGTGACCC
ATGACGAAGTCCGGAAGCACACCCCAATCCCGCAACACCGCGAACGATGCCACCTCCACCGCGAACAACG
CGGGCTGAGCAAATTCGGTGCTGTCAAGCAAATCCGCATCGGCACCCCAAATAACGTCGCGCAGCGGCAA
CCGCAGATGCCGGTCCAACTCGTCGGCCACCGCATCGAATGCCTGCGCAAACACGGGCAACTCGCCGTAC
AACTCGCGGCCCATCCCGATGCGCTGCGCGCCCTGCCCAGGAAACACGACCACCGTCTTGCCCACCGACC
CTGGCTGACCGACCGCCACGCCGGCACCCGGCTCGCCCGCCGCGAGCCCAGCCAGCCCGGCAATCAGTTG
CTCACGGCTTGCGCCGACCACCACCGCTCGGTGCTCAAACACCGAGCGACTGGCCAACGAGCACCCCACA
TCGATCGGATCCAGCCCTGGGTTGGCCTGCACGTGGGCCATAAGTCGACCCGCCTGCGCCGTCAACGCCT
CAGCCGATCTCGCCGAAATCA
Protein Sequence 
>gi|15610083|ref|NP_217462.1| polyketide synthase [Mycobacterium tuberculosis H37Rv] MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pks1 mutant is attenuated in mice (Sirakova et al., 2003).
COG COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sirakova et al., 2003: Sirakova TD, Dubey VS, Cynamon MH, Kolattukudy PE. Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis. Journal of bacteriology. 2003; 185(10); 2999-3008. [PubMed: 12730158].