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cyp125

Victor ID 266
Gene Name cyp125
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 887782
NCBI Protein GI 15610681
Locus Tag Rv3545c
Protein Accession NP_218062.1
Other Database IDs UniProtKB-ID: CP125_MYCTU
UniRef100: UniRef100_P63710
UniRef90: UniRef90_P63710
UniRef50: UniRef50_P63710
UniParc: UPI0000126BAD
EMBL: BX842583
EMBL: AE000516
EMBL-CDS: CAB05061.1
EMBL-CDS: AAK48008.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 2X5W
PDB: 3IVY
PDB: 3IW0
PDB: 3IW1
PDB: 3IW2
EnsemblGenome: EBMYCG00000002521
EnsemblGenome_TRS: EBMYCT00000002523
EnsemblGenome_PRO: EBMYCP00000002523
EnsemblGenome: EBMYCG00000070756
EnsemblGenome_TRS: EBMYCT00000070761
EnsemblGenome_PRO: EBMYCP0
Taxonomy ID 83332
Gene Starting Position 3984143
Gene Ending Position 3985444
Gene Strand (Orientation) -
Protein Name PROBABLE CYTOCHROME P450 125 CYP125
DNA Sequence 
>gi|57116681:3984143-3985444 Mycobacterium tuberculosis H37Rv, complete genome
ATTAGTGAGCAACCGGGCATCTACCGGTGTAGTCGACCTGCCAGTGCTTAATGCCGTTGAGCCAGCCGGA
CCGCAGCCGCTCGGGCGCCGAGATCGGCTTGAGGTCGGGCATGTGGTCGGCTACGGCGTTAAAGATTAGG
TTGATCGTCATCCGGGCCAGATTCGCACCGATGCAGTAGTGAGCGCCGGTGCCGCCGAAGCCGACGTGCG
GGTTGGGGTTGCGCAGGATGTTAAATGTGAACGGATCCTGGAAAACCTCTTCGTCGAAGTTAGCCGACCG
GTAGAACATCACCACCCGCTGACCCTTCTTAATCTGTACGCCGGACAACTCGTAGTCCCGCAGCGCGGTG
CGCTGAAAAGCGGTGACCGGGGTTGCCCAGCGCACGATCTCATCGGCCGCGGTCTCCGGACGCACTTTCT
TGTACAGCTCCCACTGGTCGGGGTGTTCAGCGAACGCCATCATGCCCTGGGTGATGGAGTTGCGGGTGGT
CTCGTTACCGGCCACCGCCAGCATCACCACGAAGAAGCCGAACTCGTCGTCGGAGAGCTTCTCGCCGTCG
ATATCGGCTTGGATCAACTGAGTCACGATGTCGTCGGCGGGGTTCTTCGCCTTCTCCTCGGCCATCTTCA
TCGCATAGCCGATCAGCTCCGCCGAGGACGCCTTCGGATCGATGTGGGCGTATTCCGGATCCTCGTTGCC
GGTCATCTCGTTTGACCAGTGGAACAGCTTGCCGCGGTCCTCCTGCGGCACGCCCAGCAAGCCCGCGATC
GCCTGCAATGGCAGCTCACAGGAAACCTGCTCGACAAAGTCTCCAGAACCCGCGGCGGCCGCCTCCGCGG
CGATCTTCTGGGCGCGCTCCTGGAGCTCGTCATGCAGGCGTCCGACCGCACGTGGCGTGAAGCCGCGAGA
GATGATCTTGCGCAGCCGGGTGTGGTGCGGCGCGTCCATGTTGAGCATGACGAAGCGCTGAACCTCGATG
TCCTCACGCGCGATGTCGTTCTTGAATCGCGGGATCACCCCGTTTTCGTAGCTGGAGAACACGTCGCTAT
GCCGCGATATCTCTTTGACGTCGTTGAGTTTGGTGATCGCCCAGAAACCGCCGTCGTGAAAGCCGCCGCC
CTTGCCAGGATCCTGCCCGTTCCACCAGATCGGCGCCGCGGACCGCAGCTCGGCGAATTCGGCAACCGGC
AGCCGTTCGGCGTAGATTGCGGGGTCGGTGAAATCGAACCCGGGCGGCAGATTGGGGCTGGGCACGGTAG
TTCTCCTTACTGCAATCTCCACTGACTGGTGATTCCACGACA
Protein Sequence 
>gi|15610681|ref|NP_218062.1| steroid C26-monooxygenase [Mycobacterium tuberculosis H37Rv] MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: attenuated in mice (Sassetti and Rubin, 2003).
COG COG2124Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Sassetti and Rubin, 2003: Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22); 12989-12994. [PubMed: 14569030].