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Rv3676

Victor ID 110
Gene Name Rv3676
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Rv
NCBI Gene ID 885502
Uniprot ID O69644
NCBI Protein GI 15610812
Locus Tag Rv3676
Protein Accession NP_218193.1
Other Database IDs UniProtKB-ID: O69644_MYCTU
UniRef100: UniRef100_A5U900
UniRef90: UniRef90_Q0S8M5
UniRef50: UniRef50_A9WTJ5
UniParc: UPI00000D5FBC
EMBL: AE000516
EMBL: BX842583
EMBL-CDS: AAK48144.1
EMBL-CDS: CAA17998.1
RefSeq_NT: NC_000962.2
RefSeq_NT: NC_002755.2
PDB: 3D0S
PDB: 3H3U
PDB: 3I54
PDB: 3I59
EnsemblGenome: EBMYCG00000003752.
EnsemblGenome_TRS: EBMYCT00000003754
EnsemblGenome_PRO: EBMYCP00000003754
EnsemblGenome: EBMYCG00000071433.
EnsemblGenome_TRS: EBMYCT00000071438
EnsemblGenome_PRO: EBMYCP00000069
Taxonomy ID 83332
Gene Starting Position 4116477
Gene Ending Position 4117151
Gene Strand (Orientation) +
Protein Name PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY CRP/FNR-FAMILY)
DNA Sequence 
>gi|57116681:4116477-4117151 Mycobacterium tuberculosis H37Rv, complete genome
CGTGGACGAGATCCTGGCCAGGGCAGGAATCTTCCAAGGCGTGGAGCCCAGCGCAATCGCCGCACTGACG
AAACAGCTGCAGCCCGTCGACTTCCCCCGTGGACACACGGTCTTCGCGGAAGGGGAGCCGGGCGATCGGC
TGTACATCATCATCTCGGGGAAGGTCAAGATCGGTCGCCGGGCACCAGACGGCCGAGAAAACCTGTTAAC
CATCATGGGCCCGTCGGACATGTTCGGCGAGTTGTCGATCTTCGACCCGGGTCCGCGCACGTCCAGCGCG
ACCACGATCACCGAGGTGCGGGCGGTGTCGATGGACCGCGACGCGCTGCGGTCATGGATCGCCGATCGTC
CCGAAATCTCCGAACAGCTGCTGCGGGTGCTGGCCCGCCGGCTGCGCCGCACCAACAACAACCTGGCCGA
CCTCATCTTCACCGATGTGCCCGGTCGGGTGGCCAAGCAGCTGTTGCAGCTCGCCCAGCGTTTCGGCACC
CAGGAAGGTGGCGCATTGCGGGTCACCCACGACCTGACACAGGAAGAAATCGCCCAGCTGGTCGGGGCCT
CACGCGAGACGGTGAACAAGGCACTGGCTGATTTCGCTCACCGCGGCTGGATCCGCCTTGAGGGCAAGAG
TGTGCTGATCTCTGACTCCGAAAGACTGGCCCGCCGAGCGAGGTA
Protein Sequence 
>gi|15610812|ref|NP_218193.1| cAMP receptor protein [Mycobacterium tuberculosis H37Rv] MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Rv3676 mutant is attenuated in human macrophages and mice (Rickman et al., 2005).
Predicted Interacting Host Protein A1L494; B0LPF3; B1PKY1; B2R5T5; B7Z4Z5; B7ZLX4; B9A012; O43572; O43687; O75100; O75400; P00533; P01891; P04439; P10644; P11802; P13612; P14672; P17612; P24864;
P24941; P31321; P35250; P51817; P62993; P84022; Q05BQ3; Q05C41; Q13402; Q13485; Q14191; Q15796; Q2TAJ5; Q53XR6; Q59F09; Q59FR3; Q5JQC9; Q75MT5; Q86TH5; Q92667;
Q9BSF0; Q9H8W4; Q9P0M2; Q9P0T0; Q9UKA4; Q9ULJ8; Q9ULZ3; Q9Y6D5
COG COG0664T, under T: Signal transduction mechanisms
References
Rickman et al., 2005: Rickman L, Scott C, Hunt DM, Hutchinson T, Menéndez MC, Whalan R, Hinds J, Colston MJ, Green J, Buxton RS. A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor. Molecular microbiology. 2005; 56(5); 1274-1286. [PubMed: 15882420].