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ilvB1 from Mycobacterium tuberculosis H37Ra

Victor ID 1900
Gene Name ilvB1 from Mycobacterium tuberculosis H37Ra
Sequence Strain (Species/Organism) Mycobacterium tuberculosis H37Ra
NCBI Gene ID 5215324
NCBI Protein GI 148662854
Locus Tag MRA_3033
Protein Accession YP_001284377.1
Other Database IDs UniProtKB-ID: A5U715_MYCTA
UniRef100: UniRef100_P0A622
UniRef90: UniRef90_P0A622
UniRef50: UniRef50_Q59498
UniParc: UPI000012D536
EMBL: CP000611
EMBL-CDS: ABQ74815.1
RefSeq_NT: NC_009525.1
EnsemblGenome: EBMYCG00000066279.
EnsemblGenome_TRS: EBMYCT00000066284
EnsemblGenome_PRO: EBMYCP00000064394
GenomeReviews: CP000611_GR
KEGG: mra:MRA_3033
eggNOG: COG0028
HOGENOM: HBG323037
OMA: DVAVCMA
ProtClustDB: PRK07789
BioCyc: MTUB419947:MRA_3033-MONOMER
Taxonomy ID 419947
Gene Starting Position 3373298
Gene Ending Position 3375154
Gene Strand (Orientation) -
Protein Name acetolactate synthase 1 catalytic subunit
DNA Sequence 
>gi|148659757:3373298-3375154 Mycobacterium tuberculosis H37Ra, complete genome
ATCAGGCGTGGCCTTCGGTGATGTCGTCGAACAGGGGGCGAATGCCGCGGGCGGCCTGGATCTCGTCATT
GCTGGTGCCCGCGGCCACCATCGGCCACACTTGCGCGTCGGCACCGACGATGAAGTCGATCACCACCGGG
CAGTCGTTGATCGCCCGCGCCTGGTTGATGACGTCGACGACGTCCTCTTCCCGCTCGCACCGCAACCCCA
CACACCCCAAGGCCTCGGCCAGTTTCACGAAGTCGGGGATGCGGTGCGAATGAGTGGCCAGGTCGGTCTG
CGAGTACCGCTCGGCATAGAACAGGCTCTGCCACTGCCGCACCATGCCCAGGTTGCCGTTGTTGATCAGC
GCCACCTTGACCGGTATGCCCTCGACCGCGCAGGTGGCCAGCTCCTGGTTGGTCATCTGGAAGCAACCGT
CGCCGTCGATCGCCCAGACCTCGGTGCCGGGGAGGGCGATCTTGGCGCCCATGGCCGCCGGGATGGCAAA
CCCCATGGTGCCCAGACCGCCGGAGTTCAGCCAGCTGCGCGGCTTTTCGTATCTGATGAACTGCGCGGCC
CACATCTGGTGCTGGCCGACGCCGGCGACGAAGACGGCGTCCGGCCCGGCGATCTCGCCGAGCTTTTCGA
TCACGTATTCCGGGCTCAGGCTGCCGTCGCTCTGCGGCCCATAGCTCAGCGGATAGGTCTTGCGCACACC
GTTCAGGTATGCCCACCAGTCGGCCATCTCGATGGTGCCGGGAATGTGGTGGTGGCGCAGCATCGCGATC
AGTTCGGTGATGACGGCCTTGACGTCACCGACGATGGGCACGTCGGCGTGGCGGTTCTTGCCGATCTCGG
CCGGGTCGATGTCGGCGTGGATGACCTTGGCTTCCGGCGCGAACGAGTCGAGCTTGCCGGTCACCCGGTC
GTCGAAGCGGGTACCCAGCGCGATCAGCAGGTCGCTGCGCTGCAGCGCCGCCACGGCGGCCACCGTGCCG
TGCATGCCGGGCATGCCGAGGTTTTGCCGGTGGCTGTCGGGAAACGCGCCGCGGGCCATCAGCGTGGTGA
CCACCGGGATGCCGGTCAGCTCGGCCAGCTCCCGGAGCTGCTCGGTGGCCTCACCGCGGATGACGCCGCC
GCCGACATACAGCACCGGCTTGCGCGCGGCCGCGATCAGCTTGGCGGCCTCGCGGACCTGCCGGCTGTGC
GGTTTGGTGTTGGGCTTGTAGCCGGGCAGCTCCATCCGCGGCGGCCAGCTGAACGTGCACTGGCCCTGCA
GCACGTCCTTGGGGATGTCGACCAGCACCGCGCCCGGACGGCCGGAGGCCGCGATGTGGAAGGCCTCGGC
CAGCACCCGCGGAATGTCGTCACCGGAGCGGACCAGAAAGTTGTGCTTGGTGATCGGCATCGTGATGCCC
GAGATGTCGGCCTCCTGGAAGGCGTCGGTGCCGATCAGCCCCCGCCCGACCTGACCGGTGATAGCGACCA
CCGGGATCGAGTCCATCTGCGCGTCGGCCAGCGGGGTCACCAGGTTGGTCGCTCCGGGACCCGACGTTGC
CATGCACACGCCCACCCGGCCGGTGACGTGCGCGTAGCCGCTGGCGGCATGCCCGGCGCCCTGTTCGTGG
CGGACCAGCACGTGGCGCAGCTTTTTCGAGTCGAACAGCGGGTCATACACCGGCAGCACCGCACCGCCCG
GAATCCCGAAAATGACGTCGACGCCGAGTTCCTCCAGCGACCGGATGACCGCCTGTGCACCGGTAAGCTG
CTGCAGTGCAACATGTTTCGGACGAGCCGCCGGGTGCTTTGGCTCATTCGCCGCGCTGTGTGGCTCTGGC
TTGAATGTCGGTGAGTGTGGCTTGGTTGGTGCGCTCA
Protein Sequence 
>gi|148662854|ref|YP_001284377.1| acetolactate synthase 1 catalytic subunit [Mycobacterium tuberculosis H37Ra] MSAPTKPHSPTFKPEPHSAANEPKHPAARPKHVALQQLTGAQAVIRSLEELGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAHVTGRVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITMPITKHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGYKPNTKPHSRQVREAAKLIAAARKPVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMARGAFPDSHRQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHADIDPAEIGKNRHADVPIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLSYGPQSDGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSGGLGTMGFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPVKVALINNGNLGMVRQWQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCVGLRCEREEDVVDVINQARAINDCPVVIDFIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDITEGHA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvB1 mutant is attenuated in mice (Awasthy et al., 2009).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Awasthy et al., 2009: Awasthy D, Gaonkar S, Shandil RK, Yadav R, Bharath S, Marcel N, Subbulakshmi V, Sharma U. Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice. Microbiology (Reading, England). 2009; 155(Pt 9); 2978-2987. [PubMed: 19542000].