| Victors ID |
Gene Name |
Sequence Strain (Species/Organism) |
NCBI Gene ID |
NCBI Nucleotide GI |
NCBI Protein GI |
Locus Tag |
Genbank Accession |
Protein Accession |
Protein Name |
Molecule Role |
Molecule Role Annotation |
PMID |
|
|
leuO from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1246630
|
|
16759110
|
STY0134 |
|
NP_454727.1 |
leucine transcriptional activator |
Virulence factor |
MUTATION: leuO mutant exhibited wild-type levels of epithelial invasion but highly reduced transepithelial migration of PMN [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
gmhA from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1246837
|
|
16759305
|
STY0355 |
|
NP_454922.1 |
phosphoheptose isomerase |
Virulence factor |
MUTATION: gmhA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
cstA from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1247108
|
|
16759559
|
STY0644 |
|
NP_455176.1 |
carbon starvation protein A |
Virulence factor |
MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
sigE from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1247535
|
|
16759970
|
STY1120 |
|
NP_455587.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
sigD from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1247536
|
|
16759971
|
STY1121 |
|
NP_455588.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
pcgL from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1247855
|
|
16760281
|
STY1465 |
|
NP_455898.1 |
D-alanyl-D-alanine dipeptidase |
Virulence factor |
MUTATION: pcgL mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248080
|
|
16760497
|
STY1706 |
|
NP_456114.1 |
secretion system apparatus protein SsaV |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
ssaM from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248081
|
|
16760498
|
STY1707 |
|
NP_456115.1 |
putative pathogenicity island protein |
Virulence factor |
MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. |
15491354
|
|
|
sseD from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248093
|
|
16760510
|
STY1719 |
|
NP_456127.1 |
putative pathogenicity island effector protein |
Virulence factor |
MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
sseC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248094
|
|
16760511
|
STY1720 |
|
NP_456128.1 |
putative pathogenicity island effector protein |
Virulence factor |
MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
spiC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248101
|
|
16760518
|
STY1727 |
|
NP_456135.1 |
putative pathogenicity island 2 secreted effector protein |
Virulence factor |
MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. |
10406797
|
|
|
fliC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248507
|
|
16760903
|
STY2167 |
|
NP_456520.1 |
flagellin |
Virulence factor |
MUTATION: fliC mutants were attenuated in orally inoculated chicks [Ref6523:Parker and Guard-Petter, 2001]. |
11731137
|
|
|
aroC |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1248939
|
|
16761308
|
STY2616 |
|
NP_456925.1 |
chorismate synthase |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
prgK from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249300
|
|
16761648
|
STY2992 |
|
NP_457265.1 |
pathogenicity 1 island effector protein |
Virulence factor |
MUTATION: prgK mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgJ from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249301
|
|
16761649
|
STY2993 |
|
NP_457266.1 |
pathogenicity 1 island effector protein |
Virulence factor |
MUTATION: prgJ mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
sipC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249313
|
|
16761661
|
STY3007 |
|
NP_457278.1 |
pathogenicity island 1 effector protein |
Virulence factor |
MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells [Ref6525:Chang et al., 2005]. |
15720547
|
|
|
spaS from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249316
|
|
16761664
|
STY3010 |
|
NP_457281.1 |
surface presentation of antigens protein SpaS |
Virulence factor |
MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain [Ref6526:Darwin and Miller, 2000]. |
10692170
|
|
|
spaR from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249317
|
|
16761665
|
STY3011 |
|
NP_457282.1 |
secretory protein (associated with virulence) |
Virulence factor |
MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaQ from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249318
|
|
16761666
|
STY3012 |
|
NP_457283.1 |
secretory protein (associated with virulence) |
Virulence factor |
MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaP from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249319
|
|
16761667
|
STY3013 |
|
NP_457284.1 |
surface presentation of antigens protein SpaP |
Virulence factor |
MUTATION: spaP mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaO from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249320
|
|
16761668
|
STY3014 |
|
NP_457285.1 |
surface presentation of antigens protein SpaO |
Virulence factor |
MUTATION: spaO mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaN from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249321
|
|
16761669
|
STY3015 |
|
NP_457286.1 |
surface presentation of antigens protein (associated with type III secretion and virulence) |
Virulence factor |
MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
spaM from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249322
|
|
16761670
|
STY3016 |
|
NP_457287.1 |
secretory protein (associated with virulence) |
Virulence factor |
MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
invH from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1249329
|
|
16761677
|
STY3023 |
|
NP_457294.1 |
cell adherance/invasion protein |
Virulence factor |
MUTATION: invH mutants are attenuated in calves [Ref6529:Watson et al., 1998]. |
9529064
|
|
|
cstA from Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
Salmonella enterica subsp. enterica serovar Typhi str. CT18 |
1251088
|
|
16763338
|
STY4890 |
|
NP_458955.1 |
probable carbon starvation protein |
Virulence factor |
MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
sseC from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3333877
|
|
62179991
|
SC1421 |
|
YP_216408.1 |
Secretion system effector SseC |
Virulence factor |
MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
sseD from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3333878
|
|
62179992
|
SC1422 |
|
YP_216409.1 |
Secretion system effector SseD |
Virulence factor |
MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
ssaM from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3333890
|
|
62180004
|
SC1434 |
|
YP_216421.1 |
Secretion system apparatus SsaM |
Virulence factor |
MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. |
15491354
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3333891
|
|
62180005
|
SC1435 |
|
YP_216422.1 |
secretion system apparatus protein SsaV |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
sopE2 from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3334328
|
|
62180422
|
SC1852 |
|
YP_216839.1 |
TypeIII-secreted protein effector: invasion-associated protein |
Virulence factor |
MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. |
10735884
|
|
|
sptP from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3335312
|
|
62181380
|
SC2810 |
|
YP_217797.1 |
protein tyrosine phosphate |
Virulence factor |
MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
spaR from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3335322
|
|
62181390
|
SC2820 |
|
YP_217807.1 |
surface presentation of antigens; secretory proteins |
Virulence factor |
MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaQ from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3335323
|
|
62181391
|
SC2821 |
|
YP_217808.1 |
surface presentation of antigens; secretory proteins |
Virulence factor |
MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
tdcA from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 |
3335702
|
|
62181761
|
SC3191 |
|
YP_218178.1 |
DNA-binding transcriptional activator |
Virulence factor |
MUTATION: tdcA mutant is less invasive of cultured epithelial cells and attenuated in mice [Ref6585:Kim et al., 2009]. |
19812899
|
|
|
cstA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1067015
|
|
29144816
|
t4582 |
|
NP_808158.1 |
probable carbon starvation protein |
Virulence factor |
MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
leuO from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1067696
|
|
29140660
|
t0119 |
|
NP_804002.1 |
leucine transcriptional activator |
Virulence factor |
MUTATION: leuO mutant exhibited wild-type levels of epithelial invasion but highly reduced transepithelial migration of PMN [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
tdcA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068432
|
|
29143502
|
t3165 |
|
NP_806844.1 |
DNA-binding transcriptional activator |
Virulence factor |
MUTATION: tdcA mutant is less invasive of cultured epithelial cells and attenuated in mice [Ref6585:Kim et al., 2009]. |
19812899
|
|
|
invE from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068841
|
|
29143158
|
t2799 |
|
NP_806500.1 |
cell invasion protein |
Virulence factor |
MUTATION: invE mutants were unable to penetrate Henle-407 human intestinal cells and Madin-Darby canine kidney cells [Ref6679:Ginocchio et al., 1992]. |
1631083
|
|
|
invH from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068847
|
|
29143161
|
t2802 |
|
NP_806503.1 |
cell adherance/invasion protein |
Virulence factor |
MUTATION: invH mutants are attenuated in calves [Ref6529:Watson et al., 1998]. |
9529064
|
|
|
spaM from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068849
|
|
29143154
|
t2795 |
|
NP_806496.1 |
virulence-associated secretory protein |
Virulence factor |
MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
spaR from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068857
|
|
29143149
|
t2790 |
|
NP_806491.1 |
virulence-associated secretory protein |
Virulence factor |
MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaQ from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068858
|
|
29143150
|
t2791 |
|
NP_806492.1 |
virulence-associated secretory protein |
Virulence factor |
MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaO from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068861
|
|
29143152
|
t2793 |
|
NP_806494.1 |
surface presentation of antigens protein SpaO |
Virulence factor |
MUTATION: spaO mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaN from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068866
|
|
29143153
|
t2794 |
|
NP_806495.1 |
antigen presentation protein SpaN |
Virulence factor |
MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
spaP from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068867
|
|
29143151
|
t2792 |
|
NP_806493.1 |
surface presentation of antigens protein SpaP |
Virulence factor |
MUTATION: spaP mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaS from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068878
|
|
29143148
|
t2789 |
|
NP_806490.1 |
surface presentation of antigens protein SpaS |
Virulence factor |
MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain [Ref6526:Darwin and Miller, 2000]. |
10692170
|
|
|
sipC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068886
|
|
29143145
|
t2786 |
|
NP_806487.1 |
pathogenicity island 1 effector protein |
Virulence factor |
MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells [Ref6525:Chang et al., 2005]. |
15720547
|
|
|
orgA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068896
|
|
29143131
|
t2772 |
|
NP_806473.1 |
oxygen-regulated invasion protein |
Virulence factor |
MUTATION: orgA mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgK from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068898
|
|
29143132
|
t2773 |
|
NP_806474.1 |
pathogenicity 1 island effector protein |
Virulence factor |
MUTATION: prgK mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgJ from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068904
|
|
29143133
|
t2774 |
|
NP_806475.1 |
pathogenicity 1 island effector protein |
Virulence factor |
MUTATION: prgJ mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
orgA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1068912
|
|
29143130
|
t2771 |
|
NP_806472.1 |
oxygen-regulated invasion protein |
Virulence factor |
MUTATION: orgA mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
waaP |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1069221
|
|
29144077
|
t3797 |
|
NP_807419.1 |
lipopolysaccharide core biosynthesis protein |
Virulence factor |
MUTATION: waaP mutant is avirulent in mice [Ref6680:Yethon et al., 2000]. |
10899846
|
|
|
cstA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1069355
|
|
29142668
|
t2268 |
|
NP_806010.1 |
carbon starvation protein A |
Virulence factor |
MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
fliC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070204
|
|
29141405
|
t0918 |
|
NP_804747.1 |
flagellin |
Virulence factor |
MUTATION: fliC mutants were attenuated in orally inoculated chicks [Ref6523:Parker and Guard-Petter, 2001]. |
11731137
|
|
|
spiC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070679
|
|
29141722
|
t1261 |
|
NP_805064.1 |
putative pathogenicity island secreted effector protein |
Virulence factor |
MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. |
10406797
|
|
|
sseC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070690
|
|
29141729
|
t1268 |
|
NP_805071.1 |
putative pathogenicity island effector protein |
Virulence factor |
MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
sseD from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070691
|
|
29141730
|
t1269 |
|
NP_805072.1 |
putative pathogenicity island effector protein |
Virulence factor |
MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
ssaM from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070703
|
|
29141742
|
t1281 |
|
NP_805084.1 |
putative pathogenicity island protein |
Virulence factor |
MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. |
15491354
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070705
|
|
29141743
|
t1282 |
|
NP_805085.1 |
secretion system apparatus protein SsaV |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
pcgL from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1070960
|
|
29141952
|
t1508 |
|
NP_805294.1 |
D-alanyl-D-alanine dipeptidase |
Virulence factor |
MUTATION: pcgL mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
sigD from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1071478
|
|
29142258
|
t1828 |
|
NP_805600.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
sigE from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
Salmonella enterica subsp. enterica serovar Typhi str. Ty2 |
1071574
|
|
29142259
|
t1829 |
|
NP_805601.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
sigE from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3175884
|
|
56413915
|
SPA1760 |
|
YP_150990.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
spiC from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3175900
|
|
56413636
|
SPA1460 |
|
YP_150711.1 |
putative pathogenicity island secreted effector protein |
Virulence factor |
MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. |
10406797
|
|
|
spaN from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3176267
|
|
56414844
|
SPA2750 |
|
YP_151919.1 |
antigen presentation protein SpaN |
Virulence factor |
MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
spaM from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3176515
|
|
56414845
|
SPA2751 |
|
YP_151920.1 |
virulence-associated secretory protein |
Virulence factor |
MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
sopE2 from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3176679
|
|
56413227
|
SPA1018 |
|
YP_150302.1 |
Type III-secreted protein effector: invasion-associated protein |
Virulence factor |
MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. |
10735884
|
|
|
sigD from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3177911
|
|
56413914
|
SPA1759 |
|
YP_150989.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
slyA from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3178280
|
|
56413587
|
SPA1409 |
|
YP_150662.1 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. |
8290552
|
|
|
sodC from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3178557
|
|
56413591
|
SPA1413 |
|
YP_150666.1 |
superoxide dismutase |
Virulence factor |
MUTATION: sodC mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
sopE |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3178700
|
|
56414668
|
SPA2564 |
|
YP_151743.1 |
invasion-associated secreted protein. |
Virulence factor |
MUTATION: sopE mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 |
3178773
|
|
56413615
|
SPA1439 |
|
YP_150690.1 |
secretion system apparatus protein SsaV |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
sopA from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
7692994
|
|
228931267
|
pU302L_002 |
AY333434 |
YP_194809 |
plasmid-partitioning protein SopA |
Virulence factor |
MUTATION: sopA mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. |
12065528
|
|
|
sopB from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
3259856
|
|
58383240
|
pU302L_003 |
|
YP_194810.1 |
stabilization of plasmid protein B |
Virulence factor |
MUTATION: sopB mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. |
12065528
|
|
|
ydjA from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
7693157
|
|
32470173
|
R64_p042 |
AP005147 |
NP_863397 |
hypothetical protein |
Virulence factor |
MUTATION: ydjA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
PSLT072 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256164
|
|
17233503
|
PSLT072 |
|
NP_490559.1 |
putative transglycosylase |
Virulence factor |
MUTATION: PSLT072 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
spvR |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256197
|
|
17233493
|
PSLT041 |
|
NP_490531.1 |
regulator of spv operon |
Virulence factor |
MUTATION: spvR mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
spvB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256199
|
|
17233491
|
PSLT039 |
|
NP_490529.1 |
hydrophilic protein |
Virulence factor |
MUTATION: spvB mutants are attenuated in mice [Ref6708:Lesnick et al., 2001].
TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells [Ref6708:Lesnick et al., 2001]. |
11260464
|
|
|
spvA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256200
|
|
17233492
|
PSLT040 |
|
NP_490530.1 |
outer membrane protein |
Virulence factor |
MUTATION: spvA mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
spvC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256201
|
|
17233490
|
PSLT038 |
|
NP_490528.1 |
hydrophilic protein |
Virulence factor |
MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [Ref6709:Matsui et al., 2001]. |
11443102
|
|
|
spvD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256202
|
|
17233489
|
PSLT037 |
|
NP_490527.1 |
hydrophilic protein |
Virulence factor |
MUTATION: spvD mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
pefC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256222
|
|
17233482
|
PSLT017 |
|
NP_490509.1 |
usher protein |
Virulence factor |
MUTATION: pefC mutants are attenuated in mice [Ref6710:Bäumler et al., 1996]. |
8557375
|
|
|
rcK from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256230
|
|
17233474
|
PSLT009 |
|
NP_490501.1 |
resistance to complement killing |
Virulence factor |
MUTATION: rck mutants reduces serum resistance and eukaryotic cell invasion [Ref6711:Cirillo et al., 1996]. |
8675302
|
|
|
STM0016 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251534
|
|
16763406
|
STM0016 |
|
NP_459021.1 |
hypothetical protein |
Virulence factor |
MUTATION: STM0016 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0030 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251548
|
|
16763420
|
STM0030 |
|
NP_459035.1 |
putative transcriptional regulator |
Virulence factor |
MUTATION: STM0030 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0036 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251554
|
|
16763426
|
STM0036 |
|
NP_459041.1 |
putative arylsulfatase regulator |
Virulence factor |
MUTATION: STM0036 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
leuO from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251633
|
|
16763505
|
STM0115 |
|
NP_459120.1 |
leucine transcriptional activator |
Virulence factor |
MUTATION: leuO mutant exhibited wild-type levels of epithelial invasion but highly reduced transepithelial migration of PMN [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
dgt |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251726
|
|
16763598
|
STM0208 |
|
NP_459213.1 |
deoxyguanosinetriphosphate triphosphohydrolase |
Virulence factor |
MUTATION: dgt mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yafS |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251780
|
|
16763645
|
STM0262 |
|
NP_459260.1 |
putative SAM-dependent methyltransferase |
Virulence factor |
MUTATION: yagS mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0298 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251817
|
|
0
|
STM0298 |
|
- |
- |
Virulence factor |
MUTATION: STM0298 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
safA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251818
|
|
16763682
|
STM0299 |
|
NP_459297.1 |
putative outer membrane protein |
Virulence factor |
MUTATION: safA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
gmhA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251829
|
|
16763693
|
STM0310 |
|
NP_459308.1 |
phosphoheptose isomerase |
Virulence factor |
MUTATION: gmhA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
dinP |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251832
|
|
16763696
|
STM0313 |
|
NP_459311.1 |
DNA polymerase IV |
Virulence factor |
MUTATION: dinP mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0328.s |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251847
|
|
39546292
|
STM0328.s |
|
NP_459323.2 |
putative permease |
Virulence factor |
MUTATION: STM0328 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
stbD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251856
|
|
16763717
|
STM0337 |
|
NP_459332.1 |
putative fimbrial usher |
Virulence factor |
MUTATION: stbD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
stbC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251857
|
|
16763718
|
STM0338 |
|
NP_459333.1 |
putative fimbrial usher |
Virulence factor |
MUTATION: stbC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
yaiU |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251892
|
|
16763753
|
STM0373 |
|
NP_459368.1 |
flagellar protein |
Virulence factor |
MUTATION: yaiU mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
sbcD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251915
|
|
16763776
|
STM0396 |
|
NP_459391.1 |
exonuclease subunit SbcD |
Virulence factor |
MUTATION: sbcD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM0438 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251958
|
|
16763819
|
STM0438 |
|
NP_459434.1 |
tetratricopeptide repeat protein |
Virulence factor |
MUTATION: STM0438 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
cyoB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251962
|
|
16763823
|
STM0442 |
|
NP_459438.1 |
cytochrome o ubiquinol oxidase subunit I |
Virulence factor |
MUTATION: cyoB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
clpP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251968
|
|
16763829
|
STM0448 |
|
NP_459444.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: clpP mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
ybaJ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251994
|
|
16763854
|
STM0474 |
|
NP_459469.1 |
hypothetical protein |
Virulence factor |
MUTATION: ybaJ mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
gip |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252038
|
|
16763898
|
STM0518 |
|
NP_459513.1 |
hydroxypyruvate isomerase |
Virulence factor |
MUTATION: gip mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0520 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252040
|
|
16763900
|
STM0520 |
|
NP_459515.1 |
putative permease |
Virulence factor |
MUTATION: STM0520 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
allD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252048
|
|
16763908
|
STM0528 |
|
NP_459523.1 |
ureidoglycolate dehydrogenase |
Virulence factor |
MUTATION: allD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
fimA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252063
|
|
39546299
|
STM0543 |
|
NP_459538.2 |
fimbrin |
Virulence factor |
MUTATION: fimA mutants are attenuated in mice and swine [Ref6712:Althouse et al., 2003]. |
14573666
|
|
|
fimH |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252067
|
|
16763927
|
STM0547 |
|
NP_459542.1 |
minor fimbrial subunit |
Virulence factor |
MUTATION: fimH mutants were impaired in binding and internalization of HeLa cells [Ref6713:Guo et al., 2007]. |
17379714
|
|
|
fimW |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252072
|
|
16763932
|
STM0552 |
|
NP_459547.1 |
putative fimbrial protein |
Virulence factor |
MUTATION: fimW mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0557 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252077
|
|
16763935
|
STM0557 |
|
NP_459550.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: STM0557 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfbI |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252079
|
|
16763937
|
STM0559 |
|
NP_459552.1 |
putative glycosyl translocase |
Virulence factor |
MUTATION: rfbl mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
nfnB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252098
|
|
16763955
|
STM0578 |
|
NP_459570.1 |
dihydropteridine reductase |
Virulence factor |
MUTATION: nfnB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
fepA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252105
|
|
16763962
|
STM0585 |
|
NP_459577.1 |
outer membrane ferric enterobactin receptor precursor |
Virulence factor |
MUTATION: fepA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
cstA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252120
|
|
16763977
|
STM0600 |
|
NP_459592.1 |
carbon starvation protein |
Virulence factor |
MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
citC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252144
|
|
16764001
|
STM0624 |
|
NP_459616.1 |
citrate lyase synthetase |
Virulence factor |
MUTATION: citC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
dpiA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252146
|
|
16764003
|
STM0626 |
|
NP_459618.1 |
DNA-binding response regulator in two-component regulatory system with citA |
Virulence factor |
MUTATION: dpiA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
cspE |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252149
|
|
16764006
|
STM0629 |
|
NP_459621.1 |
cold shock protein E |
Virulence factor |
MUTATION: cspE mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
hscC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252179
|
|
16764036
|
STM0659 |
|
NP_459651.1 |
putative heatshock protein |
Virulence factor |
MUTATION: hscC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM0723 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252243
|
|
16764093
|
STM0723 |
|
NP_459708.1 |
putative ABC-type polysaccharide/polyol phosphate transport system ATPase component |
Virulence factor |
MUTATION: STM0723 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM0765 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252285
|
|
16764130
|
STM0765 |
|
NP_459745.1 |
putative cation transporter |
Virulence factor |
MUTATION: STM0765 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
slrP |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252320
|
|
16764163
|
STM0800 |
|
NP_459778.1 |
leucine-rich repeat protein |
Virulence factor |
MUTATION: slrP mutant is attenuated in mice [Ref6714:Tsolis et al., 1999]. |
10569754
|
|
|
ybhM |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252328
|
|
16764171
|
STM0808 |
|
NP_459786.1 |
putative integral membrane protein |
Virulence factor |
MUTATION: ybhM mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
mdfA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252385
|
|
16764228
|
STM0866 |
|
NP_459843.1 |
multidrug translocase |
Virulence factor |
MUTATION: mdfA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
pflA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252488
|
|
161353606
|
STM0970 |
|
NP_459945.2 |
pyruvate formate lyase-activating enzyme 1 |
Virulence factor |
MUTATION: pflA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM0972 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252490
|
|
16764332
|
STM0972 |
|
NP_459947.1 |
SopD-like protein |
Virulence factor |
MUTATION: STM0972 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
focA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252492
|
|
16764334
|
STM0974 |
|
NP_459949.1 |
formate transporter |
Virulence factor |
MUTATION: focA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM1002 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252520
|
|
16764362
|
STM1002 |
|
NP_459977.1 |
diaminopropionate ammonia-lyase |
Virulence factor |
MUTATION: STM1002 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sseI |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252569
|
|
16764411
|
STM1051 |
|
NP_460026.1 |
secreted effector protein |
Virulence factor |
MUTATION: sseI mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
pyrD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252576
|
|
16764417
|
STM1058 |
|
NP_460032.1 |
dihydroorotate dehydrogenase 2 |
Virulence factor |
MUTATION: pyrD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ycbG |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252587
|
|
16764428
|
STM1069 |
|
NP_460043.1 |
hypothetical protein |
Virulence factor |
MUTATION: ycbG mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
pipA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252605
|
|
16764445
|
STM1087 |
|
NP_460060.1 |
pathogenicity island-encoded protein A |
Virulence factor |
MUTATION: pipA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
pipC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252608
|
|
16764448
|
STM1090 |
|
NP_460063.1 |
pathogenicity island-encoded protein C |
Virulence factor |
MUTATION: pipC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
sopB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252609
|
|
16764449
|
STM1091 |
|
NP_460064.1 |
secreted effector protein |
Virulence factor |
MUTATION: sopB mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. |
12065528
|
|
|
pipD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252612
|
|
16764452
|
STM1094 |
|
NP_460067.1 |
pathogenicity island-encoded protein D |
Virulence factor |
MUTATION: pipD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
copS |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252613
|
|
16764453
|
STM1095 |
|
NP_460068.1 |
copper resistance protein |
Virulence factor |
MUTATION: copS mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
csgF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252658
|
|
16764496
|
STM1140 |
|
NP_460111.1 |
curli assembly protein CsgF |
Virulence factor |
MUTATION: csgF mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
csgD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252660
|
|
16764498
|
STM1142 |
|
NP_460113.1 |
DNA-binding transcriptional activator in two-component regulatory system |
Virulence factor |
MUTATION: csgD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
csgC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252663
|
|
16764501
|
STM1145 |
|
NP_460116.1 |
putative curli production protein precursor |
Virulence factor |
MUTATION: csgC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
solA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252678
|
|
16764516
|
STM1160 |
|
NP_460131.1 |
N-methyltryptophan oxidase |
Virulence factor |
MUTATION: solA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sifA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252742
|
|
16764579
|
STM1224 |
|
NP_460194.1 |
secreted effector protein |
Virulence factor |
MUTATION: sifA mutants are attenuated in mice and don't induce Salmonella-produced filaments in epithelial cells [Ref6715:Stein et al., 1996]. |
8861213
|
|
|
pagC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252764
|
|
16764600
|
STM1246 |
|
NP_460215.1 |
virulence membrane protein PAGC precursor |
Virulence factor |
MUTATION: pagC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yeaJ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252801
|
|
16764634
|
STM1283 |
|
NP_460249.1 |
putative methyl-accepting chemotaxis protein |
Virulence factor |
MUTATION: yeaJ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
ydjA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252814
|
|
16764647
|
STM1296 |
|
NP_460262.1 |
putative oxidoreductase |
Virulence factor |
MUTATION: ydjA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
celA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252830
|
|
16764663
|
STM1312 |
|
NP_460278.1 |
N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB |
Virulence factor |
MUTAITON: celA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
celF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252834
|
|
16764667
|
STM1316 |
|
NP_460282.1 |
phospho-beta-glucosidase/cellobiose-6-phosphate hydrolase |
Virulence factor |
MUTATION: celF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
nlpC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252861
|
|
16764694
|
STM1343 |
|
NP_460309.1 |
lipoprotein |
Virulence factor |
MUTATION: nlpC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
ydiK |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252882
|
|
16764714
|
STM1364 |
|
NP_460329.1 |
predicted inner membrane protein |
Virulence factor |
MUTATION: ydiK mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
ssrB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252909
|
|
16764741
|
STM1391 |
|
NP_460356.1 |
transcriptional activator |
Virulence factor |
MUTATION: ssrB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssrA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252910
|
|
16764742
|
STM1392 |
|
NP_460357.1 |
sensor kinase |
Virulence factor |
MUTATION: ssrA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252911
|
|
16764743
|
STM1393 |
|
NP_460358.1 |
secreted effector protein |
Virulence factor |
MUTATION: ssaB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252912
|
|
16764744
|
STM1394 |
|
NP_460359.1 |
outer membrane secretin precursor |
Virulence factor |
MUTATION: ssaC mutant is attenuated in murine macrophages [Ref6716:Chan et al., 2005]. |
16113260
|
|
|
ssaD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252913
|
|
16764745
|
STM1395 |
|
NP_460360.1 |
virulence protein |
Virulence factor |
MUTATION: ssaD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaE |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252914
|
|
16764746
|
STM1396 |
|
NP_460361.1 |
secretion system effector |
Virulence factor |
MUTATION: ssaE mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sseA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252915
|
|
16764747
|
STM1397 |
|
NP_460362.1 |
secretion system chaperone protein |
Virulence factor |
MUTATION: sseA mutant is attenuated in pigs (Carnell et al., 2007). |
|
|
|
sseB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252916
|
|
16764748
|
STM1398 |
|
NP_460363.1 |
translocation machinery component |
Virulence factor |
MUTATION: sseB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sseC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252918
|
|
16764750
|
STM1400 |
|
NP_460365.1 |
translocation machinery component |
Virulence factor |
MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
sseD from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252919
|
|
16764751
|
STM1401 |
|
NP_460366.1 |
translocation machinery component |
Virulence factor |
MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. |
11159962
|
|
|
sseE |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252920
|
|
16764752
|
STM1402 |
|
NP_460367.1 |
secreted effector protein |
Virulence factor |
MUTATION: sseE mutant is defective for replication in murine macrophages [Ref6716:Chan et al., 2005]. |
16113260
|
|
|
sseF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252922
|
|
16764754
|
STM1404 |
|
NP_460369.1 |
secreted effector protein |
Virulence factor |
MUTATION: sseF mutant is defective for replication in murine macrophages [Ref6716:Chan et al., 2005]. |
16113260
|
|
|
sseG |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252923
|
|
16764755
|
STM1405 |
|
NP_460370.1 |
secreted effector protein |
Virulence factor |
MUTATION: sseG mutant has a defect in replication in murine macrophages [Ref6716:Chan et al., 2005]. |
16113260
|
|
|
ssaG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252924
|
|
16764756
|
STM1406 |
|
NP_460371.1 |
type III secretion system apparatus protein |
Virulence factor |
MUTATION: ssaG mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaJ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252927
|
|
16764759
|
STM1409 |
|
NP_460374.1 |
needle complex inner membrane lipoprotein |
Virulence factor |
MUTATION: ssaJ mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaK |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252929
|
|
16764761
|
STM1411 |
|
NP_460376.1 |
type III secretion system apparatus protein |
Virulence factor |
MUTATION: ssaK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaL |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252930
|
|
16764762
|
STM1412 |
|
NP_460377.1 |
type III secretion system apparatus protein |
Virulence factor |
MUTATION: ssaL mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaM from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252931
|
|
16764763
|
STM1413 |
|
NP_460378.1 |
type III secretion system apparatus protein |
Virulence factor |
MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. |
15491354
|
|
|
ssaN |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252933
|
|
16764765
|
STM1415 |
|
NP_460380.1 |
type III secretion system ATPase |
Virulence factor |
MUTATION: ssaN mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
ssaQ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252936
|
|
16764768
|
STM1418 |
|
NP_460383.1 |
type III secretion system protein |
Virulence factor |
MUTATION: ssaQ mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaR |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252937
|
|
16764769
|
STM1419 |
|
NP_460384.1 |
type III secretion system protein |
Virulence factor |
MUTATION: ssaR mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaS |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252938
|
|
16764770
|
STM1420 |
|
NP_460385.1 |
type III secretion system apparatus protein |
Virulence factor |
MUTATION: ssaS mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ssaU |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252940
|
|
16764772
|
STM1422 |
|
NP_460387.1 |
secretion system apparatus protein SsaU |
Virulence factor |
MUTATION: ssaU mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
slyA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252962
|
|
161353603
|
STM1444 |
|
NP_460407.2 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. |
8290552
|
|
|
ydgF from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253000
|
|
16764827
|
STM1482 |
|
NP_460442.1 |
multidrug efflux system protein MdtJ |
Virulence factor |
MUTATION: ydgF mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM1527 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253045
|
|
16764872
|
STM1527 |
|
NP_460487.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: STM1527 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM1549 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253067
|
|
16764894
|
STM1549 |
|
NP_460509.1 |
putative translation initiation inhibitor |
Virulence factor |
MUTATION: STM1549 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yddX from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253082
|
|
16764908
|
STM1564 |
|
NP_460523.1 |
biofilm-dependent modulation protein |
Virulence factor |
MUTATION: yddX mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM1583 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253101
|
|
16764927
|
STM1583 |
|
NP_460542.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM1583 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yncB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253107
|
|
16764933
|
STM1589 |
|
NP_460548.1 |
putative NADP-dependent oxidoreductase |
Virulence factor |
MUTAITON: yncB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sseJ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253149
|
|
16764975
|
STM1631 |
|
NP_460590.1 |
secreted effector protein |
Virulence factor |
MUTATION: sseJ mutants are defective in intracellular replication in cultured epithelial cells and are attenuated in mice [Ref6717:Ohlson et al., 2005]. |
16177296
|
|
|
ynaF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253170
|
|
16764996
|
STM1652 |
|
NP_460611.1 |
putative universal stress protein |
Virulence factor |
MUTATION: ynaF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM1668 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253186
|
|
16765011
|
STM1668 |
|
NP_460626.1 |
hypothetical protein |
Virulence factor |
MUTATION: STM1668 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM1669 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253187
|
|
16765012
|
STM1669 |
|
NP_460627.1 |
invasin-like protein |
Virulence factor |
MUTATION: STM1669 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yciH from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253225
|
|
16765050
|
STM1706 |
|
NP_460665.1 |
translation initiation factor Sui1 |
Virulence factor |
MUTATION: yciH mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yciF from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253248
|
|
16765073
|
STM1729 |
|
NP_460688.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: yciF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
hns |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253270
|
|
16765095
|
STM1751 |
|
NP_460710.1 |
global DNA-binding transcriptional dual regulator H-NS |
Virulence factor |
MUTATION: hns mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
fadD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253337
|
|
16765159
|
STM1818 |
|
NP_460774.1 |
long-chain-fatty-acid--CoA ligase |
Virulence factor |
MUTATION: fadD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
cspC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253356
|
|
16765178
|
STM1837 |
|
NP_460793.1 |
cold shock-like protein cspC |
Virulence factor |
MUTATION: cspC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sopE2 from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253374
|
|
16765196
|
STM1855 |
|
NP_460811.1 |
type III-secreted effector protein |
Virulence factor |
MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. |
10735884
|
|
|
pagO |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253381
|
|
16765203
|
STM1862 |
|
NP_460818.1 |
integral membrane protein |
Virulence factor |
MUTATION: pagO mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM1864 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253383
|
|
16765205
|
STM1864 |
|
NP_460820.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: STM1864 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
pagK |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253386
|
|
16765207
|
STM1867 |
|
NP_460822.1 |
PagK |
Virulence factor |
MUTATION: pagK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
znuA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253412
|
|
161353595
|
STM1891 |
|
NP_460848.2 |
high-affinity zinc transporter periplasmic component |
Virulence factor |
MUTATION: znuABC mutant is attenuated in mice [Ref6718:Pesciaroli et al., 2011]. |
21219981
|
|
|
znuC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253413
|
|
39546331
|
STM1892.S |
|
NP_460849.2 |
high-affinity zinc transporter ATPase |
Virulence factor |
MUTATION: znuABC mutant is attenuated in mice [Ref6718:Pesciaroli et al., 2011]. |
21219981
|
|
|
znuB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253414
|
|
16765235
|
STM1893 |
|
NP_460850.1 |
high-affinity zinc transporter membrane component |
Virulence factor |
MUTATION: znuABC mutant is attenuated in mice [Ref6718:Pesciaroli et al., 2011]. |
21219981
|
|
|
STM1896 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253417
|
|
16765238
|
STM1896 |
|
NP_460853.1 |
putative cytoplasmic protein |
Virulence factor |
MUTAITON: STM1896 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM1934 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253455
|
|
16765275
|
STM1934 |
|
NP_460890.1 |
putative outer membrane lipoprotein |
Virulence factor |
MUTATION: STM1934 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
uvrY |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253468
|
|
16765285
|
STM1947 |
|
NP_460900.1 |
response regulator |
Virulence factor |
MUTATION: sirA mutant is defective for intracellular replication, invasion of epithelial cells and defective in murine macrophages [Ref6716:Chan et al., 2005]. |
16113260
|
|
|
fliC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253480
|
|
16765297
|
STM1959 |
|
NP_460912.1 |
flagellin |
Virulence factor |
MUTATION: fliC mutants were attenuated in orally inoculated chicks [Ref6523:Parker and Guard-Petter, 2001]. |
11731137
|
|
|
fliQ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253501
|
|
16765318
|
STM1980 |
|
NP_460933.1 |
flagellar biosynthesis protein FliQ |
Virulence factor |
MUTATION: fliQ mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
yeeI |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253522
|
|
16765336
|
STM2001 |
|
NP_460951.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: yeeI mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
sopA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253587
|
|
16765396
|
STM2066 |
|
NP_461011.1 |
secreted effector protein |
Virulence factor |
MUTATION: sopA mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. |
12065528
|
|
|
udg |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253601
|
|
16765410
|
STM2080 |
|
NP_461025.1 |
UDP-glucose/GDP-mannose dehydrogenase |
Virulence factor |
MUTATION: udg mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
rfbP |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253603
|
|
16765412
|
STM2082 |
|
NP_461027.1 |
undecaprenol-phosphate galactosephosphotransferase/O-antigen transferase |
Virulence factor |
MUTATION: rfbP mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
rfbK |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253604
|
|
16765413
|
STM2083 |
|
NP_461028.1 |
phosphomannomutase |
Virulence factor |
MUTATION: rfbK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfbM |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253605
|
|
16765414
|
STM2084 |
|
NP_461029.1 |
mannose-1-phosphate guanylyltransferase |
Virulence factor |
MUTATION: rfbM mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
rfbN |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253606
|
|
16765415
|
STM2085 |
|
NP_461030.1 |
rhamnosyl transferase |
Virulence factor |
MUTATION: rfbN mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfbH |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253611
|
|
16765420
|
STM2090 |
|
NP_461035.1 |
CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase |
Virulence factor |
MUTATION: rfbH mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfbI from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253614
|
|
16765423
|
STM2093 |
|
NP_461038.1 |
CDP-6-deoxy-delta-3,4-glucoseen reductase |
Virulence factor |
MUTATION: rfbI mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfbC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253615
|
|
16765424
|
STM2094 |
|
NP_461039.1 |
dTDP-4,deoxyrhamnose 3,5 epimerase |
Virulence factor |
MUTATION: rfbC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
rfbA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253616
|
|
16765425
|
STM2095 |
|
NP_461040.1 |
dTDP-glucose pyrophosphorylase |
Virulence factor |
MUTATION: rfbA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
rfbD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253617
|
|
16765426
|
STM2096 |
|
NP_461041.1 |
dTDP-4-dehydrorhamnose reductase |
Virulence factor |
MUTATION: rfbD mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
rfbB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253618
|
|
16765427
|
STM2097 |
|
NP_461042.1 |
dTDP-glucose 4,6 dehydratase |
Virulence factor |
MUTATION: rfbB mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
galF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253619
|
|
16765428
|
STM2098 |
|
NP_461043.1 |
UTP--glucose-1-phosphate uridylyltransferase subunit GalF |
Virulence factor |
MUTATION: galF mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
wcaM |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253620
|
|
16765429
|
STM2099 |
|
NP_461044.1 |
putative colanic acid biosynthetic protein |
Virulence factor |
MUTATION: wcaM mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
wcaE |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253632
|
|
16765441
|
STM2111 |
|
NP_461056.1 |
predicted glycosyl transferase |
Virulence factor |
MUTATION: wcaE mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
yegQ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253657
|
|
16765465
|
STM2136 |
|
NP_461080.1 |
putative protease |
Virulence factor |
MUTATION: yegQ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM2137 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253658
|
|
16765466
|
STM2137 |
|
NP_461081.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM2137 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
stcD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253670
|
|
16765478
|
STM2149 |
|
NP_461093.1 |
putative outer membrane lipoprotein |
Virulence factor |
MUTATION: stcD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
stcC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253671
|
|
16765479
|
STM2150 |
|
NP_461094.1 |
putative outer membrane protein |
Virulence factor |
MUTATION: stcC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
bglX |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253688
|
|
16765496
|
STM2166 |
|
NP_461111.1 |
periplasmic beta-D-glucoside glucohydrolase |
Virulence factor |
MUTATION: bglX mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yeiA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253709
|
|
16765517
|
STM2187 |
|
NP_461132.1 |
dihydropyrimidine dehydrogenase |
Virulence factor |
MUTATION: yeiA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM2197 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253719
|
|
16765527
|
STM2197 |
|
NP_461142.1 |
putative phosphoserine phosphatase |
Virulence factor |
MUTATION: STM2197 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM2243 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253765
|
|
16765571
|
STM2243 |
|
NP_461186.1 |
putative tail fiber protein of phage |
Virulence factor |
MUTATION: STM2243 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM2245 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253767
|
|
16765573
|
STM2245 |
|
NP_461188.1 |
putative outer membrane protein |
Virulence factor |
MUTATION: STM2245 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM2373 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253895
|
|
16765700
|
STM2373 |
|
NP_461315.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM2373 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
ppk |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254023
|
|
16765821
|
STM2501 |
|
NP_461436.1 |
polyphosphate kinase |
Virulence factor |
MUTATION: ppk mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM2503 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254025
|
|
16765823
|
STM2503 |
|
NP_461438.1 |
putative diguanylate cyclase |
Virulence factor |
MUTATION: STM2503 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
shdA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254035
|
|
16765833
|
STM2513 |
|
NP_461448.1 |
AIDA autotransporter-like protein |
Virulence factor |
MUTATION: shdA mutants exhibit a shedding defect in mice [Ref6719:Kingsley et al., 2003]. |
12540539
|
|
|
ratB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254036
|
|
16765834
|
STM2514 |
|
NP_461449.1 |
putative outer membrane protein |
Virulence factor |
MUTATION: ratB mutant are unable to colonize the cecum in mice, but are still able to colonize the eyer's patches, mesenteric lymph nodes, and spleen of mice [Ref6719:Kingsley et al., 2003]. |
12540539
|
|
|
cadB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254080
|
|
16765878
|
STM2558 |
|
NP_461493.1 |
predicted lysine/cadaverine transporter |
Virulence factor |
MUTATION: cadB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM2574 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254096
|
|
16765894
|
STM2574 |
|
NP_461509.1 |
putative permease |
Virulence factor |
MUTATION: STM2574 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
yfhL |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254098
|
|
16765896
|
STM2576 |
|
NP_461511.1 |
putative ferredoxin |
Virulence factor |
MUTATION: yfhL mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM2585 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254107
|
|
16765905
|
STM2585 |
|
NP_461520.1 |
transposase-like protein |
Virulence factor |
MUTATION: STM2585 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
clpB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254183
|
|
16765976
|
STM2660 |
|
NP_461591.1 |
protein disaggregation chaperone |
Virulence factor |
MUTATION: clpB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM2680 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254203
|
|
16765995
|
STM2680 |
|
NP_461610.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM2680 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM2689 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254212
|
|
0
|
STM2689 |
|
- |
pseudo |
Virulence factor |
MUTATION: STM2689 (bapA) mutant strain showed a significantly lower colonization rate at the intestinal cell barrier and consequently a decreased efficiency for organ invasion compared with the wild-type strain in mice [Ref6720:Latasa et al., 2005]. |
16313619
|
|
|
fljA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254293
|
|
16766082
|
STM2770 |
|
NP_461697.1 |
phase-1 flagellin repressor |
Virulence factor |
MUTATION: fljA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
mig-14 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254305
|
|
16766093
|
STM2782 |
|
NP_461708.1 |
putative transcriptional activator |
Virulence factor |
MUTATION: mig-14 mutants are cleared by mice compared to the wild type which is fatal to mice in the doses given [Ref6721:Valdivia et al., 2000]. |
11083839
|
|
|
yqaE |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254319
|
|
16766107
|
STM2796 |
|
NP_461722.1 |
putative transport protein |
Virulence factor |
MUTATION: ygaE mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
hilC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254390
|
|
16766173
|
STM2867 |
|
NP_461788.1 |
invasion regulatory protein |
Virulence factor |
MUTATION: hilC mutants have decreased invasion of HEp-2 cells compared to the wild type [Ref6722:Schechter et al., 1999]. |
10320584
|
|
|
orgB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254392
|
|
16766175
|
STM2869 |
|
NP_461790.1 |
needle complex export protein |
Virulence factor |
MUTATION: orgB mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
orgA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254393
|
|
16766176
|
STM2870 |
|
NP_461791.1 |
needle complex assembly protein |
Virulence factor |
MUTATION: orgA mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgK from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254394
|
|
16766177
|
STM2871 |
|
NP_461792.1 |
needle complex inner membrane lipoprotein |
Virulence factor |
MUTATION: prgK mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgJ from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254395
|
|
16766178
|
STM2872 |
|
NP_461793.1 |
needle complex minor subunit |
Virulence factor |
MUTATION: prgJ mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgI |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254396
|
|
16766179
|
STM2873 |
|
NP_461794.1 |
needle complex major subunit |
Virulence factor |
MUTATION: prgI mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
prgH |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254397
|
|
16766180
|
STM2874 |
|
NP_461795.1 |
needle complex inner membrane protein |
Virulence factor |
MUTATION: prgH mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. |
10816487
|
|
|
hilD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254398
|
|
16766181
|
STM2875 |
|
NP_461796.1 |
invasion protein regulatory protein |
Virulence factor |
MUTATION: hilD mutants have decreased invasion of HEp-2 cells compared to the wild type [Ref6722:Schechter et al., 1999]. |
10320584
|
|
|
hilA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254399
|
|
16766182
|
STM2876 |
|
NP_461797.1 |
invasion protein regulator |
Virulence factor |
MUTATION: hilA mutants have reduced ability to invade HEp-2 cells and to colonize murine Peyer’s patches [Ref6723:Tsolis et al., 1999]. |
10456944
|
|
|
sptP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254401
|
|
16766184
|
STM2878 |
|
NP_461799.1 |
protein tyrosine phosphatase/GTPase activating protein |
Virulence factor |
MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
iacP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254404
|
|
16766187
|
STM2881 |
|
NP_461802.1 |
acyl carrier protein |
Virulence factor |
MUTAITON: iacP mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sipA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254405
|
|
16766188
|
STM2882 |
|
NP_461803.1 |
secreted effector protein |
Virulence factor |
MUTATION: sipA mutants have a decreased invasion of MDCK cells as compared to the wild type [Ref6724:Perrett and Jepson, 2009]. |
19046340
|
|
|
sipC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254407
|
|
16766190
|
STM2884 |
|
NP_461805.1 |
translocation machinery component |
Virulence factor |
MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells [Ref6525:Chang et al., 2005]. |
15720547
|
|
|
sicA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254409
|
|
16766192
|
STM2886 |
|
NP_461807.1 |
secretion chaperone |
Virulence factor |
MUTATION: sicA mutants are unable to invade cultured epithelial cells [Ref6725:Kaniga et al., 1995]. |
7608068
|
|
|
spaS from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254410
|
|
16766193
|
STM2887 |
|
NP_461808.1 |
surface presentation of antigens protein SpaS |
Virulence factor |
MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain [Ref6526:Darwin and Miller, 2000]. |
10692170
|
|
|
spaR from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254411
|
|
16766194
|
STM2888 |
|
NP_461809.1 |
needle complex export protein |
Virulence factor |
MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaQ from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254412
|
|
16766195
|
STM2889 |
|
NP_461810.1 |
needle complex export protein |
Virulence factor |
MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254413
|
|
16766196
|
STM2890 |
|
NP_461811.1 |
surface presentation of antigens protein SpaP |
Virulence factor |
MUTATION: spaP mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
spaO from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254414
|
|
16766197
|
STM2891 |
|
NP_461812.1 |
surface presentation of antigens protein SpaO |
Virulence factor |
MUTATION: spaO mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. |
8751894
|
|
|
invJ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254415
|
|
16766198
|
STM2892 |
|
NP_461813.1 |
needle length control protein |
Virulence factor |
MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
invI |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254416
|
|
16766199
|
STM2893 |
|
NP_461814.1 |
needle complex assembly protein |
Virulence factor |
MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
invC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254417
|
|
16766200
|
STM2894 |
|
NP_461815.1 |
ATP synthase SpaL |
Virulence factor |
MUTATION: invC mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. |
9087319
|
|
|
invB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254418
|
|
16766201
|
STM2895 |
|
NP_461816.1 |
secretion chaperone |
Virulence factor |
MUTATION: In the absence of InvB, the ΔsopB ΔsopE2 strain was severely defective in its ability to invade cultured intestinal cells, indicating that InvB is required for the translocation of SopE into host cells [Ref6727:Lee and Galán, 2003]. |
14645290
|
|
|
invA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254419
|
|
16766202
|
STM2896 |
|
NP_461817.1 |
needle complex export protein |
Virulence factor |
MUTATION: invA mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. |
9087319
|
|
|
invE from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254420
|
|
16766203
|
STM2897 |
|
NP_461818.1 |
invasion protein |
Virulence factor |
MUTATION: invE mutants were unable to penetrate Henle-407 human intestinal cells and Madin-Darby canine kidney cells [Ref6679:Ginocchio et al., 1992]. |
1631083
|
|
|
invG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254421
|
|
16766204
|
STM2898 |
|
NP_461819.1 |
outer membrane secretin precursor |
Virulence factor |
MUTATION: invG mutants have reduced ability to enter into cultured epithelial cells [Ref6728:Kaniga et al., 1994]. |
7997169
|
|
|
invF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254422
|
|
16766205
|
STM2899 |
|
NP_461820.1 |
invasion regulatory protein |
Virulence factor |
MUTATION: invF mutants have reduced ability to enter into cultured epithelial cells [Ref6728:Kaniga et al., 1994]. |
7997169
|
|
|
invH from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254423
|
|
16766206
|
STM2900 |
|
NP_461821.1 |
needle complex outer membrane lipoprotein precursor |
Virulence factor |
MUTATION: invH mutants are attenuated in calves [Ref6529:Watson et al., 1998]. |
9529064
|
|
|
sopD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254468
|
|
16766251
|
STM2945 |
|
NP_461866.1 |
secreted effector protein |
Virulence factor |
MUTATION: sopD mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. |
12065528
|
|
|
barA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254481
|
|
16766264
|
STM2958 |
|
NP_461879.1 |
hybrid sensory histidine kinase BarA |
Virulence factor |
MUTATION: barA mutant is inefficient in invasion of HEp-2 epithelial cells [Ref6716:Chan et al., 2005]. |
16113260
|
|
|
kduI |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254541
|
|
16766320
|
STM3018 |
|
NP_461935.1 |
5-keto-4-deoxyuronate isomerase |
Virulence factor |
MUTATION: kdul mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM3036 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254559
|
|
16766338
|
STM3036 |
|
NP_461953.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: STM3036 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM3128 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254651
|
|
16766428
|
STM3128 |
|
NP_462043.1 |
putative oxidoreductase |
Virulence factor |
MUTATION: STM3128 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM3192 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254715
|
|
16766492
|
STM3192 |
|
NP_462107.1 |
putative arylsulfate sulfotransferase |
Virulence factor |
MUTATION: STM3192 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
tdcA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254768
|
|
16766544
|
STM3245 |
|
NP_462159.1 |
DNA-binding transcriptional activator |
Virulence factor |
MUTATION: tdcA mutant is less invasive of cultured epithelial cells and attenuated in mice [Ref6585:Kim et al., 2009]. |
19812899
|
|
|
sspA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254865
|
|
16766637
|
STM3342 |
|
NP_462252.1 |
stringent starvation protein A |
Virulence factor |
MUTATION: sspA mutants are not able to cause lethal infection in calves, however these mutants are still able to cause diarrhea in calves [Ref6729:Tsolis et al., 2000]. |
10816458
|
|
|
fkpA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254976
|
|
16766742
|
STM3453 |
|
NP_462357.1 |
FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) |
Virulence factor |
MUTATION: fkpA mutant exhibited a reduced ability to survive intracellularly in J774.A1 cells [Ref6730:Horne et al., 1997]. |
9009347
|
|
|
slyD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254978
|
|
16766744
|
STM3455 |
|
NP_462359.1 |
FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) |
Virulence factor |
MUTATION: slyD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
crp |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1254989
|
|
16766754
|
STM3466 |
|
NP_462369.1 |
cAMP-regulatory protein |
Virulence factor |
MUTATION: crp deletion mutants are attenuated in mice [Ref6731:Curtiss et al., 1988]. |
3291452
|
|
|
dam |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255007
|
|
16766772
|
STM3484 |
|
NP_462387.1 |
DNA adenine methylase |
Virulence factor |
MUTATION: Lack of Dam methylation causes severe attenuation in animal models. Defects in virulence in dam mutants include such as impaired expression and secretion of invasion proteins, reduced cytotoxicity on M cells , inefficient colonization of Peyer’s patches and mesenteric lymph nodes, sensitivity to components of innate immunity, envelope instability and changes in LPS expression [Ref6732:Giacomodonato et al., 2009]. |
19762965
|
|
|
envZ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255024
|
|
16766789
|
STM3501 |
|
NP_462404.1 |
osmolarity sensor protein |
Virulence factor |
MUTATION: envZ mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
STM3602 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255125
|
|
16766888
|
STM3602 |
|
NP_462503.1 |
putative regulatory protein |
Virulence factor |
MUTATION: STM3602 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
yiaO |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255197
|
|
16766958
|
STM3673 |
|
NP_462573.1 |
putative periplasmic dicarboxylate-binding protein |
Virulence factor |
MUTATION: yiaO mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM3690 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255214
|
|
16766975
|
STM3690 |
|
NP_462590.1 |
putative inner membrane lipoprotein |
Virulence factor |
MUTATION: STM3690 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yibD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255231
|
|
16766992
|
STM3707 |
|
NP_462607.1 |
predicted glycosyl transferase |
Virulence factor |
MUTATION: yibD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
rfaK |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255238
|
|
16766999
|
STM3714 |
|
NP_462614.1 |
putative hexose transferase |
Virulence factor |
MUTATION: rfaK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfaZ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255239
|
|
16767000
|
STM3715 |
|
NP_462615.1 |
lipopolysaccharide core biosynthesis protein |
Virulence factor |
MUTATION: rfaZ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
rfaB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255243
|
|
16767004
|
STM3719 |
|
NP_462619.1 |
UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase |
Virulence factor |
MUTATION: rfaB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rfaG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255246
|
|
16767007
|
STM3722 |
|
NP_462622.1 |
glucosyltransferase I |
Virulence factor |
MUTATION: rfaG mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
sugR |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255277
|
|
16767037
|
STM3753 |
|
NP_462652.1 |
ATP binding protein |
Virulence factor |
MUTATION: sugR mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
rhuM |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255279
|
|
16767039
|
STM3755 |
|
NP_462654.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: rhuM mutant has diminished capacity to invade cultured epithelial cells compared to the wild type [Ref6516:Tenor et al., 2004]. |
15182677
|
|
|
misL from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255281
|
|
16767041
|
STM3757 |
|
NP_462656.1 |
putative autotransporter |
Virulence factor |
MUTATION: misL mutant is attenuated in mice [Ref6733:Dorsey et al., 2005]. |
15948960
|
|
|
marT |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255283
|
|
39546372
|
STM3759.S |
|
NP_462658.2 |
putative transcriptional regulator |
Virulence factor |
MUTATION: marT mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
mgtC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255288
|
|
16767048
|
STM3764 |
|
NP_462663.1 |
Mg2+ transport protein |
Virulence factor |
MUTATION: mgtC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
ibpA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255336
|
|
39546376
|
STM3809.S |
|
NP_462709.2 |
heat shock protein IbpA |
Virulence factor |
MUTATION: ibpA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
torD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255348
|
|
16767106
|
STM3821 |
|
NP_462721.1 |
chaperone protein TorD |
Virulence factor |
MUTATION: torD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM3907 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255433
|
|
16767183
|
STM3907 |
|
NP_462798.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM3907 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
ppiC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255436
|
|
16767186
|
STM3910 |
|
NP_462801.1 |
peptidyl-prolyl cis-trans isomerase C |
Virulence factor |
MUTATION: ppiC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
trxA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255441
|
|
16767191
|
STM3915 |
|
NP_462806.1 |
thioredoxin |
Virulence factor |
MUTATION: trxA mutant is attenuated in mice [Ref6734:Peters et al., 2010]. |
19884329
|
|
|
wecE |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255451
|
|
16767200
|
STM3925 |
|
NP_462815.1 |
TDP-4-oxo-6-deoxy-D-glucose transaminase |
Virulence factor |
MUTATION: wecE mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
yigF |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255479
|
|
16767223
|
STM3953 |
|
NP_462838.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: yigF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
yigG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255480
|
|
16767224
|
STM3954 |
|
NP_462839.1 |
hypothetical protein |
Virulence factor |
MUTATION: yigG mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM3980 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255506
|
|
16767250
|
STM3980 |
|
NP_462865.1 |
putative outer membrane protein |
Virulence factor |
MUTATION: STM3980 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4051 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255578
|
|
16767317
|
STM4051 |
|
NP_462932.1 |
putative outer membrane protein |
Virulence factor |
MUTAITON: STM4051 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yneB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255605
|
|
16767344
|
STM4078 |
|
NP_462959.1 |
aldolase |
Virulence factor |
MUTATION: yneB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yneC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255606
|
|
39546390
|
STM4079.S |
|
NP_462960.2 |
autoinducer-2 (AI-2) modifying protein LsrG |
Virulence factor |
MUTATION: yneC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4155 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255681
|
|
16767409
|
STM4155 |
|
NP_463024.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: STM4155 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4158 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255684
|
|
16767412
|
STM4158 |
|
NP_463027.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM4158 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yjaG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255695
|
|
16767423
|
STM4169 |
|
NP_463038.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: yjaG mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
purD |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255701
|
|
16767429
|
STM4175 |
|
NP_463044.1 |
phosphoribosylamine--glycine ligase |
Virulence factor |
MUTATION: purD mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. |
7618105
|
|
|
metA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255708
|
|
16767432
|
STM4182 |
|
NP_463047.1 |
homoserine O-succinyltransferase |
Virulence factor |
MUTATION: metA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4198 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255724
|
|
16767448
|
STM4198 |
|
NP_463063.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM4198 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
STM4206 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255732
|
|
16767456
|
STM4206 |
|
NP_463071.1 |
putative phage glucose translocase |
Virulence factor |
MUTATION: STM4206 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4260 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255786
|
|
16767510
|
STM4260 |
|
NP_463125.1 |
predicted cation efflux pump |
Virulence factor |
MUTATION: STM4260 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4261 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255787
|
|
16767511
|
STM4261 |
|
NP_463126.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: STM4261 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yjdB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255819
|
|
16767543
|
STM4293 |
|
NP_463158.1 |
predicted metal dependent hydrolase |
Virulence factor |
MUTATION: yjdB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4316 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255842
|
|
16767566
|
STM4316 |
|
NP_463181.1 |
putative cytoplasmic protein |
Virulence factor |
MUTATION: STM4316 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
phoN |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255845
|
|
16767569
|
STM4319 |
|
NP_463184.1 |
non-specific acid phosphatase |
Virulence factor |
MUTATION: phoN mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
yjeJ |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255858
|
|
16767581
|
STM4332 |
|
NP_463196.1 |
putative inner membrane protein |
Virulence factor |
MUTATION: yjeJ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
STM4433 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255959
|
|
16767679
|
STM4433 |
|
NP_463294.1 |
myo-inositol 2-dehydrogenase |
Virulence factor |
MUTATION: STM4433 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. |
17526851
|
|
|
idnK |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256011
|
|
16767730
|
STM4485 |
|
NP_463345.1 |
D-gluconate kinase |
Virulence factor |
MUTATION: idnK mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
sthA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1256120
|
|
16767835
|
STM4594 |
|
NP_463450.1 |
putative fimbrial chaparone |
Virulence factor |
MUTATION: sthA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. |
16518469
|
|
|
fur |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6947533
|
|
207856151
|
SEN0657 |
|
YP_002242802.1 |
ferric uptake regulator |
Virulence factor |
MUTATION: fur mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
sodC from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6947663
|
|
207856621
|
SEN1149 |
|
YP_002243272.1 |
phage encoded superoxide dismutase [cu-zn] 1 precursor (ec 1.15.1.1) (sodCI) |
Virulence factor |
MUTATION: sodC mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
sopE2 from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6947689
|
|
207856639
|
SEN1182 |
|
YP_002243290.1 |
invasion-associated secreted effector protein (sopE2) |
Virulence factor |
MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. |
10735884
|
|
|
sodC from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6947830
|
|
207857056
|
SEN1607 |
|
YP_002243707.1 |
superoxide dismutase |
Virulence factor |
MUTATION: sodC mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
rpoS |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6948133
|
|
207858184
|
SEN2763 |
|
YP_002244835.1 |
RNA polymerase sigma factor RpoS |
Virulence factor |
MUTATION: rpoS mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
relA |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6948145
|
|
207858222
|
SEN2801 |
|
YP_002244873.1 |
GDP/GTP pyrophosphokinase |
Virulence factor |
MUTATION: relA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
htrA |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6948918
|
|
207855725
|
SEN0214 |
|
YP_002242376.1 |
serine endoprotease |
Virulence factor |
MUTATION: htrA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
ompR |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6948995
|
|
207858742
|
SEN3328 |
|
YP_002245393.1 |
osmolarity response regulator |
Virulence factor |
MUTATION: ompR mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
galE |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6949187
|
|
207856214
|
SEN0721 |
|
YP_002242865.1 |
UDP-galactose-4-epimerase |
Virulence factor |
MUTATION: galE mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
invA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6949452
|
|
207858158
|
SEN2737 |
|
YP_002244809.1 |
possible secretory protein (associated with virulence) |
Virulence factor |
MUTATION: invA mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. |
9087319
|
|
|
invC from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6949458
|
|
207858156
|
SEN2735 |
|
YP_002244807.1 |
ATP synthase SpaL |
Virulence factor |
MUTATION: invC mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. |
9087319
|
|
|
hfq |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6949622
|
|
207859507
|
SEN4128 |
|
YP_002246158.1 |
RNA-binding protein Hfq |
Virulence factor |
MUTATION: hfq mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
phoP |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950049
|
|
207857262
|
SEN1818 |
|
YP_002243913.1 |
DNA-binding transcriptional regulator PhoP |
Virulence factor |
MUTATION: phoP mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
rfaL |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950110
|
|
207858950
|
SEN3535 |
|
YP_002245601.1 |
O-antigen ligase |
Virulence factor |
MUTATION: rfaL mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
rfaG from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950120
|
|
207858959
|
SEN3544 |
|
YP_002245610.1 |
lipopolysaccharide core biosynthesis protein |
Virulence factor |
MUTATION: rfaG mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
misL from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950173
|
|
207858990
|
SEN3580 |
|
YP_002245641.1 |
putative autotransported protein (MisL) |
Virulence factor |
MUTATION: misL mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
spoT |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950239
|
|
207858979
|
SEN3564 |
|
YP_002245630.1 |
bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase |
Virulence factor |
MUTATION: spoT mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
aroA |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950322
|
|
207856369
|
SEN0882 |
|
YP_002243020.1 |
3-phosphoshikimate 1-carboxyvinyltransferase |
Virulence factor |
MUTATION: aroA mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
iacP from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950340
|
|
207858143
|
SEN2722 |
|
YP_002244794.1 |
acyl carrier protein |
Virulence factor |
MUTATION: iacP mutants were noninvasive in chicks [Ref6523:Parker and Guard-Petter, 2001]. |
11731137
|
|
|
sipD |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950346
|
|
207858145
|
SEN2724 |
|
YP_002244796.1 |
pathogenicity island 1 effector protein |
Virulence factor |
MUTATION: sipD mutants were noninvasive in chicks [Ref6523:Parker and Guard-Petter, 2001]. |
11731137
|
|
|
sipB |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950348
|
|
207858147
|
SEN2726 |
|
YP_002244798.1 |
pathogenicity island 1 effector protein |
Virulence factor |
MUTATION: sipB mutants were significantly less invasive in chickens than the wild-type [Ref6811:Li et al., 2009]. |
19322708
|
|
|
slyA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950363
|
|
207857052
|
SEN1603 |
|
YP_002243703.1 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. |
8290552
|
|
|
ssrA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950412
|
|
207857102
|
SEN1653 |
|
YP_002243753.1 |
putative two-component sensor kinase |
Virulence factor |
MUTATION: ssrA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950423
|
|
207857080
|
SEN1631 |
|
YP_002243731.1 |
secretion system apparatus protein SsaV |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
sseA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950437
|
|
207857097
|
SEN1648 |
|
YP_002243748.1 |
putative pathogenicity island protein |
Virulence factor |
MUTATION: sseA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
clpP from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6950532
|
|
207855928
|
SEN0430 |
|
YP_002242579.1 |
ATP-dependent Clp protease proteolytic subunit |
Virulence factor |
MUTATION: clpP mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
aroD |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6951022
|
|
207857135
|
SEN1686 |
|
YP_002243786.1 |
3-dehydroquinate dehydratase |
Virulence factor |
MUTATION: aroD mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. |
19577637
|
|
|
sopE2 from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6922302
|
|
205352482
|
SG1261 |
|
YP_002226283.1 |
invasion-associated secreted effector protein (sopE2) |
Virulence factor |
MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. |
10735884
|
|
|
slyA from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6924868
|
|
205352843
|
SG1674 |
|
YP_002226644.1 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. |
8290552
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6924929
|
|
205352870
|
SG1702 |
|
YP_002226671.1 |
secretion system apparatus protein SsaV |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
slyA from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7554805
|
|
224584047
|
SPC_2287 |
|
YP_002637845.1 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. |
8290552
|
|
|
ssaV from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7554835
|
|
224584075
|
SPC_2315 |
|
YP_002637873.1 |
putative type III secretion protein |
Virulence factor |
MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. |
19745519
|
|
|
spiC from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7554856
|
|
224584096
|
SPC_2336 |
|
YP_002637894.1 |
putative pathogenicity island secreted effector protein |
Virulence factor |
MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. |
10406797
|
|
|
sigD from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7555182
|
|
224584403
|
SPC_2659 |
|
YP_002638201.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
sigE from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7555183
|
|
224584404
|
SPC_2660 |
|
YP_002638202.1 |
cell invasion protein |
Virulence factor |
MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. |
9537377
|
|
|
spaN from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7555466
|
|
224584670
|
SPC_2934 |
|
YP_002638468.1 |
antigen presentation protein SpaN |
Virulence factor |
MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
spaM from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7555467
|
|
224584671
|
SPC_2935 |
|
YP_002638469.1 |
virulence-associated secretory protein |
Virulence factor |
MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. |
7752894
|
|
|
slyA from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7555494
|
|
224584698
|
SPC_2962 |
|
YP_002638496.1 |
transcriptional regulator SlyA |
Virulence factor |
MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. |
8290552
|
|
|
pefC from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
8541844
|
|
261888691
|
pSLTBT_p010 |
|
YP_003264378.1 |
plasmid-encoded fimbrial usher protein |
Virulence factor |
MUTATION: pefC mutants are attenuated in mice [Ref6710:Bäumler et al., 1996]. |
8557375
|
|
|
spvB from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
8541860
|
|
261888705
|
pSLTBT_p025 |
|
YP_003264392.1 |
Salmonella plasmid virulence protein |
Virulence factor |
MUTATION: spvB mutants are attenuated in mice [Ref6708:Lesnick et al., 2001].
TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells [Ref6708:Lesnick et al., 2001]. |
11260464
|
|
|
spvC from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
8541862
|
|
261888704
|
pSLTBT_p024 |
|
YP_003264391.1 |
Salmonella plasmid virulence protein |
Virulence factor |
MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [Ref6709:Matsui et al., 2001]. |
11443102
|
|
|
rck from Salmonella enterica subsp. enterica serovar Typhimurium |
Salmonella enterica subsp. enterica serovar Typhimurium |
8541866
|
|
261888683
|
pSLTBT_p002 |
|
YP_003264370.1 |
resistance to complement killing |
Virulence factor |
MUTATION: rck mutants reduces serum resistance and eukaryotic cell invasion [Ref6711:Cirillo et al., 1996]. |
8675302
|
|
|
spvB from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7552347
|
|
224504238
|
SPC_p003 |
|
YP_002635577.1 |
SpvB |
Virulence factor |
MUTATION: spvB mutants are attenuated in mice [Ref6708:Lesnick et al., 2001].
TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells [Ref6708:Lesnick et al., 2001]. |
11260464
|
|
|
spvC from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 |
7552348
|
|
224504239
|
SPC_p004 |
|
YP_002635578.1 |
SpvC |
Virulence factor |
MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [Ref6709:Matsui et al., 2001]. |
11443102
|
|
|
LPS |
Salmonella |
|
|
|
|
|
|
|
Virulence factor |
MUTATION: an O-antigen-deficient serovar Typhimurium strain through deletion of the wbaP gene was constructed. The mutant stratin showed a severe defect in motility and an attenuated phenotype in a competitive mouse infection experiment compared to the wild type [Ref7295:Ilg et al., 2009]. |
19364844
|
|
|
asd |
Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S |
|
|
267995764
|
|
|
|
aspartate-semialdehyde dehydrogenase |
Virulence factor |
MUTATION: An asd mutant, alone or in combination with a rfc mutation, is attenuated in mice [Ref7345:Piao et al., 2010]. |
20799091
|
|
|
cbiA |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6923268
|
|
205353181
|
SG2061 |
AM933173 |
YP_002226982 |
cobyrinic acid a,c-diamide synthase |
Virulence factor |
MUTATION: A cbiA mutant, in combination with a cobS mutation, is attenuated in chickens [Ref7346:Penha et al., 2010]. |
20153354
|
|
|
cobS |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6923296
|
|
205353166
|
SG2041 |
AM933173 |
YP_002226967 |
cobalamin synthase |
Virulence factor |
MUTATION: A cobS mutant, in combination with a cbiA mutation, is attenuated in chickens [Ref7346:Penha et al., 2010]. |
20153354
|
|
|
guaB |
Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 |
6949287
|
|
207857921
|
SEN2491 |
AM933172 |
YP_002244572 |
inosine 5'-monophosphate dehydrogenase |
Virulence factor |
MUTATION: guaB mutant is attenuated in BALB/c mice [Ref7347:Adriaensen et al., 2007]. |
17261603
|
|
|
lon from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6923289
|
|
205351761
|
SG0461 |
AM933173 |
YP_002225562 |
DNA-binding ATP-dependent protease La |
Virulence factor |
MUTATION: A lon mutant is attenuated in mice [Ref7348:Matsuda et al., 2010]. |
20487719
|
|
|
lon from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251970
|
|
16763831
|
STM0450 |
AE006468 |
NP_459446 |
DNA-binding ATP-dependent protease La |
Virulence factor |
MUTATION: lon mutant is attenuated in mice [Ref7349:Matsui et al., 2003]. |
12496146
|
|
|
cpxR from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6923307
|
|
205354363
|
SG3362 |
AM933173 |
YP_002228164 |
DNA-binding transcriptional regulator CpxR |
Virulence factor |
MUTATION: A cpxR mutant is attenuated in mice [Ref7348:Matsuda et al., 2010]. |
20487719
|
|
|
lppB |
Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S |
|
|
267993263
|
|
|
|
putative methyl-accepting chemotaxis protein |
Virulence factor |
MUTATION: lppB mutant is attenuated in mice [Ref7350:Liu et al., 2008]. |
17997275
|
|
|
lppA |
Salmonella enterica subsp. enterica serovar Typhimurium str. 4/74 |
|
|
323129647
|
|
|
|
major outer membrane lipoprotein |
Virulence factor |
MUTATION: lppAB mutant is attenuated in mice [Ref7350:Liu et al., 2008]. |
17997275
|
|
|
msbB |
Salmonella enterica subsp. enterica serovar Typhimurium |
|
|
4104731
|
|
|
|
lipid A acyltransferase |
Virulence factor |
MUTATION: msbB mutant is attenuated in mice [Ref7350:Liu et al., 2008]. |
17997275
|
|
|
nmpC |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253090
|
|
16764916
|
STM1572 |
AE006468 |
NP_460531 |
outer membrane porin precursor |
Virulence factor |
MUTATION: nmpC (ompD) mutant is attenuated in swine [Ref7351:Selke et al., 2007]. |
17296750
|
|
|
nuoG |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6924283
|
|
205353438
|
SG2352 |
AM933173 |
YP_002227239 |
NADH dehydrogenase subunit G |
Virulence factor |
MUTATION: A nuoG mutant is attenuated in chickens [Ref7352:Zhang-Barber et al., 1998]. |
9682335
|
|
|
rfc |
Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S |
|
|
267993210
|
|
|
|
O-antigen polymerase |
Virulence factor |
MUTATION: An rfc mutant, in combination with an asd mutation, is attenuated in mice [Ref7352:Zhang-Barber et al., 1998]. |
9682335
|
|
|
ruvB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253415
|
|
16765236
|
STM1894 |
AE006468 |
NP_460851 |
Holliday junction DNA helicase RuvB |
Virulence factor |
MUTATION: A ruvB mutant is attenuated in mice [Ref7353:Choi et al., 2010]. |
20670908
|
|
|
tolA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1252267
|
|
16764117
|
STM0747 |
AE006468 |
NP_459732 |
cell envelope integrity inner membrane protein TolA |
Virulence factor |
MUTATION: A tolA mutant is attenuated in mice [Ref7354:Paterson et al., 2009]. |
19118362
|
|
|
atpA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255394
|
|
16767151
|
STM3867 |
AE006468 |
NP_462766 |
F0F1 ATP synthase subunit alpha |
Virulence factor |
MUTATION: An atpA mutant is attenuated in mice [Ref7411:Chaudhuri et al., 2009]. |
19649318
|
|
|
cpxA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255585
|
|
16767324
|
STM4058 |
AE006468 |
NP_462939 |
two-component sensor protein |
Virulence factor |
MUTATION: cpxA mutants are attenuated in mice [Ref7412:Humphreys et al., 2004]. |
15271926
|
|
|
cya |
Salmonella enterica subsp. enterica serovar Typhimurium |
|
|
581756
|
|
|
|
adenylate cyclase |
Virulence factor |
MUTATION: A cya and crp mutant is attenuated in mice[Ref7413:Curtiss and Kelly, 1987]. |
3316029
|
|
|
gyrA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1253794
|
|
16765599
|
STM2272 |
AE006468 |
NP_461214 |
DNA gyrase subunit A |
Virulence factor |
MUTATION: A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated in pigs [Ref7414:Roesler et al., 2004]. |
15542179
|
|
|
lon |
Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 |
6923289
|
|
205351761
|
SG0461 |
AM933173 |
YP_002225562 |
DNA-binding ATP-dependent protease La |
Virulence factor |
MUTATION: ion mutant is attenuated in chickens [Ref7348:Matsuda et al., 2010]. |
20487719
|
|
|
yjeA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255870
|
|
16767593
|
STM4344 |
AE006468 |
NP_463208 |
lysyl-tRNA synthetase |
Virulence factor |
MUTATION: A poxA mutant is attenuated in mice [Ref7415:Kaniga et al., 1998]. |
9826331
|
|
|
rpoB |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1255679
|
|
16767407
|
STM4153 |
AF170176 |
NP_463022 |
DNA-directed RNA polymerase subunit beta |
Virulence factor |
MUTATION: A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated in pigs [Ref7414:Roesler et al., 2004]. |
15542179
|
|
|
surA |
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
1251610
|
|
16763482
|
STM0092 |
AE006468 |
NP_459097 |
peptidyl-prolyl cis-trans isomerase SurA |
Virulence factor |
MUTATION: A surA mutant (BRD1115) is attenuated in BALB/c mice [Ref7416:Sydenham et al., 2000]. |
10678914
|
