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pyrD

Victor ID 2632
Gene Name pyrD
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1252576
NCBI Protein GI 16764417
Locus Tag STM1058
Protein Accession NP_460032.1
Other Database IDs UniProtKB-ID: PYRD_SALTY
UniRef100: UniRef100_B5F1U2
UniRef90: UniRef90_B7UN24
UniRef50: UniRef50_Q2Y5H8
UniParc: UPI0000132C9F
EMBL: X55636
EMBL: AE006468
EMBL-CDS: CAA39161.1
EMBL-CDS: AAL19991.1
RefSeq_NT: NC_003197.1
GenomeReviews: AE006468_GR
KEGG: stm:STM1058
HOGENOM: HBG351027
OMA: SYVTVNI
ProtClustDB: PRK05286
BioCyc: STYP99287:STM1058-MONOMER
Taxonomy ID 99287
Gene Starting Position 1146960
Gene Ending Position 1147970
Gene Strand (Orientation) +
Protein Name dihydroorotate dehydrogenase 2
DNA Sequence 
>gi|16763390:1146960-1147970 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
CATGTACTATCCCTTCGTTCGTAAAGCCCTTTTCCAGCTCGATCCAGAGCGCGCTCATGAATTTACATTT
CAACAATTACGCCGCATTACAGGTACGCCGCTGGAAGCGCTGGTGCGCCAGAAAGTACCGACAAAGCCGG
TTACCTGCATGGGACTTACCTTTAAAAATCCACTGGGGCTGGCTGCCGGTCTGGATAAAGACGGGGAGTG
CATCGACGCGTTAGGCGCGATGGGGTTTGGCTCCCTGGAAATCGGCACCGTGACGCCGCGCCCACAGCCG
GGTAACGATAAGCCGCGTCTTTTTCGTCTGGTGGATGCTGAAGGTCTGATCAATCGGATGGGCTTTAATA
ATCTGGGCGTCGATAACCTGGTCGAGAATGTTAAAAAAGCCCATTTTGATGGTATTCTGGGAATTAACAT
CGGTAAAAATAAAGATACGCCTGTCGAAAATGGCAAAGATGACTACCTGATTTGTATGGAAAAAGTCTAT
GCTTATGCGGGTTATATCGCCATTAATATTTCTTCGCCGAATACGCCAGGGCTACGTACGCTCCAGTATG
GCGATGCGCTGGACGATCTGTTAACTGCCATTAAAAATAAGCAAAACGATCTTCAGGCGATCCACCATAA
ATATGTGCCGGTGGCAGTAAAGATCGCGCCGGATCTTTGTGAAGAAGAATTGATCCAGGTTGCCGATAGC
CTGCTTCGTCATAATATTGATGGGGTGATTGCGACAAATACCACCCTCGATCGTTCTCTGGTACAAGGAA
TGAAAAATTGCCAGCAAACGGGGGGATTAAGTGGCCGGCCATTACAATTAAAAAGCACAGAAATTATTCG
CCGTTTATCCCAGGAGTTAAAGGGACAATTGCCTATTATCGGCGTCGGCGGCATTGACTCAGTTATCGCC
GCGCGCGAGAAGATAGCGGCAGGAGCTACGCTGGTACAAATTTATTCCGGCTTTATTTTTAAAGGCCCGC
CATTGATTAAAGAAATCGTAACGCACATCTA
Protein Sequence 
>gi|16764417|ref|NP_460032.1| dihydroorotate dehydrogenase 2 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPLEALVRQKVPTKPVTCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSLEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHFDGILGINIGKNKDTPVENGKDDYLICMEKVYAYAGYIAINISSPNTPGLRTLQYGDALDDLLTAIKNKQNDLQAIHHKYVPVAVKIAPDLCEEELIQVADSLLRHNIDGVIATNTTLDRSLVQGMKNCQQTGGLSGRPLQLKSTEIIRRLSQELKGQLPIIGVGGIDSVIAAREKIAAGATLVQIYSGFIFKGPPLIKEIVTHI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyrD mutant is attenuated in pigs (Carnell et al., 2007).
COG COG0167F, under F: Nucleotide transport and metabolism
References
Carnell et al., 2007: Carnell SC, Bowen A, Morgan E, Maskell DJ, Wallis TS, Stevens MP. Role in virulence and protective efficacy in pigs of Salmonella enterica serovar Typhimurium secreted components identified by signature-tagged mutagenesis. Microbiology (Reading, England). 2007; 153(Pt 6); 1940-1952. [PubMed: 17526851].