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spaS from Salmonella enterica subsp. enterica serovar Typhi str. CT18

Victor ID 1193
Gene Name spaS from Salmonella enterica subsp. enterica serovar Typhi str. CT18
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhi str. CT18
NCBI Gene ID 1249316
NCBI Protein GI 16761664
Locus Tag STY3010
Protein Accession NP_457281.1
Other Database IDs UniProtKB-ID: Q8Z492_SALTI
UniRef100: UniRef100_B5BEU5
UniRef90: UniRef90_P40702
UniRef50: UniRef50_P40702
UniParc: UPI000005A36E
EMBL: AE014613
EMBL: AL627276
EMBL-CDS: AAO70350.1
EMBL-CDS: CAD05994.1
RefSeq_NT: NC_003198.1
RefSeq_NT: NC_004631.1
GenomeReviews: AE014613_GR
GenomeReviews: AL513382_GR
KEGG: stt:t2789
KEGG: sty:STY3010
HOGENOM: HBG529770
OMA: QPNPGAY
ProtClustDB: PRK08156
BioCyc: SENT209261:T2789-MONOMER
BioCyc: SENT220341:STY3010-MONOMER
Taxonomy ID 220341
Gene Starting Position 2883532
Gene Ending Position 2884602
Gene Strand (Orientation) -
Protein Name surface presentation of antigens protein SpaS
DNA Sequence 
>gi|16758993:2883532-2884602 Salmonella enterica subsp. enterica serovar Typhi str. CT18 chromosome, complete genome
CTCAATGCCGTACCTCGTTTTCTTGTGGCTGAATAACGTCTTTGCCCGCGTTTTCTACCTCTTCCAGCCA
AACCAGAAGACGTAAAACTTCATCAATTTCTTCCAGACTCACCAGATCATAACGGCGATGGGTTTTGAAA
AGACTGCGCGCCAGTTTGATATCGACGATCACAGGTACGCCAACCTTCTCCGCATAGGCGCGGACGGCCA
GTGCGCGCTGATTCGTTTCATACACCGAGATCATCGGAATCGGCATCAATTCGGGTTTAAAATAAATCCC
GATCGTAATATGCGTGGGGTTGGCAACAATCAGGCGTGAGTTTTCAATATCGGATTTCACCTGTTCAGAC
AGAATTTCCATATGAACTTCACGTCTTTTAGATTTAACCTCTGGGTTCCCTTCCTGCTCCTTCATTTCAC
GCTTCACTTCTTCCTTATCCATTTTCATATCTTTCATGGTCAGGAAATATTCCGCAATAGCATCCAATAA
TAAGACAATCAATGCGCAAGCAAGGCAAGTTAATACCAATGCGAGGAGAAGTTCACGCCAAATGACGGCA
ATATCCACAACATTGCCATTTAACTGAGAAAAGATTTCAACCTTATATTTCTTCCAGCAAATGATGGCGG
CCACCACAAAGGATGAGAGATACAGTAGGGTTTTGACCGTATCTTTAACCGTGCGCATACTAAAAAGTTT
TTTCGCCCCTTCTACCGGGTTTAACGCCGATAAATTAGGTTTTAATGCTTCTGTCGCCAGCACGAAACCG
GCCTGTAATAACGCCGGTAATGCGGAACACACTAAACAGAGCAGCATAAATGGAATCAGATATTTTAATC
CTATCCCAAAAACGGCCAAACTGTAATCAGCCATGCTCTGATCAAAATTATCCGCAATAATGATCTTAAT
TATCCCCATAAACTCATTAAATGAGCCATACGACACCAGATAGGCAATTCCTCCCAGCGTCAGACAGGCG
ATAATGAGATCTTTACTTTTAAATGACTGGCCTTTTTTAGCGGAGTCTTCCAGCCGTTTTTTAGTCGGTT
TTTCTGTTTTATTCGAGGACA
Protein Sequence 
>gi|16761664|ref|NP_457281.1| secretory protein [Salmonella enterica subsp. enterica serovar Typhi str. CT18] MSSNKTEKPTKKRLEDSAKKGQSFKSKDLIIACLTLGGIAYLVSYGSFNEFMGIIKIIIADNFDQSMADYSLAVFGIGLKYLIPFMLLCLVCSALPALLQAGFVLATEALKPNLSALNPVEGAKKLFSMRTVKDTVKTLLYLSSFVVAAIICWKKYKVEIFSQLNGNVVDIAVIWRELLLALVLTCLACALIVLLLDAIAEYFLTMKDMKMDKEEVKREMKEQEGNPEVKSKRREVHMEILSEQVKSDIENSRLIVANPTHITIGIYFKPELMPIPMISVYETNQRALAVRAYAEKVGVPVIVDIKLARSLFKTHRRYDLVSLEEIDEVLRLLVWLEEVENAGKDVIQPQENEVRH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain (Darwin and Miller, 2000).
COG COG1377NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Darwin and Miller, 2000: Darwin KH, Miller VL. The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes. Molecular microbiology. 2000; 35(4); 949-960. [PubMed: 10692170].