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sptP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Victor ID 2751
Gene Name sptP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1254401
NCBI Protein GI 16766184
Locus Tag STM2878
Protein Accession NP_461799.1
Other Database IDs UniProtKB-ID: SPTP_SALTY
UniRef100: UniRef100_P74873
UniRef90: UniRef90_Q5PEA9
UniRef50: UniRef50_Q5PEA9
UniParc: UPI00000D00EE
EMBL: U63293
EMBL: AE006468
EMBL-CDS: AAC44349.1
EMBL-CDS: AAL21758.1
RefSeq_NT: NC_003197.1
PDB: 1G4U
PDB: 1G4W
PDB: 1JYO
PptaseDB: P3D0410147
GenomeReviews: AE006468_GR
KEGG: stm:STM2878
NMPDR: fig|99287.1.peg.2776
HOGENOM: HBG671449
OMA: ALEAHMK
ProtClustDB: CLSK894366
BioCyc: STYP99287:STM2878-MONOMER
Taxonomy ID 99287
Gene Starting Position 3022070
Gene Ending Position 3023701
Gene Strand (Orientation) -
Protein Name protein tyrosine phosphatase/GTPase activating protein
DNA Sequence 
>gi|16763390:3022070-3023701 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
ATCAGCTTGCCGTCGTCATAAGCAACTGGGCTTGCATTGCTTTTAGTTGTACAAACTGTGAGGCGTCTTC
CAGCATTCTATTGTTCCGTGAATCCCGGAAATCTGCACGTACCTGCTCCAGATTACTATGAGGATTATCC
TTAAGTACAAGGGCCGCCGCCATCGTTCCGGTTCTTCCCACTCCGCCCAGACAATGAATCATCGGTAAAT
GCTTATCTGATGAACTACGCCCCGGCGCGCCATTTTGGTTACTATTTTTCACCCTATCCGCCAGGTATTC
TAACTGATCCGTAGACGGTAACGGCTGGTGATCTGGCCAATTTTTCACATGCAATACCGGGATTGTATAC
CGCTTTTCCCCGCAGGACAGTTGCATATTGTATTGGTCTATCGCTTCTCCCTGACTGGCTGAGCTCACTT
TTTGGCTGTTGGTATGCACCTCGCCAAAGGTGTAGCTCCCTCTGAAATAGGGTGGTAATTGTTTTGCCTG
CATCTGATCTTCCGACGTTAACACCACCAGGCACGAGCATTCTTTTTCAAGAAGCATTTTCATATGCGCT
TCCAGCGCATCCGGCGTATTTTTTGGGTACGAACCGGCTAATGCCACAGGCTTACCGTCAAAAGTTAACG
TATTCACTGGCACAGGCATTCCATCGCTCAGTTTCACCTGGGTTTGCTGATTAATTGGAATGCTGCTGAC
CGCAAATCGTGCCAGGCCCAGTGTCGGTCCGCTCATCGTCTGTGGCATTGGCGCGCCGGCTTCTATTTTC
TCAAGTTCAGCTGTAACATTTTTCAGTTCTTTAGCAATAACGTGAATTTTTTTTACAGCCTGGGTTAATT
CATGAGTAGAGGCTTTATCAACCCACCTCTCAACCTCTCCTCCACAGGTTCCCCATTGTGAGAACCGGGC
TACACCGACCTGAATATTTGTTAACGTTGTAACATAATCATTAAGTTGTTTAGCCTCTGGAATTTTATTT
AAATTCTGTAAATTCGTCATTAATGAACGCAGCGGGCCGTTACCTGAAGCCATCTCCTGGAAGTTTTCTC
GCAGGCTATTTCCATCCATTTGTTCCAGTTGCGGTAATGTTCTTTTAAGTCCCTTTAGCGCGATATCGAG
TAAAGGTTGCTTACTTTCTGCTCCAACATCGTTATTTTTTTCTGCCACTTTTGTATCGCCGCCTTTTATG
ACTAAAGCGGCATTCCTGACACCAACATTATCCTTGCTCTTAATAAGGTTTATAAACCCTTCGTCAGCAG
CTTTTACACACTCCGTGATCTGCACTGCTAAACGTTGGGTAAGGGGTTTGTTCATATTTATACGGGACAT
TAACAGTGCGTCATTAACCGCTGTTTCCCCATATTTTTCCGTTAGTGCATGGAGAAATGTCTGTAAAATC
TTTTGGTCCTGTACTCTGATATTTTCCGTATGTTTTTGCACCACTTCAGTGTTTTTAAATAACGGCATTT
TTCCAAGCCAGGTTAATACTTTTGACGAAAATTTTTCAGGCGCAACATATGCCTTATCAGTATTTTCCTT
AGCAATATAAAGTCGGGCATCATTCGACACACCAACTTTTGAAAACGAAGACAACGTTAAATTATTCAAT
TTTCTCTCCTCATACTTTAGCA
Protein Sequence 
>gi|16766184|ref|NP_461799.1| secreted effector protein SptP [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MLKYEERKLNNLTLSSFSKVGVSNDARLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQDQKILQTFLHALTEKYGETAVNDALLMSRINMNKPLTQRLAVQITECVKAADEGFINLIKSKDNVGVRNAALVIKGGDTKVAEKNNDVGAESKQPLLDIALKGLKRTLPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQNLNKIPEAKQLNDYVTTLTNIQVGVARFSQWGTCGGEVERWVDKASTHELTQAVKKIHVIAKELKNVTAELEKIEAGAPMPQTMSGPTLGLARFAVSSIPINQQTQVKLSDGMPVPVNTLTFDGKPVALAGSYPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPPYFRGSYTFGEVHTNSQKVSSASQGEAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIHCLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRDSRNNRMLEDASQFVQLKAMQAQLLMTTAS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica (Tenor et al., 2004).
COG COG2453T, under T: Signal transduction mechanisms
References
Tenor et al., 2004: Tenor JL, McCormick BA, Ausubel FM, Aballay A. Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions. Current biology : CB. 2004; 14(11); 1018-1024. [PubMed: 15182677].