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sipC from Salmonella enterica subsp. enterica serovar Typhi str. CT18

Victor ID 1192
Gene Name sipC from Salmonella enterica subsp. enterica serovar Typhi str. CT18
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhi str. CT18
NCBI Gene ID 1249313
NCBI Protein GI 16761661
Locus Tag STY3007
Protein Accession NP_457278.1
Other Database IDs UniProtKB-ID: SIPC_SALTI
UniRef100: UniRef100_Q56135
UniRef90: UniRef90_Q56135
UniRef50: UniRef50_Q56135
UniParc: UPI000005A36B
EMBL: X82670
EMBL: AE014613
EMBL: AL627276
EMBL-CDS: CAA57989.1
EMBL-CDS: AAO70347.1
EMBL-CDS: CAD05991.1
RefSeq_NT: NC_003198.1
RefSeq_NT: NC_004631.1
GenomeReviews: AE014613_GR
GenomeReviews: AL513382_GR
KEGG: stt:t2786
KEGG: sty:STY3007
HOGENOM: HBG415831
OMA: AMESINQ
ProtClustDB: CLSK862847
BioCyc: SENT209261:T2786-MONOMER
BioCyc: SENT220341:STY3007-MONOMER
Taxonomy ID 220341
Gene Starting Position 2879856
Gene Ending Position 2881085
Gene Strand (Orientation) -
Protein Name pathogenicity island 1 effector protein
DNA Sequence 
>gi|16758993:2879856-2881085 Salmonella enterica subsp. enterica serovar Typhi str. CT18 chromosome, complete genome
ATTAAGCGCGAATATTGCCTGCGATAGCAGCGAGTGCGGATGCTTTCGACTGGTTAATGCTCTCCATTGT
TTTCAGCATTTCCTGAATCAGGCTGGTCGATTTACGTGAACTTTCACGGGCTTCGTCCGATGCGGTGCTG
GCAACCCGGTTATTCACCTGGCTAATTTGCTGCTCGGAACGTTCCTGAGTAGCGGCGTACTGCCTGGACG
CCCCTGCAATACCACCGACCGTGACTGAGTTCTTCATAATCAGATCGCCCGTCATCTGCATCTTGCGCGC
ATCGATTCGGGTCATATCCATGGTATTCTGCTCAAGACGAATATCGGATTCGACAGACTCAAGACGTTTC
GACAGAATAGCCTGATGTTCAGGGGAGATTTGTTTATTACTGTTTTTAATACCCAGACTTTCCGTGGCGC
TGGTTCCGGCATTAGATTTAAGCGTCGCATCATTAAGATTTTTCGTCGCATCGGTACCGGTTTTCTTCAT
ATTTAACGATTTCAGAGAATCGACGCCTTCAGCACCAAGTTTGACGCTATTCTGCCCGTTCAGCACGTTT
TTAATACTGTGGCTTTCAGTGGTCAGTTTATCGATCTTCGCGGCATTATGTTTAAGCGCGCCTCTTTCAT
TCTGCAGCCCCTTATATTCCAGTTTGGCGCCCACGCCAGTGATCCCCAACTGAAGCGCGCTCTGGGAAAT
ACTACCGGACAACGCATTCATCCCTTCGCGCATCATGGAGCTTGCCGTCGTTTTAGCTGCATCAAAACTG
ACTAATGACAACTTACCAGACAGTTTGCTATCAGCCTGGTTCAACGTCAGCATTAACGTATTCGCGGCAG
CCAACAGCGCAACGGCACTGGAAGACATTCCGCTAATATCAAAAAACTTTCCGACTTCTGCCTGCTGCTC
GCGTAACTGGGTTTGCACAACCTCATTCGCTTTAGTCGTGACATTATTTGCCAGGGCATTCAAATCCTGA
TTCATGTCGGTATTTTGAATACTGGCTTTTAAAAAGGACGTGATCGTTCCGGGGGTTTGCGTTAATACCC
CTGGCGCAGGCGCGCTCAGTGTAGGACTCAACCCCAGGTCACTGACTTTACTGCTGCTAATACCAATACT
ATTCAGAATATCTTTAGCGCTAACGGATTGCGAAGCTGTCTGTGAACTATTCTCAACAGAATGATTATTT
AAATAAGCGGCGGGATTTATTCCCACATTACTAATTAACA
Protein Sequence 
>gi|16761661|ref|NP_457278.1| pathogenicity island 1 effector protein [Salmonella enterica subsp. enterica serovar Typhi str. CT18] MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGVDSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKNSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASRQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells (Chang et al., 2005).
References
Chang et al., 2005: Chang J, Chen J, Zhou D. Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC. Molecular microbiology. 2005; 55(5); 1379-1389. [PubMed: 15720547].