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spvB from Salmonella enterica subsp. enterica serovar Typhimurium

Victor ID 3836
Gene Name spvB from Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium
NCBI Gene ID 8541860
NCBI Protein GI 261888705
Locus Tag pSLTBT_p025
Protein Accession YP_003264392.1
Other Database IDs UniProtKB-ID: D0R799_SALTD
UniRef100: UniRef100_D0R799
UniRef90: UniRef90_P24419
UniRef50: UniRef50_P24419
UniParc: UPI00000D2F22
EMBL: FN432031
EMBL-CDS: CBA11356.1
RefSeq_NT: NC_013437.1
RefSeq_NT: NC_014476.1
GenomeReviews: FN432031_GR
HOGENOM: HBG673219
Taxonomy ID 90371
Plasmid No pSLT-BT
Gene Starting Position 25226
Gene Ending Position 27001
Gene Strand (Orientation) -
Protein Name Salmonella plasmid virulence protein
DNA Sequence 
>gi|261888681:25226-27001 Salmonella enterica subsp. enterica serovar Typhimurium plasmid pSLT-BT, complete sequence
TCTATGAGTTGAGTACCCTCATGTTTATTATTCTTTTTATCCTGTTTGTGTCAGCAGTTGCATCATCACT
TAATCTCAGCTTACTAAGCTGGCTTGCAAAGTCTTGGGATCCACAATTTACAATGCTTTCGATTTTGAGT
TTAGTATTTGGAGGGAAAAGCATCTCTGCCTCTCCCTTAAAATGTGCAACATCTCCGAGTATTCTACCTT
TATGTCCTTTTTCTAGGTATATGTTGAGAATAGTGTCATTTATCCATGCCTTATCTGGCGATGTACTCAT
AAAAGCTTTATCTATTATTATATTACCTATAGTAGTGTATTCCTTCAGCACATCCGATAATGCGGGCTTA
TCAAGCTTCAGGCCCCGGTATACGACTCTGTGATCTGTTTCGGGAAGTGAACTTAATCCCTCCGCAATAT
CATTTATATAAACTGACATGGCATTTTTAAACTCCTCATCACTGGGTTCATTTGTGGAAAGATAGTCTCT
GGAGAGCAGAGTTTCTTTTGCCTGTGTTTCAGGATAATCATCCCCACGTAAATATTTATTAATCACACTG
TACCCTTGAGCTGAATAGTACCTCAGAGCTTGAATCTGCTTTGATTCCTCTACAATCGCCCATTTTGATT
TTGGTCGAGATGAATTACCTCCCATCATCGGAGGAGGCGGTGGCGGTGGCATCATATTGTTGACAGGAGC
TCTTCTATAACCGTCGCCTTCATAGGCCAGCGTCCGAGCAGCGCAAAGCTGTGTCAGTATCGGATTTTCG
TCATACTCCAGCAGCAGACGGGAAACCAGCGTATCGGCTTCACCCAGTTCATCAGGAAAGTGGTGGAACA
TCAGGACTTGGCGGCACAGGCGATGGAGGCGGATCTCAAAGCCGTAGTTATACAGGGAGAAGGGATCCTG
GCGGGCGAGCCAGCTGTTCTGAGCAGTGAATGCAGGCGGTACCTGTGGATCTACACCACGTTCGCCGTAG
TCAAACACTAGGGTGAACAGCCACTGTACCGCGGGTGTGGCGCTAGTCCAGAGGTACAGATCGGCGGCGG
GGGTCGCGTTGCCATACTGTACCTTGCTGAGATAGCGCATGGCGCTGCGATCGCGTCCGGCCTCGTTCCC
ATTGAGGTCCACATTGTCACCGTTCTCCGCCAAGTAGGAGTAATAGATATGCTCGCCGGCAGGGGTCACC
GACTCCTCAACCAGCCATTGCGCCGTATGAGAGGCGGCCTGCGGATCGCTGAGGCGTGCTGCGGCGGTTT
TCCCCAGCAGGTGCAGGATGCCGTTACTGTCATGCAGTAACCAGAAATCATCGCCGTTGCTGTTGCCCAC
CCAGTACTCCAGGCGATAAAAACTGCTCTCCGTGCGGGGCTGATAGCGGGTCACCGTGTAGCTTTGCGGG
AACGATACGTCACCGTACGCGAAGCAGGTGACGGGATTGGGGGCATCACCGGTGCTGAGCGTTTGAACCA
GCACTTCTCCGTCCGGCCCCAGAAACTCATCGCTGTCGTTATACTGCGGCACGCCATGGCTGGTGCGGCG
GGCAATGCTCATTGTCGCGCAGGACCAGCCCACGCCGAAGGGGCCATTGCCGCCACCGCTGCTGTAGTGC
AGCGCCAGCGCAGGCGCAAAGCCGCGTTCGGCGCTGATGGGCAGAGGCAGCGTTATACTGGCTAGGCCGT
CAGGGCCTGACTGACTCAGCGCCTTGCCCCCTTTTGGCAGGAAAGGGGGAGTGATCAGCGCTAAAGTGGC
AGATGAAAAACCATTTAGTATCAACA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spvB mutants are attenuated in mice (Lesnick et al., 2001).

TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells (Lesnick et al., 2001).
References
Lesnick et al., 2001: Lesnick ML, Reiner NE, Fierer J, Guiney DG. The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells. Molecular microbiology. 2001; 39(6); 1464-1470. [PubMed: 11260464].