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spiC from Salmonella enterica subsp. enterica serovar Typhi str. CT18

Victor ID 1187
Gene Name spiC from Salmonella enterica subsp. enterica serovar Typhi str. CT18
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhi str. CT18
NCBI Gene ID 1248101
NCBI Protein GI 16760518
Locus Tag STY1727
Protein Accession NP_456135.1
Other Database IDs UniProtKB-ID: SPIC_SALTI
UniRef100: UniRef100_P74863
UniRef90: UniRef90_P74863
UniRef50: UniRef50_P74863
UniParc: UPI0000059DF1
EMBL: AL627271
EMBL: AE014613
EMBL-CDS: CAD01972.1
EMBL-CDS: AAO68913.1
RefSeq_NT: NC_003198.1
RefSeq_NT: NC_004631.1
GenomeReviews: AE014613_GR
GenomeReviews: AL513382_GR
KEGG: stt:t1261
KEGG: sty:STY1727
HOGENOM: HBG673238
OMA: IQDIRAE
ProtClustDB: CLSK894176
BioCyc: SENT209261:T1261-MONOMER
BioCyc: SENT220341:STY1727-MONOMER
Taxonomy ID 220341
Gene Starting Position 1646268
Gene Ending Position 1646651
Gene Strand (Orientation) -
Protein Name putative pathogenicity island 2 secreted effector protein
DNA Sequence 
>gi|16758993:1646268-1646651 Salmonella enterica subsp. enterica serovar Typhi str. CT18 chromosome, complete genome
TTTATACCCCACCCGAATAAAGTTTATGGTGATTGCGTATTACATTTTTTAAAATGCAAGTTAAAGCCAG
GTGTTTTTCTATCTCAATAGCAATAAGCTCAGAGCTACTACTTGTGGTATAATAACCGTTTAACCATCCC
CCATCCGCTGTGAGCTGTATAGCATAGTCATGGACGTCCGGGTGTGCTGCAAGCAGTAGTGTCACATAGG
CAAGACAAGGCTTAGGTAAGCTTTCCAGGTCATTTAAGAACAAAGAAATAGAAAATGCTTCTGAGAAAAT
TTCTCCTCTGGCAGGATGCCCATCAATAGTCATTATCCAGGATCGGCTATTACCTTCGGCCCTGATATCC
TGAATTAATGGAATGCCTTTTAAAACTGCCAGCA
Protein Sequence 
>gi|16760518|ref|NP_456135.1| pathogenicity island 2 secreted effector protein [Salmonella enterica subsp. enterica serovar Typhi str. CT18] MLAVLKGIPLIQDIRAEGNSRSWIMTIDGHPARGEIFSEAFSISLFLNDLESLPKPCLAYVTLLLAAHPDVHDYAIQLTADGGWLNGYYTTSSSSELIAIEIEKHLALTCILKNVIRNHHKLYSGGV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice (Uchiya et al., 1999).
References
Uchiya et al., 1999: Uchiya K, Barbieri MA, Funato K, Shah AH, Stahl PD, Groisman EA. A Salmonella virulence protein that inhibits cellular trafficking. The EMBO journal. 1999; 18(14); 3924-3933. [PubMed: 10406797].