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tolA

Victor ID 4933
Gene Name tolA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1252267
NCBI Protein GI 16764117
Locus Tag STM0747
Genbank Accession AE006468
Protein Accession NP_459732
Taxonomy ID 700720
Gene Starting Position 814616
Gene Ending Position 815839
Gene Strand (Orientation) +
Protein Name cell envelope integrity inner membrane protein TolA
Protein pI 9.79
Protein Weight 40772.04
Protein Length 407
Protein Note inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
DNA Sequence 
>gi|16763390:814616-815839 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
AGTGTCAAAGGCAACCGAACAAAACGACAAGCTCAAACGGGCGATAATTATTTCAGCCGTGCTGCATATC
ATCTTATTTGCAGTGCTGATCTGGAGTTCGTTTGATGAGCATATAGAGGCTTCTGCCGGCGGCGGCGGTG
GTTCCGCTATCGACGCGGTGATGGTCGATCCTGGCGCCGTTGTGCAGCAGTACAACCGTCAGCAGGATCA
ACAGGCCAGCGCCAGACGCGCGGAAGAAGAGCGTAAAAAGCTGCAACAGCAGCAAGCAGAGGAGCTGCAG
CAGAAGCAGGCTGCTGAACAGGAGCGGTTGAAACAACTTGAGAAAGAACGTTTAGCGGCTCAGGAGCAGC
AAAAGCAGGCTGAAGAAGCGGCAAAACTGGCGCAACAGCAGCAGCAACAGGCCGAAGAAGCGGCGAAAGC
GGCGGCGGACGCGAAGAAAAAAGCGGAGGCCGAGGCGGCGAAAGCGGCGGCGGACGCGAAGAAGAAAGCG
GAAGCCGAAGCGGTAAAAGCGGCAGCGGACGCGAAGAAGAAAGCGGAAGCCGAAGCGGCGAAAGCGGCGG
CGGACGCGAAGAAGAAAGCAGAGGCCGAAGCGGCGAAAGCGGCGGCGGAGGCGAAGAAGAAAGCGGAAGC
CGAAGCGGCGAAAGCGGCGGCGGAGGCGAAGAAGAAAGCGGATGCCGAGGCGGCGAAAGCGGCGGCGGAG
GCGAAGAAGAAAGCGGATGCCGCGGCGGCGAAAGCGGCGGCGGAGGCGAAGAAGAAAGCGGATGCCGCGG
CGGCGAAAGCAGCGGCGGACGCTAAGAAGAAAGCGGCTGCCGAAAAAGCGGCCGCCGCAGAAGGCGTCGA
CGATCTGCTTGGCGATCTCAGCTCGGGTAAGAATGCGCCGAAAACCGGCGGCGGCGCGAAAGGGAATGGT
CAGCCATCGAAAGATAGCGGTACATCGGGCGCTAACGGTGGGGCGACAGGCGCTGATATCAGCGCCTACG
CGAAACAGATTCAGGTCGCCATTCAGAGCCGTCTGTACGATGCGAGCCTGTATCAGGGCAAACAATGTGT
CTTGCATATTAGCCTGGCGCCGGATGGCTCATTAAAAAGCATTACGTCTGAGGGCGGCGATCCGGCGCTT
TGTCAGGCGGCGTTAATGGCGGCAAAAACCGCGAAAATTCCTAAACCGCCAAGCCAGGCTGTTTATGAGA
AAATAAAGGATGCCAAACTAGACTTTAAACTGTA
Protein Sequence 
>gi|16764117|ref|NP_459732.1| cell envelope integrity inner membrane protein TolA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSKATEQNDKLKRAIIISAVLHIILFAVLIWSSFDEHIEASAGGGGGSAIDAVMVDPGAVVQQYNRQQDQ
QASARRAEEERKKLQQQQAEELQQKQAAEQERLKQLEKERLAAQEQQKQAEEAAKLAQQQQQQAEEAAKA
AADAKKKAEAEAAKAAADAKKKAEAEAVKAAADAKKKAEAEAAKAAADAKKKAEAEAAKAAAEAKKKAEA
EAAKAAAEAKKKADAEAAKAAAEAKKKADAAAAKAAAEAKKKADAAAAKAAADAKKKAAAEKAAAAEGVD
DLLGDLSSGKNAPKTGGGAKGNGQPSKDSGTSGANGGATGADISAYAKQIQVAIQSRLYDASLYQGKQCV
LHISLAPDGSLKSITSEGGDPALCQAALMAAKTAKIPKPPSQAVYEKIKDAKLDFKL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A tolA mutant is attenuated in mice (Paterson et al., 2009).
COG COG3064M, under M: Cell wall/membrane/envelope biogenesis
References
Paterson et al., 2009: Paterson GK, Northen H, Cone DB, Willers C, Peters SE, Maskell DJ. Deletion of tolA in Salmonella Typhimurium generates an attenuated strain with vaccine potential. Microbiology (Reading, England). 2009; 155(Pt 1); 220-228. [PubMed: 19118362].