Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

prgH

Victor ID 2748
Gene Name prgH
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1254397
NCBI Protein GI 16766180
Locus Tag STM2874
Protein Accession NP_461795.1
Other Database IDs UniProtKB-ID: PRGH_SALTY
UniRef100: UniRef100_P41783
UniRef90: UniRef90_P41783
UniRef50: UniRef50_P41783
UniParc: UPI00001321A0
EMBL: U21676
EMBL: AE006468
EMBL-CDS: AAB60188.1
EMBL-CDS: AAL21754.1
RefSeq_NT: NC_003197.1
PDB: 3GR0
PDB: 3GR1
GenomeReviews: AE006468_GR
KEGG: stm:STM2874
NMPDR: fig|99287.1.peg.2772
HOGENOM: HBG390911
OMA: PGDFEVD
ProtClustDB: CLSK894364
BioCyc: STYP99287:STM2874-MONOMER
Taxonomy ID 99287
Gene Starting Position 3016341
Gene Ending Position 3017519
Gene Strand (Orientation) -
Protein Name needle complex inner membrane protein
DNA Sequence 
>gi|16763390:3016341-3017519 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
ATTAAAGTGGGCTTGGGAAATACCAATGGCCTGGGCTCATTTTGATATAACCTTCCGCCCCGTACTGAAA
TGAGCGCCCCTTGAGCCAGTCATCTTTTAATTCGATCGCAAACTGCACATAGCGTCCTCCCCATGTGCGG
TAATAGCTATCGACAAATTGACGGGCTCTGAGTATTTCTACATCATCGAGCGCCCCCTGAATAACAAACG
TTACGCCCCCCTTATGATTCCTGCGGGAATAAGGTAACGCCTGCTGTTTTAGCCCCGCTTCCGCCTGGCC
TGCTGCGGTAACATCGTCCATCAACGTGATGTTAACCGAATCCGCGTAAGGCATTAGCGCTCTCAGCTTT
TGACTTAACACCTCGAGCTCTTTCTTGCTCATCGTGTTTCGCTGGCGGCTTAGCCAGAAAACGGGTTTAC
GCGGCTCATCGAAATGAATCCGATAATAAGCCAGCTGCGGATAATAGGTATCCAGCCAGATAGAGATACG
CTTATTTTCTTCGTTTTCGTTAATCACTCGCGCATTTTTATCATAATCGCCCCTCGCTAAAACCTGACGA
GCCCACAACGTATCTCTTTCATTTTGCGCAGCGACATAGAGCATTTTGTCCCGGCCTGGCAACACCTGAA
AACGCTCCTTCTCCTGCCCCAATAACGAATCGAGCTCTGCGGCCTGCCGCTGCGGCGAGTTAAGTATCCA
TAACGTCCCCACAGTCCCAATTCCCAATATAAAAAACCCGGCCAGTGCTGCTACAATTCCGTTTTTAAAA
CGCGGCTCGTTCTTTTTTGCAGACGTTTCTAACTTCTCAGGCTGCTCGGGCACCCACGGCTCGCTTTCCG
GGCGAATCAGGATAAGCAATTCACCGACCTGTATTGGCGTATTTAATTGCACCGAACGAGATTCAGAATT
TCCTTCTTTCAGCTCATGGAGTATAATTTCGGTCGCATCCGTATCCACCTGGATTTCAAAATTTACTCCG
CCATGGTCCAGCGGGATAAAAAAGCTATCGGCAGGTATATCAGGGAGTTGACCTGAAGCAGTGAGCGCAT
CACTCTGACCTACCACAAAGAGTGTTCGGCCTGTCAGCAATGGAAACTCACAGCCGTTCAGTGAGCTGTT
AAGTAATCGAACTATGTATGGCCCTGGGCTTGTTATCGTCTTCTCTTTTGATGTTTCCA
Protein Sequence 
>gi|16766180|ref|NP_461795.1| secretion system protein PrgH [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] METSKEKTITSPGPYIVRLLNSSLNGCEFPLLTGRTLFVVGQSDALTASGQLPDIPADSFFIPLDHGGVNFEIQVDTDATEIILHELKEGNSESRSVQLNTPIQVGELLILIRPESEPWVPEQPEKLETSAKKNEPRFKNGIVAALAGFFILGIGTVGTLWILNSPQRQAAELDSLLGQEKERFQVLPGRDKMLYVAAQNERDTLWARQVLARGDYDKNARVINENEENKRISIWLDTYYPQLAYYRIHFDEPRKPVFWLSRQRNTMSKKELEVLSQKLRALMPYADSVNITLMDDVTAAGQAEAGLKQQALPYSRRNHKGGVTFVIQGALDDVEILRARQFVDSYYRTWGGRYVQFAIELKDDWLKGRSFQYGAEGYIKMSPGHWYFPSPL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: prgH mutants are attenuated in their ability to invade HEp-2 cells (Klein et al., 2000).
References
Klein et al., 2000: Klein JR, Fahlen TF, Jones BD. Transcriptional organization and function of invasion genes within Salmonella enterica serovar Typhimurium pathogenicity island 1, including the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes. Infection and immunity. 2000; 68(6); 3368-3376. [PubMed: 10816487].