Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

cpxA

Victor ID 5001
Gene Name cpxA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1255585
NCBI Protein GI 16767324
Locus Tag STM4058
Genbank Accession AE006468
Protein Accession NP_462939
Taxonomy ID 700720
Gene Starting Position 4268375
Gene Ending Position 4269748
Gene Strand (Orientation) -
Protein Name two-component sensor protein
Protein pI 5.57
Protein Weight 49326.93
Protein Length 457
Protein Note part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
DNA Sequence 
>gi|16763390:4268375-4269748 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
TTTAGGTTCGCTTGTACAGCGGTAGCCACAGCGTAAGCCGCAACCCACCCAGCGGGCTATCGTCAGCCTT
CACCCAGCCGCGGTGCTGCTGCATGGCGCTTTCGACAATCGCCAGCCCCAGCCCGGTGCCGCCAGACTCG
CGGTCGCGCGCCTCATCAGTGCGATAGAACGGACGGAAGATCTGCTCGCGGTCTTCAGGGCTGACGCCCG
GCCCGTCGTCATCGACCGTGATCGTAATACCGTCTTTATCCACCGAGAAGCCGACTTCAATCTTCGTATG
TGAATAGCGCAGCGCATTACGAACTATATTTTCCAGCGCGCTTTCCAGCGCGTTTGGGTTGCCATAGAGC
GGCCACGGCCCCGGCGGATAATTTACCGTTAACGACTTGCCCATCTGTTCGGCTTCAAAGGCGGCGTTAT
CCAGCACTTCGCCCCATAGCTGATTGGCTTTCATCGTTTCGCTGACCAGCGCATTTTTCTGTTGGTTACG
CGACATCACCAGCAGGTCATTGATCATGCTGTCCAGACGCTGCGCTTCGGTTTCAATACGCTCCAGCTCT
TTGCTTTCGCCGCCACGACGACGCAGCAGCGCGGTACCCAGTTGCAGGCGCGTAAGGGGCGTTCGTAGCT
CATGGGAGATGTCTGACAGCAAACGCTGCTGCGAGGTCATCATCCGTTCCAGCGCCGTCACCATCTGGTT
AAAACTGGCGCCAGCGGCGAGGAACTCCTGCGGACCCGCCTCCAGCTCCGGATGCTGACGCAGGTTGCCT
TGCGCCACTTCATCAGCCGCGTTTTTCAACTTACGCGCCGGTTTCGCCAGACTCCATGCCAGCCATAGCA
AGAGCGGCGAACTGACCAGCATCGTGACAATGAGCAACAGAAGCGGGCGGTCAAACAGCAGATTAATAAA
ATCGGATTGCGAACTGCTGGCCGGTCGAATCAAGTAAAGCTGGTAATTATCCTCTCCGTCGCGAACGGAG
AACGGCCCCACCATCTCTACGCGGCCATATTTTTTCTTCTGCGGATGATCGGCGTTATCCGCCTGACCAA
TGAAGTTACGAATGATCTGCATTTCGCTGCGTTCAGCGCCGATCACGCGTCCTTCAGAGGTCACCAGTAA
TAACCGCTGTCCAGGCGGCGCCCACTTATCGATCGCGCGGAACAGGCGACGCCACCACATCAGGTCGTTG
GGCGGATCGTTCGCAAGTTCAGCTTCTACATGTTGCTCTATCATCAATCCCTGGCGCTGTTCGCTGTCCA
GCAGCTCGGTCATCTGGCGTGAATCGAGCTTGGGCAACATCAGGACCAGCATTAGCACCAGCGCCAGCGT
CAACCAGAAGATGGCGAAGATGCGCGCGGTTAAACTTCCTATCA
Protein Sequence 
>gi|16767324|ref|NP_462939.1| two-component sensor protein [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRR
LFRAIDKWAPPGQRLLLVTSEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVEMVGPFSVRDGEDN
YQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSSPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPE
LEAGPQEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRGGESKELERIETE
AQRLDSMINDLLVMSRNQQKNALVSETMKANQLWGEVLDNAAFEAEQMGKSLTVNYPPGPWPLYGNPNAL
ESALENIVRNALRYSHTKIEVGFSVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLG
LAIVESAMQQHRGWVKADDSPLGGLRLTLWLPLYKRT
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cpxA mutants are attenuated in mice (Humphreys et al., 2004).
COG COG0642T, under T: Signal transduction mechanisms
References
Humphreys et al., 2004: Humphreys S, Rowley G, Stevenson A, Anjum MF, Woodward MJ, Gilbert S, Kormanec J, Roberts M. Role of the two-component regulator CpxAR in the virulence of Salmonella enterica serotype Typhimurium. Infection and immunity. 2004; 72(8); 4654-4661. [PubMed: 15271926 ].