Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 1177 leuO from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1246630 16759110 STY0134 NP_454727.1 leucine transcriptional activator Virulence factor MUTATION: leuO mutant exhibited wild-type levels of epithelial invasion but highly reduced transepithelial migration of PMN [Ref6516:Tenor et al., 2004]. COG0583K, under K: Transcription 15182677 1178 gmhA from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1246837 16759305 STY0355 NP_454922.1 phosphoheptose isomerase Virulence factor MUTATION: gmhA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG0279G, under G: Carbohydrate transport and metabolism 15182677 1179 cstA from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1247108 16759559 STY0644 NP_455176.1 carbon starvation protein A Virulence factor MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG1966T, under T: Signal transduction mechanisms 15182677 1180 sigE from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1247535 16759970 STY1120 NP_455587.1 cell invasion protein Virulence factor MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 1181 sigD from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1247536 16759971 STY1121 NP_455588.1 cell invasion protein Virulence factor MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 1182 pcgL from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1247855 16760281 STY1465 NP_455898.1 D-alanyl-D-alanine dipeptidase Virulence factor MUTATION: pcgL mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2173M, under M: Cell wall/membrane/envelope biogenesis 17526851 1183 ssaV from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248080 16760497 STY1706 NP_456114.1 secretion system apparatus protein SsaV Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 1184 ssaM from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248081 16760498 STY1707 NP_456115.1 putative pathogenicity island protein Virulence factor MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. 15491354 1185 sseD from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248093 16760510 STY1719 NP_456127.1 putative pathogenicity island effector protein Virulence factor MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. 11159962 1186 sseC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248094 16760511 STY1720 NP_456128.1 putative pathogenicity island effector protein Virulence factor MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. COG5613S, under S: Function unknown 11159962 1187 spiC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248101 16760518 STY1727 NP_456135.1 putative pathogenicity island 2 secreted effector protein Virulence factor MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. 10406797 1188 fliC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248507 16760903 STY2167 NP_456520.1 flagellin Virulence factor MUTATION: fliC mutants were attenuated in orally inoculated chicks [Ref6523:Parker and Guard-Petter, 2001]. COG1344N, under N: Cell motility 11731137 1189 aroC Salmonella enterica subsp. enterica serovar Typhi str. CT18 1248939 16761308 STY2616 NP_456925.1 chorismate synthase Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG0082E, under E: Amino acid transport and metabolism 19745519 1190 prgK from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249300 16761648 STY2992 NP_457265.1 pathogenicity 1 island effector protein Virulence factor MUTATION: prgK mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. COG4669U, under U: Intracellular trafficking, secretion, and vesicular transport 10816487 1191 prgJ from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249301 16761649 STY2993 NP_457266.1 pathogenicity 1 island effector protein Virulence factor MUTATION: prgJ mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 1192 sipC from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249313 16761661 STY3007 NP_457278.1 pathogenicity island 1 effector protein Virulence factor MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells [Ref6525:Chang et al., 2005]. 15720547 1193 spaS from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249316 16761664 STY3010 NP_457281.1 surface presentation of antigens protein SpaS Virulence factor MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain [Ref6526:Darwin and Miller, 2000]. COG1377NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10692170 1194 spaR from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249317 16761665 STY3011 NP_457282.1 secretory protein (associated with virulence) Virulence factor MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4791U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 1195 spaQ from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249318 16761666 STY3012 NP_457283.1 secretory protein (associated with virulence) Virulence factor MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4794U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 1196 spaP from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249319 16761667 STY3013 NP_457284.1 surface presentation of antigens protein SpaP Virulence factor MUTATION: spaP mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4790U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 1197 spaO from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249320 16761668 STY3014 NP_457285.1 surface presentation of antigens protein SpaO Virulence factor MUTATION: spaO mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG1886NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 8751894 1198 spaN from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249321 16761669 STY3015 NP_457286.1 surface presentation of antigens protein (associated with type III secretion and virulence) Virulence factor MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 1199 spaM from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249322 16761670 STY3016 NP_457287.1 secretory protein (associated with virulence) Virulence factor MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 1200 invH from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1249329 16761677 STY3023 NP_457294.1 cell adherance/invasion protein Virulence factor MUTATION: invH mutants are attenuated in calves [Ref6529:Watson et al., 1998]. 9529064 1201 cstA from Salmonella enterica subsp. enterica serovar Typhi str. CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18 1251088 16763338 STY4890 NP_458955.1 probable carbon starvation protein Virulence factor MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG1966T, under T: Signal transduction mechanisms 15182677 1639 sseC from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3333877 62179991 SC1421 YP_216408.1 Secretion system effector SseC Virulence factor MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. COG5613S, under S: Function unknown 11159962 1640 sseD from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3333878 62179992 SC1422 YP_216409.1 Secretion system effector SseD Virulence factor MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. 11159962 1641 ssaM from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3333890 62180004 SC1434 YP_216421.1 Secretion system apparatus SsaM Virulence factor MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. 15491354 1642 ssaV from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3333891 62180005 SC1435 YP_216422.1 secretion system apparatus protein SsaV Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 1643 sopE2 from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3334328 62180422 SC1852 YP_216839.1 TypeIII-secreted protein effector: invasion-associated protein Virulence factor MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. 10735884 1644 sptP from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3335312 62181380 SC2810 YP_217797.1 protein tyrosine phosphate Virulence factor MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica [Ref6516:Tenor et al., 2004]. COG2453T, under T: Signal transduction mechanisms 15182677 1645 spaR from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3335322 62181390 SC2820 YP_217807.1 surface presentation of antigens; secretory proteins Virulence factor MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4791U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 1646 spaQ from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3335323 62181391 SC2821 YP_217808.1 surface presentation of antigens; secretory proteins Virulence factor MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4794U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 1647 tdcA from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67 3335702 62181761 SC3191 YP_218178.1 DNA-binding transcriptional activator Virulence factor MUTATION: tdcA mutant is less invasive of cultured epithelial cells and attenuated in mice [Ref6585:Kim et al., 2009]. COG0583K, under K: Transcription 19812899 2301 cstA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1067015 29144816 t4582 NP_808158.1 probable carbon starvation protein Virulence factor MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG1966T, under T: Signal transduction mechanisms 15182677 2302 leuO from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1067696 29140660 t0119 NP_804002.1 leucine transcriptional activator Virulence factor MUTATION: leuO mutant exhibited wild-type levels of epithelial invasion but highly reduced transepithelial migration of PMN [Ref6516:Tenor et al., 2004]. COG0583K, under K: Transcription 15182677 2303 tdcA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068432 29143502 t3165 NP_806844.1 DNA-binding transcriptional activator Virulence factor MUTATION: tdcA mutant is less invasive of cultured epithelial cells and attenuated in mice [Ref6585:Kim et al., 2009]. COG0583K, under K: Transcription 19812899 2304 invE from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068841 29143158 t2799 NP_806500.1 cell invasion protein Virulence factor MUTATION: invE mutants were unable to penetrate Henle-407 human intestinal cells and Madin-Darby canine kidney cells [Ref6679:Ginocchio et al., 1992]. 1631083 2305 invH from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068847 29143161 t2802 NP_806503.1 cell adherance/invasion protein Virulence factor MUTATION: invH mutants are attenuated in calves [Ref6529:Watson et al., 1998]. 9529064 2306 spaM from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068849 29143154 t2795 NP_806496.1 virulence-associated secretory protein Virulence factor MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 2307 spaR from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068857 29143149 t2790 NP_806491.1 virulence-associated secretory protein Virulence factor MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4791U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 2308 spaQ from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068858 29143150 t2791 NP_806492.1 virulence-associated secretory protein Virulence factor MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4794U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 2309 spaO from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068861 29143152 t2793 NP_806494.1 surface presentation of antigens protein SpaO Virulence factor MUTATION: spaO mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG1886NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 8751894 2310 spaN from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068866 29143153 t2794 NP_806495.1 antigen presentation protein SpaN Virulence factor MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 2311 spaP from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068867 29143151 t2792 NP_806493.1 surface presentation of antigens protein SpaP Virulence factor MUTATION: spaP mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4790U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 2312 spaS from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068878 29143148 t2789 NP_806490.1 surface presentation of antigens protein SpaS Virulence factor MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain [Ref6526:Darwin and Miller, 2000]. COG1377NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10692170 2313 sipC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068886 29143145 t2786 NP_806487.1 pathogenicity island 1 effector protein Virulence factor MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells [Ref6525:Chang et al., 2005]. 15720547 2314 orgA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068896 29143131 t2772 NP_806473.1 oxygen-regulated invasion protein Virulence factor MUTATION: orgA mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2315 prgK from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068898 29143132 t2773 NP_806474.1 pathogenicity 1 island effector protein Virulence factor MUTATION: prgK mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. COG4669U, under U: Intracellular trafficking, secretion, and vesicular transport 10816487 2316 prgJ from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068904 29143133 t2774 NP_806475.1 pathogenicity 1 island effector protein Virulence factor MUTATION: prgJ mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2317 orgA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1068912 29143130 t2771 NP_806472.1 oxygen-regulated invasion protein Virulence factor MUTATION: orgA mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2318 waaP Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1069221 29144077 t3797 NP_807419.1 lipopolysaccharide core biosynthesis protein Virulence factor MUTATION: waaP mutant is avirulent in mice [Ref6680:Yethon et al., 2000]. 10899846 2319 cstA from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1069355 29142668 t2268 NP_806010.1 carbon starvation protein A Virulence factor MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG1966T, under T: Signal transduction mechanisms 15182677 2320 fliC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070204 29141405 t0918 NP_804747.1 flagellin Virulence factor MUTATION: fliC mutants were attenuated in orally inoculated chicks [Ref6523:Parker and Guard-Petter, 2001]. COG1344N, under N: Cell motility 11731137 2321 spiC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070679 29141722 t1261 NP_805064.1 putative pathogenicity island secreted effector protein Virulence factor MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. 10406797 2322 sseC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070690 29141729 t1268 NP_805071.1 putative pathogenicity island effector protein Virulence factor MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. COG5613S, under S: Function unknown 11159962 2323 sseD from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070691 29141730 t1269 NP_805072.1 putative pathogenicity island effector protein Virulence factor MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. 11159962 2324 ssaM from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070703 29141742 t1281 NP_805084.1 putative pathogenicity island protein Virulence factor MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. 15491354 2325 ssaV from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070705 29141743 t1282 NP_805085.1 secretion system apparatus protein SsaV Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 2326 pcgL from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1070960 29141952 t1508 NP_805294.1 D-alanyl-D-alanine dipeptidase Virulence factor MUTATION: pcgL mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2173M, under M: Cell wall/membrane/envelope biogenesis 17526851 2327 sigD from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1071478 29142258 t1828 NP_805600.1 cell invasion protein Virulence factor MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 2328 sigE from Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 1071574 29142259 t1829 NP_805601.1 cell invasion protein Virulence factor MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 2567 sigE from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3175884 56413915 SPA1760 YP_150990.1 cell invasion protein Virulence factor MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 2568 spiC from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3175900 56413636 SPA1460 YP_150711.1 putative pathogenicity island secreted effector protein Virulence factor MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. 10406797 2569 spaN from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3176267 56414844 SPA2750 YP_151919.1 antigen presentation protein SpaN Virulence factor MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 2570 spaM from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3176515 56414845 SPA2751 YP_151920.1 virulence-associated secretory protein Virulence factor MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 2571 sopE2 from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3176679 56413227 SPA1018 YP_150302.1 Type III-secreted protein effector: invasion-associated protein Virulence factor MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. 10735884 2572 sigD from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3177911 56413914 SPA1759 YP_150989.1 cell invasion protein Virulence factor MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 2573 slyA from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3178280 56413587 SPA1409 YP_150662.1 transcriptional regulator SlyA Virulence factor MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. COG1846K, under K: Transcription 8290552 2574 sodC from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3178557 56413591 SPA1413 YP_150666.1 superoxide dismutase Virulence factor MUTATION: sodC mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 19577637 2575 sopE Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3178700 56414668 SPA2564 YP_151743.1 invasion-associated secreted protein. Virulence factor MUTATION: sopE mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. 19577637 2576 ssaV from Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 3178773 56413615 SPA1439 YP_150690.1 secretion system apparatus protein SsaV Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 2577 sopA from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 7692994 228931267 pU302L_002 AY333434 YP_194809 plasmid-partitioning protein SopA Virulence factor MUTATION: sopA mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. 12065528 2578 sopB from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 3259856 58383240 pU302L_003 YP_194810.1 stabilization of plasmid protein B Virulence factor MUTATION: sopB mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. 12065528 2579 ydjA from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 7693157 32470173 R64_p042 AP005147 NP_863397 hypothetical protein Virulence factor MUTATION: ydjA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2580 PSLT072 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256164 17233503 PSLT072 NP_490559.1 putative transglycosylase Virulence factor MUTATION: PSLT072 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0741M, under M: Cell wall/membrane/envelope biogenesis 16518469 2581 spvR Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256197 17233493 PSLT041 NP_490531.1 regulator of spv operon Virulence factor MUTATION: spvR mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG0583K, under K: Transcription 7618105 2582 spvB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256199 17233491 PSLT039 NP_490529.1 hydrophilic protein Virulence factor MUTATION: spvB mutants are attenuated in mice [Ref6708:Lesnick et al., 2001].; TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells [Ref6708:Lesnick et al., 2001]. 11260464 2583 spvA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256200 17233492 PSLT040 NP_490530.1 outer membrane protein Virulence factor MUTATION: spvA mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. 7618105 2584 spvC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256201 17233490 PSLT038 NP_490528.1 hydrophilic protein Virulence factor MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [Ref6709:Matsui et al., 2001]. 11443102 2585 spvD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256202 17233489 PSLT037 NP_490527.1 hydrophilic protein Virulence factor MUTATION: spvD mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. 7618105 2586 pefC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256222 17233482 PSLT017 NP_490509.1 usher protein Virulence factor MUTATION: pefC mutants are attenuated in mice [Ref6710:Bäumler et al., 1996]. COG3188NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 8557375 2587 rcK from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256230 17233474 PSLT009 NP_490501.1 resistance to complement killing Virulence factor MUTATION: rck mutants reduces serum resistance and eukaryotic cell invasion [Ref6711:Cirillo et al., 1996]. COG3637M, under M: Cell wall/membrane/envelope biogenesis 8675302 2588 STM0016 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251534 16763406 STM0016 NP_459021.1 hypothetical protein Virulence factor MUTATION: STM0016 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3926R, under R: General function prediction only 16518469 2589 STM0030 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251548 16763420 STM0030 NP_459035.1 putative transcriptional regulator Virulence factor MUTATION: STM0030 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0583K, under K: Transcription 16518469 2590 STM0036 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251554 16763426 STM0036 NP_459041.1 putative arylsulfatase regulator Virulence factor MUTATION: STM0036 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0641R, under R: General function prediction only 17526851 2591 leuO from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251633 16763505 STM0115 NP_459120.1 leucine transcriptional activator Virulence factor MUTATION: leuO mutant exhibited wild-type levels of epithelial invasion but highly reduced transepithelial migration of PMN [Ref6516:Tenor et al., 2004]. COG0583K, under K: Transcription 15182677 2592 dgt Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251726 16763598 STM0208 NP_459213.1 deoxyguanosinetriphosphate triphosphohydrolase Virulence factor MUTATION: dgt mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0232F, under F: Nucleotide transport and metabolism 16518469 2593 yafS Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251780 16763645 STM0262 NP_459260.1 putative SAM-dependent methyltransferase Virulence factor MUTATION: yagS mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2226H, under H: Coenzyme transport and metabolism 16518469 2594 STM0298 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251817 0 STM0298 - - Virulence factor MUTATION: STM0298 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2595 safA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251818 16763682 STM0299 NP_459297.1 putative outer membrane protein Virulence factor MUTATION: safA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2596 gmhA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251829 16763693 STM0310 NP_459308.1 phosphoheptose isomerase Virulence factor MUTATION: gmhA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG0279G, under G: Carbohydrate transport and metabolism 15182677 2597 dinP Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251832 16763696 STM0313 NP_459311.1 DNA polymerase IV Virulence factor MUTATION: dinP mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0389L, under L: Replication, recombination and repair 16518469 2598 STM0328.s Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251847 39546292 STM0328.s NP_459323.2 putative permease Virulence factor MUTATION: STM0328 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2814G, under G: Carbohydrate transport and metabolism 17526851 2599 stbD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251856 16763717 STM0337 NP_459332.1 putative fimbrial usher Virulence factor MUTATION: stbD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2600 stbC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251857 16763718 STM0338 NP_459333.1 putative fimbrial usher Virulence factor MUTATION: stbC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3188NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 17526851 2601 yaiU Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251892 16763753 STM0373 NP_459368.1 flagellar protein Virulence factor MUTATION: yaiU mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 17526851 2602 sbcD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251915 16763776 STM0396 NP_459391.1 exonuclease subunit SbcD Virulence factor MUTATION: sbcD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0420L, under L: Replication, recombination and repair 17526851 2603 STM0438 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251958 16763819 STM0438 NP_459434.1 tetratricopeptide repeat protein Virulence factor MUTATION: STM0438 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0790R, under R: General function prediction only 17526851 2604 cyoB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251962 16763823 STM0442 NP_459438.1 cytochrome o ubiquinol oxidase subunit I Virulence factor MUTATION: cyoB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0843C, under C: Energy production and conversion 16518469 2605 clpP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251968 16763829 STM0448 NP_459444.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 7618105 2606 ybaJ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251994 16763854 STM0474 NP_459469.1 hypothetical protein Virulence factor MUTATION: ybaJ mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2607 gip Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252038 16763898 STM0518 NP_459513.1 hydroxypyruvate isomerase Virulence factor MUTATION: gip mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3622G, under G: Carbohydrate transport and metabolism 16518469 2608 STM0520 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252040 16763900 STM0520 NP_459515.1 putative permease Virulence factor MUTATION: STM0520 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2271G, under G: Carbohydrate transport and metabolism 16518469 2609 allD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252048 16763908 STM0528 NP_459523.1 ureidoglycolate dehydrogenase Virulence factor MUTATION: allD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2055C, under C: Energy production and conversion 16518469 2610 fimA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252063 39546299 STM0543 NP_459538.2 fimbrin Virulence factor MUTATION: fimA mutants are attenuated in mice and swine [Ref6712:Althouse et al., 2003]. COG3539NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 14573666 2611 fimH Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252067 16763927 STM0547 NP_459542.1 minor fimbrial subunit Virulence factor MUTATION: fimH mutants were impaired in binding and internalization of HeLa cells [Ref6713:Guo et al., 2007]. COG3539NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 17379714 2612 fimW Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252072 16763932 STM0552 NP_459547.1 putative fimbrial protein Virulence factor MUTATION: fimW mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2613 STM0557 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252077 16763935 STM0557 NP_459550.1 putative inner membrane protein Virulence factor MUTATION: STM0557 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2614 rfbI Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252079 16763937 STM0559 NP_459552.1 putative glycosyl translocase Virulence factor MUTATION: rfbl mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2246S, under S: Function unknown 17526851 2615 nfnB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252098 16763955 STM0578 NP_459570.1 dihydropteridine reductase Virulence factor MUTATION: nfnB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0778C, under C: Energy production and conversion 16518469 2616 fepA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252105 16763962 STM0585 NP_459577.1 outer membrane ferric enterobactin receptor precursor Virulence factor MUTATION: fepA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG4771P, under P: Inorganic ion transport and metabolism 17526851 2617 cstA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252120 16763977 STM0600 NP_459592.1 carbon starvation protein Virulence factor MUTATION: cstA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. COG1966T, under T: Signal transduction mechanisms 15182677 2618 citC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252144 16764001 STM0624 NP_459616.1 citrate lyase synthetase Virulence factor MUTATION: citC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3053C, under C: Energy production and conversion 17526851 2619 dpiA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252146 16764003 STM0626 NP_459618.1 DNA-binding response regulator in two-component regulatory system with citA Virulence factor MUTATION: dpiA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG4565KT, under K: Transcription; T: Signal transduction mechanisms 17526851 2620 cspE Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252149 16764006 STM0629 NP_459621.1 cold shock protein E Virulence factor MUTATION: cspE mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1278K, under K: Transcription 16518469 2621 hscC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252179 16764036 STM0659 NP_459651.1 putative heatshock protein Virulence factor MUTATION: hscC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0443O, under O: Posttranslational modification, protein turnover, chaperones 17526851 2622 STM0723 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252243 16764093 STM0723 NP_459708.1 putative ABC-type polysaccharide/polyol phosphate transport system ATPase component Virulence factor MUTATION: STM0723 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1134GM, under G: Carbohydrate transport and metabolism; M: Cell wall/membrane/envelope biogenesis 16518469 2623 STM0765 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252285 16764130 STM0765 NP_459745.1 putative cation transporter Virulence factor MUTATION: STM0765 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0471P, under P: Inorganic ion transport and metabolism 17526851 2624 slrP Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252320 16764163 STM0800 NP_459778.1 leucine-rich repeat protein Virulence factor MUTATION: slrP mutant is attenuated in mice [Ref6714:Tsolis et al., 1999]. COG4886S, under S: Function unknown 10569754 2625 ybhM Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252328 16764171 STM0808 NP_459786.1 putative integral membrane protein Virulence factor MUTATION: ybhM mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0670R, under R: General function prediction only 17526851 2626 mdfA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252385 16764228 STM0866 NP_459843.1 multidrug translocase Virulence factor MUTATION: mdfA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2814G, under G: Carbohydrate transport and metabolism 17526851 2627 pflA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252488 161353606 STM0970 NP_459945.2 pyruvate formate lyase-activating enzyme 1 Virulence factor MUTATION: pflA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1180O, under O: Posttranslational modification, protein turnover, chaperones 17526851 2628 STM0972 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252490 16764332 STM0972 NP_459947.1 SopD-like protein Virulence factor MUTATION: STM0972 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2629 focA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252492 16764334 STM0974 NP_459949.1 formate transporter Virulence factor MUTATION: focA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2116P, under P: Inorganic ion transport and metabolism 16518469 2630 STM1002 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252520 16764362 STM1002 NP_459977.1 diaminopropionate ammonia-lyase Virulence factor MUTATION: STM1002 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1171E, under E: Amino acid transport and metabolism 16518469 2631 sseI Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252569 16764411 STM1051 NP_460026.1 secreted effector protein Virulence factor MUTATION: sseI mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2632 pyrD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252576 16764417 STM1058 NP_460032.1 dihydroorotate dehydrogenase 2 Virulence factor MUTATION: pyrD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0167F, under F: Nucleotide transport and metabolism 17526851 2633 ycbG Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252587 16764428 STM1069 NP_460043.1 hypothetical protein Virulence factor MUTATION: ycbG mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3120S, under S: Function unknown 16518469 2634 pipA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252605 16764445 STM1087 NP_460060.1 pathogenicity island-encoded protein A Virulence factor MUTATION: pipA mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type [Ref6516:Tenor et al., 2004]. 15182677 2635 pipC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252608 16764448 STM1090 NP_460063.1 pathogenicity island-encoded protein C Virulence factor MUTATION: pipC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2636 sopB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252609 16764449 STM1091 NP_460064.1 secreted effector protein Virulence factor MUTATION: sopB mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. 12065528 2637 pipD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252612 16764452 STM1094 NP_460067.1 pathogenicity island-encoded protein D Virulence factor MUTATION: pipD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG4690E, under E: Amino acid transport and metabolism 16518469 2638 copS Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252613 16764453 STM1095 NP_460068.1 copper resistance protein Virulence factor MUTATION: copS mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0642T, under T: Signal transduction mechanisms 16518469 2639 csgF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252658 16764496 STM1140 NP_460111.1 curli assembly protein CsgF Virulence factor MUTATION: csgF mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2640 csgD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252660 16764498 STM1142 NP_460113.1 DNA-binding transcriptional activator in two-component regulatory system Virulence factor MUTATION: csgD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2197TK, under T: Signal transduction mechanisms; K: Transcription 16518469 2641 csgC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252663 16764501 STM1145 NP_460116.1 putative curli production protein precursor Virulence factor MUTATION: csgC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2642 solA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252678 16764516 STM1160 NP_460131.1 N-methyltryptophan oxidase Virulence factor MUTATION: solA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0665E, under E: Amino acid transport and metabolism 16518469 2643 sifA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252742 16764579 STM1224 NP_460194.1 secreted effector protein Virulence factor MUTATION: sifA mutants are attenuated in mice and don't induce Salmonella-produced filaments in epithelial cells [Ref6715:Stein et al., 1996]. 8861213 2644 pagC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252764 16764600 STM1246 NP_460215.1 virulence membrane protein PAGC precursor Virulence factor MUTATION: pagC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3637M, under M: Cell wall/membrane/envelope biogenesis 16518469 2645 yeaJ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252801 16764634 STM1283 NP_460249.1 putative methyl-accepting chemotaxis protein Virulence factor MUTATION: yeaJ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2199T, under T: Signal transduction mechanisms 16518469 2646 ydjA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252814 16764647 STM1296 NP_460262.1 putative oxidoreductase Virulence factor MUTATION: ydjA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0778C, under C: Energy production and conversion 17526851 2647 celA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252830 16764663 STM1312 NP_460278.1 N,N'-diacetylchitobiose-specific PTS system transporter subunit IIB Virulence factor MUTAITON: celA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1440G, under G: Carbohydrate transport and metabolism 16518469 2648 celF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252834 16764667 STM1316 NP_460282.1 phospho-beta-glucosidase/cellobiose-6-phosphate hydrolase Virulence factor MUTATION: celF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1486G, under G: Carbohydrate transport and metabolism 17526851 2649 nlpC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252861 16764694 STM1343 NP_460309.1 lipoprotein Virulence factor MUTATION: nlpC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0791M, under M: Cell wall/membrane/envelope biogenesis 16518469 2650 ydiK Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252882 16764714 STM1364 NP_460329.1 predicted inner membrane protein Virulence factor MUTATION: ydiK mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0628R, under R: General function prediction only 16518469 2651 ssrB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252909 16764741 STM1391 NP_460356.1 transcriptional activator Virulence factor MUTATION: ssrB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2197TK, under T: Signal transduction mechanisms; K: Transcription 17526851 2652 ssrA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252910 16764742 STM1392 NP_460357.1 sensor kinase Virulence factor MUTATION: ssrA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0642T, under T: Signal transduction mechanisms 17526851 2653 ssaB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252911 16764743 STM1393 NP_460358.1 secreted effector protein Virulence factor MUTATION: ssaB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2654 ssaC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252912 16764744 STM1394 NP_460359.1 outer membrane secretin precursor Virulence factor MUTATION: ssaC mutant is attenuated in murine macrophages [Ref6716:Chan et al., 2005]. COG1450NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 16113260 2655 ssaD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252913 16764745 STM1395 NP_460360.1 virulence protein Virulence factor MUTATION: ssaD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2656 ssaE Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252914 16764746 STM1396 NP_460361.1 secretion system effector Virulence factor MUTATION: ssaE mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2657 sseA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252915 16764747 STM1397 NP_460362.1 secretion system chaperone protein Virulence factor MUTATION: sseA mutant is attenuated in pigs (Carnell et al., 2007). 2658 sseB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252916 16764748 STM1398 NP_460363.1 translocation machinery component Virulence factor MUTATION: sseB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2659 sseC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252918 16764750 STM1400 NP_460365.1 translocation machinery component Virulence factor MUTATION: sseC mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. COG5613S, under S: Function unknown 11159962 2660 sseD from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252919 16764751 STM1401 NP_460366.1 translocation machinery component Virulence factor MUTATION: sseD mutant is attenuated in mice [Ref6521:Klein and Jones, 2001]. 11159962 2661 sseE Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252920 16764752 STM1402 NP_460367.1 secreted effector protein Virulence factor MUTATION: sseE mutant is defective for replication in murine macrophages [Ref6716:Chan et al., 2005]. 16113260 2662 sseF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252922 16764754 STM1404 NP_460369.1 secreted effector protein Virulence factor MUTATION: sseF mutant is defective for replication in murine macrophages [Ref6716:Chan et al., 2005]. 16113260 2663 sseG Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252923 16764755 STM1405 NP_460370.1 secreted effector protein Virulence factor MUTATION: sseG mutant has a defect in replication in murine macrophages [Ref6716:Chan et al., 2005]. 16113260 2664 ssaG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252924 16764756 STM1406 NP_460371.1 type III secretion system apparatus protein Virulence factor MUTATION: ssaG mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2665 ssaJ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252927 16764759 STM1409 NP_460374.1 needle complex inner membrane lipoprotein Virulence factor MUTATION: ssaJ mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG4669U, under U: Intracellular trafficking, secretion, and vesicular transport 17526851 2666 ssaK Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252929 16764761 STM1411 NP_460376.1 type III secretion system apparatus protein Virulence factor MUTATION: ssaK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2667 ssaL Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252930 16764762 STM1412 NP_460377.1 type III secretion system apparatus protein Virulence factor MUTATION: ssaL mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2668 ssaM from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252931 16764763 STM1413 NP_460378.1 type III secretion system apparatus protein Virulence factor MUTATION: ssaM mutant is attenuated in mice [Ref6520:Yu et al., 2004]. 15491354 2669 ssaN Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252933 16764765 STM1415 NP_460380.1 type III secretion system ATPase Virulence factor MUTATION: ssaN mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1157NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 16518469 2670 ssaQ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252936 16764768 STM1418 NP_460383.1 type III secretion system protein Virulence factor MUTATION: ssaQ mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1886NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 17526851 2671 ssaR Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252937 16764769 STM1419 NP_460384.1 type III secretion system protein Virulence factor MUTATION: ssaR mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG4790U, under U: Intracellular trafficking, secretion, and vesicular transport 17526851 2672 ssaS Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252938 16764770 STM1420 NP_460385.1 type III secretion system apparatus protein Virulence factor MUTATION: ssaS mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG4794U, under U: Intracellular trafficking, secretion, and vesicular transport 17526851 2673 ssaU Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252940 16764772 STM1422 NP_460387.1 secretion system apparatus protein SsaU Virulence factor MUTATION: ssaU mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG4792U, under U: Intracellular trafficking, secretion, and vesicular transport 16518469 2674 slyA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252962 161353603 STM1444 NP_460407.2 transcriptional regulator SlyA Virulence factor MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. COG1846K, under K: Transcription 8290552 2675 ydgF from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253000 16764827 STM1482 NP_460442.1 multidrug efflux system protein MdtJ Virulence factor MUTATION: ydgF mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2076P, under P: Inorganic ion transport and metabolism 16518469 2676 STM1527 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253045 16764872 STM1527 NP_460487.1 putative inner membrane protein Virulence factor MUTATION: STM1527 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3781S, under S: Function unknown 17526851 2677 STM1549 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253067 16764894 STM1549 NP_460509.1 putative translation initiation inhibitor Virulence factor MUTATION: STM1549 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0251J, under J: Translation, ribosomal structure and biogenesis 16518469 2678 yddX from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253082 16764908 STM1564 NP_460523.1 biofilm-dependent modulation protein Virulence factor MUTATION: yddX mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2679 STM1583 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253101 16764927 STM1583 NP_460542.1 putative cytoplasmic protein Virulence factor MUTATION: STM1583 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2680 yncB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253107 16764933 STM1589 NP_460548.1 putative NADP-dependent oxidoreductase Virulence factor MUTAITON: yncB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2130R, under R: General function prediction only 16518469 2681 sseJ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253149 16764975 STM1631 NP_460590.1 secreted effector protein Virulence factor MUTATION: sseJ mutants are defective in intracellular replication in cultured epithelial cells and are attenuated in mice [Ref6717:Ohlson et al., 2005]. COG3240IR, under I: Lipid transport and metabolism; R: General function prediction only 16177296 2682 ynaF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253170 16764996 STM1652 NP_460611.1 putative universal stress protein Virulence factor MUTATION: ynaF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0589T, under T: Signal transduction mechanisms 17526851 2683 STM1668 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253186 16765011 STM1668 NP_460626.1 hypothetical protein Virulence factor MUTATION: STM1668 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2684 STM1669 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253187 16765012 STM1669 NP_460627.1 invasin-like protein Virulence factor MUTATION: STM1669 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2685 yciH from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253225 16765050 STM1706 NP_460665.1 translation initiation factor Sui1 Virulence factor MUTATION: yciH mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0023J, under J: Translation, ribosomal structure and biogenesis 16518469 2686 yciF from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253248 16765073 STM1729 NP_460688.1 putative cytoplasmic protein Virulence factor MUTATION: yciF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3685S, under S: Function unknown 17526851 2687 hns Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253270 16765095 STM1751 NP_460710.1 global DNA-binding transcriptional dual regulator H-NS Virulence factor MUTATION: hns mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2916R, under R: General function prediction only 17526851 2688 fadD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253337 16765159 STM1818 NP_460774.1 long-chain-fatty-acid--CoA ligase Virulence factor MUTATION: fadD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism 16518469 2689 cspC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253356 16765178 STM1837 NP_460793.1 cold shock-like protein cspC Virulence factor MUTATION: cspC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1278K, under K: Transcription 16518469 2690 sopE2 from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253374 16765196 STM1855 NP_460811.1 type III-secreted effector protein Virulence factor MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. 10735884 2691 pagO Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253381 16765203 STM1862 NP_460818.1 integral membrane protein Virulence factor MUTATION: pagO mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0697GER, under G: Carbohydrate transport and metabolism; E: Amino acid transport and metabolism; R: General function prediction only 17526851 2692 STM1864 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253383 16765205 STM1864 NP_460820.1 putative inner membrane protein Virulence factor MUTATION: STM1864 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1495O, under O: Posttranslational modification, protein turnover, chaperones 17526851 2693 pagK Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253386 16765207 STM1867 NP_460822.1 PagK Virulence factor MUTATION: pagK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2694 znuA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253412 161353595 STM1891 NP_460848.2 high-affinity zinc transporter periplasmic component Virulence factor MUTATION: znuABC mutant is attenuated in mice [Ref6718:Pesciaroli et al., 2011]. COG4531P, under P: Inorganic ion transport and metabolism 21219981 2695 znuC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253413 39546331 STM1892.S NP_460849.2 high-affinity zinc transporter ATPase Virulence factor MUTATION: znuABC mutant is attenuated in mice [Ref6718:Pesciaroli et al., 2011]. COG1121P, under P: Inorganic ion transport and metabolism 21219981 2696 znuB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253414 16765235 STM1893 NP_460850.1 high-affinity zinc transporter membrane component Virulence factor MUTATION: znuABC mutant is attenuated in mice [Ref6718:Pesciaroli et al., 2011]. COG1108P, under P: Inorganic ion transport and metabolism 21219981 2697 STM1896 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253417 16765238 STM1896 NP_460853.1 putative cytoplasmic protein Virulence factor MUTAITON: STM1896 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2698 STM1934 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253455 16765275 STM1934 NP_460890.1 putative outer membrane lipoprotein Virulence factor MUTATION: STM1934 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2699 uvrY Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253468 16765285 STM1947 NP_460900.1 response regulator Virulence factor MUTATION: sirA mutant is defective for intracellular replication, invasion of epithelial cells and defective in murine macrophages [Ref6716:Chan et al., 2005]. COG2197TK, under T: Signal transduction mechanisms; K: Transcription 16113260 2700 fliC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253480 16765297 STM1959 NP_460912.1 flagellin Virulence factor MUTATION: fliC mutants were attenuated in orally inoculated chicks [Ref6523:Parker and Guard-Petter, 2001]. COG1344N, under N: Cell motility 11731137 2701 fliQ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253501 16765318 STM1980 NP_460933.1 flagellar biosynthesis protein FliQ Virulence factor MUTATION: fliQ mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG1987NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 7618105 2702 yeeI Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253522 16765336 STM2001 NP_460951.1 putative inner membrane protein Virulence factor MUTATION: yeeI mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3228S, under S: Function unknown 17526851 2703 sopA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253587 16765396 STM2066 NP_461011.1 secreted effector protein Virulence factor MUTATION: sopA mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. COG1357S, under S: Function unknown 12065528 2704 udg Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253601 16765410 STM2080 NP_461025.1 UDP-glucose/GDP-mannose dehydrogenase Virulence factor MUTATION: udg mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1004M, under M: Cell wall/membrane/envelope biogenesis 16518469 2705 rfbP Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253603 16765412 STM2082 NP_461027.1 undecaprenol-phosphate galactosephosphotransferase/O-antigen transferase Virulence factor MUTATION: rfbP mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2148M, under M: Cell wall/membrane/envelope biogenesis 16518469 2706 rfbK Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253604 16765413 STM2083 NP_461028.1 phosphomannomutase Virulence factor MUTATION: rfbK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1109G, under G: Carbohydrate transport and metabolism 17526851 2707 rfbM Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253605 16765414 STM2084 NP_461029.1 mannose-1-phosphate guanylyltransferase Virulence factor MUTATION: rfbM mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG0836M, under M: Cell wall/membrane/envelope biogenesis 7618105 2708 rfbN Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253606 16765415 STM2085 NP_461030.1 rhamnosyl transferase Virulence factor MUTATION: rfbN mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1216R, under R: General function prediction only 17526851 2709 rfbH Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253611 16765420 STM2090 NP_461035.1 CDP-6-deoxy-D-xylo-4-hexulose-3-dehydrase Virulence factor MUTATION: rfbH mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0399M, under M: Cell wall/membrane/envelope biogenesis 17526851 2710 rfbI from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253614 16765423 STM2093 NP_461038.1 CDP-6-deoxy-delta-3,4-glucoseen reductase Virulence factor MUTATION: rfbI mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0543HC, under H: Coenzyme transport and metabolism; C: Energy production and conversion 17526851 2711 rfbC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253615 16765424 STM2094 NP_461039.1 dTDP-4,deoxyrhamnose 3,5 epimerase Virulence factor MUTATION: rfbC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1898M, under M: Cell wall/membrane/envelope biogenesis 16518469 2712 rfbA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253616 16765425 STM2095 NP_461040.1 dTDP-glucose pyrophosphorylase Virulence factor MUTATION: rfbA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1209M, under M: Cell wall/membrane/envelope biogenesis 16518469 2713 rfbD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253617 16765426 STM2096 NP_461041.1 dTDP-4-dehydrorhamnose reductase Virulence factor MUTATION: rfbD mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG1091M, under M: Cell wall/membrane/envelope biogenesis 7618105 2714 rfbB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253618 16765427 STM2097 NP_461042.1 dTDP-glucose 4,6 dehydratase Virulence factor MUTATION: rfbB mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG1088M, under M: Cell wall/membrane/envelope biogenesis 7618105 2715 galF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253619 16765428 STM2098 NP_461043.1 UTP--glucose-1-phosphate uridylyltransferase subunit GalF Virulence factor MUTATION: galF mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1210M, under M: Cell wall/membrane/envelope biogenesis 16518469 2716 wcaM Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253620 16765429 STM2099 NP_461044.1 putative colanic acid biosynthetic protein Virulence factor MUTATION: wcaM mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2717 wcaE Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253632 16765441 STM2111 NP_461056.1 predicted glycosyl transferase Virulence factor MUTATION: wcaE mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0463M, under M: Cell wall/membrane/envelope biogenesis 17526851 2718 yegQ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253657 16765465 STM2136 NP_461080.1 putative protease Virulence factor MUTATION: yegQ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0826O, under O: Posttranslational modification, protein turnover, chaperones 16518469 2719 STM2137 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253658 16765466 STM2137 NP_461081.1 putative cytoplasmic protein Virulence factor MUTATION: STM2137 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2720 stcD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253670 16765478 STM2149 NP_461093.1 putative outer membrane lipoprotein Virulence factor MUTATION: stcD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2721 stcC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253671 16765479 STM2150 NP_461094.1 putative outer membrane protein Virulence factor MUTATION: stcC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3188NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 16518469 2722 bglX Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253688 16765496 STM2166 NP_461111.1 periplasmic beta-D-glucoside glucohydrolase Virulence factor MUTATION: bglX mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1472G, under G: Carbohydrate transport and metabolism 16518469 2723 yeiA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253709 16765517 STM2187 NP_461132.1 dihydropyrimidine dehydrogenase Virulence factor MUTATION: yeiA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0167F, under F: Nucleotide transport and metabolism 16518469 2724 STM2197 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253719 16765527 STM2197 NP_461142.1 putative phosphoserine phosphatase Virulence factor MUTATION: STM2197 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0560E, under E: Amino acid transport and metabolism 16518469 2725 STM2243 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253765 16765571 STM2243 NP_461186.1 putative tail fiber protein of phage Virulence factor MUTATION: STM2243 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG5301R, under R: General function prediction only 17526851 2726 STM2245 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253767 16765573 STM2245 NP_461188.1 putative outer membrane protein Virulence factor MUTATION: STM2245 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2727 STM2373 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253895 16765700 STM2373 NP_461315.1 putative cytoplasmic protein Virulence factor MUTATION: STM2373 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2728 ppk Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254023 16765821 STM2501 NP_461436.1 polyphosphate kinase Virulence factor MUTATION: ppk mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0855P, under P: Inorganic ion transport and metabolism 17526851 2729 STM2503 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254025 16765823 STM2503 NP_461438.1 putative diguanylate cyclase Virulence factor MUTATION: STM2503 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2200T, under T: Signal transduction mechanisms 17526851 2730 shdA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254035 16765833 STM2513 NP_461448.1 AIDA autotransporter-like protein Virulence factor MUTATION: shdA mutants exhibit a shedding defect in mice [Ref6719:Kingsley et al., 2003]. COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 12540539 2731 ratB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254036 16765834 STM2514 NP_461449.1 putative outer membrane protein Virulence factor MUTATION: ratB mutant are unable to colonize the cecum in mice, but are still able to colonize the eyer's patches, mesenteric lymph nodes, and spleen of mice [Ref6719:Kingsley et al., 2003]. 12540539 2732 cadB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254080 16765878 STM2558 NP_461493.1 predicted lysine/cadaverine transporter Virulence factor MUTATION: cadB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0531E, under E: Amino acid transport and metabolism 17526851 2733 STM2574 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254096 16765894 STM2574 NP_461509.1 putative permease Virulence factor MUTATION: STM2574 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2223P, under P: Inorganic ion transport and metabolism 17526851 2734 yfhL Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254098 16765896 STM2576 NP_461511.1 putative ferredoxin Virulence factor MUTATION: yfhL mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1143C, under C: Energy production and conversion 16518469 2735 STM2585 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254107 16765905 STM2585 NP_461520.1 transposase-like protein Virulence factor MUTATION: STM2585 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2736 clpB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254183 16765976 STM2660 NP_461591.1 protein disaggregation chaperone Virulence factor MUTATION: clpB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0542O, under O: Posttranslational modification, protein turnover, chaperones 17526851 2737 STM2680 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254203 16765995 STM2680 NP_461610.1 putative cytoplasmic protein Virulence factor MUTATION: STM2680 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2738 STM2689 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254212 0 STM2689 - pseudo Virulence factor MUTATION: STM2689 (bapA) mutant strain showed a significantly lower colonization rate at the intestinal cell barrier and consequently a decreased efficiency for organ invasion compared with the wild-type strain in mice [Ref6720:Latasa et al., 2005]. 16313619 2739 fljA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254293 16766082 STM2770 NP_461697.1 phase-1 flagellin repressor Virulence factor MUTATION: fljA mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2740 mig-14 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254305 16766093 STM2782 NP_461708.1 putative transcriptional activator Virulence factor MUTATION: mig-14 mutants are cleared by mice compared to the wild type which is fatal to mice in the doses given [Ref6721:Valdivia et al., 2000]. 11083839 2741 yqaE Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254319 16766107 STM2796 NP_461722.1 putative transport protein Virulence factor MUTATION: ygaE mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0401S, under S: Function unknown 16518469 2742 hilC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254390 16766173 STM2867 NP_461788.1 invasion regulatory protein Virulence factor MUTATION: hilC mutants have decreased invasion of HEp-2 cells compared to the wild type [Ref6722:Schechter et al., 1999]. COG2207K, under K: Transcription 10320584 2743 orgB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254392 16766175 STM2869 NP_461790.1 needle complex export protein Virulence factor MUTATION: orgB mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2744 orgA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254393 16766176 STM2870 NP_461791.1 needle complex assembly protein Virulence factor MUTATION: orgA mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2745 prgK from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254394 16766177 STM2871 NP_461792.1 needle complex inner membrane lipoprotein Virulence factor MUTATION: prgK mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. COG4669U, under U: Intracellular trafficking, secretion, and vesicular transport 10816487 2746 prgJ from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254395 16766178 STM2872 NP_461793.1 needle complex minor subunit Virulence factor MUTATION: prgJ mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2747 prgI Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254396 16766179 STM2873 NP_461794.1 needle complex major subunit Virulence factor MUTATION: prgI mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2748 prgH Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254397 16766180 STM2874 NP_461795.1 needle complex inner membrane protein Virulence factor MUTATION: prgH mutants are attenuated in their ability to invade HEp-2 cells [Ref6524:Klein et al., 2000]. 10816487 2749 hilD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254398 16766181 STM2875 NP_461796.1 invasion protein regulatory protein Virulence factor MUTATION: hilD mutants have decreased invasion of HEp-2 cells compared to the wild type [Ref6722:Schechter et al., 1999]. COG2207K, under K: Transcription 10320584 2750 hilA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254399 16766182 STM2876 NP_461797.1 invasion protein regulator Virulence factor MUTATION: hilA mutants have reduced ability to invade HEp-2 cells and to colonize murine Peyer’s patches [Ref6723:Tsolis et al., 1999]. COG3710K, under K: Transcription 10456944 2751 sptP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254401 16766184 STM2878 NP_461799.1 protein tyrosine phosphatase/GTPase activating protein Virulence factor MUTATION: sptP mutants have reduced epithelial cell invasion and reduced transepithelial migration of PMN compared to the wild type. Competition experiments indicate that sptP mutants fail to colonize the spleen of mice when coinoculated with wild-type S. enterica [Ref6516:Tenor et al., 2004]. COG2453T, under T: Signal transduction mechanisms 15182677 2752 iacP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254404 16766187 STM2881 NP_461802.1 acyl carrier protein Virulence factor MUTAITON: iacP mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0236IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism 16518469 2753 sipA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254405 16766188 STM2882 NP_461803.1 secreted effector protein Virulence factor MUTATION: sipA mutants have a decreased invasion of MDCK cells as compared to the wild type [Ref6724:Perrett and Jepson, 2009]. 19046340 2754 sipC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254407 16766190 STM2884 NP_461805.1 translocation machinery component Virulence factor MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells [Ref6525:Chang et al., 2005]. 15720547 2755 sicA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254409 16766192 STM2886 NP_461807.1 secretion chaperone Virulence factor MUTATION: sicA mutants are unable to invade cultured epithelial cells [Ref6725:Kaniga et al., 1995]. 7608068 2756 spaS from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254410 16766193 STM2887 NP_461808.1 surface presentation of antigens protein SpaS Virulence factor MUTATION: spaS mutant was 30-fold reduced for invasion into HEp-2 cells when compared with the wild-type strain [Ref6526:Darwin and Miller, 2000]. COG1377NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10692170 2757 spaR from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254411 16766194 STM2888 NP_461809.1 needle complex export protein Virulence factor MUTATION: spaR mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4791U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 2758 spaQ from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254412 16766195 STM2889 NP_461810.1 needle complex export protein Virulence factor MUTATION: spaQ mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4794U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 2759 spaP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254413 16766196 STM2890 NP_461811.1 surface presentation of antigens protein SpaP Virulence factor MUTATION: spaP mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG4790U, under U: Intracellular trafficking, secretion, and vesicular transport 8751894 2760 spaO from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254414 16766197 STM2891 NP_461812.1 surface presentation of antigens protein SpaO Virulence factor MUTATION: spaO mutant is severely impaired in entry to Henle-407 cells [Ref6527:Collazo and Galán, 1996]. COG1886NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 8751894 2761 invJ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254415 16766198 STM2892 NP_461813.1 needle length control protein Virulence factor MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 2762 invI Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254416 16766199 STM2893 NP_461814.1 needle complex assembly protein Virulence factor MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 2763 invC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254417 16766200 STM2894 NP_461815.1 ATP synthase SpaL Virulence factor MUTATION: invC mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. COG1157NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 9087319 2764 invB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254418 16766201 STM2895 NP_461816.1 secretion chaperone Virulence factor MUTATION: In the absence of InvB, the ΔsopB ΔsopE2 strain was severely defective in its ability to invade cultured intestinal cells, indicating that InvB is required for the translocation of SopE into host cells [Ref6727:Lee and Galán, 2003]. 14645290 2765 invA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254419 16766202 STM2896 NP_461817.1 needle complex export protein Virulence factor MUTATION: invA mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 9087319 2766 invE from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254420 16766203 STM2897 NP_461818.1 invasion protein Virulence factor MUTATION: invE mutants were unable to penetrate Henle-407 human intestinal cells and Madin-Darby canine kidney cells [Ref6679:Ginocchio et al., 1992]. 1631083 2767 invG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254421 16766204 STM2898 NP_461819.1 outer membrane secretin precursor Virulence factor MUTATION: invG mutants have reduced ability to enter into cultured epithelial cells [Ref6728:Kaniga et al., 1994]. COG1450NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 7997169 2768 invF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254422 16766205 STM2899 NP_461820.1 invasion regulatory protein Virulence factor MUTATION: invF mutants have reduced ability to enter into cultured epithelial cells [Ref6728:Kaniga et al., 1994]. COG2207K, under K: Transcription 7997169 2769 invH from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254423 16766206 STM2900 NP_461821.1 needle complex outer membrane lipoprotein precursor Virulence factor MUTATION: invH mutants are attenuated in calves [Ref6529:Watson et al., 1998]. 9529064 2770 sopD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254468 16766251 STM2945 NP_461866.1 secreted effector protein Virulence factor MUTATION: sopD mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type [Ref6705:Zhang et al., 2002]. 12065528 2771 barA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254481 16766264 STM2958 NP_461879.1 hybrid sensory histidine kinase BarA Virulence factor MUTATION: barA mutant is inefficient in invasion of HEp-2 epithelial cells [Ref6716:Chan et al., 2005]. 16113260 2772 kduI Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254541 16766320 STM3018 NP_461935.1 5-keto-4-deoxyuronate isomerase Virulence factor MUTATION: kdul mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3717G, under G: Carbohydrate transport and metabolism 17526851 2773 STM3036 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254559 16766338 STM3036 NP_461953.1 putative inner membrane protein Virulence factor MUTATION: STM3036 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2774 STM3128 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254651 16766428 STM3128 NP_462043.1 putative oxidoreductase Virulence factor MUTATION: STM3128 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0665E, under E: Amino acid transport and metabolism 16518469 2775 STM3192 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254715 16766492 STM3192 NP_462107.1 putative arylsulfate sulfotransferase Virulence factor MUTATION: STM3192 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2776 tdcA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254768 16766544 STM3245 NP_462159.1 DNA-binding transcriptional activator Virulence factor MUTATION: tdcA mutant is less invasive of cultured epithelial cells and attenuated in mice [Ref6585:Kim et al., 2009]. COG0583K, under K: Transcription 19812899 2777 sspA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254865 16766637 STM3342 NP_462252.1 stringent starvation protein A Virulence factor MUTATION: sspA mutants are not able to cause lethal infection in calves, however these mutants are still able to cause diarrhea in calves [Ref6729:Tsolis et al., 2000]. COG0625O, under O: Posttranslational modification, protein turnover, chaperones 10816458 2778 fkpA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254976 16766742 STM3453 NP_462357.1 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) Virulence factor MUTATION: fkpA mutant exhibited a reduced ability to survive intracellularly in J774.A1 cells [Ref6730:Horne et al., 1997]. COG0545O, under O: Posttranslational modification, protein turnover, chaperones 9009347 2779 slyD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254978 16766744 STM3455 NP_462359.1 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) Virulence factor MUTATION: slyD mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1047O, under O: Posttranslational modification, protein turnover, chaperones 17526851 2780 crp Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1254989 16766754 STM3466 NP_462369.1 cAMP-regulatory protein Virulence factor MUTATION: crp deletion mutants are attenuated in mice [Ref6731:Curtiss et al., 1988]. COG0664T, under T: Signal transduction mechanisms 3291452 2781 dam Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255007 16766772 STM3484 NP_462387.1 DNA adenine methylase Virulence factor MUTATION: Lack of Dam methylation causes severe attenuation in animal models. Defects in virulence in dam mutants include such as impaired expression and secretion of invasion proteins, reduced cytotoxicity on M cells , inefficient colonization of Peyer’s patches and mesenteric lymph nodes, sensitivity to components of innate immunity, envelope instability and changes in LPS expression [Ref6732:Giacomodonato et al., 2009]. COG0338L, under L: Replication, recombination and repair 19762965 2782 envZ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255024 16766789 STM3501 NP_462404.1 osmolarity sensor protein Virulence factor MUTATION: envZ mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG0642T, under T: Signal transduction mechanisms 7618105 2783 STM3602 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255125 16766888 STM3602 NP_462503.1 putative regulatory protein Virulence factor MUTATION: STM3602 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG2188K, under K: Transcription 17526851 2784 yiaO Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255197 16766958 STM3673 NP_462573.1 putative periplasmic dicarboxylate-binding protein Virulence factor MUTATION: yiaO mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1638G, under G: Carbohydrate transport and metabolism 16518469 2785 STM3690 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255214 16766975 STM3690 NP_462590.1 putative inner membrane lipoprotein Virulence factor MUTATION: STM3690 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2786 yibD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255231 16766992 STM3707 NP_462607.1 predicted glycosyl transferase Virulence factor MUTATION: yibD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0463M, under M: Cell wall/membrane/envelope biogenesis 16518469 2787 rfaK Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255238 16766999 STM3714 NP_462614.1 putative hexose transferase Virulence factor MUTATION: rfaK mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17526851 2788 rfaZ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255239 16767000 STM3715 NP_462615.1 lipopolysaccharide core biosynthesis protein Virulence factor MUTATION: rfaZ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2789 rfaB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255243 16767004 STM3719 NP_462619.1 UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase Virulence factor MUTATION: rfaB mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17526851 2790 rfaG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255246 16767007 STM3722 NP_462622.1 glucosyltransferase I Virulence factor MUTATION: rfaG mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17526851 2791 sugR Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255277 16767037 STM3753 NP_462652.1 ATP binding protein Virulence factor MUTATION: sugR mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG3950R, under R: General function prediction only 17526851 2792 rhuM Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255279 16767039 STM3755 NP_462654.1 putative cytoplasmic protein Virulence factor MUTATION: rhuM mutant has diminished capacity to invade cultured epithelial cells compared to the wild type [Ref6516:Tenor et al., 2004]. COG3943R, under R: General function prediction only 15182677 2793 misL from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255281 16767041 STM3757 NP_462656.1 putative autotransporter Virulence factor MUTATION: misL mutant is attenuated in mice [Ref6733:Dorsey et al., 2005]. COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 15948960 2794 marT Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255283 39546372 STM3759.S NP_462658.2 putative transcriptional regulator Virulence factor MUTATION: marT mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3710K, under K: Transcription 16518469 2795 mgtC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255288 16767048 STM3764 NP_462663.1 Mg2+ transport protein Virulence factor MUTATION: mgtC mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG1285S, under S: Function unknown 17526851 2796 ibpA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255336 39546376 STM3809.S NP_462709.2 heat shock protein IbpA Virulence factor MUTATION: ibpA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2797 torD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255348 16767106 STM3821 NP_462721.1 chaperone protein TorD Virulence factor MUTATION: torD mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3381R, under R: General function prediction only 16518469 2798 STM3907 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255433 16767183 STM3907 NP_462798.1 putative cytoplasmic protein Virulence factor MUTATION: STM3907 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG5606S, under S: Function unknown 16518469 2799 ppiC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255436 16767186 STM3910 NP_462801.1 peptidyl-prolyl cis-trans isomerase C Virulence factor MUTATION: ppiC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0760O, under O: Posttranslational modification, protein turnover, chaperones 16518469 2800 trxA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255441 16767191 STM3915 NP_462806.1 thioredoxin Virulence factor MUTATION: trxA mutant is attenuated in mice [Ref6734:Peters et al., 2010]. COG3118O, under O: Posttranslational modification, protein turnover, chaperones 19884329 2801 wecE Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255451 16767200 STM3925 NP_462815.1 TDP-4-oxo-6-deoxy-D-glucose transaminase Virulence factor MUTATION: wecE mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0399M, under M: Cell wall/membrane/envelope biogenesis 17526851 2802 yigF Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255479 16767223 STM3953 NP_462838.1 putative inner membrane protein Virulence factor MUTATION: yigF mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2803 yigG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255480 16767224 STM3954 NP_462839.1 hypothetical protein Virulence factor MUTATION: yigG mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2804 STM3980 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255506 16767250 STM3980 NP_462865.1 putative outer membrane protein Virulence factor MUTATION: STM3980 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2805 STM4051 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255578 16767317 STM4051 NP_462932.1 putative outer membrane protein Virulence factor MUTAITON: STM4051 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2806 yneB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255605 16767344 STM4078 NP_462959.1 aldolase Virulence factor MUTATION: yneB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1830G, under G: Carbohydrate transport and metabolism 16518469 2807 yneC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255606 39546390 STM4079.S NP_462960.2 autoinducer-2 (AI-2) modifying protein LsrG Virulence factor MUTATION: yneC mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1359S, under S: Function unknown 16518469 2808 STM4155 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255681 16767409 STM4155 NP_463024.1 putative inner membrane protein Virulence factor MUTATION: STM4155 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2809 STM4158 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255684 16767412 STM4158 NP_463027.1 putative cytoplasmic protein Virulence factor MUTATION: STM4158 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2810 yjaG from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255695 16767423 STM4169 NP_463038.1 putative cytoplasmic protein Virulence factor MUTATION: yjaG mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3068S, under S: Function unknown 16518469 2811 purD Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255701 16767429 STM4175 NP_463044.1 phosphoribosylamine--glycine ligase Virulence factor MUTATION: purD mutant is attenuated in mice [Ref6707:Hensel et al., 1995]. COG0151F, under F: Nucleotide transport and metabolism 7618105 2812 metA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255708 16767432 STM4182 NP_463047.1 homoserine O-succinyltransferase Virulence factor MUTATION: metA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG1897E, under E: Amino acid transport and metabolism 16518469 2813 STM4198 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255724 16767448 STM4198 NP_463063.1 putative cytoplasmic protein Virulence factor MUTATION: STM4198 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2814 STM4206 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255732 16767456 STM4206 NP_463071.1 putative phage glucose translocase Virulence factor MUTATION: STM4206 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2246S, under S: Function unknown 16518469 2815 STM4260 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255786 16767510 STM4260 NP_463125.1 predicted cation efflux pump Virulence factor MUTATION: STM4260 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0845M, under M: Cell wall/membrane/envelope biogenesis 16518469 2816 STM4261 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255787 16767511 STM4261 NP_463126.1 putative inner membrane protein Virulence factor MUTATION: STM4261 mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2817 yjdB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255819 16767543 STM4293 NP_463158.1 predicted metal dependent hydrolase Virulence factor MUTATION: yjdB mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG2194R, under R: General function prediction only 16518469 2818 STM4316 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255842 16767566 STM4316 NP_463181.1 putative cytoplasmic protein Virulence factor MUTATION: STM4316 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. 17526851 2819 phoN Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255845 16767569 STM4319 NP_463184.1 non-specific acid phosphatase Virulence factor MUTATION: phoN mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG0671I, under I: Lipid transport and metabolism 16518469 2820 yjeJ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255858 16767581 STM4332 NP_463196.1 putative inner membrane protein Virulence factor MUTATION: yjeJ mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. 16518469 2821 STM4433 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255959 16767679 STM4433 NP_463294.1 myo-inositol 2-dehydrogenase Virulence factor MUTATION: STM4433 mutant is attenuated in pigs [Ref6518:Carnell et al., 2007]. COG0673R, under R: General function prediction only 17526851 2822 idnK Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256011 16767730 STM4485 NP_463345.1 D-gluconate kinase Virulence factor MUTATION: idnK mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3265G, under G: Carbohydrate transport and metabolism 16518469 2823 sthA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1256120 16767835 STM4594 NP_463450.1 putative fimbrial chaparone Virulence factor MUTATION: sthA mutant is attenuated in mice [Ref6706:Lawley et al., 2006]. COG3121NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 16518469 3400 fur Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6947533 207856151 SEN0657 YP_002242802.1 ferric uptake regulator Virulence factor MUTATION: fur mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0735P, under P: Inorganic ion transport and metabolism 19577637 3401 sodC from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6947663 207856621 SEN1149 YP_002243272.1 phage encoded superoxide dismutase [cu-zn] 1 precursor (ec 1.15.1.1) (sodCI) Virulence factor MUTATION: sodC mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 19577637 3402 sopE2 from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6947689 207856639 SEN1182 YP_002243290.1 invasion-associated secreted effector protein (sopE2) Virulence factor MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. 10735884 3403 sodC from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6947830 207857056 SEN1607 YP_002243707.1 superoxide dismutase Virulence factor MUTATION: sodC mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 19577637 3404 rpoS Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6948133 207858184 SEN2763 YP_002244835.1 RNA polymerase sigma factor RpoS Virulence factor MUTATION: rpoS mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0568K, under K: Transcription 19577637 3405 relA Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6948145 207858222 SEN2801 YP_002244873.1 GDP/GTP pyrophosphokinase Virulence factor MUTATION: relA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG0317TK, under T: Signal transduction mechanisms; K: Transcription 19577637 3406 htrA Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6948918 207855725 SEN0214 YP_002242376.1 serine endoprotease Virulence factor MUTATION: htrA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG0265O, under O: Posttranslational modification, protein turnover, chaperones 19577637 3407 ompR Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6948995 207858742 SEN3328 YP_002245393.1 osmolarity response regulator Virulence factor MUTATION: ompR mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 19577637 3408 galE Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6949187 207856214 SEN0721 YP_002242865.1 UDP-galactose-4-epimerase Virulence factor MUTATION: galE mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG1087M, under M: Cell wall/membrane/envelope biogenesis 19577637 3409 invA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6949452 207858158 SEN2737 YP_002244809.1 possible secretory protein (associated with virulence) Virulence factor MUTATION: invA mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 9087319 3410 invC from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6949458 207858156 SEN2735 YP_002244807.1 ATP synthase SpaL Virulence factor MUTATION: invC mutants are attenuated in chicks infected orally but not intraperitoneally [Ref6726:Porter and Curtiss, 1997]. COG1157NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 9087319 3411 hfq Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6949622 207859507 SEN4128 YP_002246158.1 RNA-binding protein Hfq Virulence factor MUTATION: hfq mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG1923R, under R: General function prediction only 19577637 3412 phoP Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950049 207857262 SEN1818 YP_002243913.1 DNA-binding transcriptional regulator PhoP Virulence factor MUTATION: phoP mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 19577637 3413 rfaL Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950110 207858950 SEN3535 YP_002245601.1 O-antigen ligase Virulence factor MUTATION: rfaL mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG3307M, under M: Cell wall/membrane/envelope biogenesis 19577637 3414 rfaG from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950120 207858959 SEN3544 YP_002245610.1 lipopolysaccharide core biosynthesis protein Virulence factor MUTATION: rfaG mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 19577637 3415 misL from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950173 207858990 SEN3580 YP_002245641.1 putative autotransported protein (MisL) Virulence factor MUTATION: misL mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG3468MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 19577637 3416 spoT Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950239 207858979 SEN3564 YP_002245630.1 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase Virulence factor MUTATION: spoT mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0317TK, under T: Signal transduction mechanisms; K: Transcription 19577637 3417 aroA Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950322 207856369 SEN0882 YP_002243020.1 3-phosphoshikimate 1-carboxyvinyltransferase Virulence factor MUTATION: aroA mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0128E, under E: Amino acid transport and metabolism 19577637 3418 iacP from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950340 207858143 SEN2722 YP_002244794.1 acyl carrier protein Virulence factor MUTATION: iacP mutants were noninvasive in chicks [Ref6523:Parker and Guard-Petter, 2001]. COG0236IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism 11731137 3419 sipD Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950346 207858145 SEN2724 YP_002244796.1 pathogenicity island 1 effector protein Virulence factor MUTATION: sipD mutants were noninvasive in chicks [Ref6523:Parker and Guard-Petter, 2001]. 11731137 3420 sipB Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950348 207858147 SEN2726 YP_002244798.1 pathogenicity island 1 effector protein Virulence factor MUTATION: sipB mutants were significantly less invasive in chickens than the wild-type [Ref6811:Li et al., 2009]. 19322708 3421 slyA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950363 207857052 SEN1603 YP_002243703.1 transcriptional regulator SlyA Virulence factor MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. COG1846K, under K: Transcription 8290552 3422 ssrA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950412 207857102 SEN1653 YP_002243753.1 putative two-component sensor kinase Virulence factor MUTATION: ssrA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG0642T, under T: Signal transduction mechanisms 19577637 3423 ssaV from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950423 207857080 SEN1631 YP_002243731.1 secretion system apparatus protein SsaV Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 3424 sseA from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950437 207857097 SEN1648 YP_002243748.1 putative pathogenicity island protein Virulence factor MUTATION: sseA mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. 19577637 3425 clpP from Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6950532 207855928 SEN0430 YP_002242579.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6704:Karasova et al., 2009]. COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 19577637 3426 aroD Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6951022 207857135 SEN1686 YP_002243786.1 3-dehydroquinate dehydratase Virulence factor MUTATION: aroD mutants are attenuated in mice [Ref6704:Karasova et al., 2009]. COG0710E, under E: Amino acid transport and metabolism 19577637 3427 sopE2 from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6922302 205352482 SG1261 YP_002226283.1 invasion-associated secreted effector protein (sopE2) Virulence factor MUTATION: sopE2 mutant has reduced ability to invade HeLa cells compared to wild-type [Ref6584:Bakshi et al., 2000]. 10735884 3428 slyA from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6924868 205352843 SG1674 YP_002226644.1 transcriptional regulator SlyA Virulence factor MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. COG1846K, under K: Transcription 8290552 3429 ssaV from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6924929 205352870 SG1702 YP_002226671.1 secretion system apparatus protein SsaV Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 3827 slyA from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7554805 224584047 SPC_2287 YP_002637845.1 transcriptional regulator SlyA Virulence factor MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. COG1846K, under K: Transcription 8290552 3828 ssaV from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7554835 224584075 SPC_2315 YP_002637873.1 putative type III secretion protein Virulence factor MUTATION: ssaV and aroC double mutants are attenuated in humans [Ref6519:Daigle, 2008]. COG4789U, under U: Intracellular trafficking, secretion, and vesicular transport 19745519 3829 spiC from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7554856 224584096 SPC_2336 YP_002637894.1 putative pathogenicity island secreted effector protein Virulence factor MUTATION: spiC mutant cannot survive within macrophages and is attenuated in mice [Ref6522:Uchiya et al., 1999]. 10406797 3830 sigD from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7555182 224584403 SPC_2659 YP_002638201.1 cell invasion protein Virulence factor MUTATION: sigD mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 3831 sigE from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7555183 224584404 SPC_2660 YP_002638202.1 cell invasion protein Virulence factor MUTATION: sigE mutant is less invasive than the wild type in both HEp-2 and CHO cell lines [Ref6517:Hong and Miller, 1998]. 9537377 3832 spaN from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7555466 224584670 SPC_2934 YP_002638468.1 antigen presentation protein SpaN Virulence factor MUTATION: invJ mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 3833 spaM from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7555467 224584671 SPC_2935 YP_002638469.1 virulence-associated secretory protein Virulence factor MUTATION: invI mutants are defective for entry into cultured epithelial cells [Ref6528:Collazo et al., 1995]. 7752894 3834 slyA from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7555494 224584698 SPC_2962 YP_002638496.1 transcriptional regulator SlyA Virulence factor MUTATION: slyA mutant is attenuated in mice [Ref6703:Libby et al., 1994]. COG1846K, under K: Transcription 8290552 3835 pefC from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 8541844 261888691 pSLTBT_p010 YP_003264378.1 plasmid-encoded fimbrial usher protein Virulence factor MUTATION: pefC mutants are attenuated in mice [Ref6710:Bäumler et al., 1996]. 8557375 3836 spvB from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 8541860 261888705 pSLTBT_p025 YP_003264392.1 Salmonella plasmid virulence protein Virulence factor MUTATION: spvB mutants are attenuated in mice [Ref6708:Lesnick et al., 2001].; TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells [Ref6708:Lesnick et al., 2001]. 11260464 3837 spvC from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 8541862 261888704 pSLTBT_p024 YP_003264391.1 Salmonella plasmid virulence protein Virulence factor MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [Ref6709:Matsui et al., 2001]. 11443102 3838 rck from Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium 8541866 261888683 pSLTBT_p002 YP_003264370.1 resistance to complement killing Virulence factor MUTATION: rck mutants reduces serum resistance and eukaryotic cell invasion [Ref6711:Cirillo et al., 1996]. 8675302 3839 spvB from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7552347 224504238 SPC_p003 YP_002635577.1 SpvB Virulence factor MUTATION: spvB mutants are attenuated in mice [Ref6708:Lesnick et al., 2001].; TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells [Ref6708:Lesnick et al., 2001]. 11260464 3840 spvC from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 7552348 224504239 SPC_p004 YP_002635578.1 SpvC Virulence factor MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence [Ref6709:Matsui et al., 2001]. 11443102 4869 LPS Salmonella Virulence factor MUTATION: an O-antigen-deficient serovar Typhimurium strain through deletion of the wbaP gene was constructed. The mutant stratin showed a severe defect in motility and an attenuated phenotype in a competitive mouse infection experiment compared to the wild type [Ref7295:Ilg et al., 2009]. 19364844 4919 asd Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S 267995764 aspartate-semialdehyde dehydrogenase Virulence factor MUTATION: An asd mutant, alone or in combination with a rfc mutation, is attenuated in mice [Ref7345:Piao et al., 2010]. 20799091 4920 cbiA Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6923268 205353181 SG2061 AM933173 YP_002226982 cobyrinic acid a,c-diamide synthase Virulence factor MUTATION: A cbiA mutant, in combination with a cobS mutation, is attenuated in chickens [Ref7346:Penha et al., 2010]. COG1797H, under H: Coenzyme transport and metabolism 20153354 4921 cobS Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6923296 205353166 SG2041 AM933173 YP_002226967 cobalamin synthase Virulence factor MUTATION: A cobS mutant, in combination with a cbiA mutation, is attenuated in chickens [Ref7346:Penha et al., 2010]. COG0368H, under H: Coenzyme transport and metabolism 20153354 4922 guaB Salmonella enterica subsp. enterica serovar Enteritidis str. P125109 6949287 207857921 SEN2491 AM933172 YP_002244572 inosine 5'-monophosphate dehydrogenase Virulence factor MUTATION: guaB mutant is attenuated in BALB/c mice [Ref7347:Adriaensen et al., 2007]. COG0516F, under F: Nucleotide transport and metabolism 17261603 4923 lon from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6923289 205351761 SG0461 AM933173 YP_002225562 DNA-binding ATP-dependent protease La Virulence factor MUTATION: A lon mutant is attenuated in mice [Ref7348:Matsuda et al., 2010]. COG0466O, under O: Posttranslational modification, protein turnover, chaperones 20487719 4924 lon from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251970 16763831 STM0450 AE006468 NP_459446 DNA-binding ATP-dependent protease La Virulence factor MUTATION: lon mutant is attenuated in mice [Ref7349:Matsui et al., 2003]. COG0466O, under O: Posttranslational modification, protein turnover, chaperones 12496146 4925 cpxR from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6923307 205354363 SG3362 AM933173 YP_002228164 DNA-binding transcriptional regulator CpxR Virulence factor MUTATION: A cpxR mutant is attenuated in mice [Ref7348:Matsuda et al., 2010]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 20487719 4926 lppB Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S 267993263 putative methyl-accepting chemotaxis protein Virulence factor MUTATION: lppB mutant is attenuated in mice [Ref7350:Liu et al., 2008]. 17997275 4927 lppA Salmonella enterica subsp. enterica serovar Typhimurium str. 4/74 323129647 major outer membrane lipoprotein Virulence factor MUTATION: lppAB mutant is attenuated in mice [Ref7350:Liu et al., 2008]. 17997275 4928 msbB Salmonella enterica subsp. enterica serovar Typhimurium 4104731 lipid A acyltransferase Virulence factor MUTATION: msbB mutant is attenuated in mice [Ref7350:Liu et al., 2008]. 17997275 4929 nmpC Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253090 16764916 STM1572 AE006468 NP_460531 outer membrane porin precursor Virulence factor MUTATION: nmpC (ompD) mutant is attenuated in swine [Ref7351:Selke et al., 2007]. COG3203M, under M: Cell wall/membrane/envelope biogenesis 17296750 4930 nuoG Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6924283 205353438 SG2352 AM933173 YP_002227239 NADH dehydrogenase subunit G Virulence factor MUTATION: A nuoG mutant is attenuated in chickens [Ref7352:Zhang-Barber et al., 1998]. COG1034C, under C: Energy production and conversion 9682335 4931 rfc Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S 267993210 O-antigen polymerase Virulence factor MUTATION: An rfc mutant, in combination with an asd mutation, is attenuated in mice [Ref7352:Zhang-Barber et al., 1998]. 9682335 4932 ruvB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253415 16765236 STM1894 AE006468 NP_460851 Holliday junction DNA helicase RuvB Virulence factor MUTATION: A ruvB mutant is attenuated in mice [Ref7353:Choi et al., 2010]. COG2255L, under L: Replication, recombination and repair 20670908 4933 tolA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1252267 16764117 STM0747 AE006468 NP_459732 cell envelope integrity inner membrane protein TolA Virulence factor MUTATION: A tolA mutant is attenuated in mice [Ref7354:Paterson et al., 2009]. COG3064M, under M: Cell wall/membrane/envelope biogenesis 19118362 5000 atpA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255394 16767151 STM3867 AE006468 NP_462766 F0F1 ATP synthase subunit alpha Virulence factor MUTATION: An atpA mutant is attenuated in mice [Ref7411:Chaudhuri et al., 2009]. COG0056C, under C: Energy production and conversion 19649318 5001 cpxA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255585 16767324 STM4058 AE006468 NP_462939 two-component sensor protein Virulence factor MUTATION: cpxA mutants are attenuated in mice [Ref7412:Humphreys et al., 2004]. COG0642T, under T: Signal transduction mechanisms 15271926 5002 cya Salmonella enterica subsp. enterica serovar Typhimurium 581756 adenylate cyclase Virulence factor MUTATION: A cya and crp mutant is attenuated in mice[Ref7413:Curtiss and Kelly, 1987]. 3316029 5003 gyrA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1253794 16765599 STM2272 AE006468 NP_461214 DNA gyrase subunit A Virulence factor MUTATION: A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated in pigs [Ref7414:Roesler et al., 2004]. COG0188L, under L: Replication, recombination and repair 15542179 5004 lon Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91 6923289 205351761 SG0461 AM933173 YP_002225562 DNA-binding ATP-dependent protease La Virulence factor MUTATION: ion mutant is attenuated in chickens [Ref7348:Matsuda et al., 2010]. COG0466O, under O: Posttranslational modification, protein turnover, chaperones 20487719 5005 yjeA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255870 16767593 STM4344 AE006468 NP_463208 lysyl-tRNA synthetase Virulence factor MUTATION: A poxA mutant is attenuated in mice [Ref7415:Kaniga et al., 1998]. COG2269J, under J: Translation, ribosomal structure and biogenesis 9826331 5006 rpoB Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1255679 16767407 STM4153 AF170176 NP_463022 DNA-directed RNA polymerase subunit beta Virulence factor MUTATION: A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated in pigs [Ref7414:Roesler et al., 2004]. COG0085K, under K: Transcription 15542179 5007 surA Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 1251610 16763482 STM0092 AE006468 NP_459097 peptidyl-prolyl cis-trans isomerase SurA Virulence factor MUTATION: A surA mutant (BRD1115) is attenuated in BALB/c mice [Ref7416:Sydenham et al., 2000]. COG0760O, under O: Posttranslational modification, protein turnover, chaperones 10678914