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fadD

Victor ID 2688
Gene Name fadD
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1253337
NCBI Protein GI 16765159
Locus Tag STM1818
Protein Accession NP_460774.1
Other Database IDs UniProtKB-ID: LCFA_SALTY
UniRef100: UniRef100_P63522
UniRef90: UniRef90_Q8XDR6
UniRef50: UniRef50_Q8ZES9
UniParc: UPI0000059D3B
EMBL: AE006468
EMBL-CDS: AAL20733.1
RefSeq_NT: NC_003197.1
GenomeReviews: AE006468_GR
KEGG: stm:STM1818
HOGENOM: HBG547964
OMA: PGELCIK
ProtClustDB: PRK08974
BioCyc: STYP99287:STM1818-MONOMER
Taxonomy ID 99287
Gene Starting Position 1915221
Gene Ending Position 1916906
Gene Strand (Orientation) -
Protein Name long-chain-fatty-acid--CoA ligase
DNA Sequence 
>gi|16763390:1915221-1916906 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
CTCAGGCTTTATTGTCTACTTTGCCACGGGCTTCGTCACGCAGTTCTCGTCGTAAAATTTTCCCAACGTT
AGATTTTGGTAATTCCTCGCGAAACTCGACCTGTTTGGGCACCTTATATCCGGTCAGATGGCGACGGCAG
AAGGTGATCAACGCATCGTCAGTCAATGCCGGATCTTTCTTAACCACAAAAAGCTTCACCGCTTCGCCGC
TACTACCGGAAGGCACGCCAACCGCCGCGACTTCCTGCACGCCAGAATGCTGCATCACCACATCTTCAAT
TTCGTTTGGATAAACGTTGAAACCAGAAACCAGAATCATATCTTTCTTACGATCGACAATCCGCAGAAAG
CCGTCTTCATCCATAACCGCAATATCGCCCGTATGCAGCCAGCCATCTTTAATGATTTCATCCGTCGCGT
CAGGACGCTGCCAGTATCCCAGCATAACCTGCGGGCCTTTCACGCAAAGCTCTCCGGCCTCACCCGGCGC
GACTTCGTTGTCATCGTCATCCACCAGTTTGGCTTCTGTTGACGGTACTGGCAGGCCGATACTGCCGCTG
TGATAATCAATATCATGCGGGTTGACGCTCACCAGCGGGGCGCACTCGGTCAGCCCGTAGCCTTCCAGCA
GGTATTGCCCGGTCAGCTTTACCCAACGTTCCGCAACGACGTTTTGCACCGGCATCCCGCCGCCGGCTGA
CAGATGCAGCGAAGAAAAATCCAGCTGTTGAAACTCTTTATTATTGAGCAGGGCGTTGAATAACGTATTA
ACGCCAGTCATCGCCGTAAATGGATATTTCGCCAGCTCCTTGACCAGACCGGGGATATCACGCGGATTGG
TAATCAGCAGGTTTTGCCCACCCAGCTCGATAAAAAGCAGACAGTTCATGGTTAAGGCAAAAATGTGATA
CAGCGGCAGCGCGGTCACTACCAGCTCTTTCCCCGGGTGCAGCAGCGGCCCATAGGTCGCTTTCACCTGC
TCCAGATTCGCCAGCATATTGCGGTGGGTCAACATCGCGCCTTTCGCCACGCCCGTCGTACCGCCGGTAT
ATTGCAGGAAAGCCAGATCTTCAGCGACAACCTCGGGTTTGACATACTGCATACGGTAGCCATGCTGTAG
CGCGCTGCGAAACGAGATCGCATCTGGCAAGTGGTATTTTGGCACCAGACGCTTGATGTATTTCACGACA
AAGTTAACAACCGTACCTTTGGCGGTAGAAAGCTGGTCGCCCATCCGCGTCAGAATAACGTGCTGTACCG
ACGTTTTCTCGACTACTTTTTCCAGCGTATGGGCAAAGTTAGAAACAATAATGATTGCCGCCGCGCCGCT
ATCGTTAAGCTGATGCTCAAGTTCGCGCGGCGTGTACAGCGGGTTAACGTTCACCACAATCATGCCAGCG
CGTAAAATACCAAATAGCGCGACAGGATACTGCAACAGGTTTGGCATCATCAGCGCCACACGGTCGCCTT
TTTTGAGTCCCAGCCCTTGTTGTAAATAAGCCGCAAATGCCCGACTACGTTCTTCTAATTTACGGAAGGT
CATTACCTCCCCCATATTGACGAACGCAGGCTGATCGGCATAGCGCGTCGCCGCATGTTCAAACAGTTCA
ACCAGGGATTGATAACGGTCAGGGTTGATCTCCGCCGGAACATCAGCAGGATAACGGTTAAGCCAAACCT
TCTTCA
Protein Sequence 
>gi|16765159|ref|NP_460774.1| long-chain-fatty-acid--CoA ligase [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MKKVWLNRYPADVPAEINPDRYQSLVELFEHAATRYADQPAFVNMGEVMTFRKLEERSRAFAAYLQQGLGLKKGDRVALMMPNLLQYPVALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAAAIIIVSNFAHTLEKVVEKTSVQHVILTRMGDQLSTAKGTVVNFVVKYIKRLVPKYHLPDAISFRSALQHGYRMQYVKPEVVAEDLAFLQYTGGTTGVAKGAMLTHRNMLANLEQVKATYGPLLHPGKELVVTALPLYHIFALTMNCLLFIELGGQNLLITNPRDIPGLVKELAKYPFTAMTGVNTLFNALLNNKEFQQLDFSSLHLSAGGGMPVQNVVAERWVKLTGQYLLEGYGLTECAPLVSVNPHDIDYHSGSIGLPVPSTEAKLVDDDDNEVAPGEAGELCVKGPQVMLGYWQRPDATDEIIKDGWLHTGDIAVMDEDGFLRIVDRKKDMILVSGFNVYPNEIEDVVMQHSGVQEVAAVGVPSGSSGEAVKLFVVKKDPALTDDALITFCRRHLTGYKVPKQVEFREELPKSNVGKILRRELRDEARGKVDNKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: fadD mutant is attenuated in mice (Lawley et al., 2006).
COG COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Lawley et al., 2006: Lawley TD, Chan K, Thompson LJ, Kim CC, Govoni GR, Monack DM. Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse. PLoS pathogens. 2006; 2(2); e11. [PubMed: 16518469].