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sipC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Victor ID 2754
Gene Name sipC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1254407
NCBI Protein GI 16766190
Locus Tag STM2884
Protein Accession NP_461805.1
Other Database IDs UniProtKB-ID: SIPC_SALTY
UniRef100: UniRef100_Q56020
UniRef90: UniRef90_Q56135
UniRef50: UniRef50_Q56135
UniParc: UPI00000D0180
EMBL: U25631
EMBL: U30491
EMBL: AE006468
EMBL-CDS: AAA75170.1
EMBL-CDS: AAC43547.1
EMBL-CDS: AAL21764.1
RefSeq_NT: NC_003197.1
GenomeReviews: AE006468_GR
KEGG: stm:STM2884
HOGENOM: HBG415831
OMA: AMESINQ
ProtClustDB: CLSK862847
BioCyc: STYP99287:STM2884-MONOMER
Taxonomy ID 99287
Gene Starting Position 3027856
Gene Ending Position 3029085
Gene Strand (Orientation) -
Protein Name translocation machinery component
DNA Sequence 
>gi|16763390:3027856-3029085 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
ATTAAGCGCGAATATTGCCTGCGATAGCAGCGAGTGCGGATGCTTTCGACTGGTTAATGCTCTCCATTGT
TTTCAGCATTTCCTGAATCAGGCTGGTCGATTTACGTGAACTTTCACGGGCTTCGTCCGATGCGGTGCTG
GCAACCCGGTTATTCACCTGGCTAATTTGCTGCTCGGAACGTTCCTGAGTAGCGGCGTACTGCCCGGACG
CCCCTGCAATACCACCGACCGTGACCGAGTTCTTCATAATCAGATCGCCCGTCATCTGCATCTTGCGCGC
ATCGATTCGGGTCATATCCATGGTATTCTGCTCAAGACGAATATCGGATTCGACAGACTCAAGACGTTTC
GACAGAATAGCCTGATGTTCAGGGGAGATTTGTTTATTACTGTCTTTAATACCCAGACTTTCCGTGGCGC
TGGTTCCGGCATTAGATTTAAGCGTCGCATCATTAAGATTTTTCGTCGCATCGGTACCGGTTTTCTTCAT
ATTTAACGATTTCAGAGAATCGACGCCTTCAGCACCGAGTTTGACGCTATTCTGCCCGTTCAGCACGTTT
TTAATACTGTGGCTTTCAGTGGTCAGTTTATCGATCTTCGCGGCATTATGTTTAAGCGCGCCTCTTTCAT
TCTGCAGCCCCTTATATTCCAGTTTGGCGCCCACGCCAGTGATCCCCAACTGAAGCGCGCTCTGGGAAAT
ACTACCGGACAACGCATTCATCCCTTCGCGCATCATGGAGCTTGCCGTCGTTTTAGCTGCATCAAAACTG
ACTAATGACAACTTACCAGACAGTTTGCTATCAGCCTGGTTCAACGTCAGCATTAACGTATTCGCGGCAG
CCAACAGCGCAACGGCACTGGAAGACATTCCGCTAATATCAAAAAACTTTCCGACTTCTGCCTGCTGCTC
GCGTAACTGGGTTTGCACAACCTCATTCGCTTTAGTCGTGACATTATTTGCCAGAGCATTCAAATCCTGA
TTCATGTCGGTATTTTGAATACTGGCTTTTAAAAAGGACGTGATCGTTCCGGGGGTTTGCGTTAATACCC
CTGGCGCAGGCGCGCTCAGTGTAGGACTCAACCCCAGGTCACTGACTTTACTGCTGCTAATACCAATACT
ATTCAGAATATCTTTAGCGCTAACGGATTGCGAAGCTGTCTGTGAACTATTCTCAACAGAATGATTATTT
AAATAAGCGGCGGGATTTATTCCCACATTACTAATTAACA
Protein Sequence 
>gi|16766190|ref|NP_461805.1| cell invasion protein SipC [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGVDSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKDSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASGQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A SipC nucleation-deficient mutant, which maintained its effector translocation activity, had significantly reduced ability to induce actin cytoskeleton rearrangements, resulting in lower bacterial invasion into HeLa cells (Chang et al., 2005).
References
Chang et al., 2005: Chang J, Chen J, Zhou D. Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC. Molecular microbiology. 2005; 55(5); 1379-1389. [PubMed: 15720547].