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sopA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Victor ID 2703
Gene Name sopA from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1253587
NCBI Protein GI 16765396
Locus Tag STM2066
Protein Accession NP_461011.1
Other Database IDs UniProtKB-ID: SOPA_SALTY
UniRef100: UniRef100_D0ZMG9
UniRef90: UniRef90_B5EX33
UniRef50: UniRef50_B4TMK5
UniParc: UPI00000CD19E
EMBL: AE006468
EMBL-CDS: AAL20970.1
RefSeq_NT: NC_003197.1
PDB: 2QYU
PDB: 2QZA
DIP: DIP-46397N
GenomeReviews: AE006468_GR
KEGG: stm:STM2066
NMPDR: fig|99287.1.peg.1991
HOGENOM: HBG671380
OMA: KSILMTI
ProtClustDB: CLSK264007
BioCyc: STYP99287:STM2066-MONOMER
Taxonomy ID 99287
Gene Starting Position 2141569
Gene Ending Position 2143917
Gene Strand (Orientation) +
Protein Name secreted effector protein
DNA Sequence 
>gi|16763390:2141569-2143917 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
AATGAAGATATCATCAGGCGCAATTAATTTTTCTACTATTCCTAACCAGGTTAAAAAATTAATTACCTCT
ATTCGTGAACATACGAAAAACGGGCTCACCTCAAAAATAACCAGTGTTAAAAACACGCATACATCTTTAA
ATGAAAAATTTAAAACAGGAAAGGACTCACCGATTGAGTTCGCGTTACCACAAAAAATAAAAGACTTCTT
TCAGCCGAAAGATAAAAACACCTTAAACAAAACATTGATTACTGTTAAAAATATTAAAGATACAAATAAT
GCAGGCAAGAAAAATATTTCAGCAGAAGATGTCTCAAAAATGAATGCAGCATTCATGCGTAAGCATATTG
CAAATCAAACATGTGATTATAATTACAGAATGACAGGTGCGGCCCCGCTCCCCGGTGGAGTCTCTGTATC
AGCCAATAACAGGCCCACGGTTTCTGAAGGTAGAACACCACCAGTATCCCCCTCCCTCTCACTTCAGGCT
ACCTCTTCCCCGTCATCACCTGCCGACTGGGCTAAGAAACTCACGGATGCAGTTTTACGACAGAAAGCCG
GAGAAACCCTTACGGCCGCAGATCGCGATTTTTCAAACGCAGATTTCCGTAATATTACATTCAGCAAAAT
ATTGCCCCCCAGCTTCATGGAGCGAGACGGCGATATTATTAAGGGGTTCAACTTTTCAAATTCAAAATTT
ACTTATTCTGATATATCTCATTTACATTTTGACGAATGCCGATTCACTTATTCGACACTGAGTGATGTAG
TCTGCAGTAATACGAAATTTAGTAATTCAGACATGAATGAAGTGTTTTTACAGTATTCAATTACTACACA
ACAACAGCCCTCGTTTATTGATACAACATTAAAAAATACGCTTATACGTCACAAAGCCAACCTCTCTGGC
GTTATTTTAAATGAACCGGATAATTCATCACCTCCGTCAGTGTCAGGGGGCGGAAATTTTATTCGTCTAG
GTGATATCTGGCTGCAAATGCCACTCCTTTGGACTGAGAACGCTGTGGATGGATTTTTAAATCATGAGCA
CAATAATGGTAAAAGTATTCTGATGACCATTGACAGCCTGCCCGATAAATACAGTCAGGAAAAAGTCCAG
GCAATGGAAGACCTGGTTAAGTCATTGCGGGGTGGCCGCTTAACAGAGGCATGTATCCGGCCAGTTGAAA
GTTCGCTGGTAAGCGTACTGGCCCACCCCCCCTATACGCAAAGTGCGCTTATCAGCGAGTGGCTCGGGCC
TGTTCAGGAACGTTTTTTTGCCCACCAGTGCCAGACCTATAATGACGTTCCCCTGCCGGCTCCTGACACA
TATTATCAGCAGCGCATACTGCCTGTGTTGCTGGATTCGTTTGACAGGAACAGCGCCGCCATGACCACTC
ACAGCGGACTCTTTAATCAGGTGATTTTACACTGTATGACAGGCGTGGACTGCACTGATGGCACCCGCCA
GAAAGCTGCAGCGCTTTATGAACAGTATCTTGCTCACCCGGCGGTGTCTCCCCACATCCATAATGGGCTC
TTCGGCAATTATGATGGCAGCCCGGACTGGACAACCCGCGCTGCAGATAATTTCCTGCTGCTTTCCTCCC
AAGATTCAGACACGGCGATGATGCTCTCCACTGACACGCTGTTAACAATGCTAAACCCTACTCCTGACAC
TGCATGGGACAACTTTTACCTGCTGCGAGCCGGAGAGAACGTTTCCACCGCGCAAATCTCTCCGGTAGAG
TTATTCCGTCATGACTTTCCGGTGTTTCTCGCCGCATTTAATCAGCAGGCCACGCAGCGACGCTTTGGGG
AGCTGATTGATATCATCCTCAGCACTGAAGAGCACGGGGAGCTGAACCAGCAGTTTCTTGCCGCCACGAA
CCAGAAACATTCCACCGTGAAGTTGATTGATGATGCCTCAGTGTCGCGTCTGGCCACCATTTTTGACCCC
TTGCTTCCTGAAGGCAAACTCAGCCCGGCACACTACCAGCACATCCTCAGTGCTTATCACCTGACGGACG
CCACCCCACAGAAGCAGGCGGAAACCCTGTTCTGTCTCAGTACCGCATTCGCACGCTATTCCTCCAGCGC
CATTTTCGGCACTGAGCATGACTCTCCGCCGGCCCTGAGAGGCTATGCGGAGGCGCTGATGCAGAAAGCC
TGGGAGCTGTCTCCGGCGATATTCCCATCCAGCGAACAGTTTACCGAGTGGTCCGACCGTTTTCACGGCC
TCCATGGCGCCTTTACCTGTACCAGCGTTGTGGCGGATAGTATGCAACGTCATGCCAGAAAATATTTCCC
GAGTGTTCTGTCATCCATCCTGCCACTGGCCTGGGCGTA
Protein Sequence 
>gi|16765396|ref|NP_461011.1| E3 ubiquitin-protein ligase SopA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MKISSGAINFSTIPNQVKKLITSIREHTKNGLTSKITSVKNTHTSLNEKFKTGKDSPIEFALPQKIKDFFQPKDKNTLNKTLITVKNIKDTNNAGKKNISAEDVSKMNAAFMRKHIANQTCDYNYRMTGAAPLPGGVSVSANNRPTVSEGRTPPVSPSLSLQATSSPSSPADWAKKLTDAVLRQKAGETLTAADRDFSNADFRNITFSKILPPSFMERDGDIIKGFNFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSDMNEVFLQYSITTQQQPSFIDTTLKNTLIRHKANLSGVILNEPDNSSPPSVSGGGNFIRLGDIWLQMPLLWTENAVDGFLNHEHNNGKSILMTIDSLPDKYSQEKVQAMEDLVKSLRGGRLTEACIRPVESSLVSVLAHPPYTQSALISEWLGPVQERFFAHQCQTYNDVPLPAPDTYYQQRILPVLLDSFDRNSAAMTTHSGLFNQVILHCMTGVDCTDGTRQKAAALYEQYLAHPAVSPHIHNGLFGNYDGSPDWTTRAADNFLLLSSQDSDTAMMLSTDTLLTMLNPTPDTAWDNFYLLRAGENVSTAQISPVELFRHDFPVFLAAFNQQATQRRFGELIDIILSTEEHGELNQQFLAATNQKHSTVKLIDDASVSRLATIFDPLLPEGKLSPAHYQHILSAYHLTDATPQKQAETLFCLSTAFARYSSSAIFGTEHDSPPALRGYAEALMQKAWELSPAIFPSSEQFTEWSDRFHGLHGAFTCTSVVADSMQRHARKYFPSVLSSILPLAWA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sopA mutants induce significantly less fluid accumulation in bovine ligated ileal loops than the wild-type (Zhang et al., 2002).
COG COG1357S, under S: Function unknown
References
Zhang et al., 2002: Zhang S, Santos RL, Tsolis RM, Stender S, Hardt WD, Bäumler AJ, Adams LG. The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves. Infection and immunity. 2002; 70(7); 3843-3855. [PubMed: 12065528].