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clpB

Victor ID 2736
Gene Name clpB
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1254183
NCBI Protein GI 16765976
Locus Tag STM2660
Protein Accession NP_461591.1
Other Database IDs UniProtKB-ID: CLPB_SALTY
UniRef100: UniRef100_Q7AMH5
UniRef90: UniRef90_P63285
UniRef50: UniRef50_Q6GIB2
UniParc: UPI000005A2CE
EMBL: AE006468
EMBL-CDS: AAL21550.1
RefSeq_NT: NC_003197.1
GenomeReviews: AE006468_GR
KEGG: stm:STM2660
HOGENOM: HBG413133
OMA: HISNALN
ProtClustDB: PRK10865
BioCyc: STYP99287:STM2660-MONOMER
Taxonomy ID 99287
Gene Starting Position 2802115
Gene Ending Position 2804688
Gene Strand (Orientation) -
Protein Name protein disaggregation chaperone
DNA Sequence 
>gi|16763390:2802115-2804688 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
CTTACTGCACTGCCACAATACGATCATCATTGGCTTCAAGGCGAATCACTTTGCCAGGAACCAGTTCACC
AGACAGGATTTGCTGCGCCAGTGGGTTTTCGATCTGCTGTTGAATAGCACGTTTTAACGGACGCGCCCCG
TAGACCGGATCGTAACCGTTGGCGCTCAACAGTTTCAGCGCCTCGTCGGAGATATGGATTTCATAACCAC
GTTCTTCCAGACGTTTGTACAGACGCTGCAGCTGGATCTGAGCAATAGAAGCGATGTGTTGTTCACCTAA
CGGATGGAATACCACAACTTCATCAATACGGTTGATAAATTCCGGACGGAAGTTTTGGCTAACCACACCC
AGCACCATCTCTTTCATTCGACCGTAATCCAGTTCGCCAAAGCGCTCCTGAATGAGATCGGAACCGAGGT
TAGAAGTCATAATGACCACCGTATTACGGAAGTCGACCGTTCTCCCCTGCCCGTCAGTCAGTCGACCGTC
GTCCAGCACCTGCAACAGAATGTTGAATACATCCGGATGCGCTTTTTCCACTTCATCCAACAAGATGACG
GAATAAGGGCGACGGCGCACCGCTTCCGTCAAATAACCGCCTTCTTCATAGCCGACATATCCCGGAGGCG
CCCCGACCAAACGAGACACGGAGTGTTTCTCCATAAACTCAGACATGTCGATACGCACCATCGCGTCGTC
GCTGTCGAACATAAAGTTAGCCAGTGCTTTACACAGTTCGGTTTTACCGACCCCCGTCGGCCCCAGGAAC
AGGAAGGAACCAATCGGACGGTTCGGATCGGACAGCCCAGCACGGCTACGACGTATGGCGTTCGATACTG
CTTCAACGGCTTCATTCTGCCCGATCACACGGCTGTGTAACTCTTGTTCCATACGCAACAGTTTTTCACG
TTCGCCTTCCAGCATTCTGGAAACCGGAATACCGGTCCAGCGCGCTAGCACTTCGGCAATTTCCGCATCC
GTTACTTTGTTACGTAACAGACGCATGGTTTTACCTTCCGACTGGGTCGCGGCTTCCAGCTGTTTTTCCA
GCTCCGGAATTTTGCCGTACTGCAGTTCAGACATTCGCGCCAGGTCGCCAACGCGACGCGCCTGCTCGAT
GGCAATCTTCGCCTGCTCCAGCTCCGCTTTAATAGTTTGCGTACCAGAGAGCGACGCTTTTTCCGCTTTC
CACTCTTCTTCCAGCTCAGAATACTGGCGCTCTTTGTCGTCCAGTTCTTCGTTGAGCATATCGAGACGTT
TTTTACTCGCCTCGTCAGACTCTTTCATCAACGCCTGCTGTTCCAGTTTGAGCTGAATAATGCGGCGGTC
GAGTCTGTCCAGCTCCTCCGGCTTAGAGTCAATCTGCATACGAATGCTGGATGCAGCTTCATCGATGAGG
TCGATAGCTTTATCCGGCAACTGACGGTCGGCGATATAGCGGTGAGATAATGTTGCCGCCGCCACAATCG
CCGGGTCAGTGATCTGCACATGGTGGTGCAGCTCGTAACGTTCTTTCAGGCCACGCAGAATAGCGATGGT
GTCTTCCACTGAAGGTTCTGCGACAAACACTTTTTGAAAACGACGTTCCAGCGCCGCGTCTTTTTCAATG
TACTGACGGTATTCATCCAGCGTGGTGGCGCCCACACAGTGCAGTTCACCACGCGCCAGCGCCGGTTTCA
GCATATTCCCGGCGTCCATTGCGCCATCAGCCTTACCTGCGCCAACCATCGTGTGCAGCTCGTCAATAAA
CAGGATGACGTTGCCTTCCTGTTTCGCCAGATCGTTCAGCACGCCTTTCAGACGCTCTTCAAATTCGCCG
CGATATTTCGCCCCCGCCACCAGCGCGCCCATATCCAGCGCCAGTACGCGGCGACCTTTTAAGCCTTCAG
GGACTTCACCGTTAATAATGCGCTGCGCCAGTCCTTCAACAATTGCCGTTTTACCGACCCCTGGCTCACC
GATTAACACCGGGTTGTTTTTGGTACGACGTTGCAGTACCTGAATGGTACGGCGAATTTCTTCATCACGA
CCAATTACCGGGTCAAGCTTGCCTTGTTCAGCCCGCTCGGTCAGATCGACGGTATATTTTTTCAAGGCCT
GACGTTGGTCTTCAGCCCCTTGATCGTTCACGCTTTCACCTCCGCGCATCTGTTCAATTGCCTGAGTGAT
ATTGGCCGTGGTCGCACCGGCTGATTTCAGCAGATCGGTTAACGTGCCGCGAGACTCAAGCGCCGCCAGA
ACAAACAGCTCTGACGAAATAAAATTGTCTCCCCGTTTTTGCGCCAGCTTGTCGCAAAGGTTCAGTACGC
GTACCAGTTCCGAAGAAGGCTGTACGTCGCCGCCGGTGCCTTCCACCTGCGGTAAACGGCTCAGCGCCTG
ATCGATAGCGGTGCGCAACTGGCCAGCATTAATGCCGGCGGAGGTTAATAAAGGACGTATCGATCCCCCT
TCCTGGTTCAGCAAGGCGCTCATTAAATGAAGAGGTTCGATGAATTGGTTGTCGTGCCCCAGCGCGAGCG
ACTGGGCATCGGCAAGAGCAAGCTGGAATTTGTTAGTAAGACGATCCAGACGCA
Protein Sequence 
>gi|16765976|ref|NP_461591.1| chaperone protein ClpB [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSIRPLLTSAGINAGQLRTAIDQALSRLPQVEGTGGDVQPSSELVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLTDLLKSAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLALDMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELDDKERQYSELEEEWKAEKASLSGTQTIKAELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQSEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMLEGEREKLLRMEQELHSRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSDLIQERFGELDYGRMKEMVLGVVSQNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLQRLYKRLEERGYEIHISDEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEANDDRIVAVQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: clpB mutant is attenuated in pigs (Carnell et al., 2007).
COG COG0542O, under O: Posttranslational modification, protein turnover, chaperones
References
Carnell et al., 2007: Carnell SC, Bowen A, Morgan E, Maskell DJ, Wallis TS, Stevens MP. Role in virulence and protective efficacy in pigs of Salmonella enterica serovar Typhimurium secreted components identified by signature-tagged mutagenesis. Microbiology (Reading, England). 2007; 153(Pt 6); 1940-1952. [PubMed: 17526851].