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dam

Victor ID 2781
Gene Name dam
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1255007
NCBI Protein GI 16766772
Locus Tag STM3484
Protein Accession NP_462387.1
Other Database IDs UniProtKB-ID: DMA_SALTY
UniRef100: UniRef100_P0A292
UniRef90: UniRef90_P0AEE9
UniRef50: UniRef50_A5F520
UniParc: UPI000005A7C8
EMBL: U76993
EMBL: AE006468
EMBL-CDS: AAB19116.1
EMBL-CDS: AAL22346.1
RefSeq_NT: NC_003197.1
REBASE: 2891
REBASE: 5605
GenomeReviews: AE006468_GR
KEGG: stm:STM3484
HOGENOM: HBG586381
OMA: KARRTIS
ProtClustDB: PRK10904
BioCyc: STYP99287:STM3484-MONOMER
Taxonomy ID 99287
Gene Starting Position 3638689
Gene Ending Position 3639525
Gene Strand (Orientation) -
Protein Name DNA adenine methylase
DNA Sequence 
>gi|16763390:3638689-3639525 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
ATTATTTTCTTGCAGGCGTTGCGACTCCTGGTTGGTACAGAGCCAGCAGTTCGTCCACCTTTTTACGTGT
GCCGCCGTTGCTGCTTATACTGCGTCTAACTTTGACGACATGCAATTTTGCGAGTTGATACCACTCGCGT
GTGAGCGCCGTATCATGGTTGGAAATGAGCACCGGTATCCGGTTACTGACCAGATTCTCAGCGATTTCCG
CCAGATGCGCTTGTTGCGTCAGGCTAAAACTATTGGTGTGATACGCTGTGAAGTTAGCCGTGGCGGACAA
CGGCGCATAAGGCGGATCGCAATAGACCACCGACGACTTGTCCGCACGCGCCATACTGTCTGCGTATGAC
TCACAGTAAAAGAACGCATTCTGCGCTTTTTCTGCAAAGTGGTACAACTCCGCTTCCGGGAAGTAAGGTC
TTTTATAACGACCAAACGGTACATTAAATTCCCCGCGTAAGTTATAGCGACAGAGTCCGTTATAACCGTA
GCGGTTCAGATATAAAAACAGTACCGCCCGACGAAAGGGGTCCTGGCAGGTGTTGAACTCCTCGCGGAGT
TGGTAATAGACCTCAGCCTGGTTAGTTTCAGGCATAAACAGCTCGCGCGAAGCCTGTACATACTCGTCAG
TACGTAACTTCACGATGTTATAGAGGCTAATAAGGTCGCTGTTGATATCGGCGAGGATATAACGAGAAAA
GTCGGTGTTAAGAAACACCGATCCGGCACCCACAAAAGGTTCGACAAGGCACTCGCCTTTTGGCAAATGT
CGTTTGATATCATCAAGCAGAGGGTATTTTCCCCCTGCCCACTTCAAAAAAGCGCGATTTTTTTTCA
Protein Sequence 
>gi|16766772|ref|NP_462387.1| DNA adenine methylase [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MKKNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKLRTDEYVQASRELFMPETNQAEVYYQLREEFNTCQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKRPYFPEAELYHFAEKAQNAFFYCESYADSMARADKSSVVYCDPPYAPLSATANFTAYHTNSFSLTQQAHLAEIAENLVSNRIPVLISNHDTALTREWYQLAKLHVVKVRRSISSNGGTRKKVDELLALYQPGVATPARK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Lack of Dam methylation causes severe attenuation in animal models. Defects in virulence in dam mutants include such as impaired expression and secretion of invasion proteins, reduced cytotoxicity on M cells , inefficient colonization of Peyer’s patches and mesenteric lymph nodes, sensitivity to components of innate immunity, envelope instability and changes in LPS expression (Giacomodonato et al., 2009).
COG COG0338L, under L: Replication, recombination and repair
References
Giacomodonato et al., 2009: Giacomodonato MN, Sarnacki SH, Llana MN, Cerquetti MC. Dam and its role in pathogenicity of Salmonella enterica. Journal of infection in developing countries. 2009; 3(7); 484-490. [PubMed: 19762965].