Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

sipA

Victor ID 2753
Gene Name sipA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1254405
NCBI Protein GI 16766188
Locus Tag STM2882
Protein Accession NP_461803.1
Other Database IDs UniProtKB-ID: SIPA_SALTY
UniRef100: UniRef100_Q56027
UniRef90: UniRef90_Q8VQB5
UniRef50: UniRef50_Q8VQB5
UniParc: UPI00000CD31C
EMBL: U40013
EMBL: AE006468
EMBL: U30491
EMBL-CDS: AAA86618.1
EMBL-CDS: AAL21762.1
EMBL-CDS: AAC43549.1
RefSeq_NT: NC_003197.1
PDB: 1Q5Z
PDB: 2FM8
PDB: 2FM9
GenomeReviews: AE006468_GR
KEGG: stm:STM2882
NMPDR: fig|99287.1.peg.2779
HOGENOM: HBG671451
OMA: ETPSFDE
ProtClustDB: CLSK894369
BioCyc: STYP99287:STM2882-MONOMER
Taxonomy ID 99287
Gene Starting Position 3024678
Gene Ending Position 3026735
Gene Strand (Orientation) -
Protein Name secreted effector protein
DNA Sequence 
>gi|16763390:3024678-3026735 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
ATTAACGCTGCATGTGCAAGCCATCAACGGTAGTAATAACCCGATCCACGCCAGGTTTATTCAGGTATGA
CTCGTAAGCCGGGCCAGCTCGCCAGCTACCGTCTCCGATAAGGCCGTCCAGCACATTACTTAACACATAG
TCAGTTTCCCCTTTTAGCCTGGTCAGCCCCGCCTCTCTGGCAAACTGCAGTGCAATCTCAGCCAGTTTTT
CTTTTTGTGGATGATGAGTAATGACCTCTTTGAGAGTCTCCATTTTCGCTTTCAATTCTGGGTGCTTGTC
AATATCGCTACATTGCGCTTTCAACGCTGCACTCTTTATCGTGTCATTGGGTAATATTTCCGCACGCAAG
CCGTCAAACGCTCTGCGTACAGGGAACGGTGTGGAGGTATCTGGCTCCAGGGCTTTACGTATCACACCCA
AAAACGTCTCACGGGCGTCGAAATGCATTGAATGCATATTCGTAACGCTCGGTACTGTTGAGAGGAAACT
ATTTTGCTTAAACTTCAAACCAGAAAATGGGCCAGTCTTATCTGTCTGACTATTATCATTATCGGTCGTA
CCGGCTTTATTACCTGTAATTACCGTCGTGTCTGATTGTAAGGTATCGGTTTTAACATTCTCGACGCCAG
CCAGTTGACTGGCAAGCGGCTTCACATTCACAATCTCTGCCGTCTGGCTTTGCTGTTTATTATCATCAAC
GCCGTGCACCGTGGCCTGTACCGGCTTGCCGATAATGCTCTTGCTGGTTACGCCATCGACTTCATCAAAA
GAGGTTGTTTCACCCGTAGTGCCCTTTTCTGACGTGACCACCTTTCCATCTTTACTTTCGGATGAAGCGT
TGGTCACAGCCTCTGCCGTCGCATGAGCCGTGACGTCAATTTTACCCGCGATGCCATGGTCAATTGCCCC
TGTGCTGGCGCTGTGTGCCGTCTCCGTTTGATGCGTAGTCGAATCCACACGCGAATGACTATGACTTACG
TTGCTGCTGTTAGTCGAATGGTGTGACTCGCCATTGCGTTGGCTGTTATCAATAAATGTTCGGCTATTAT
CAATCGTCTTCCGGCTATTATCATGGTTGCTATTATCGATATGGCGCTGGCTATTATCGACATGGCTTCG
GCTATTGTTAATATGCTTACTGTTATCCACGCTATGGTTACTGCTATCAATATTAATATTGATATTAATA
CCCGTAGGTTCTGCTTTTTTCCCACCATCAGGTACTGGTCCAGCCGCAGGCTCCGGAATTTTAGGGTCAG
GCAGTTTATCTGCAGGAATTTGTGCAAAAACATTACGTAGCAGCAGGGGTATCAACGTTTGCATTTCAAG
GTGCCGGGCTTCCCGTCCTACGCTGGTACCCTGCTCTTGCGTTAATTTTTGGTGGCACATATCAAGCGCC
TCAACAGCCTTCGCCGCCGCTTTGTCAACAAGGTGCGTAAGATTGCTGCGGGTTAACGGATCTAACGTAC
AGCCAAAGTTATGTTCAATGCAGCTGGCAATATAGGGCATCACCTCCTGCATAACAAGATTCGTCGATAA
TTTACTTAATTCACCGCCAGTGTTATTTTTGATAATATCTAACAGCTGCTTTTCCAGGTTTTCCAGCTTC
GCTTCCGCTTTCTTTGTTTCTGGCAGCCATGGCCCAAAAGCTGACTTTTCTTTCAGGCCATCTTTTATGA
TTTGCGCGGTATACTCTGCCCCCACCTTCATCAGTAGCGTCTTCGCCTCAGGAGAATCACTGGTGGCGTT
GAGCGCTGAACGAAAGAGCCCGGCAAACTCCATTATCGCTTTCTTACCGGCGACATTATTTGAATTGGTA
AAAACTTCTTTTAACGCCTCAGCGTCTTTCCCGCATTTAAACAATGCATCCAGACTCGCCTGTTTGATCA
GCGCGGGAAAATCTTCCAGTTGCGGGCCTTTAATTTCCCCTGACAGCGTCGCTGTGGCACTTTCTCTGAC
TGCGGAAAGATTCGCCGCAAGATTCGTGGCCTGCGTTTTGATCTCGGTCTGCATACCTGGCATTATGACG
GGGGGCTGAGTCCTTACACTTGTAACCA
Protein Sequence 
>gi|16766188|ref|NP_461803.1| cell invasion protein SipA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTHLVDKAAAKAVEALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRNGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDVTAHATAEAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKTDTLQSDTTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMHFDARETFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRLKGETDYVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sipA mutants have a decreased invasion of MDCK cells as compared to the wild type (Perrett and Jepson, 2009).
References
Perrett and Jepson, 2009: Perrett CA, Jepson MA. Regulation of Salmonella-induced membrane ruffling by SipA differs in strains lacking other effectors. Cellular microbiology. 2009; 11(3); 475-487. [PubMed: 19046340].