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spvC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Victor ID 2584
Gene Name spvC from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1256201
NCBI Protein GI 17233490
Locus Tag PSLT038
Protein Accession NP_490528.1
Other Database IDs UniProtKB-ID: VRP3_SALTY
UniRef100: UniRef100_P0A2N0
UniRef90: UniRef90_P15805
UniRef50: UniRef50_Q327I2
UniParc: UPI0000167F7B
EMBL: M34355
EMBL: AE006471
EMBL-CDS: AAA27162.1
EMBL-CDS: AAL23529.1
RefSeq_NT: NC_003277.1
RefSeq_NT: NC_013437.1
RefSeq_NT: NC_014476.1
PDB: 2Z8M
PDB: 2Z8N
PDB: 2Z8O
PDB: 2Z8P
DIP: DIP-46403N
GenomeReviews: AE006471_GR
KEGG: stm:PSLT038
NMPDR: fig|99287.1.peg.4459
HOGENOM: HBG673220
OMA: ESDVHPE
ProtClustDB: CLSK862802
BioCyc: STYP99287:PSLT038-MONOMER
Taxonomy ID 99287
Plasmid No pSLT
Gene Starting Position 27177
Gene Ending Position 27911
Gene Strand (Orientation) -
Protein Name hydrophilic protein
DNA Sequence 
>gi|17233403:27177-27911 Salmonella typhimurium LT2 plasmid pSLT, complete sequence
CTTACTCTGTCATCAAACGATAAAACGGTTCCTCACGTAAAGCCTGTCTCTGCATTTCGCCACCATCACG
CCCACTTCGTAGTTCATTACGATAACTGAGATATTTCCAATTTTCAGGATGAACGTCTGACTCAGGACAC
TGTCCTGAAATAACCCCATTTTCGGATAGTCTGGATTCCAGACACTCTATAAATTGCCGTGTCTTGTGGA
GAAACGACGCACTGTACTGCGAATTTTCCTGGTCTGGTTTTATATACAACGTGAACTGAGCGCCCAGGCT
AACACGGGCTTGTTGAACGACCTTCTCCATATCGGTCACTTTCCACTTATCTACCGGACTGTCCTCTGAA
AACAGCAATCCGGACAGCGCTTGAAATGCTTGTGGCACCATATCCCTGAGCACACTGATGTGGAACTTGT
CACCGGCAAATTTGCCCTGAGACTGAGGTGATTCTCGACGAGCATGGATGAAAACATCGTAACCATGGTT
ATTCAGCTGAAAACCTTGGCTCATAGCAAAGAAACCACTCTGGCGCATCCCTGAATAGTCAGGCACATCC
AGCGCCTCTTTAAAGTGGGATACCGGCATCTTCCGCATTTGGTTGTGCAAGGAGTTGAAATTATTTTTCA
GGTGCTTATTTGTAGATGGTATTTCCGCCCCATCATAAGCAGCTACAATATTCAAAGGAGGGATGTTTAG
ATTTAGATTAGGCCTATTTATGGGCATGGGAAATC
Protein Sequence 
>gi|17233490|ref|NP_490528.1| hydrophilic protein [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MPINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The spvBC-bearing plasmid was capable of replacing all of the spv genes, as well as the entire virulence plasmid, of serovar Typhimurium for causing systemic infection in BALB/c mice after subcutaneous, but not oral, inoculation. A point mutation in the spvBC plasmid preventing translation but not transcription of spvC eliminated the ability of the plasmid to confer virulence (Matsui et al., 2001).
References
Matsui et al., 2001: Matsui H, Bacot CM, Garlington WA, Doyle TJ, Roberts S, Gulig PA. Virulence plasmid-borne spvB and spvC genes can replace the 90-kilobase plasmid in conferring virulence to Salmonella enterica serovar Typhimurium in subcutaneously inoculated mice. Journal of bacteriology. 2001; 183(15); 4652-4658. [PubMed: 11443102].