Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

spvB from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594

Victor ID 3839
Gene Name spvB from Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594
NCBI Gene ID 7552347
NCBI Protein GI 224504238
Locus Tag SPC_p003
Protein Accession YP_002635577.1
Other Database IDs UniProtKB-ID: C0Q8H0_SALPC
UniRef100: UniRef100_C0Q8H0
UniRef90: UniRef90_P24419
UniRef50: UniRef50_P24419
UniParc: UPI000195111C
EMBL: CP000858
EMBL-CDS: ACN48776.1
RefSeq_NT: NC_012124.1
GenomeReviews: CP000858_GR
KEGG: sei:SPC_p003
ProtClustDB: CLSK862801
Taxonomy ID 476213
Plasmid No pSPCV
Gene Starting Position 2354
Gene Ending Position 4129
Gene Strand (Orientation) +
Protein Name SpvB
DNA Sequence 
>gi|224504235:2354-4129 Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594 plasmid pSPCV, complete sequence
TATGTTGATACTAAATGGTTTTTCATCTGCCACTTTAGCGCTGATCACTCCCCCTTTCCTGCCAAAAGGG
GGCAAGGCGCTGAGTCAGTCAGGCCCTGACGGCCTAGCCAGTATAACGCTGCCTCTGCCCATCAGCGCCG
AACGCGGCTTTGCGCCTGCGCTGGCGCTGCACTACAGCAGCGGTGGCGGCAATGGCCCCTTCGGCGTGGG
CTGGTCCTGCGCGACAATGAGCATTGCCCGCCGCACCAGCCATGGCGTGCCGCAGTATAACGACAGCGAT
GAGTTTCTGGGGCCGGACGGAGAAGTGCTGGTTCAAACGCTCAGCACCGGTGATGCCCCCAATCCCGTCA
CCTGCTTCGCGTACGGTGACGTATCGTTCCCGCAAAGCTACACGGTGACCCGCTATCAGCCCCGCACGGA
GAGCAGTTTTTATCGCCTGGAGTACTGGGTGGGCAACAGCAACGGCGATGATTTCTGGTTACTGCATGAC
AGTAACGGCATCCTGCACCTACTGGGGAAAACCGCCGCAGCACGCCTCAGCGATCCGCAGGCCGCCTCTC
ATACGGCGCAATGGCTGGTTGAGGAGTCGGTGACCCCTGCCGGCGAGCATATCTATTACTCCTACTTGGC
GGAGAACGGTGACAATGTGGACCTCAATGGGAACGAGGCCGGACGCGATCGCAGCGCCATGCGCTATCTC
AGCAAGGTACAGTATGGCAACGCGACCCCCGCCGCCGATCTGTACCTCTGGACTAGCGCCACACCCGCGG
TACAGTGGCTGTTCACCCTAGTGTTTGACTACGGCGAACGTGGTGTAGATCCACAGGTACCGCCTGCATT
CACTGCTCAGAACAGCTGGCTCGCCCGCCAGGATCCCTTCTCCCTGTATAACTACGGCTTTGAGATCCGC
CTCCATCGCCTGTGCCGCCAAGTCCTGATGTTCCACCACTTTCCTGATGAACTGGGTGAAGCCGATACGC
TGGTTTCCCGTCTGCTGCTGGAGTATGACGAAAATCCGATACTGACACAGCTTTGCGCTGCTCGGACGCT
GGCCTATGAAGGCGACGGTTATAGAAGAGCTCCTGTCAACAATATGATGCCACCGCCAGCGCCTCCTCCG
ATGATGGGAGGTAATTCATCTCGACCAAAATCAAAATGGGCGATTGTAGAGGAATCAAAGCAGATTCAAG
CTCTGAGGTACTATTCAGCTCAAGGGTACAGTGTGATTAATAAATATTTACGTGGGGATGATTATCCTGA
AACACAGGCAAAAGAAACTCTGCTCTCCAGAGACTATCTTTCCACAAATGAACCCAGTGATGAGGAGTTT
AAAAATGCCATGTCAGTTTATATAAATGATATTGCGGAGGGATTAAGTTCACTTCCCGAAACAGATCACA
GAGTCGTATACCGGGGCCTGAAGCTTGATAAGCCCGCATTATCGGATGTGCTGAAGGAATACACTACTAT
AGGTAATATAATAATAGATAAAGCTTTTATGAGTACATCGCCAGATAAGGCATGGATAAATGACACTATT
CTCAACATATACCTAGAAAAAGGACATAAAGGTAGAATACTCGGAGATGTTGCACATTTTAAGGGAGAGG
CAGAGATGCTTTTCCCTCCAAATACTAAACTCAAAATCGAAAGCATTGTAAATTGTGGATCCCAAGACTT
TGCAAGCCAGCTTAGTAAGCTGAGATTAAGTGATGATGCAACTGCTGACACAAACAGGATAAAAAGAATA
ATAAACATGAGGGTACTCAACTCATA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spvB mutants are attenuated in mice (Lesnick et al., 2001).

TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells (Lesnick et al., 2001).
References
Lesnick et al., 2001: Lesnick ML, Reiner NE, Fierer J, Guiney DG. The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells. Molecular microbiology. 2001; 39(6); 1464-1470. [PubMed: 11260464].