Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

spvB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Victor ID 2582
Gene Name spvB from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1256199
NCBI Protein GI 17233491
Locus Tag PSLT039
Protein Accession NP_490529.1
Other Database IDs UniProtKB-ID: P74846_SALTY
UniRef100: UniRef100_D0R799
UniRef90: UniRef90_P24419
UniRef50: UniRef50_P24419
UniParc: UPI00000D2F22
EMBL: AE006471
EMBL: AB576781
EMBL: Z11557
EMBL-CDS: AAL23530.1
EMBL-CDS: BAJ15338.1
EMBL-CDS: CAA77649.1
RefSeq_NT: NC_003277.1
RefSeq_NT: NC_013437.1
RefSeq_NT: NC_014476.1
GenomeReviews: AE006471_GR
KEGG: stm:PSLT039
NMPDR: fig|99287.1.peg.4460
HOGENOM: HBG673219
OMA: AWINDTI
ProtClustDB: CLSK862801
BioCyc: STYP99287:PSLT039-MONOMER
Taxonomy ID 99287
Plasmid No pSLT
Gene Starting Position 27911
Gene Ending Position 29965
Gene Strand (Orientation) -
Protein Name hydrophilic protein
DNA Sequence 
>gi|17233403:27911-29965 Salmonella typhimurium LT2 plasmid pSLT, complete sequence
CTCCTTTGCGATATGGATATATCGCCATATTATTAGATATAAATTCTCAGTTTTTTTTTAATAAAACGAT
TAGTTATCCAGAAAACCTCATTTTTTATCAGGCGAAAAAATGATATTTCGGTCCGTTCCGAGCAGAAAGT
TAAAGAAGGGTAATGGCAAAAGTTTAGATGCACTACTTTGCGGGCCTAGGCCTAGGGTGACGGAAAAATC
TGGGGTTCCGGAGTATAACCCCTTATAGAGCTAGGCCGCTCATACCACTTCTGGAATAGATTCTTAGTAT
CTATGAGTTGAGTACCCTCATGTTTATTATTCTTTTTATCCTGTTTGTGTCAGCAGTTGCATCATCACTT
AATCTCAGCTTACTAAGCTGGCTTGCAAAGTCTTGGGATCCACAATTTACAATGCTTTCGATTTTGAGTT
TAGTATTTGGAGGGAAAAGCATCTCTGCCTCTCCCTTAAAATGTGCAACATCTCCGAGTATTCTACCTTT
ATGTCCTTTTTCTAGGTATATGTTGAGAATAGTGTCATTTATCCATGCCTTATCTGGCGATGTACTCATA
AAAGCTTTATCTATTATTATATTACCTATAGTAGTGTATTCCTTCAGCACATCCGATAATGCGGGCTTAT
CAAGCTTCAGGCCCCGGTATACGACTCTGTGATCTGTTTCGGGAAGTGAACTTAATCCCTCCGCAATATC
ATTTATATAAACTGACATGGCATTTTTAAACTCCTCATCACTGGGTTCATTTGTGGAAAGATAGTCTCTG
GAGAGCAGAGTTTCTTTTGCCTGTGTTTCAGGATAATCATCCCCACGTAAATATTTATTAATCACACTGT
ACCCTTGAGCTGAATAGTACCTCAGAGCTTGAATCTGCTTTGATTCCTCTACAATCGCCCATTTTGATTT
TGGTCGAGATGAATTACCTCCCATCATCGGAGGAGGCGGTGGCGGTGGCATCATATTGTTGACAGGAGCT
CTTCTATAACCGTCGCCTTCATAGGCCAGCGTCCGAGCAGCGCAAAGCTGTGTCAGTATCGGATTTTCGT
CATACTCCAGCAGCAGACGGGAAACCAGCGTATCGGCTTCACCCAGTTCATCAGGAAAGTGGTGGAACAT
CAGGACTTGGCGGCACAGGCGATGGAGGCGGATCTCAAAGCCGTAGTTATACAGGGAGAAGGGATCCTGG
CGGGCGAGCCAGCTGTTCTGAGCAGTGAATGCAGGCGGTACCTGTGGATCTACACCACGTTCGCCGTAGT
CAAACACTAGGGTGAACAGCCACTGTACCGCGGGTGTGGCGCTAGTCCAGAGGTACAGATCGGCGGCGGG
GGTCGCGTTGCCATACTGTACCTTGCTGAGATAGCGCATGGCGCTGCGATCGCGTCCGGCCTCGTTCCCA
TTGAGGTCCACATTGTCACCGTTCTCCGCCAAGTAGGAGTAATAGATATGCTCGCCGGCAGGGGTCACCG
ACTCCTCAACCAGCCATTGCGCCGTATGAGAGGCGGCCTGCGGATCGCTGAGGCGTGCTGCGGCGGTTTT
CCCCAGCAGGTGCAGGATGCCGTTACTGTCATGCAGTAACCAGAAATCATCGCCGTTGCTGTTGCCCACC
CAGTACTCCAGGCGATAAAAACTGCTCTCCGTGCGGGGCTGATAGCGGGTCACCGTGTAGCTTTGCGGGA
ACGATACGTCACCGTACGCGAAGCAGGTGACGGGATTGGGGGCATCACCGGTGCTGAGCGTTTGAACCAG
CACTTCTCCGTCCGGCCCCAGAAACTCATCGCTGTCGTTATACTGCGGCACGCCATGGCTGGTGCGGCGG
GCAATGCTCATTGTCGCGCAGGACCAGCCCACGCCGAAGGGGCCATTGCCGCCACCGCTGCTGTAGTGCA
GCGCCAGCGCAGGCGCAAAGCCGCGTTCGGCGCTGATGGGCAGAGGCAGCGTTATACTGGCTAGGCCGTC
AGGGCCTGACTGACTCAGCGCCTTGCCCCCTTTTGGCAGGAAAGGGGGAGTGATCAGCGCTAAAGTGGCA
GATGAAAAACCATTTAGTATCAACA
Protein Sequence 
>gi|17233491|ref|NP_490529.1| hydrophilic protein [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALHYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLHRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPILTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIGNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spvB mutants are attenuated in mice (Lesnick et al., 2001).

TOXIN: spvB encodes an ADP-ribosylating enzyme that uses actin as a substrate and depolymerizes actin filaments when expressed in CHO cells (Lesnick et al., 2001).
References
Lesnick et al., 2001: Lesnick ML, Reiner NE, Fierer J, Guiney DG. The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells. Molecular microbiology. 2001; 39(6); 1464-1470. [PubMed: 11260464].