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gyrA

Victor ID 5003
Gene Name gyrA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1253794
NCBI Protein GI 16765599
Locus Tag STM2272
Genbank Accession AE006468
Protein Accession NP_461214
Taxonomy ID 700720
Gene Starting Position 2373710
Gene Ending Position 2376346
Gene Strand (Orientation) -
Protein Name DNA gyrase subunit A
Protein pI 4.73
Protein Weight 89524.22
Protein Length 878
Protein Note negatively supercoils closed circular double-stranded DNA
DNA Sequence 
>gi|16763390:2373710-2376346 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
ATTACTCGTCAGCGTCATCCGCAACGTCGTCATCGCTTTCCGCTTCCGGGGCGATATCCTCATCCCCTTC
CGCCACGCTGCCGTCGATAGCGTCGAGTTCTTCGTCATCTACCGGTTCAGCAACGCGTTGCAGACCCACC
ACGTTTTCATCTTCCGCCGTGCGGATAAGGATAACGCCCTGGGTATTACGTCCCACTACGCTGATCTCGG
ACACACGGGTACGCACCAGAGTACCGGCATCCGTGATCATCATGATCTGGTCGCAATCGTCTACCTGTAC
CGCACCGACAACGGAACCGTTGCGCTCGGTCACTTTGATAGAGATAACGCCCTGCGTCGCACGAGACTTG
GTCGGGTACTCGTCCGCTGCGGTACGCTTCCCGTAGCCGTTTTGCGTTACGGTCAGAATAGCGCCTTCGC
CGCGTGGGATGATCAGAGAGACGACTTTATCGTCTCCCGCCAGCTTAATACCGCGCACACCGGTCGCGGT
ACGCCCCATCGCACGGACGGCGTCTTCTTTGAAGCGCACCACTTTACCCGCGGCCGAGAACAGCATGACT
TCGTCAGAACCAGAAGTCAGGTCAACGCCAATCAGCTCGTCGCCGTCGTTGAGGTTCACCGCGATAATAC
CGGCGGAACGCGGACGGCTGAATTCGGTCAGCGCCGTTTTCTTCACGGTACCGCTGGCGGTCGCCATAAA
GACGTTGACGCCTTCTTCATACTCACGAACCGGCAGAATCGCGGTGATACGTTCGTTGGCTTCCAGCGGC
AGCAGGTTGACGATCGGACGACCGCGCGCGCCGCGGCTGGCTTCCGGCAGCTGATAGACCTTCATCCAGT
ACAGACGGCCCCGGCTGGAGAAGCAGAGGATGGTGTCATGGGTGTTAGCCACCAGCAGGCGGTCGATAAA
GTCTTCTTCTTTAATACGCGCGGCAGATTTACCTTTCCCACCACGACGTTGCGCTTCGTAATCTGTCAGC
GGTTGATATTTGACGTAACCCTGGTGAGACAGCGTCACGACAACATCTTCCTGGCTAATCAGATCTTCGA
TATTAATATCGGCGCTGTTGGCGGTGATTTCGGTACGACGCTCATCGCCGAACTGATCGCGAATTAACTC
CATCTCTTCGCGGATCACTTCCATCAGGCGATCGGCGCTGCCCAGAATGTGCAGCAATTCAGCAATCTGC
TCCAGCAGCTCTTTGTATTCGTCGAGCAGTTTTTCATGCTCCAGGCCGGTCAGTTTCTGCAAACGCAGAT
CCAGAATCGCCTGCGCCTGCTGTTCAGTCAGGTAGTACTGACCGTCACGCACGCCAAATTCTGGCTCCAG
CCATTCCGGACGCGCGGCGTCATCACCAGCGCGCTCCAGCATCGCAGCAACGTTGCCCAGATCCCACGGA
CGCGAAATCAGCGCCGCTTTTGCTTCCGCCGGCGTTGGCGCGCGGCGAATCAGTTCGATAATCGGGTCGA
TGTTGGCCAGCGCAATCGCCAGAGCTTCAAGGATATGCGCACGGTCACGGGCTTTACGCAGTTCAAAAAT
AGTCCGACGCGTCACCACTTCACGGCGGTGGCGCACGAACGCTGAAATGATATCTTTCAGGTTCATGATC
TTCGGCTGGCCGTGATGCAGCGCCACCATGTTAATACCGAAGGAAACCTGTAGCTGGGTCTGGGAGTAGA
GATTATTAAGCACCACCTCGCCCACCGCATCGCGTTTCACTTCAATCACGATGCGCATCCCGTCTTTGTC
GGATTCGTCACGCAGCGCGCTGATGCCTTCCACGCGTTTATCTTTCACCAGCTCGGCGATTTTCTCGATC
AGGCGCGCTTTGTTCACCTGATAGGGAATTTCATGGACGATGATGGTTTCACGGCCCGTTTTGGCGTCAG
CTTCAACTTCCGCGCGGGCGCGAATGTACACTTTGCCACGACCGGTGCGGTAGGCTTCTTCGATACCACG
ACGACCGTTGATGATCGCGGCGGTCGGGAAGTCCGGCCCCGGAATATGTTCCATCAGCCCTTCAATGCTG
ATGTCTTCGTTGTCGATATACGCCAGGCAGCCGTTAATCACTTCCGTCAGGTTGTGCGGCGGGATATTCG
TCGCCATACCTACTGCGATACCGGAAGAACCGTTCACCAGCAGATTCGGAATTTTGGTCGGCATGACGTC
CGGAATTTTTTCCGTACCGTCATAGTTATCCACGAAATCCACCGTCTCTTTTTCGAGATCGGCCATCAGT
TCGTGGGCGATTTTCGCCAGACGGATCTCCGTATAACGCATTGCCGCCGCGGAGTCGCCGTCAATAGAAC
CGAAGTTACCCTGACCATCCACCAGCATGTAACGCAGCGAGAATGGCTGCGCCATACGAACGATGGTGTC
ATACACTGCGGAATCGCCGTGGGGATGGTATTTACCGATTACGTCACCAACGACACGGGCAGATTTTTTA
TAGGCTTTGTTCCAGTCATTGCCCAATACGTTCATGGCGTAAAGTACGCGACGGTGTACCGGCTTCAGGC
CATCTCGGACATCCGGCAGCGCACGGCCAACAATGACCGACATCGCATAATCCAGATAGGAGCTCTTCAG
CTCCTCCTCAATGTTGACCGGTGTAATTTCTCTCGCAAGGTCGCTCA
Protein Sequence 
>gi|16765599|ref|NP_461214.1| DNA gyrase subunit A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVV
GDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEK
ETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDNEDISIEGLME
HIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAEL
VKDKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDI
ISAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNV
AAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLH
ILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANER
ITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAA
GKVVRFKEDAVRAMGRTATGVRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQG
VISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVA
EPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A gyrA-cpxA-rpoB Salmonella Typhimurium mutant was attenuated in pigs (Roesler et al., 2004).
COG COG0188L, under L: Replication, recombination and repair
References
Roesler et al., 2004: Roesler U, Marg H, Schröder I, Mauer S, Arnold T, Lehmann J, Truyen U, Hensel A. Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant. Vaccine. 2004; 23(5); 595-603. [PubMed: 15542179].