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sifA

Victor ID 2643
Gene Name sifA
Sequence Strain (Species/Organism) Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID 1252742
NCBI Protein GI 16764579
Locus Tag STM1224
Protein Accession NP_460194.1
Other Database IDs UniProtKB-ID: SIFA_SALTY
UniRef100: UniRef100_Q56061
UniRef90: UniRef90_Q56061
UniRef50: UniRef50_Q56061
UniParc: UPI0000049ED6
EMBL: U51867
EMBL: AE006468
EMBL-CDS: AAA97467.1
EMBL-CDS: AAL20153.1
RefSeq_NT: NC_003197.1
PDB: 3CXB
PDB: 3HW2
DIP: DIP-46411N
GenomeReviews: AE006468_GR
KEGG: stm:STM1224
NMPDR: fig|99287.1.peg.1185
HOGENOM: HBG671339
OMA: AFLETMT
ProtClustDB: PRK09498
BioCyc: STYP99287:STM1224-MONOMER
Taxonomy ID 99287
Gene Starting Position 1309843
Gene Ending Position 1310853
Gene Strand (Orientation) -
Protein Name secreted effector protein
DNA Sequence 
>gi|16763390:1309843-1310853 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome
TTTATAAAAAACAACATAAACAGCCGCTTTGTTGTTCTGAGCGAACGTGTAGCGTGGTTAACTGTTCTTC
CGCCATTTTTTGTATAGCCTGGGGGTCTATTCTAAAAATGGCGTGAAAAACCTGATCAGAGATGGCTTCG
ACTATCTCAGCTAACATACTTTGGCTGGTGCTGGGATCCGTTACGAGGAACGCCTGAAACGTCTTATCCG
CTAGTAAAACCTCTTTTACCATTTTTTCAATAGGTATGTGGGTATGCGGTGGTGGTATTTCAAGCTGTTT
TAATCCACACATCGCCATTGTTTCTAAAAATGCGTTTTGCTGAGTACTTTCGGATATATTCGCATGGTGT
AAAATGCGCGTTGTCTTTTCAATCCCAGACTGAATTTTCGCTGCCAGGTAGGTTGCCTTTTCTTGCGCTT
TCCACCCATCTAAATGTCCTTTTCTCAATTCAGTATATAAATACCCCTCTATGTTGTCTAATGGAACCGA
TAATATCGGCGCGCCAGCAGGATTGAGACATAATGTCGAAGGGAGGGGGTAGTCTACGATTTCGCTATAT
CTTCTCTTAATCATGGCCGTCATTTGTGGATGCGATTTTAAAATATCCGGGCGATCTTTCATTAAAAAAT
AAAGATTCCCCATGACTTCACAGCTAAAGGTATCGGTATTTTGAGTGATACGTAACAATTCGTTCTCTTC
GTTTTGATCCATGATGCGAAGAATAATGGTGGCATCATTTTCATGAGGATTATGAACCTGAAATCTATCT
CTTTGCGATGCGCAGGCTAACTCTTTCAACTCAAAAAAAATCTCTGTAAGCCGCTCTCGTGTGGGGGCGC
GTTCGGCAAACAACATCTCATGTAGACAACGGTCCGCTTTTGCTTTGCCAGTAGAAAAAAAGAAGTCTTT
AATTTTTTCCCATAAAACTTTCCACCATGCTTCTTTCGTATTCCTTGGGGAGTTGGTAAGGATTTCACTT
TTTAAAAAACCATTCCCTATAGTAATCGGCA
Protein Sequence 
>gi|16764579|ref|NP_460194.1| secreted effector protein SifA [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MPITIGNGFLKSEILTNSPRNTKEAWWKVLWEKIKDFFFSTGKAKADRCLHEMLFAERAPTRERLTEIFFELKELACASQRDRFQVHNPHENDATIILRIMDQNEENELLRITQNTDTFSCEVMGNLYFLMKDRPDILKSHPQMTAMIKRRYSEIVDYPLPSTLCLNPAGAPILSVPLDNIEGYLYTELRKGHLDGWKAQEKATYLAAKIQSGIEKTTRILHHANISESTQQNAFLETMAMCGLKQLEIPPPHTHIPIEKMVKEVLLADKTFQAFLVTDPSTSQSMLAEIVEAISDQVFHAIFRIDPQAIQKMAEEQLTTLHVRSEQQSGCLCCFL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: sifA mutants are attenuated in mice and don't induce Salmonella-produced filaments in epithelial cells (Stein et al., 1996).
References
Stein et al., 1996: Stein MA, Leung KY, Zwick M, Garcia-del Portillo F, Finlay BB. Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Molecular microbiology. 1996; 20(1); 151-164. [PubMed: 8861213].